Clary B Clish

Clary B Clish

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Clary B Clish

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Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.

Cell Metab 2019 Sep 25;30(3):573-593.e8. Epub 2019 Jul 25.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.06.018DOI Listing
September 2019

Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions.

Metabolites 2019 Sep 7;9(9). Epub 2019 Sep 7.

PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA.

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http://dx.doi.org/10.3390/metabo9090179DOI Listing
September 2019

Identifying metabolomic profiles of inflammatory diets in postmenopausal women.

Clin Nutr 2019 Jun 17. Epub 2019 Jun 17.

Division of Women's Health, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA; Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1016/j.clnu.2019.06.010DOI Listing
June 2019

Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.

Cell Host Microbe 2019 05;25(5):668-680.e7

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128193020
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http://dx.doi.org/10.1016/j.chom.2019.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544385PMC
May 2019

Selenium Deficiency Is Associated with Pro-longevity Mechanisms.

Cell Rep 2019 May;27(9):2785-2797.e3

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689410PMC
May 2019

Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis.

Neurology 2019 Apr 14;92(18):e2081-e2088. Epub 2018 Nov 14.

From the Departments of Nutrition (K.B., É.J.O., Z.Z., A.A.) and Epidemiology (J.E.M., A.A.), Harvard T.H. Chan School of Public Health, Boston, MA; School of Public Health (É.J.O.), College of Medicine, University College Cork, Ireland; Department of Neurology (J.D.B., M.A.S.), Massachusetts General Hospital (S.P.), Boston; Metabolomics Platform (C.B.C., S.J.), Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge; Department of Oncology (I.K.), Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI; Epidemiology Program (L.N.K., L.L.M.), University of Hawaii Cancer Center, Honolulu; Epidemiology Research Program (M.L.M.), American Cancer Society, Atlanta, GA; Department of Physical Medicine and Rehabilitation (S.P.), Spaulding Rehabilitation Hospital, Charlestown; Harvard Medical School (S.P., M.A.S.), Boston, MA; Department of Epidemiology (E.O.T.), Graduate School of Public Health, University of Pittsburgh, PA; Department of Epidemiology (R.B.W.), College of Public Health, University of Iowa, Iowa City; and Department of Medicine (J.E.M.) and Channing Division of Network Medicine (A.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000006669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512885PMC
April 2019

Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD Recycling.

Cell Metab 2019 Apr 24;29(4):856-870.e7. Epub 2019 Jan 24.

Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA; Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Metabolism Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447447PMC
April 2019

The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling.

ACS Infect Dis 2019 Apr 21;5(4):515-520. Epub 2019 Feb 21.

Harvard T.H. Chan School of Public Health , 665 Huntington Avenue , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.8b00363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747701PMC
April 2019

Prediagnostic plasma metabolomics and the risk of amyotrophic lateral sclerosis.

Neurology 2019 Apr 29;92(18):e2089-e2100. Epub 2019 Mar 29.

From the Departments of Nutrition (K.B., Z.Z., É.J.O., D.D.W., A.A.) and Epidemiology (L.L., J.E.M., A.A.), Harvard T.H. Chan School of Public Health, Boston, MA; School of Public Health (É.J.O.), College of Medicine, University College Cork, Ireland; Department of Neurology (J.D.B., M.A.S.), Massachusetts General Hospital, Boston; Metabolomics Platform (C.B.C., A.D., S.J., K.A.P.), Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA; Department of Oncology (I.K.), Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI; Channing Division of Network Medicine (R.S.K., A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Epidemiology Program (L.N.K., L.L.M.), University of Hawaii Cancer Center, Honolulu; Behavioral and Epidemiology Research Group (M.L.M.), American Cancer Society, Atlanta, GA; Department of Physical Medicine and Rehabilitation (S.P.), Spaulding Rehabilitation Hospital and Massachusetts General Hospital; Harvard Medical School (S.P., M.A.S.), Boston, MA; Family Medicine and Public Health (A.H.S.), School of Medicine, University of California San Diego; Epidemiology and Environmental Health, Public Health and Health Professions (J.W.-W.), University at Buffalo, NY; Behavioral and Epidemiology Research Group (Y.W.), American Cancer Society, Atlanta, GA; and Department of Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000007401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512888PMC
April 2019

Variability of Two Metabolomic Platforms in CKD.

