Publications by authors named "Clare Quigley"

8 Publications

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Post-Coronavirus Disease 2019 (COVID-19) Syndrome Associated with Central Retinal Vein Occlusion: A Case Report.

Ocul Immunol Inflamm 2021 Oct 12:1-3. Epub 2021 Oct 12.

Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.

Purpose: Coronavirus Disease 2019 (COVID-19) pneumonia may predispose to thromboembolic disease, including after the acute phase. We report on a unique case of central retinal vein occlusion (CRVO) occurring eight months after diagnosis of Coronavirus Disease 2019 (COVID-19) pneumonia in a likely case of post-COVID-19 syndrome.

Case Report: A 42-year-old man developed blurred vision in his right eye eight months after symptoms of pneumonia. He had no underlying medical conditions, but experienced exertional chest pain since diagnosis of COVID-19 was confirmed by detection of SARS-CoV-2 on nasopharyngeal swab and was also seeing cardiology for management of myocarditis. His best-corrected visual acuity on snellen chart testing was reduced to 6/18 in the affected right eye, and dilated fundal examination revealed a non-ischaemic CRVO.

Conclusion: The thromboembolic complications of COVID-19 may extend to CRVO, which in this case presented months after onset of symptoms of pneumonia, in association with myocarditis.
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http://dx.doi.org/10.1080/09273948.2021.1977830DOI Listing
October 2021

Comment on: 'Neuroradiology for ophthalmologists'.

Authors:
Clare Quigley

Eye (Lond) 2021 04 6;35(4):1284. Epub 2020 Jul 6.

Royal Victoria Eye and Ear Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1038/s41433-020-1075-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115654PMC
April 2021

Iris-fixated phakic intraocular lens explantation.

Eur J Ophthalmol 2021 May 14;31(3):988-993. Epub 2020 Jun 14.

Mater Private Hospital, Dublin, Ireland.

Background/aims: To evaluate the visual outcomes and indication for surgery in a series of patients who underwent explantation of a phakic intraocular lens (PIOL).

Methods: A retrospective case series of patients who underwent PIOL explantation in our institution was performed. The indication for explantation and visual and refractive outcomes were examined. The method of explantation is described.

Results: Twenty-two eyes of 16 patients underwent PIOL explantation with a mean time to explantation of 7 ± 3 years (range 3-11.4). The mean age at explantation was 50.3 ± 9.3 years. Sixteen Artisan PIOLs and six Artiflex PIOLs were explanted. The indications for explanation were cataract development (17/22), endothelial cell loss (4/22) and synechiae formation (1/22). All patients with cataract underwent a combined procedure with explantation and phacoemulsification and the placement of a posterior chamber IOL. Mean corrected vision after explantation was 0.22 ± 0.10 logMAR (range 0.1-0.3 logMAR). One patient with endothelial cell loss required a Descemet's Stripping Endothelial Keratoplasty (DSEK).

Conclusion: Removal of PIOLs was necessitated most frequently by cataract followed by endothelial cell loss. Both explantation alone and explantation with concurrent phacoemulsification are safe procedures with good visual outcomes and will become more frequent in the future as more patients with PIOLs reach cataractous age.
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http://dx.doi.org/10.1177/1120672120934985DOI Listing
May 2021

Refractive error and vision problems in children: association with increased sedentary behavior and reduced exercise in 9-year-old children in Ireland.

J AAPOS 2019 06 16;23(3):159.e1-159.e6. Epub 2019 May 16.

Department of Ophthalmology, Galway University Hospital, Ireland.

Purpose: To investigate whether refractive error and vision problems in children are associated with increased sedentary behavior and reduced participation in physical activity and sport and, secondarily, to examine the relationship between vision problems and body mass index.

Methods: This was a cross-sectional study of the first wave of the Growing Up in Ireland (GUI) Study, a nationally representative study of children in Ireland. Data was collected between August 2007 and May 2008. Body mass index (BMI) was calculated at the time of the interview. The presence of a vision problem requiring treatment, including refractive error, was detected by report of the primary care giver, usually the mother. Association between vision problems and sedentary behavior, physical activity, and level of participation in sports was investigated in adjusted regression analysis.

Results: A total of 8,568 children (mean age, 9 ± 0.13 years; 4,024 [48.68%] males) were included. The presence of refractive error or a vision problem was reported for 1,000 (11.68%) children. The majority of children had normal weight, but 1,497 (17.5%) were overweight, and 446 (5.2%) were obese. A positive association between vision problems and sedentary behavior (P = 0.00089) and an inverse association with exercise (P = 0.01) were found. Overall, vision problems were not associated with BMI.

Conclusions: In this study cohort, refractive error and vision problems were associated with increased sedentary behavior and decreased physical activity, although no causal relationship was established.
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http://dx.doi.org/10.1016/j.jaapos.2018.12.011DOI Listing
June 2019

National incidence of eyelid cancer in Ireland (2005-2015).

