Publications

Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study.
Leuk Res 2018 Jan 11;64:34-41. Epub 2017 Nov 11.
Center for Therapeutic Innovation, Miller School of Medicine, University of Miami, Miami, FL, United States; Department of Psychiatry and Behavioral Sciences, United States. Electronic address:

Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens.
Mol Cell Neurosci 2017 Dec 18;85:183-189. Epub 2017 Oct 18.
Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, United States. Electronic address:



The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models.
Psychopharmacology (Berl) 2016 Oct 11;233(19-20):3553-63. Epub 2016 Aug 11.
Center for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine (IKE), Linköping University, SE-581 83, Linköping, Sweden.

The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans.
Mol Cell Neurosci 2016 Jul 19;74:49-57. Epub 2016 Mar 19.
Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1501 NW 10th Ave, Biomedical Research Building (M-860), Miami, FL 33136, USA. Electronic address:

Functional annotation of the vlinc class of non-coding RNAs using systems biology approach.
Nucleic Acids Res 2016 Apr 21;44(7):3233-52. Epub 2016 Mar 21.
Institute of Genomics, School of Biomedical Sciences, Huaqiao University, 668 Jimei Road, Xiamen 361021, China St. Laurent Institute, 317 New Boston St., Suite 201, Woburn, MA 01801, USA

C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.
Exp Neurol 2016 Mar 31;277:171-177. Epub 2015 Dec 31.
Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:

Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen.
J Biomol Screen 2015 Oct 14;20(9):1132-41. Epub 2015 Jul 14.
Department of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, FL, USA Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA

Bromodomain inhibitors regulate the C9ORF72 locus in ALS.
Exp Neurol 2015 Sep 20;271:241-50. Epub 2015 Jun 20.
Center for Therapeutic Innovation and Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.
Proc Natl Acad Sci U S A 2015 Jul 25;112(27):8326-31. Epub 2015 Jun 25.
Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL 33136;

The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.
J Biol Chem 2014 Dec 29;289(51):35494-502. Epub 2014 Oct 29.
From the Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery and the Sylvester Cancer Center and Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida 33136


BET bromodomain proteins are required for glioblastoma cell proliferation.
Epigenetics 2014 Apr 19;9(4):611-20. Epub 2014 Feb 19.
Center For Therapeutic Innovation; Department of Psychiatry and Behavioral Sciences; University of Miami Miller School of Medicine; Miami, FL USA.

Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome.
Hum Genet 2014 Jan 5;133(1):59-67. Epub 2013 Sep 5.
Department of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL, 33136, USA,

Regulation of the apolipoprotein gene cluster by a long noncoding RNA.
Cell Rep 2014 Jan 2;6(1):222-30. Epub 2014 Jan 2.
Center for Therapeutic Innovation, University of Miami, Miller School of Medicine, NW 10(th) Avenue, Miami, FL 33136, USA; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, NW 10(th) Avenue, Miami, FL 33136, USA. Electronic address:

Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation.
Nat Biotechnol 2012 Mar 25;30(5):453-9. Epub 2012 Mar 25.
Department of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.

MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.
Proc Natl Acad Sci U S A 2012 Feb 6;109(8):3125-30. Epub 2012 Feb 6.
Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, Jupiter, FL 33458, USA.

The reality of pervasive transcription.
PLoS Biol 2011 Jul 12;9(7):e1000625; discussion e1001102. Epub 2011 Jul 12.
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.


The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.
Nat Genet 2009 May 19;41(5):553-62. Epub 2009 Apr 19.
RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa, Japan.

MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction.
Proc Natl Acad Sci U S A 2009 Mar 5;106(9):3507-12. Epub 2009 Feb 5.
Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.

A small molecule enhances RNA interference and promotes microRNA processing.
Nat Biotechnol 2008 Aug 20;26(8):933-40. Epub 2008 Jul 20.
Department of Human Genetics, Emory University School of Medicine, 615 Michael St, Atlanta, Georgia 30322, USA.

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase.
Nat Med 2008 Jul 29;14(7):723-30. Epub 2008 Jun 29.
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, Florida 33458, USA.


Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.
Proc Natl Acad Sci U S A 2007 Mar 5;104(11):4401-6. Epub 2007 Mar 5.
Wenner-Gren Institute, Arrhenius Laboratories, Stockholm University, SE-106 91 Stockholm, Sweden.


Pseudo-messenger RNA: phantoms of the transcriptome.
PLoS Genet 2006 Apr 28;2(4):e23. Epub 2006 Apr 28.
Genome Exploration Research Group (Genome Network Project Core Group), RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan.



Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells.
Front Genet 2015 10;6:263. Epub 2015 Aug 10.
Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami Miami, FL, USA.


The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.
Curr Alzheimer Res 2016 ;13(9):985-95
Center for Therapeutic Innovation & Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1501 NW 10th Ave, BRB 508, Miami, FL 33136, USA.

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