Claire Harris

Claire Harris

UNVERIFIED PROFILE

Are you Claire Harris?   Register this Author

Register author
Claire Harris

Claire Harris

Publications by authors named "Claire Harris"

Are you Claire Harris?   Register this Author

99Publications

-Reads

Characterizing a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis.

Immunology 2018 Jul 7. Epub 2018 Jul 7.

Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.

View Article
July 2018

Extracting the barbs from complement assays: Identification and optimisation of a safe substitute for traditional buffers.

Immunobiology 2018 Jul 19. Epub 2018 Jul 19.

Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address:

View Article
July 2018

Rituximab induction therapy for de novo ANCA associated vasculitis in pregnancy: a case report.

BMC Nephrol 2018 Jun 28;19(1):152. Epub 2018 Jun 28.

Division of Nephrology, University of British Columbia, Vancouver, BC, Canada.

View Article
June 2018

Sustainability in Health care by Allocating Resources Effectively (SHARE) 11: reporting outcomes of an evidence-driven approach to disinvestment in a local healthcare setting.

BMC Health Serv Res 2018 May 30;18(1):386. Epub 2018 May 30.

School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

View Article
May 2018

Expanding horizons in complement drug discovery: challenges and emerging strategies.

Authors:
Claire L Harris

Semin Immunopathol 2018 Jan 6;40(1):125-140. Epub 2017 Oct 6.

Complement Therapeutics Research Group and National Renal Complement Therapeutics Centre, Institute of Cellular Medicine, Newcastle University, 3rd floor William Leech Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

View Article
January 2018

Sustainability in Health care by Allocating Resources Effectively (SHARE) 9: conceptualising disinvestment in the local healthcare setting.

BMC Health Serv Res 2017 Sep 8;17(1):633. Epub 2017 Sep 8.

Medicine Program, Monash Health, Melbourne, Australia.

View Article
September 2017

Sustainability in Health care by Allocating Resources Effectively (SHARE) 10: operationalising disinvestment in a conceptual framework for resource allocation.

BMC Health Serv Res 2017 Sep 8;17(1):632. Epub 2017 Sep 8.

Menzies Centre for Health Policy, Sydney School of Public Health, University of Sydney, Sydney, Australia.

View Article
September 2017

Sustainability in Health care by Allocating Resources Effectively (SHARE) 2: identifying opportunities for disinvestment in a local healthcare setting.

BMC Health Serv Res 2017 05 5;17(1):328. Epub 2017 May 5.

Ageing and Aged Care Branch, Department of Health and Human Services, Victoria, Australia.

View Article
May 2017

Islet cell transplantation improves nerve conduction velocity in type 1 diabetes compared with intensive medical therapy over six years.

Diabetes Res Clin Pract 2016 Dec 19;122:101-105. Epub 2016 Oct 19.

Department of Medicine, Vancouver General Hospital and University of British Columbia, Canada. Electronic address:

View Article
December 2016

Complement, a target for therapy in inflammatory and degenerative diseases.

Nat Rev Drug Discov 2015 Dec 23;14(12):857-77. Epub 2015 Oct 23.

Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.

View Article
December 2015

An anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice.

Proc Natl Acad Sci U S A 2015 Nov 2;112(46):14319-24. Epub 2015 Nov 2.

Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom;

View Article
November 2015

The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.

Mol Immunol 2015 Aug 11;66(2):263-73. Epub 2015 Apr 11.

Centro Investigaciones Biológicas, Ramiro de Maeztu 9, 28040 Madrid, Spain; Ciber de Enfermedades Raras, Ramiro de Maeztu 9, 28040 Madrid, Spain. Electronic address:

View Article
August 2015

Response to Comment on "Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis".

J Immunol 2015 Jul;195(1)

Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom;

View Article
July 2015

Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy.

Mol Immunol 2015 Jun 25;65(2):302-9. Epub 2015 Feb 25.

Division of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan.

View Article
June 2015

Functional analysis of a complement polymorphism (rs17611) associated with rheumatoid arthritis.

J Immunol 2015 Apr 27;194(7):3029-34. Epub 2015 Feb 27.

Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom;

View Article
April 2015

A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases.

Mol Immunol 2015 Mar 19;64(1):170-6. Epub 2014 Dec 19.

Department of Clinical Sciences, University of Cape Town, South Africa; Institute of Infection and Immunity, Cardiff University, Cardiff, UK; Allergy Diagnostic and Clinical Research Unit, Department of Medicine, Lung Institute, University of Cape Town, South Africa. Electronic address:

View Article
March 2015

Complement activation in multiple sclerosis plaques: an immunohistochemical analysis.