Clin J Am Soc Nephrol 2019 Jan 20;14(1):40-48. Epub 2018 Dec 20.

Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland;

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http://dx.doi.org/10.2215/CJN.07070618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364529PMC
January 2019

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism.

Mol Psychiatry 2018 12 18;23(12):2287-2301. Epub 2018 Jun 18.

Section of Integrative Physiology and Metabolism, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA, 02215, USA.

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http://www.nature.com/articles/s41380-018-0086-5
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http://dx.doi.org/10.1038/s41380-018-0086-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294739PMC
December 2018

Clinical and metabolomic risk factors associated with rapid renal function decline in sickle cell disease.

Am J Hematol 2018 12 27;93(12):1451-1460. Epub 2018 Sep 27.

Department of Medicine, Division of Hematology and Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1002/ajh.25263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397774PMC
December 2018

Metabolites Associated With the Risk of Incident Venous Thromboembolism: A Metabolomic Analysis.

J Am Heart Assoc 2018 11;7(22):e010317

3 Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA.

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http://dx.doi.org/10.1161/JAHA.118.010317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404443PMC
November 2018

Endospores and other lysis-resistant bacteria comprise a widely shared core community within the human microbiota.

ISME J 2018 10 13;12(10):2403-2416. Epub 2018 Jun 13.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41396-018-0192-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157131PMC
October 2018

An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma.

Chest 2018 08 13;154(2):335-348. Epub 2018 Jun 13.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1016/j.chest.2018.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689076PMC
August 2018

Time-Dependent Molecular Responses Differ between Gastric Bypass and Dieting but Are Conserved Across Species.

Cell Metab 2018 08 28;28(2):310-323.e6. Epub 2018 Jun 28.

Center for Basic and Translational Obesity Research, Division of Endocrinology, CLS16066, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628900PMC
August 2018

Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma.

Proc Natl Acad Sci U S A 2018 07 18;115(27):E6283-E6290. Epub 2018 Jun 18.

Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1711888115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142220PMC
July 2018

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.

Cell Rep 2018 Jul;24(4):838-850

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156773PMC
July 2018

Ablation of insulin receptor substrates 1 and 2 suppresses -driven lung tumorigenesis.

Proc Natl Acad Sci U S A 2018 04 2;115(16):4228-4233. Epub 2018 Apr 2.

Center for Basic and Translational Obesity Research, Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1718414115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910837PMC
April 2018

Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites.

Cell Rep 2018 03;22(11):3072-3086

Section of Integrative Physiology and Metabolism, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880543PMC
March 2018

Plasma lipidome patterns associated with cardiovascular risk in the PREDIMED trial: A case-cohort study.

Int J Cardiol 2018 02;253:126-132

University of Navarra, Department of Preventive Medicine and Public Health, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759348PMC
February 2018

Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol.

Atherosclerosis 2018 01 21;268:196-206. Epub 2017 Sep 21.

Center for Genomic Medicine and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.08.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750127PMC
January 2018

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass.

Science 2017 11 12;358(6365):941-946. Epub 2017 Oct 12.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aam9305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748897PMC
November 2017

Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.

Cancer Res 2017 10 3;77(19):5272-5286. Epub 2017 Aug 3.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772763PMC
October 2017

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.

Nat Commun 2017 09 20;8(1):623. Epub 2017 Sep 20.

Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, 02139, USA.

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http://dx.doi.org/10.1038/s41467-017-00353-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606996PMC
September 2017

Comprehensive Metabolomic Profiling and Incident Cardiovascular Disease: A Systematic Review.

J Am Heart Assoc 2017 Sep 28;6(10). Epub 2017 Sep 28.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

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http://dx.doi.org/10.1161/JAHA.117.005705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721826PMC
September 2017

Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy.