Eye (Lond) 2019 10 11;33(10):1534-1539. Epub 2019 Apr 11.

Sligo University Hospital, Sligo, Ireland.

Aims: We report on the incidence of cutaneous eyelid tumours in Ireland over the 11-year-period from 2005 to 2015, we identify associations between demographic factors and cutaneous eyelid tumour risk.

Methods: Skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), melanoma, and other cancers, located on the eyelid or canthus according to ICD-10 coding, as registered by the National Cancer Registry of Ireland (NCRI), were captured from the period 2005 to 2015. Age standardised rates (ASR) were calculated according to the European Standard Population (2013). Longitudinal data analysis using linear regression, and associations with age and sex were evaluated with the statistics program R.

Results: There were 4824 patients diagnosed with eyelid BCC during the study period, the ASR in men and women was mean 15.87 and 13.49 per 100,00, respectively. The relative risk for eyelid BCC in men compared with women was 1.18, age was associated with incidence. There were 528 patients diagnosed with SCC; the ASR of eyelid SCC in men and women was 2.10 and 1.39 per 100,000, respectively, and increased in women annually (β = 0.07, p = 0.0005). The relative risk for eyelid SCC in men compared with women was 1.51, and age was exponentially associated with SCC. Melanoma and other eyelid tumours were uncommon-50 and 55 cases, respectively.

Conclusion: Incidence of both BCC and SCC increases with age and male sex. The incidence of eyelid SCC is increasing in women, and under age 50, eyelid BCC is more common in women than men.

Synopsis: We describe the recent incidence of eyelid cancers in Ireland, from National Cancer Registry Data. We find eyelid BCC, and also SCC, are associated with increased age. Rate of eyelid SCC is increasing in women.
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http://dx.doi.org/10.1038/s41433-019-0437-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002498PMC
October 2019

A retrospective evaluation of bilateral medial rectus recession for management of accommodative esotropia according to prism-adapted motor response preoperatively.

J AAPOS 2017 Apr 14;21(2):157-159.e1. Epub 2017 Feb 14.

Department of Ophthalmology, Sligo Regional Hospital, Sligo, Ireland.

The prism adaptation test (PAT) is a preoperative tool that may fine-tune surgical dosage and reduce under- and overcorrection in pediatric partially accommodative esotropia; however, it is resource intensive and the benefits are uncertain. PAT involves correction of esodeviation with prisms, with subsequent assessment for and quantification of change in angle of esodeviation, thereby augmenting the surgical target angle in a subset of patients. We evaluated PAT response and postoperative outcomes in a cohort of children who underwent bilateral medial rectus recession and found that 36% of patients showed a requirement for increase of prism dosage to retain orthotropia during PAT; these patients did better than those whose deviation was stable, with postoperative rate of motor success (defined as ≤10 esotropia) of 100% versus 56%. PAT may be a useful positive prognostic test, and it also identifies a substantial patient population who may avoid undercorrection, the prism builders. However, this cohort may do better postoperatively regardless of the target angle for surgery. Additional randomized studies are required to demonstrate definitive benefit of PAT. Identification of the builder phenotype prior to commencing adaptation may reduce the workload involved in the PAT technique.
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http://dx.doi.org/10.1016/j.jaapos.2016.10.007DOI Listing
April 2017

Association between home birth and breast feeding outcomes: a cross-sectional study in 28 125 mother-infant pairs from Ireland and the UK.

BMJ Open 2016 08 8;6(8):e010551. Epub 2016 Aug 8.

Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.

Objectives: To examine the association between breast feeding outcomes and place of birth (home vs hospital birth).

Design: Population-based cross-sectional study.

Setting: Ireland and UK.

Participants: 10 604 mother-infant pairs from the Growing Up in Ireland study (GUI, 2008-2009) and 17 521 pairs from the UK Millennium Cohort Study (UKMCS, 2001-2002) at low risk of delivery complications were included in the study.

Primary And Secondary Outcome Measures: Breast feeding initiation, exclusivity and duration.

Results: Home birth was found to be significantly associated with breast feeding at all examined time points, including at birth, 8 weeks, 6 months and breast feeding exclusively at 6 months. In GUI, adjusted OR was 1.90 (95% CI 1.19 to 3.02), 1.78 (1.18 to 2.69), 1.85 (1.23 to 2.77) and 2.77 (1.78 to 4.33), respectively, and in UKMCS it was 2.49 (1.84 to 3.44), 2.49 (1.92 to 3.26), 2.90 (2.25 to 3.73) and 2.24 (1.14 to 4.03).

Conclusions: Home birth was strongly associated with improved breast feeding outcomes in low-risk deliveries. While the association between home birth and breast feeding is unlikely to be directly causal, further research is needed to determine which factor(s) drive the observed differences, to facilitate development of perinatal care that supports breast feeding.
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http://dx.doi.org/10.1136/bmjopen-2015-010551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985866PMC
August 2016
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