Claire M Perks

Claire M Perks

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Claire M Perks

Claire M Perks

Publications by authors named "Claire M Perks"

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The Neglected Insulin: IGF-II, a Metabolic Regulator with Implications for Diabetes, Obesity, and Cancer.

Cells 2019 Oct 6;8(10). Epub 2019 Oct 6.

Department of Translational Health Science, Bristol Medical School, Faculty of Health Sciences, University of Bristol, Learning & Research Building, Southmead Hospital, Bristol, BS10 5NB, UK.

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http://dx.doi.org/10.3390/cells8101207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829378PMC
October 2019

Systemic Metabolism, Its Regulators, and Cancer: Past Mistakes and Future Potential.

Front Endocrinol (Lausanne) 2019 12;10:65. Epub 2019 Feb 12.

Faculty of Medicine, School of Translational Health Science, University of Bristol, Southmead Hospital, Bristol, United Kingdom.

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http://dx.doi.org/10.3389/fendo.2019.00065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380210PMC
February 2019

Insulin-like growth factor-II in adipocyte regulation: depot-specific actions suggest a potential role limiting excess visceral adiposity.

Am J Physiol Endocrinol Metab 2018 12 24;315(6):E1098-E1107. Epub 2018 Jul 24.

Insulin-like Growth Factors and Metabolic Endocrinology Group, Bristol Medical School, Department of Translational Health Sciences, University of Bristol, Learning and Research Building, Southmead Hospital , Bristol , United Kingdom.

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http://dx.doi.org/10.1152/ajpendo.00409.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336950PMC
December 2018

Reassessing the Association between Circulating Vitamin D and IGFBP-3: Observational and Mendelian Randomization Estimates from Independent Sources.

Cancer Epidemiol Biomarkers Prev 2018 12 2;27(12):1462-1471. Epub 2018 Aug 2.

IGFs & Metabolic Endocrinology Group, School of Translational Health Sciences, Learning & Research Building, Southmead Hospital, Bristol, United Kingdom.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837868PMC
December 2018

Hyperglycemia Promotes TMPRSS2-ERG Gene Fusion in Prostate Cancer Cells Upregulating Insulin-Like Growth Factor-Binding Protein-2.

Front Endocrinol (Lausanne) 2017 6;8:305. Epub 2017 Nov 6.

IGFs & Metabolic Endocrinology Group, School of Clinical Sciences, Southmead Hospital, Bristol, United Kingdom.

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http://dx.doi.org/10.3389/fendo.2017.00305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681733PMC
November 2017

Insulin Receptor Isoform Variations in Prostate Cancer Cells.

Front Endocrinol (Lausanne) 2016 28;7:132. Epub 2016 Sep 28.

IGFs and Metabolic Endocrinology Group, School of Clinical Sciences, Southmead Hospital, University of Bristol , Bristol , UK.

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http://dx.doi.org/10.3389/fendo.2016.00132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039983PMC
September 2016

IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?

Growth Horm IGF Res 2015 Jun 8;25(3):103-7. Epub 2015 Feb 8.

IGFs & Metabolic Endocrinology Group, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 1TD, UK.

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http://dx.doi.org/10.1016/j.ghir.2015.01.003DOI Listing
June 2015

Epigenetic regulation of insulin-like growth factor binding protein-3 (IGFBP-3) in cancer.

J Cell Commun Signal 2015 Jun 29;9(2):159-66. Epub 2015 Apr 29.

IGF & Metabolic Endocrinology Group, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol, BS10 5NB, UK,

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http://dx.doi.org/10.1007/s12079-015-0294-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458254PMC
June 2015

Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer.

Clin Cancer Res 2015 Apr 17;21(8):1877-87. Epub 2015 Feb 17.

Lund University and Skåne University Hospital, Department of Clinical Sciences, Lund, Division of Oncology and Pathology, Lund, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1748DOI Listing
April 2015

Epithelial-to-mesenchymal transition in breast cancer: a role for insulin-like growth factor I and insulin-like growth factor-binding protein 3?

Breast Cancer (Dove Med Press) 2015 19;7:9-19. Epub 2015 Jan 19.

IGFs and Metabolic Endocrinology Group, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.2147/BCTT.S43932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304531PMC
January 2015

Effects of physiological levels of the green tea extract epigallocatechin-3-gallate on breast cancer cells.

Front Endocrinol (Lausanne) 2014 7;5:61. Epub 2014 May 7.

IGFs and Metabolic Endocrinology Group, School of Clinical Sciences, Southmead Hospital, University of Bristol , Bristol , UK.