Acta Neuropathol Commun 2014 May 9;2:53. Epub 2014 May 9.

Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.

View Article
May 2014

Genotype/phenotype correlations in complement factor H deficiency arising from uniparental isodisomy.

Am J Kidney Dis 2013 Nov 16;62(5):978-83. Epub 2013 Jul 16.

Northern Molecular Genetics Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.

View Article
November 2013

High performance HRM: NHS employee perspectives.

J Health Organ Manag 2013 ;27(3):296-311

Manchester Business School, University of Manchester, Manchester, UK.

View Article
September 2013

Common polymorphisms in the complement system and susceptiblity to bacterial meningitis.

J Infect 2013 Mar 13;66(3):255-62. Epub 2012 Oct 13.

Department of Neurology, Center of Infection and Immunity Amsterdam-CINIMA, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100DD Amsterdam, The Netherlands.

View Article
March 2013

Dimerization of complement factor H-related proteins modulates complement activation in vivo.

Proc Natl Acad Sci U S A 2013 Mar 4;110(12):4685-90. Epub 2013 Mar 4.

Centre for Complement and Inflammation Research, Department of Medicine, Imperial College, London W12 0NN, United Kingdom.

View Article
March 2013

Polymerase chain displacement reaction.

Biotechniques 2013 Feb;54(2):93-7

Oxitec Ltd, Abingdon, Oxfordshire, UK.

View Article
February 2013

Associations between adolescent depression and parental mental health, before and after treatment of adolescent depression.

Eur Child Adolesc Psychiatry 2013 Jan 27;22(1):3-11. Epub 2012 Jul 27.

Section of Developmental Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 8AH, UK.

View Article
January 2013

Complement dysregulation and disease: from genes and proteins to diagnostics and drugs.

Immunobiology 2012 Nov;217(11):1034-46

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas and Centro de Investigación Biomédica en Enfermedades Raras, Ramiro de Maeztu 9, 28040 Madrid, Spain.

View Article
November 2012

The complotype: dictating risk for inflammation and infection.

Trends Immunol 2012 Oct 29;33(10):513-21. Epub 2012 Jun 29.

Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.

View Article
October 2012

Complement-induced protection: an explanation for the limitations of cell-based tumour immunotherapies.

Immunol Cell Biol 2012 Oct 10;90(9):869-71. Epub 2012 Jul 10.

The Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.

View Article
October 2012

Membrane complement regulators protect against fibrin exudation increases in a severe peritoneal inflammation model in rats.

Am J Physiol Renal Physiol 2012 May 15;302(10):F1245-51. Epub 2012 Feb 15.

Renal Replacement Therapy, Division of Nephrology, Nagoya Univ. Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan.

View Article
May 2012

A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome.

Blood 2012 Jan 4;119(2):591-601. Epub 2011 Nov 4.

Department of Infection, Immunity & Biochemistry, Cardiff University School of Medicine, Heath Park, United Kingdom.

View Article
January 2012

Dense deposit disease.

Mol Immunol 2011 Aug 24;48(14):1604-10. Epub 2011 May 24.

Department of Internal Medicine, Division of Nephrology, Carver College of Medicine, University of Iowa, 21151 PFP, 200 Hawkins Drive, Iowa City, IA 52242, USA.

View Article
August 2011

Structural basis for complement factor I control and its disease-associated sequence polymorphisms.

Proc Natl Acad Sci U S A 2011 Aug 18;108(31):12839-44. Epub 2011 Jul 18.

Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.

View Article
August 2011

Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy.

Proc Natl Acad Sci U S A 2011 Aug 25;108(32):13236-40. Epub 2011 Jul 25.

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.

View Article
August 2011

Structures of the rat complement regulator CrrY.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Jul 23;67(Pt 7):739-43. Epub 2011 Jun 23.

Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX4 3RE, England.

View Article
July 2011

Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk.

Proc Natl Acad Sci U S A 2011 May 9;108(21):8761-6. Epub 2011 May 9.

Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.

View Article
May 2011

Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities.

J Biol Chem 2011 Apr 26;286(13):11082-90. Epub 2011 Jan 26.

School of Chemistry, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

View Article
April 2011

Supporting evidence-based health care in crises: what information do humanitarian organizations need?

Disaster Med Public Health Prep 2011 Mar 26;5(1):69-72. Epub 2010 Oct 26.

Australasian Cochrane Centre, Monash University, Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia.

View Article
March 2011

Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway.

