Clara Bueno

Clara Bueno

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Clara Bueno

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Robustness of Catalytically Dead Cas9 Activators in Human Pluripotent and Mesenchymal Stem Cells.

Mol Ther Nucleic Acids 2020 Feb 27;20:196-204. Epub 2020 Feb 27.

Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer-CIBER-ONC, ISCIII, Barcelona, Spain; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2020.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068053PMC
February 2020

Retraction Note: NF-κB activation impairs somatic cell reprogramming in ageing.

Nat Cell Biol 2019 Mar;21(3):410

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006, Oviedo, Spain.

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http://www.nature.com/articles/s41556-018-0259-0
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http://dx.doi.org/10.1038/s41556-018-0259-0DOI Listing
March 2019

The "Never-Ending" Mouse Models for MLL-Rearranged Acute Leukemia Are Still Teaching Us.

Hemasphere 2018 Aug 19;2(4):e57. Epub 2018 Jun 19.

Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1097/HS9.0000000000000057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746004PMC
August 2018

Epigenome-wide analysis reveals specific DNA hypermethylation of T cells during human hematopoietic differentiation.

Epigenomics 2018 07 5;10(7):903-923. Epub 2018 Apr 5.

Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), HUCA, Universidad de Oviedo, Principado de Asturias, Spain.

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http://dx.doi.org/10.2217/epi-2017-0163DOI Listing
July 2018

Detection of inflammatory monocytes but not mesenchymal stem/stromal cells in peripheral blood of patients with myelofibrosis.

Br J Haematol 2018 04 21;181(1):133-137. Epub 2017 Feb 21.

Josep Carreras Leukaemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/bjh.14507DOI Listing
April 2018

RUNX1c Regulates Hematopoietic Differentiation of Human Pluripotent Stem Cells Possibly in Cooperation with Proinflammatory Signaling.

Stem Cells 2017 11 23;35(11):2253-2266. Epub 2017 Sep 23.

Gene Regulation, Stem Cells and Development Group, Department of Genomic Oncology, GENYO: Centre for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucía, PTS Granada, Granada, Spain.

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http://doi.wiley.com/10.1002/stem.2700
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http://dx.doi.org/10.1002/stem.2700DOI Listing
November 2017

The AF4-MLL fusion transiently augments multilineage hematopoietic engraftment but is not sufficient to initiate leukemia in cord blood CD34 cells.

Oncotarget 2017 Oct 26;8(47):81936-81941. Epub 2017 Jul 26.

Department of Biomedicine, Josep Carreras Leukemia Research Institute, School of Medicine, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.18632/oncotarget.19567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669860PMC
October 2017

Modeling mixed-lineage-rearranged leukemia initiation in CD34 cells: a "CRISPR" solution.

Haematologica 2017 09;102(9):1467-1468

Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain

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http://dx.doi.org/10.3324/haematol.2017.173740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685229PMC
September 2017

Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes.

Mol Cell 2017 07 29;67(1):55-70.e4. Epub 2017 Jun 29.

Metabolism and Cancer Group, Molecular Mechanisms And Experimental Therapy In Oncology Program, Bellvitge Biomedical Research Institute, IDIBELL, 08908 Barcelona, Spain; Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati Medical School, Cincinnati, OH 45267-0508, USA; Physiological Sciences Department, Faculty of Medicine and Health Science, University of Barcelona, 08908 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553558PMC
July 2017

Detailed Characterization of Mesenchymal Stem/Stromal Cells from a Large Cohort of AML Patients Demonstrates a Definitive Link to Treatment Outcomes.

Stem Cell Reports 2017 06 18;8(6):1573-1586. Epub 2017 May 18.

Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, Universitat de Barcelona, Casanova 143, Barcelona 08036, Spain; Centro de Investigación Biomédica en Red-Oncología (CIBERONC), ISCIII, Madrid 28031, Spain; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470078PMC
June 2017

Human acute leukemia induced pluripotent stem cells: a unique model for investigating disease development and pathogenesis.

