Publications

Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators.
Ann Rheum Dis 2018 Mar 8;77(3):459. Epub 2018 Jan 8.
Department of Internal Medicine III - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany.

Poly(ADP-ribose) polymerase-1 regulates fibroblast activation in systemic sclerosis.
Ann Rheum Dis 2018 Feb 3. Epub 2018 Feb 3.
Department of Internal Medicine 3 for Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), University Hospital of Erlangen, Erlangen, Germany.

The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis.
Ann Rheum Dis 2018 Jan 25;77(1):150-158. Epub 2017 Oct 25.
Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Bayern, Germany.

Nintedanib inhibits macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis.
Ann Rheum Dis 2017 Nov 16;76(11):1941-1948. Epub 2017 Aug 16.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment.
Ann Rheum Dis 2017 Aug 6;76(8):1467-1475. Epub 2017 May 6.
Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.

Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosis.
Ann Rheum Dis 2017 Jan 25;76(1):244-251. Epub 2016 Apr 25.
Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.


Activating transcription factor 3 regulates canonical TGFβ signalling in systemic sclerosis.
Ann Rheum Dis 2016 Mar 14;75(3):586-92. Epub 2015 Jan 14.
Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis.
Ann Rheum Dis 2016 Mar 20;75(3):609-16. Epub 2015 Jan 20.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Type 2 innate lymphoid cell counts are increased in patients with systemic sclerosis and correlate with the extent of fibrosis.
Ann Rheum Dis 2016 Mar 2;75(3):623-6. Epub 2015 Sep 2.
Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

S100A4 amplifies TGF-β-induced fibroblast activation in systemic sclerosis.
Ann Rheum Dis 2015 Sep 7;74(9):1748-55. Epub 2014 Apr 7.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.



Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis.
Ann Rheum Dis 2015 May 15;74(5):936-43. Epub 2014 Jan 15.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Cardiomyopathy in murine models of systemic sclerosis.
Arthritis Rheumatol 2015 Feb;67(2):508-16
Karolinska University Hospital, Solna, Sweden, Karolinska Institute, Stockholm, Sweden; University of Erlangen-Nuremberg, Erlangen, Germany.



The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis.
Ann Rheum Dis 2014 Jun 22;73(6):1232-9. Epub 2013 May 22.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, , Erlangen, Germany.

Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling.
Ann Rheum Dis 2014 Mar 20;73(3):624-7. Epub 2013 Nov 20.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, , Erlangen, Germany.

Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling.
Ann Rheum Dis 2013 Sep 12;72(9):1575-80. Epub 2012 Nov 12.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis.
Ann Rheum Dis 2013 Jul 17;72(7):1255-8. Epub 2013 Apr 17.
Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis.
Ann Rheum Dis 2013 May 12;72(5):761-8. Epub 2012 Sep 12.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis.
Ann Rheum Dis 2013 Apr 21;72(4):614-20. Epub 2012 Aug 21.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Ulmenweg 18, Erlangen D-91054, Germany.

Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1.
Ann Rheum Dis 2012 Dec 22;71(12):2051-4. Epub 2012 Aug 22.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Pomalidomide is effective for prevention and treatment of experimental skin fibrosis.
Ann Rheum Dis 2012 Nov 17;71(11):1895-9. Epub 2012 Aug 17.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.


Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease.
Blood 2012 Oct 22;120(14):2909-17. Epub 2012 Aug 22.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.
Ann Rheum Dis 2012 Jun 20;71(6):1081-7. Epub 2012 Jan 20.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.


Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis.
Ann Rheum Dis 2012 May 18;71(5):737-45. Epub 2012 Jan 18.
Department for Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis.
Ann Rheum Dis 2012 May 10;71(5):761-7. Epub 2012 Feb 10.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis.
Ann Rheum Dis 2012 May 8;71(5):785-9. Epub 2012 Mar 8.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.


The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis.
Ann Rheum Dis 2011 Jul 24;70(7):1320-6. Epub 2011 Apr 24.
Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Germany.


Platelet-derived serotonin links vascular disease and tissue fibrosis.
J Exp Med 2011 May 25;208(5):961-72. Epub 2011 Apr 25.
Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.

Lack of inhibitory effects of the anti-fibrotic drug imatinib on endothelial cell functions in vitro and in vivo.
J Cell Mol Med 2009 Oct;13(10):4185-91
Department for Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis.
FASEB J 2008 Jul 7;22(7):2214-22. Epub 2008 Mar 7.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Universitätsstr. 29, 91054 Erlangen, Germany.


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