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http://dx.doi.org/10.3389/fendo.2014.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019852PMC
May 2014

Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?

Cancer Metastasis Rev 2013 Dec;32(3-4):673-705

School of Clinical Science, Faculty of Medicine, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol, BS10 5NB, UK,

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http://dx.doi.org/10.1007/s10555-013-9445-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843373PMC
December 2013

Grand challenges in cancer endocrinology: endocrine related cancers, an expanding concept.

Front Endocrinol (Lausanne) 2013 8;4:141. Epub 2013 Oct 8.

Endocrinology, Department of Health Sciences, University Magna Graecia of Catanzaro , Catanzaro, Italy.

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http://dx.doi.org/10.3389/fendo.2013.00141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792368PMC
October 2013

Insulin-like growth factor binding protein-3 (IGFBP-3) plays a role in the anti-tumorigenic effects of 5-Aza-2'-deoxycytidine (AZA) in breast cancer cells.

Exp Cell Res 2013 Aug 26;319(14):2282-95. Epub 2013 Jun 26.

IGFs & Metabolic Endocrinology Group, University of Bristol, Learning & Research Building, Southmead Hospital, Bristol BS10 5NB, United Kingdom.

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http://dx.doi.org/10.1016/j.yexcr.2013.06.011DOI Listing
August 2013

Insulin-like growth factor binding protein 2 (IGFBP-2) promotes growth and survival of breast epithelial cells: novel regulation of the estrogen receptor.

Endocrinology 2013 May 20;154(5):1780-93. Epub 2013 Mar 20.

IGF and Metabolic Endocrinology Group, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 1TD, United Kingdom.

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http://dx.doi.org/10.1210/en.2012-1970DOI Listing
May 2013

Intrinsic, Pro-Apoptotic Effects of IGFBP-3 on Breast Cancer Cells are Reversible: Involvement of PKA, Rho, and Ceramide.

Front Endocrinol (Lausanne) 2011 16;2:13. Epub 2011 May 16.

IGFs and Metabolic Endocrinology Group, School of Clinical Sciences, Learning and Research Building, Southmead Hospital, University of Bristol Bristol, UK.

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http://dx.doi.org/10.3389/fendo.2011.00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356103PMC
August 2012

Insulin-like growth factor physiology: what we have learned from human studies.

Endocrinol Metab Clin North Am 2012 Jun 8;41(2):249-63, v. Epub 2012 May 8.

School of Clinical Sciences, University of Bristol, IGFs & Metabolic Endocrinology Group, Learning & Research Building, 2nd Floor, Southmead Hospital, Bristol BS10 5NB, UK.

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http://dx.doi.org/10.1016/j.ecl.2012.04.009DOI Listing
June 2012

Insulin-like growth factors in health and disease. Preface.

Endocrinol Metab Clin North Am 2012 Jun 15;41(2):xv-xvi. Epub 2012 May 15.

School of Clinical Sciences, University of Bristol, IGFs & Metabolic Endocrinology Group, Learning & Research Building, 2nd Floor, Southmead Hospital, Bristol BS10 5NB, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S08898529120004
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http://dx.doi.org/10.1016/j.ecl.2012.04.021DOI Listing
June 2012

Hormonal mechanisms underlying the relationship between obesity and breast cancer.

Endocrinol Metab Clin North Am 2011 Sep 8;40(3):485-507, vii. Epub 2011 Jul 8.

School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.1016/j.ecl.2011.05.010DOI Listing
September 2011

Green tea extract (epigallocatechin-3-gallate) reduces efficacy of radiotherapy on prostate cancer cells.

Urology 2011 Aug 14;78(2):475.e15-21. Epub 2011 Jun 14.

IGF and Metabolic Endocrinology Group, Department of Clinical Sciences North Bristol, Learning and Research Centre, Southmead Hospital, Bristol, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00904295110034
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http://dx.doi.org/10.1016/j.urology.2011.03.031DOI Listing
August 2011

IGFBP-3 can either inhibit or enhance EGF-mediated growth of breast epithelial cells dependent upon the presence of fibronectin.

J Biol Chem 2010 Dec 17;285(50):38788-800. Epub 2010 Sep 17.

School of Clinical Sciences, IGFs and Metabolic Endocrinology Group, Learning and Research Building, 2nd Floor, University of Bristol, Southmead Hospital, Bristol BS10 5NB, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.177311
Publisher Site
http://dx.doi.org/10.1074/jbc.M110.177311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998100PMC
December 2010

PTEN-mediated pathways and their association with treatment-resistant prostate cancer.