Stem Cell Investig 2017 13;4:55. Epub 2017 Jun 13.

Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.21037/sci.2017.05.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503908PMC
June 2017

Efficient Recreation of t(11;22) EWSR1-FLI1 in Human Stem Cells Using CRISPR/Cas9.

Stem Cell Reports 2017 05;8(5):1408-1420

Molecular Cytogenetics Group, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid 28029, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711173016
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http://dx.doi.org/10.1016/j.stemcr.2017.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425785PMC
May 2017

Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the "safe harbor" AAVS1 locus.

Stem Cell Res 2017 05 22;21:137-140. Epub 2017 Apr 22.

Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain; Center for Networked Biomedical Research on Cancer (CIBERONC), ISCIII, Madrid, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

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http://dx.doi.org/10.1016/j.scr.2017.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446316PMC
May 2017

Proinflammatory signals are insufficient to drive definitive hematopoietic specification of human HSCs in vitro.

Exp Hematol 2017 Jan 28;45:85-93.e2. Epub 2016 Sep 28.

Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.09.007DOI Listing
January 2017

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.

Stem Cell Reports 2016 10 22;7(4):602-618. Epub 2016 Sep 22.

Josep Carreras Leukemia Research Institute, School of Medicine, University of Barcelona, Casanova 143, 08036 Barcelona, Spain; Department of Biomedicine, School of Medicine, University of Barcelona, 08036 Barcelona, Spain; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), 08036 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063541PMC
October 2016

Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34+ HSPC But Is Insufficient to Initiate Leukemia.

Cancer Res 2016 04 2;76(8):2478-89. Epub 2016 Feb 2.

Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain. Instituciò Catalana Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2769DOI Listing
April 2016

Cellular Ontogeny and Hierarchy Influence the Reprogramming Efficiency of Human B Cells into Induced Pluripotent Stem Cells.

Stem Cells 2016 Mar 25;34(3):581-7. Epub 2016 Feb 25.

Josep Carreras Leukemia Research Institute (IJC) and School of Medicine, Department of Biomedicine, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1002/stem.2303DOI Listing
March 2016

Intra-Bone Marrow Transplantation Confers Superior Multilineage Engraftment of Murine Aorta-Gonad Mesonephros Cells Over Intravenous Transplantation.

Stem Cells Dev 2016 Feb 7;25(3):259-65. Epub 2016 Jan 7.

1 Josep Carreras Leukemia Research Institute and School of Medicine, University of Barcelona , Barcelona, Spain .

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http://dx.doi.org/10.1089/scd.2015.0309DOI Listing
February 2016

Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia.

Blood 2015 Dec 13;126(25):2676-85. Epub 2015 Oct 13.

Josep Carreras Leukemia Research Institute and School of Medicine, University of Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.

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http://dx.doi.org/10.1182/blood-2015-09-667378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683329PMC
December 2015

NF-κB activation impairs somatic cell reprogramming in ageing.

Nat Cell Biol 2015 Aug 27;17(8):1004-13. Epub 2015 Jul 27.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1038/ncb3207DOI Listing
August 2015

SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells.

Mol Ther 2015 Jan 8;23(1):158-70. Epub 2014 Oct 8.

Genomic Oncology Department, GENYO, Centre for Genomics and Oncological Research, Pfizer-University of Granada-Andalusian Regional Government, PTS Granada, Granada, Spain.

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http://dx.doi.org/10.1038/mt.2014.196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426806PMC
January 2015

HOXA9 promotes hematopoietic commitment of human embryonic stem cells.

Blood 2014 Nov 3;124(20):3065-75. Epub 2014 Sep 3.

Josep Carreras Leukemia Research Institute, Cell Therapy Program, School of Medicine, University of Barcelona, Barcelona, Spain; and Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.

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http://dx.doi.org/10.1182/blood-2014-03-558825DOI Listing
November 2014

Bone marrow mesenchymal stem cells from patients with aplastic anemia maintain functional and immune properties and do not contribute to the pathogenesis of the disease.

Haematologica 2014 Jul 11;99(7):1168-75. Epub 2014 Apr 11.

