Claire Beaumont

Claire Beaumont

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Claire Beaumont

Claire Beaumont

Publications by authors named "Claire Beaumont"

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20Publications

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An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects.

Drug Metab Dispos 2019 Dec 24;47(12):1457-1468. Epub 2019 Oct 24.

Drug Metabolism and Pharmacokinetics (A.W.H., G.Y., R.C., D.K.) and Bioanalysis, Immunogenicity and Biomarkers (A.G., A.P.), GlaxoSmithKline R&D, Ware, United Kingdom; RD Projects Clinical Platforms & Sciences (R.W.), Drug Metabolism and Pharmacokinetics (C.B.), Discovery Medicine (Y.L.M.), Biostatistics (E.J.), GlaxoSmithKline R&D and Refractory Respiratory Inflammation Discovery Performance Unit, GlaxoSmithKline, Stevenage, United Kingdom (E.M.H.); Safety and Medical Governance (M.M.) and Discovery Medicine (W.A.F.), GlaxoSmithKline R&D, Stockley Park, Uxbridge, United Kingdom; Global Clinical and Data Operations, GlaxoSmithKline R&D, Ermington, Australia (K.R.); Covance Laboratories, Harrogate, United Kingdom (L.C.); and Hammersmith Medicines Research, London, United Kingdom (D.W.).

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http://dx.doi.org/10.1124/dmd.119.088344DOI Listing
December 2019

Using simple radiologic measurements to anticipate surgical challenge in endometrial cancer: a prospective study.

Int J Gynecol Cancer 2019 01;29(1):102-107

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Of Wisconsin - Madison, Madison, Wisconsin, USA

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http://dx.doi.org/10.1136/ijgc-2018-000037DOI Listing
January 2019

Hepatosplenic volumetric assessment at MDCT for staging liver fibrosis.

Eur Radiol 2017 Jul 17;27(7):3060-3068. Epub 2016 Nov 17.

Department of Radiology, University of Wisconsin School of Medicine & Public Health, E3/311 Clinical Science Center, 600 Highland Ave., Madison, WI, 53792-3252, USA.

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http://dx.doi.org/10.1007/s00330-016-4648-0DOI Listing
July 2017

Elucidation of Drug Metabolite Structural Isomers Using Molecular Modeling Coupled with Ion Mobility Mass Spectrometry.

Anal Chem 2016 Feb 25;88(4):2273-80. Epub 2016 Jan 25.

Drug Metabolism and Pharmacokinetics, GlaxoSmithKline , Ware, Hertfordshire SG12 0DP, U.K.

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http://dx.doi.org/10.1021/acs.analchem.5b04068DOI Listing
February 2016

Purpurolic acid: A new natural alkaloid from Claviceps purpurea (Fr.) Tul.

Fungal Biol 2016 Jan 12;120(1):104-10. Epub 2015 Nov 12.

Centre for Environmental Policy, Imperial College London, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.funbio.2015.10.011DOI Listing
January 2016

Human absorption, distribution, metabolism and excretion properties of drug molecules: a plethora of approaches.

Br J Clin Pharmacol 2014 Dec;78(6):1185-200

Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Park Road, Ware, Hertfordshire, SG12 0DP, UK.

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http://dx.doi.org/10.1111/bcp.12468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256609PMC
December 2014

Prenatal imaging of caudal regression syndrome with postnatal correlation: novel insights.

Fetal Diagn Ther 2013 7;34(2):131-2. Epub 2013 May 7.

Department of Pediatric Radiology, Arkansas Children's Hospital, Little Rock, AK, USA.

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http://dx.doi.org/10.1159/000350169DOI Listing
April 2014

MR evaluation of rectal cancer: current concepts.

Curr Probl Diagn Radiol 2013 May-Jun;42(3):99-112

University of Arkansas for Medical Sciences (UAMS), Little Rock, AR 72205, USA.

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http://dx.doi.org/10.1067/j.cpradiol.2012.08.002DOI Listing
January 2014

Metabolism and disposition of vilanterol, a long-acting β(2)-adrenoceptor agonist for inhalation use in humans.

Drug Metab Dispos 2013 Jan 4;41(1):89-100. Epub 2012 Oct 4.

Division of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline R&D, Park Road, Ware, Hertfordshire, SG12 0DP, United Kingdom.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.112.048603
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http://dx.doi.org/10.1124/dmd.112.048603DOI Listing
January 2013

Human microdose evaluation of the novel EP1 receptor antagonist GSK269984A.

Br J Clin Pharmacol 2012 Dec;74(6):1033-44

Neurology Discovery Medicine, GlaxoSmithKline R&D, Harlow, UK.

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http://dx.doi.org/10.1111/j.1365-2125.2012.04296.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522817PMC
December 2012

Use of Entero-Test, a simple approach for non-invasive clinical evaluation of the biliary disposition of drugs.

Br J Clin Pharmacol 2011 Jul;72(1):133-42

Toxicokinetics and Biotransformation, DMPK, Platform Technology and Science Department, GlaxoSmithKline, Park Road,Ware, Hertfordshire SG12 0DP, UK.

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http://dx.doi.org/10.1111/j.1365-2125.2011.03956.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141195PMC
July 2011

Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism.

Xenobiotica 2011 Jun 4;41(6):464-75. Epub 2011 Mar 4.

Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.3109/00498254.2011.560295DOI Listing
June 2011

Approaches for the rapid identification of drug metabolites in early clinical studies.

Bioanalysis 2011 Jan;3(2):197-213

Structural Identification, Toxicokinetics & Biotransformation, PTS DMPK, GlaxoSmithKline R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK.

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http://dx.doi.org/10.4155/bio.10.186DOI Listing
January 2011

Sites of metabolic substitution: investigating metabolite structures utilising ion mobility and molecular modelling.

Rapid Commun Mass Spectrom 2010 Nov;24(21):3157-62

PCD DMPK, GlaxoSmithKline, Ware, Hertfordshire SG12 0DP, UK.

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http://dx.doi.org/10.1002/rcm.4742DOI Listing
November 2010