Publications by authors named "Claire Harris"

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The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.
Mol Immunol 2015 Aug 11;66(2):263-73. Epub 2015 Apr 11.
Centro Investigaciones Biológicas, Ramiro de Maeztu 9, 28040 Madrid, Spain; Ciber de Enfermedades Raras, Ramiro de Maeztu 9, 28040 Madrid, Spain. Electronic address:

Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy.
Mol Immunol 2015 Jun 25;65(2):302-9. Epub 2015 Feb 25.
Division of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan.

A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases.
Mol Immunol 2015 Mar 19;64(1):170-6. Epub 2014 Dec 19.
Department of Clinical Sciences, University of Cape Town, South Africa; Institute of Infection and Immunity, Cardiff University, Cardiff, UK; Allergy Diagnostic and Clinical Research Unit, Department of Medicine, Lung Institute, University of Cape Town, South Africa. Electronic address:




Genotype/phenotype correlations in complement factor H deficiency arising from uniparental isodisomy.
Am J Kidney Dis 2013 Nov 16;62(5):978-83. Epub 2013 Jul 16.
Northern Molecular Genetics Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.


Common polymorphisms in the complement system and susceptiblity to bacterial meningitis.
J Infect 2013 Mar 13;66(3):255-62. Epub 2012 Oct 13.
Department of Neurology, Center of Infection and Immunity Amsterdam-CINIMA, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100DD Amsterdam, The Netherlands.

Dimerization of complement factor H-related proteins modulates complement activation in vivo.
Proc Natl Acad Sci U S A 2013 Mar 4;110(12):4685-90. Epub 2013 Mar 4.
Centre for Complement and Inflammation Research, Department of Medicine, Imperial College, London W12 0NN, United Kingdom.


A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome.
Blood 2012 Jan 4;119(2):591-601. Epub 2011 Nov 4.
Department of Infection, Immunity & Biochemistry, Cardiff University School of Medicine, Heath Park, United Kingdom.


Suppression of complement activation by recombinant Crry inhibits experimental autoimmune anterior uveitis (EAAU).
Mol Immunol 2010 Nov-Dec;48(1-3):231-9. Epub 2010 Sep 16.
Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA.

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.
J Clin Invest 2010 Oct 13;120(10):3702-12. Epub 2010 Sep 13.
Centro de Investigaciones Biológicas (CIB), Consejo Superior de Investigaciones Científicas, Centro de Investigación Biomédica en Enfermedades Raras and Instituto Reina Sofía de Investigaciones Nefrológicas, Madrid, Spain.

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.
Hum Mol Genet 2009 Sep 23;18(18):3452-61. Epub 2009 Jun 23.
Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Instituto Reina Sofía de Investigaciones Nefrológicas, Madrid, Spain.

Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59.
Mol Immunol 2009 Apr 6;46(7):1561-7. Epub 2009 Feb 6.
Complement Biology Group, Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.

Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B.
Proc Natl Acad Sci U S A 2009 Mar 2;106(11):4366-71. Epub 2009 Mar 2.
Consejo Superior de Investigaciones Cientificas, Centro de Investigación Biomédica en Red de Enfermedades Raras and Fundación Renal Iñigo Alvarez de Toledo, Ramiro de Maeztu 9, 28040 Madrid, Spain.

A multi-year analysis of islet transplantation compared with intensive medical therapy on progression of complications in type 1 diabetes.
Transplantation 2008 Dec;86(12):1762-6
Departments of Surgery, Ophthalmology & Visual Sciences, and Medicine, Ike Barber Human Islet Transplantation Laboratory, University of British Columbia, Vancouver, BC, Canada.

Complement factor H binds to denatured rather than to native pentameric C-reactive protein.
J Biol Chem 2008 Nov 11;283(45):30451-60. Epub 2008 Sep 11.
Department of Medical Biochemistry and Immunology and Pharmacology, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.



Combined yeast {beta}-glucan and antitumor monoclonal antibody therapy requires C5a-mediated neutrophil chemotaxis via regulation of decay-accelerating factor CD55.
Cancer Res 2007 Aug;67(15):7421-30
Tumor Immunobiology Program of the James Graham Brown Cancer Center, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.

CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration.
J Immunol 2007 Feb;178(3):1783-90
Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome.
Proc Natl Acad Sci U S A 2007 Jan 20;104(1):240-5. Epub 2006 Dec 20.
Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain.




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