Josep Carreras Leukemia Research Institute, Cell Therapy Program of the University of Barcelona, Faculty of Medicine, Barcelona, Spain Instituciò Catalana de Reserca i Estudis Avançats (ICREA), Barcellona, Spain

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http://dx.doi.org/10.3324/haematol.2014.103580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077077PMC
July 2014

Role of BRD4 in hematopoietic differentiation of embryonic stem cells.

Epigenetics 2014 Apr 20;9(4):566-78. Epub 2014 Jan 20.

Cancer Epigenetics Laboratory; Instituto Universitario de Oncología del Principado de Asturias (IUOPA); HUCA; Universidad de Oviedo; Oviedo, Spain; Department of Immunology and Oncology; Centro Nacional de Biotecnología/CNB-CSIC; Cantoblanco; Madrid, Spain.

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http://dx.doi.org/10.4161/epi.27711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121367PMC
April 2014

Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function.

Haematologica 2013 Jul 24;98(7):1022-9. Epub 2013 Jan 24.

GENyO-Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Government, Granada, Spain.

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http://dx.doi.org/10.3324/haematol.2012.079244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696604PMC
July 2013

FLT3 activation cooperates with MLL-AF4 fusion protein to abrogate the hematopoietic specification of human ESCs.

Blood 2013 May 11;121(19):3867-78, S1-3. Epub 2013 Mar 11.

Centre for Genomics and Oncological Research, Pfizer-University of Granada-Andalusian Regional Government, Granada, Spain.

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http://dx.doi.org/10.1182/blood-2012-11-470146DOI Listing
May 2013

Specific marking of hESCs-derived hematopoietic lineage by WAS-promoter driven lentiviral vectors.

PLoS One 2012 14;7(6):e39091. Epub 2012 Jun 14.

Human DNA Variability Department, Pfizer-Universidad de Granada-Junta de Andalucía Centre for Genomics and Oncological Research, GENYO, Granada, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039091PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375235PMC
December 2012

SCL/TAL1 regulates hematopoietic specification from human embryonic stem cells.

Mol Ther 2012 Jul 10;20(7):1443-53. Epub 2012 Apr 10.

Pfizer-Universidad de Granada-Junta de Andalucia Centre for Genomics and Oncological Research (GENyO), Granada, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S15250016163257
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http://dx.doi.org/10.1038/mt.2012.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392972PMC
July 2012

Maintenance of human embryonic stem cells in mesenchymal stem cell-conditioned media augments hematopoietic specification.

Stem Cells Dev 2012 Jun 27;21(9):1549-58. Epub 2011 Oct 27.

Stem Cells, Development, and Cancer Laboratory, GENYO: Centro de Genómica e Investigación Oncológica Pfizer-Universidad de Granada-Junta de Andalucía, Granada, Spain.

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http://dx.doi.org/10.1089/scd.2011.0400DOI Listing
June 2012

The adaptation of human embryonic stem cells to different feeder-free culture conditions is accompanied by a mitochondrial response.

Stem Cells Dev 2012 May 4;21(7):1145-55. Epub 2011 Aug 4.

Andalusian Stem Cell Bank, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain.

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http://dx.doi.org/10.1089/scd.2011.0248DOI Listing
May 2012

Maintenance of human embryonic stem cells in media conditioned by human mesenchymal stem cells obviates the requirement of exogenous basic fibroblast growth factor supplementation.

Tissue Eng Part C Methods 2012 May 26;18(5):387-96. Epub 2012 Jan 26.

GENYO-Centre Pfizer-University of Granada-Government of Andalucía for Genomic and Oncological Research, Avda de la Ilustración, Granada, Spain.

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http://dx.doi.org/10.1089/ten.TEC.2011.0546DOI Listing
May 2012

Purification and long-term expansion of multipotent endothelial-like cells with potential cardiovascular regeneration.

Stem Cells Dev 2012 Mar 17;21(4):562-74. Epub 2011 Jun 17.

Biopathology and Regenerative Medicine Institute, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain.