BJU Int 2009 Aug 13;104(4):556-61. Epub 2009 Feb 13.

Department of Urology, Bristol Royal Infirmary, Bristol, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2009.08411.xDOI Listing
August 2009

Dihydrotestosterone sensitises LNCaP cells to death induced by epigallocatechin-3-Gallate (EGCG) or an IGF-I receptor inhibitor.

Prostate 2009 Feb;69(2):219-24

IGF & Metabolic Endocrinology Group, Department of Clinical Sciences North Bristol, The Medical School Unit, Southmead Hospital, Bristol, UK.

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http://doi.wiley.com/10.1002/pros.20873
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http://dx.doi.org/10.1002/pros.20873DOI Listing
February 2009

IGF binding proteins (IGFBPs) and regulation of breast cancer biology.

J Mammary Gland Biol Neoplasia 2008 Dec 25;13(4):455-69. Epub 2008 Nov 25.

Department of Clinical Sciences North Bristol, IGFs and Metabolic Endocrinology Group, University of Bristol, Southmead Hospital, The Medical School Unit, Bristol, BS10 5NB, UK.

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http://link.springer.com/10.1007/s10911-008-9106-4
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http://dx.doi.org/10.1007/s10911-008-9106-4DOI Listing
December 2008

Cancer as an endocrine problem.

Best Pract Res Clin Endocrinol Metab 2008 Aug;22(4):539-50

Department of Clinical Science at North Bristol, University of Bristol, Paul O'Gorman Lifeline Centre, Southmead Hospital, Bristol BS10 5NB, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S1521690X0800085
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http://dx.doi.org/10.1016/j.beem.2008.07.007DOI Listing
August 2008

How growth hormone may be linked to cancer: concerns and perspective.

Expert Rev Endocrinol Metab 2007 Nov;2(6):759-771

a University of Bristol, Department of Clinical Science at North Bristol, Paul O'Gorman Lifeline Centre, Southmead Hospital, Bristol BS10 5NB, UK.

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http://dx.doi.org/10.1586/17446651.2.6.759DOI Listing
November 2007

Immunohistochemical expression of insulin-like growth factor binding protein-3 in invasive breast cancers and ductal carcinoma in situ: implications for clinicopathology and patient outcome.

Breast Cancer Res 2005 23;7(1):R119-29. Epub 2004 Nov 23.

University of Bristol, Department of Clinical Sciences at South Bristol-Surgery, Bristol Royal Infirmary, Bristol, UK.

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http://dx.doi.org/10.1186/bcr963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064109PMC
January 2006

DNA damage uncouples the mitogenic response to IGF-I in MCF-7 malignant breast cancer cells by switching the roles of PI3 kinase and p21WAF1/Cip1.

Int J Cancer 2005 Sep;116(4):506-13

Department of Clinical Sciences South Bristol, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom.

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http://dx.doi.org/10.1002/ijc.21029DOI Listing
September 2005

IGFBPs and breast cancer.

Breast Dis 2003 ;17:91-104

Division of Surgery, Department of Hospital Medicine, Level 7, Bristol Royal Infirmary, Bristol, BS2 8HW, UK.

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http://dx.doi.org/10.3233/bd-2003-17109DOI Listing
March 2005

The insulin-like growth factor (IGF) family and breast cancer.

Breast Dis 2003 ;18:45-60

Division of Surgery, Department of Hospital Medicine, Level 7, Bristol Royal Infirmary, Bristol, BS2 8HW, UK. Claire

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http://dx.doi.org/10.3233/bd-2003-18106DOI Listing
March 2005

Intrinsic actions of IGFBP-3 and IGFBP-5 on Hs578T breast cancer epithelial cells: inhibition or accentuation of attachment and survival is dependent upon the presence of fibronectin.

J Cell Sci 2002 Nov;115(Pt 22):4293-303

Division of Surgery, Department of Hospital Medicine, Bristol Royal Infirmary, Bristol, BS2 8HW, UK.

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http://dx.doi.org/10.1242/jcs.00097DOI Listing
November 2002

Signalling pathways involved in the direct effects of IGFBP-5 on breast epithelial cell attachment and survival.

J Cell Biochem 2002 ;84(4):784-94

Division of Surgery, Department of Hospital Medicine, Bristol Royal Infirmary, Bristol, BS2 8HW, England, United Kingdom.

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http://dx.doi.org/10.1002/jcb.10093DOI Listing
May 2002