Publications

Nintedanib inhibits macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis.
Ann Rheum Dis 2017 Nov 16;76(11):1941-1948. Epub 2017 Aug 16.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment.
Ann Rheum Dis 2017 Aug 6;76(8):1467-1475. Epub 2017 May 6.
Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.

Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosis.
Ann Rheum Dis 2017 Jan 25;76(1):244-251. Epub 2016 Apr 25.
Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.


Activating transcription factor 3 regulates canonical TGFβ signalling in systemic sclerosis.
Ann Rheum Dis 2016 Mar 14;75(3):586-92. Epub 2015 Jan 14.
Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis.
Ann Rheum Dis 2016 Mar 20;75(3):609-16. Epub 2015 Jan 20.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Type 2 innate lymphoid cell counts are increased in patients with systemic sclerosis and correlate with the extent of fibrosis.
Ann Rheum Dis 2016 Mar 2;75(3):623-6. Epub 2015 Sep 2.
Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

S100A4 amplifies TGF-β-induced fibroblast activation in systemic sclerosis.
Ann Rheum Dis 2015 Sep 7;74(9):1748-55. Epub 2014 Apr 7.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.



Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis.
Ann Rheum Dis 2015 May 15;74(5):936-43. Epub 2014 Jan 15.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Cardiomyopathy in murine models of systemic sclerosis.
Arthritis Rheumatol 2015 Feb;67(2):508-16
Karolinska University Hospital, Solna, Sweden, Karolinska Institute, Stockholm, Sweden; University of Erlangen-Nuremberg, Erlangen, Germany.



Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling.
Ann Rheum Dis 2014 Mar 20;73(3):624-7. Epub 2013 Nov 20.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, , Erlangen, Germany.

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis.
Ann Rheum Dis 2013 Jul 17;72(7):1255-8. Epub 2013 Apr 17.
Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis.
Ann Rheum Dis 2013 May 12;72(5):761-8. Epub 2012 Sep 12.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis.
Ann Rheum Dis 2013 Apr 21;72(4):614-20. Epub 2012 Aug 21.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Ulmenweg 18, Erlangen D-91054, Germany.

Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1.
Ann Rheum Dis 2012 Dec 22;71(12):2051-4. Epub 2012 Aug 22.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Pomalidomide is effective for prevention and treatment of experimental skin fibrosis.
Ann Rheum Dis 2012 Nov 17;71(11):1895-9. Epub 2012 Aug 17.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.


Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease.
Blood 2012 Oct 22;120(14):2909-17. Epub 2012 Aug 22.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.
Ann Rheum Dis 2012 Jun 20;71(6):1081-7. Epub 2012 Jan 20.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.


Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis.
Ann Rheum Dis 2012 May 18;71(5):737-45. Epub 2012 Jan 18.
Department for Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis.
Ann Rheum Dis 2012 May 10;71(5):761-7. Epub 2012 Feb 10.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis.
Ann Rheum Dis 2012 May 8;71(5):785-9. Epub 2012 Mar 8.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis.
Nat Commun 2012 Mar 13;3:735. Epub 2012 Mar 13.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.

The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis.
Ann Rheum Dis 2011 Jul 24;70(7):1320-6. Epub 2011 Apr 24.
Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Germany.


Platelet-derived serotonin links vascular disease and tissue fibrosis.
J Exp Med 2011 May 25;208(5):961-72. Epub 2011 Apr 25.
Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.

Lack of inhibitory effects of the anti-fibrotic drug imatinib on endothelial cell functions in vitro and in vivo.
J Cell Mol Med 2009 Oct;13(10):4185-91
Department for Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis.
FASEB J 2008 Jul 7;22(7):2214-22. Epub 2008 Mar 7.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Universitätsstr. 29, 91054 Erlangen, Germany.


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