Proc Natl Acad Sci U S A 2017 08 17;114(31):8402-8407. Epub 2017 Jul 17.

Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1703338114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547614PMC
August 2017

Identifying the metabolomic fingerprint of high and low flavonoid consumers.

J Nutr Sci 2017 14;6:e34. Epub 2017 Jul 14.

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1017/jns.2017.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672306PMC
July 2017

Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease.

Kidney Int 2017 06 14;91(6):1426-1435. Epub 2017 Mar 14.

National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA; Division of Endocrinology and Metabolism, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.01.007DOI Listing
June 2017

Cigarette Smoking and Pancreatic Cancer Survival.

J Clin Oncol 2017 Jun 30;35(16):1822-1828. Epub 2017 Mar 30.

Chen Yuan, Vicente Morales-Oyarvide, Ana Babic, Zhi Rong Qian, Douglas A. Rubinson, Kimmie Ng, Shuji Ogino, Charles S. Fuchs, and Brian M. Wolpin, Dana-Farber Cancer Institute and Harvard Medical School; Chen Yuan, Peter Kraft, Edward L. Giovannucci, Shuji Ogino, Meir J. Stampfer, Howard D. Sesso, and JoAnn E. Manson, Harvard School of Public Health; Ying Bao, Edward L. Giovannucci, Shuji Ogino, Meir J. Stampfer, John Michael Gaziano, Howard D. Sesso, JoAnn E. Manson, and Charles S. Fuchs, Brigham and Women's Hospital and Harvard Medical School; John Michael Gaziano, Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston; Clary B. Clish, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA; and Barbara B. Cochrane, University of Washington School of Nursing, Seattle, WA.

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http://dx.doi.org/10.1200/JCO.2016.71.2026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455596PMC
June 2017

Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea).

Circulation 2017 May 9;135(21):2028-2040. Epub 2017 Mar 9.

From Department of Nutrition (D.D.W., W.C.W., Q.S., Y.Z., M.G.-F., C.-H.L., F.B.H.); Department of Epidemiology (D.D.W., W.C.W., L.L., F.B.H.), Department of Biostatistics (B.A.R., L.L.), Department of Genetics and Complex Diseases (C.-H.L.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutrition (M.A.M.-G.), Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain (E.T., C.R., M.R.-C., M.A.M.-G.); Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (E.T., C.R., M.R.-C., M.A.M.-G.); CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain (E.T., C.R., M.R.-C., D.C., M.F., R.E., E.R., J.L., M.F., F.A., L.S.-M., J.S.-S., M.A.M.-G.); Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University and Tufts University Friedman School of Nutrition Science and Policy, Boston, MA (A.H.); Channing Division for Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (B.A.R., W.C.W., Q.S., F.B.H.); Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institut d'Investigació Sanitària Pere Virgili, Rovira i Virgili University, Reus, Spain (M.G.-F., J.S.-S.); Department of Preventive Medicine, University of Valencia, Spain (D.C.); Department of Preventive Medicine, University of Málaga, Spain (E.G.-G.); University Institute of Health Sciences (IUNICS), University of Balearic Islands and Hospital Son Espases, Palma de Mallorca, Spain (M.F.); Department of Internal Medicine (R.E.), Lipid Clinic, Department of Endocrinology and Nutrition Institut d'Investigacions Biomediques August Pi Sunyer (IDI- BAPS), Hospital Clinic, University of Barcelona, Spain (E.R.); Department of Family Medicine, Primary Care Division of Sevilla, San Pablo Health Center, Sevilla, Spain (J.L.); Cardiovascular and Nutrition Research Group, Institut de Recerca Hospital del Mar, Barcelona, Spain (M.F.); Department of Cardiology, University Hospital of Alava, Vitoria, Spain (F.A.); Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Spain (L.S.-M.); and Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA (C.B.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496817PMC
May 2017

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis.

Neuron 2017 May 13;94(3):581-594.e5. Epub 2017 Apr 13.

