Clara Dees

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Clara Dees

Publications by authors named "Clara Dees"

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63Publications

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Poly(ADP-ribose) polymerase-1 regulates fibroblast activation in systemic sclerosis.

Ann Rheum Dis 2018 May 3;77(5):744-751. Epub 2018 Feb 3.

Department of Internal Medicine 3 for Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), University Hospital of Erlangen, Erlangen, Germany.

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May 2018

Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators.

Ann Rheum Dis 2018 Mar 8;77(3):459. Epub 2018 Jan 8.

Department of Internal Medicine III - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany.

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March 2018

Nintedanib inhibits macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis.

Ann Rheum Dis 2017 Nov 16;76(11):1941-1948. Epub 2017 Aug 16.

Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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November 2017

JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment.

Ann Rheum Dis 2017 Aug 6;76(8):1467-1475. Epub 2017 May 6.

Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.

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August 2017

Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosis.

Ann Rheum Dis 2017 Jan 25;76(1):244-251. Epub 2016 Apr 25.

Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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January 2017

Activating transcription factor 3 regulates canonical TGFβ signalling in systemic sclerosis.

Ann Rheum Dis 2016 Mar 14;75(3):586-92. Epub 2015 Jan 14.

Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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March 2016

Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis.

Ann Rheum Dis 2016 Mar 20;75(3):609-16. Epub 2015 Jan 20.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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March 2016

Type 2 innate lymphoid cell counts are increased in patients with systemic sclerosis and correlate with the extent of fibrosis.

Ann Rheum Dis 2016 Mar 2;75(3):623-6. Epub 2015 Sep 2.

Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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March 2016

From pathogenesis to therapy--Perspective on treatment strategies in fibrotic diseases.

Pharmacol Res 2015 Oct 16;100:93-100. Epub 2015 Jul 16.

Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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October 2015

S100A4 amplifies TGF-β-induced fibroblast activation in systemic sclerosis.

Ann Rheum Dis 2015 Sep 7;74(9):1748-55. Epub 2014 Apr 7.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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September 2015

Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies.

Ann Rheum Dis 2015 Aug 27;74(8):1621-5. Epub 2015 Mar 27.

Department of Internal Medicine 3,Institute for Clinical Immunology, University of Erlangen-Nuremberg, Germany.

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August 2015

Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis.

Ann Rheum Dis 2015 May 15;74(5):936-43. Epub 2014 Jan 15.

Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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May 2015

Vitamin D receptor regulates TGF-β signalling in systemic sclerosis.

Ann Rheum Dis 2015 Mar 21;74(3):e20. Epub 2014 Jan 21.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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March 2015

Cardiomyopathy in murine models of systemic sclerosis.

Arthritis Rheumatol 2015 Feb;67(2):508-16

Karolinska University Hospital, Solna, Sweden, Karolinska Institute, Stockholm, Sweden; University of Erlangen-Nuremberg, Erlangen, Germany.

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February 2015

The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis.

Ann Rheum Dis 2014 Jun 22;73(6):1232-9. Epub 2013 May 22.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, , Erlangen, Germany.

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June 2014

Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling.

Ann Rheum Dis 2014 Mar 20;73(3):624-7. Epub 2013 Nov 20.

Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, , Erlangen, Germany.

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March 2014

Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors.

Ann Rheum Dis 2013 Dec 7;72(12):2039-46. Epub 2013 Sep 7.

Department of Rheumatology, University Hospital Zurich, , Zurich, Switzerland.

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December 2013

Canonical Wnt signalling as a key regulator of fibrogenesis - implications for targeted therapies?

Exp Dermatol 2013 Nov;22(11):710-3

Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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November 2013

Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling.

Ann Rheum Dis 2013 Sep 12;72(9):1575-80. Epub 2012 Nov 12.

Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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September 2013

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis.

Ann Rheum Dis 2013 Jul 17;72(7):1255-8. Epub 2013 Apr 17.

Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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July 2013

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis.

Ann Rheum Dis 2013 May 12;72(5):761-8. Epub 2012 Sep 12.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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May 2013

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis.

Ann Rheum Dis 2013 Apr 21;72(4):614-20. Epub 2012 Aug 21.

Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Ulmenweg 18, Erlangen D-91054, Germany.

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April 2013

Activation of pregnane X receptor inhibits experimental dermal fibrosis.

Ann Rheum Dis 2013 Apr 4;72(4):621-5. Epub 2013 Jan 4.

Department of Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Ulmenweg 18, Erlangen D-91054, Germany.

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April 2013

Morphogen pathways as molecular targets for the treatment of fibrosis in systemic sclerosis.

Arch Dermatol Res 2013 Jan 4;305(1):1-8. Epub 2012 Dec 4.

Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Ulmenweg 18, 91054, Erlangen, Germany.

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January 2013

Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1.

Ann Rheum Dis 2012 Dec 22;71(12):2051-4. Epub 2012 Aug 22.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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December 2012

Pomalidomide is effective for prevention and treatment of experimental skin fibrosis.

Ann Rheum Dis 2012 Nov 17;71(11):1895-9. Epub 2012 Aug 17.

Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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November 2012

Inhibition of sumoylation prevents experimental fibrosis.

Ann Rheum Dis 2012 Nov 17;71(11):1904-8. Epub 2012 Aug 17.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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November 2012

Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease.

Blood 2012 Oct 22;120(14):2909-17. Epub 2012 Aug 22.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.

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October 2012

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.

Ann Rheum Dis 2012 Jun 20;71(6):1081-7. Epub 2012 Jan 20.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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June 2012

Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis.

Ann Rheum Dis 2012 May 18;71(5):737-45. Epub 2012 Jan 18.

Department for Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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May 2012

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis.

Ann Rheum Dis 2012 May 10;71(5):761-7. Epub 2012 Feb 10.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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May 2012

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis.

Ann Rheum Dis 2012 May 8;71(5):785-9. Epub 2012 Mar 8.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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May 2012

Inhibition of glycogen synthase kinase 3β induces dermal fibrosis by activation of the canonical Wnt pathway.

Ann Rheum Dis 2011 Dec 25;70(12):2191-8. Epub 2011 Aug 25.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Germany.

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December 2011

Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis.

Ann Rheum Dis 2011 Jul 30;70(7):1304-10. Epub 2011 Mar 30.

Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen–Nuremberg, Germany.

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July 2011

The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis.

Ann Rheum Dis 2011 Jul 24;70(7):1320-6. Epub 2011 Apr 24.

Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Germany.

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July 2011

Platelet-derived serotonin links vascular disease and tissue fibrosis.

J Exp Med 2011 May 25;208(5):961-72. Epub 2011 Apr 25.

Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.

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May 2011

Microparticles stimulate angiogenesis by inducing ELR(+) CXC-chemokines in synovial fibroblasts.

J Cell Mol Med 2011 Apr;15(4):756-62

Department for Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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April 2011

Lack of inhibitory effects of the anti-fibrotic drug imatinib on endothelial cell functions in vitro and in vivo.

J Cell Mol Med 2009 Oct;13(10):4185-91

Department for Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

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October 2009

Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis.

FASEB J 2008 Jul 7;22(7):2214-22. Epub 2008 Mar 7.

Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Universitätsstr. 29, 91054 Erlangen, Germany.

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July 2008

Src kinases in systemic sclerosis: central roles in fibroblast activation and in skin fibrosis.

Arthritis Rheum 2008 May;58(5):1475-84

Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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May 2008