Biochim Biophys Acta 2011 Jan 16;1812(1):12-22. Epub 2010 Sep 16.

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain.

View Article
January 2011

Suppression of complement activation by recombinant Crry inhibits experimental autoimmune anterior uveitis (EAAU).

Mol Immunol 2010 Nov-Dec;48(1-3):231-9. Epub 2010 Sep 16.

Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA.

View Article
January 2011

Variant-specific quantification of factor H in plasma identifies null alleles associated with atypical hemolytic uremic syndrome.

Kidney Int 2010 Oct 11;78(8):782-8. Epub 2010 Aug 11.

Department of Infection, School of Medicine, Cardiff University, Cardiff, UK.

View Article
October 2010

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.

J Clin Invest 2010 Oct 13;120(10):3702-12. Epub 2010 Sep 13.

Centro de Investigaciones Biológicas (CIB), Consejo Superior de Investigaciones Científicas, Centro de Investigación Biomédica en Enfermedades Raras and Instituto Reina Sofía de Investigaciones Nefrológicas, Madrid, Spain.

View Article
October 2010

Do small group workshops and locally adapted guidelines improve asthma patients' health outcomes? A cluster randomized controlled trial.

Fam Pract 2010 Jun 23;27(3):246-54. Epub 2010 Mar 23.

Department of Family and Community Medicine and Behavioural Sciences, University of Sharjah, Sharjah, United Arab Emirates.

View Article
June 2010

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.

Hum Mol Genet 2009 Sep 23;18(18):3452-61. Epub 2009 Jun 23.

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Instituto Reina Sofía de Investigaciones Nefrológicas, Madrid, Spain.

View Article
September 2009

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics.

Nat Rev Cancer 2009 May 3;9(5):321-6. Epub 2009 Apr 3.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.

View Article
May 2009

Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59.

Mol Immunol 2009 Apr 6;46(7):1561-7. Epub 2009 Feb 6.

Complement Biology Group, Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.

View Article
April 2009

Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B.

Proc Natl Acad Sci U S A 2009 Mar 2;106(11):4366-71. Epub 2009 Mar 2.

Consejo Superior de Investigaciones Cientificas, Centro de Investigación Biomédica en Red de Enfermedades Raras and Fundación Renal Iñigo Alvarez de Toledo, Ramiro de Maeztu 9, 28040 Madrid, Spain.

View Article
March 2009

Implication of complement system and its regulators in Alzheimer's disease.

Curr Neuropharmacol 2009 Mar;7(1):1-8

Department of Medical Biochemistry and Immunology, School of Medicine, Heath Park, Cardiff University, Cardiff CF14 4XN, UK.

View Article
March 2009

Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury.

Mol Immunol 2009 Feb 22;46(5):803-11. Epub 2008 Oct 22.

Complement Biology Group, Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.

View Article
February 2009

A multi-year analysis of islet transplantation compared with intensive medical therapy on progression of complications in type 1 diabetes.

Transplantation 2008 Dec;86(12):1762-6

Departments of Surgery, Ophthalmology & Visual Sciences, and Medicine, Ike Barber Human Islet Transplantation Laboratory, University of British Columbia, Vancouver, BC, Canada.

View Article
December 2008

Complement factor H binds to denatured rather than to native pentameric C-reactive protein.

J Biol Chem 2008 Nov 11;283(45):30451-60. Epub 2008 Sep 11.

Department of Medical Biochemistry and Immunology and Pharmacology, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.

View Article
November 2008

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic.

J Clin Invest 2008 Nov 23;118(11):3651-9. Epub 2008 Oct 23.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

View Article
November 2008

Case-control study of low-back pain referred for magnetic resonance imaging, with special focus on whole-body vibration.

Scand J Work Environ Health 2008 Oct 14;34(5):364-73. Epub 2008 Oct 14.

MRC Epidemiology Resource Centre, Southampton General Hospital, University of Southampton, Southampton, United Kingdom.

View Article
October 2008

Development of evidence-based clinical practice guidelines (CPGs): comparing approaches.

Implement Sci 2008 Oct 27;3:45. Epub 2008 Oct 27.

Centre for Clinical Effectiveness, Southern Health, Locked Bag 29, Clayton, Victoria, 3168, Australia.

View Article
October 2008

What do GPs get out of participating in research? - experience of the LEAP trial.

Aust Fam Physician 2008 May;37(5):372-5

Primary Care Research Unit, Department of General Practice, The University of Melbourne, Victoria.