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.03.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474951PMC
May 2017

Metabolomic profiles as reliable biomarkers of dietary composition.

Am J Clin Nutr 2017 03 11;105(3):547-554. Epub 2017 Jan 11.

New Balance Foundation Obesity Prevention Center, Boston Children's Hospital, Boston, MA;

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https://academic.oup.com/ajcn/article/105/3/547-554/4637851
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http://dx.doi.org/10.3945/ajcn.116.144428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320413PMC
March 2017

Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines.

J Proteome Res 2017 02 28;16(2):481-493. Epub 2016 Nov 28.

Center for Experimental Drugs and Diagnostics, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Harvard Medical School and Massachusetts General Hospital , Boston, Massachusetts 02114, United States.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.6b00628
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http://dx.doi.org/10.1021/acs.jproteome.6b00628DOI Listing
February 2017

Starved epithelial cells uptake extracellular matrix for survival.

Nat Commun 2017 01 10;8:13989. Epub 2017 Jan 10.

Division of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.

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http://www.nature.com/doifinder/10.1038/ncomms13989
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http://dx.doi.org/10.1038/ncomms13989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234072PMC
January 2017

Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C.

World J Gastroenterol 2016 Dec;22(45):9954-9965

Esperance AK Schaefer, James Meixiong, Christina Mark, Daniel L Motola, Dahlene Fusco, Andrew Yang, Cynthia Brisac, Shadi Salloum, Wenyu Lin, Lee F Peng, Raymond T Chung, Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, United States.

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http://dx.doi.org/10.3748/wjg.v22.i45.9954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143762PMC
December 2016

Revealing disease-associated pathways by network integration of untargeted metabolomics.

Nat Methods 2016 09 1;13(9):770-6. Epub 2016 Aug 1.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.3940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209295PMC
September 2016

Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) Trial.

J Am Heart Assoc 2016 09 15;5(9). Epub 2016 Sep 15.

Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain IDISNA (Instituto de Investigación Sanitaria de Navarra), Pamplona, Spain CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain

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http://dx.doi.org/10.1161/JAHA.116.003755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079035PMC
September 2016

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Cell 2016 Sep 15;167(1):171-186.e15. Epub 2016 Sep 15.

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163115
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http://dx.doi.org/10.1016/j.cell.2016.08.057DOI Listing
September 2016

Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder.

Mol Neuropsychiatry 2016 Jul 24;2(2):97-106. Epub 2016 Jun 24.

Center for Experimental Drugs and Diagnostics, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Harvard Medical School and Massachusetts General Hospital, Boston, Mass., USA; Chemical Biology Program, Broad Institute of Harvard and MIT, Mass., USA; Chemical Biology Program, Broad Institute of Harvard and MIT, Mass., USA.

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http://dx.doi.org/10.1159/000446654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996006PMC
July 2016

Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions.

Am J Clin Nutr 2016 Jun 20;103(6):1408-16. Epub 2016 Apr 20.

Human Nutrition Department, Pere Virgili Research Institute, University Hospital of Sant Joan de Reus, Rovira i Virgili University, Reus, Spain; The Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Institute Carlos III, Madrid, Spain;

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http://dx.doi.org/10.3945/ajcn.116.130492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881000PMC
June 2016

Targeting MTHFD2 in acute myeloid leukemia.

J Exp Med 2016 06 20;213(7):1285-306. Epub 2016 Jun 20.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215 Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215 Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142

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http://dx.doi.org/10.1084/jem.20151574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925018PMC
June 2016

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

Genes Dev 2016 05 28;30(9):1020-33. Epub 2016 Apr 28.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.278549.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863734PMC
May 2016

Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis.

Diabetes Care 2016 May;39(5):833-46

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA

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http://dx.doi.org/10.2337/dc15-2251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839172PMC
May 2016

Metabolomics: an emerging but powerful tool for precision medicine.

Authors:
Clary B Clish

Cold Spring Harb Mol Case Stud 2015 Oct;1(1):a000588

Broad Institute of MIT and Harvard University, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1101/mcs.a000588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850886PMC
October 2015