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http://dx.doi.org/10.1089/scd.2011.0072DOI Listing
March 2012

Expression of NG2 antigen in MLL-rearranged acute leukemias: how complex does it get?

Leuk Res 2011 Aug 13;35(8):989-90. Epub 2011 Apr 13.

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http://dx.doi.org/10.1016/j.leukres.2011.03.015DOI Listing
August 2011

Nodal/Activin signaling predicts human pluripotent stem cell lines prone to differentiate toward the hematopoietic lineage.

Mol Ther 2010 Dec 24;18(12):2173-81. Epub 2010 Aug 24.

Andalusian Stem Cell Bank, Centro de Investigación Biomédica, Consejería de Salud-Universidad de Granada, Granada, Spain.

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http://dx.doi.org/10.1038/mt.2010.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997587PMC
December 2010

The ROCK inhibitor Y-27632 negatively affects the expansion/survival of both fresh and cryopreserved cord blood-derived CD34+ hematopoietic progenitor cells: Y-27632 negatively affects the expansion/survival of CD34+HSPCs.

Stem Cell Rev Rep 2010 Jun;6(2):215-23

Andalusian Stem Cell Bank, Centro de Investigación Biomédica, Consejería de Salud-Universidad de Granada, Granada, Spain.

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http://dx.doi.org/10.1007/s12015-010-9118-5DOI Listing
June 2010

Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene.

J Exp Med 2009 Dec 7;206(13):3131-41. Epub 2009 Dec 7.

Andalusian Stem Cell Bank, Centro de Investigación Biomédica, Consejería de Salud-Universidad de Granada, 18100 Granada, Spain.

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http://dx.doi.org/10.1084/jem.20091050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806455PMC
December 2009

Etoposide induces MLL rearrangements and other chromosomal abnormalities in human embryonic stem cells.

Carcinogenesis 2009 Sep 8;30(9):1628-37. Epub 2009 Jul 8.

Andalusian Stem Cell Bank, Centro de Investigación Biomédica, Parque Tecnológico de la Salud, University of Granada, Granada 18100 Spain.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgp169DOI Listing
September 2009

The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.

J Clin Invest 2009 Apr 16;119(4):826-36. Epub 2009 Mar 16.

Section of Haemato-Oncology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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http://www.jci.org/articles/view/36428
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http://dx.doi.org/10.1172/JCI36428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662549PMC
April 2009

T cell signalling induced by bacterial superantigens.

Chem Immunol Allergy 2007 ;93:161-180

FOCIS Centre for Clinical Immunology and Immunotherapeutics, Ont., Canada.

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http://dx.doi.org/10.1159/000100894DOI Listing
May 2007

Human embryonic stem cells: potential tool for achieving immunotolerance?

Stem Cell Rev 2005 ;1(2):151-8

Krembil Centre for Stem Cell Biology and Regenerative Medicine, Robarts Research Institute, London, ON, N6A 5K8, Canada.

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http://dx.doi.org/10.1385/SCR:1:2:151DOI Listing
January 2007

Mechanism of modulation of T cell responses by N-palmitoylated peptides.

Eur J Immunol 2004 Dec;34(12):3497-507

FOCIS Center for Clinical Immunology and Immunotherapeutics, Robarts Research Institute, London, ON, Canada.

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http://dx.doi.org/10.1002/eji.200425369DOI Listing
December 2004

Incidence and characteristics of CD4(+)/HLA DRhi dendritic cell malignancies.

Haematologica 2004 Jan;89(1):58-69

Servicios de Citometria y Hematologia, Hospital Universitario de Salamanca, Centro de Investigacio' del Cancer, Universidad de Salamanca, Salamanca, Spain.

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January 2004

A new method for detecting TNF-alpha-secreting cells using direct-immunofluorescence surface membrane stainings.

J Immunol Methods 2002 Jun;264(1-2):77-87

Servicio General de Citometría and Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain.

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http://dx.doi.org/10.1016/s0022-1759(02)00083-2DOI Listing
June 2002