View Article
May 2008

Prevention of experimental autoimmune myasthenia gravis by rat Crry-Ig: A model agent for long-term complement inhibition in vivo.

Mol Immunol 2008 Jan 24;45(2):395-405. Epub 2007 Jul 24.

Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom.

View Article
January 2008

Human resource management and performance in healthcare organisations.

J Health Organ Manag 2007 ;21(4-5):448-59

University of Manchester, Manchester, UK.

View Article
December 2007

Combined yeast {beta}-glucan and antitumor monoclonal antibody therapy requires C5a-mediated neutrophil chemotaxis via regulation of decay-accelerating factor CD55.

Cancer Res 2007 Aug;67(15):7421-30

Tumor Immunobiology Program of the James Graham Brown Cancer Center, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.

View Article
August 2007

Immunization with autologous CD46 generates a strong autoantibody response in rats that targets spermatozoa.

J Reprod Immunol 2007 Apr 6;73(2):135-147. Epub 2006 Sep 6.

Complement Biology Group, Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK. Electronic address:

View Article
April 2007

CD55 in rat male reproductive tissue: differential expression in testis and expression of a unique truncated isoform on spermatozoa.

Mol Immunol 2007 Mar 27;44(7):1613-22. Epub 2006 Sep 27.

Complement Biology Group, Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.

View Article
March 2007

In vivo characterization and therapeutic efficacy of a C5-specific inhibitor from the soft tick Ornithodoros moubata.

J Biol Chem 2007 Mar 10;282(11):8292-9. Epub 2007 Jan 10.

Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom.

View Article
March 2007

CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration.

J Immunol 2007 Feb;178(3):1783-90

Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

View Article
February 2007

Decay-accelerating factor must bind both components of the complement alternative pathway C3 convertase to mediate efficient decay.

J Immunol 2007 Jan;178(1):352-9

Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, United Kingdom.

View Article
January 2007

Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome.

Proc Natl Acad Sci U S A 2007 Jan 20;104(1):240-5. Epub 2006 Dec 20.

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain.

View Article
January 2007

Complement decay accelerating factor (DAF)/CD55 in cancer.

Cancer Immunol Immunother 2006 Aug 17;55(8):987-95. Epub 2006 Feb 17.

CR UK Academic Department of Clinical Oncology, Institute of Infections Immunity and Inflammation, The University of Nottingham, NG5 1PB, Nottingham, UK.

View Article
August 2006

Copying letters to patients: the view of patients and health professionals.

J Health Serv Res Policy 2006 Jul;11(3):133-40

Manchester Business School, University of Manchester, Manchester, UK.

View Article
July 2006

'I'm just ringing for some advice...'--issues concerning GP advice lines.

Aust Fam Physician 2006 Jan-Feb;35(1-2):61-2

Health for Kids in the South East Project, Southern Health, Victoria.

View Article
April 2006

Are general practitioners equipped to detect child overweight/obesity? Survey and audit.

J Paediatr Child Health 2006 Apr;42(4):206-11

Centre for Community Child Health, Royal Children's Hospital, The University of Melbourne, Department of Paediatrics, Murdoch Childrens Research Institute, Australia.

View Article
April 2006

Spermatogenic cells distal to the blood-testis barrier in rats lack C3 convertase regulators and may be at risk of complement-mediated injury.

J Reprod Immunol 2006 Feb 27;69(1):23-34. Epub 2005 Dec 27.

Complement Biology Group, Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK.

View Article
February 2006

Holding T cells in check--a new role for complement regulators?

Trends Immunol 2006 Feb 10;27(2):102-8. Epub 2006 Jan 10.

Medical Biochemistry and Immunology, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK.

View Article
February 2006

Can Australian general practitioners tackle childhood overweight/obesity? Methods and processes from the LEAP (Live, Eat and Play) randomized controlled trial.

J Paediatr Child Health 2005 Sep-Oct;41(9-10):488-94

Centre for Community Child Health, University of Melbourne, Murdoch Childrens Research Institute, Melbourne, Australia.

View Article
January 2006

CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells.

J Biol Chem 2005 Oct 8;280(43):36342-54. Epub 2005 Aug 8.

Brain Inflammation and Immunity Group (BI2G), Department of Medical Biochemistry and Immunology, School of Medicine, Heath Park Campus, Cardiff University, Cardiff CF14 4XN, United Kingdom.

View Article
October 2005

Daily affect and daily beliefs.

J Occup Health Psychol 2005 Oct;10(4):415-28

Manchester Business School, University of Manchester, Manchester, United Kingdom.

View Article
October 2005