Claes Wahlestedt

Claes Wahlestedt

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Claes Wahlestedt

Claes Wahlestedt

Publications by authors named "Claes Wahlestedt"

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100Publications

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EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia.

Neurobiol Dis 2018 Nov 9;119:149-158. Epub 2018 Aug 9.

The Center for Therapeutic Innovation and Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:

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November 2018

Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model.

Proc Natl Acad Sci U S A 2018 Nov 5. Epub 2018 Nov 5.

Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136;

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November 2018

Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls.

Trends Genet 2018 Sep 17;34(9):704-721. Epub 2018 Jul 17.

Institute of Genomics, School of Biomedical Sciences, Huaqiao University, 201 Pan-Chinese S & T Building, 668 Jimei Road, Xiamen 361021, China. Electronic address:

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September 2018

Developments in lncRNA drug discovery: where are we heading?

Expert Opin Drug Discov 2018 Sep 6;13(9):837-849. Epub 2018 Aug 6.

a Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences , University of Miami Miller School of Medicine , Miami , FL , USA.

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September 2018

Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma.

PLoS One 2018 13;13(9):e0203173. Epub 2018 Sep 13.

Center for Therapeutic Innovation, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.

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September 2018

How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications.

Brief Bioinform 2018 05;19(3):537-543

Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1120 NW 14th St., Miami, FL, USA 33136.

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May 2018

Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway.

Hypertension 2018 Apr 26;71(4):752-760. Epub 2018 Feb 26.

From the Interdisciplinary Stem Cell Institute (W.Z., H.W., J.W., M.M.B., C.T.P., C.D.), Center for Therapeutic Innovation, Department of Psychiatry and Behavioral Sciences (G.C.S., C.R.W.), and Department of Human Genetics, John P. Hussman Institute for Human Genomics (D.M.D.), University of Miami Miller School of Medicine, FL.

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April 2018

Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme.

Mol Cancer 2018 Mar 20;17(1):74. Epub 2018 Mar 20.

Department of Psychiatry and Behavioral Sciences, Center for Therapeutic Innovation, Miami Project to Cure Paralysis, Sylvester Comprehensive Cancer Center, University of Miami Brain Tumor Initiative, University of Miami Miller School of Medicine, Miami, Florida, 33136, USA.

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March 2018

Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study.

Leuk Res 2018 01 11;64:34-41. Epub 2017 Nov 11.

Center for Therapeutic Innovation, Miller School of Medicine, University of Miami, Miami, FL, United States; Department of Psychiatry and Behavioral Sciences, United States. Electronic address:

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January 2018

Vitamin C Sensitizes Melanoma to BET Inhibitors.

Cancer Res 2018 01 27;78(2):572-583. Epub 2017 Nov 27.

John P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida.

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January 2018

Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens.

Mol Cell Neurosci 2017 12 18;85:183-189. Epub 2017 Oct 18.

Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, United States. Electronic address:

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December 2017

The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.

Curr Alzheimer Res 2016 ;13(9):985-95

Center for Therapeutic Innovation & Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1501 NW 10th Ave, BRB 508, Miami, FL 33136, USA.

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October 2017

shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics.

PLoS One 2017 11;12(5):e0176334. Epub 2017 May 11.

Center for Therapeutic Innovation, University of Miami Miller School of Medicine, 1501 NW 10th Ave., Miami, FL, 33136, United States of America.

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September 2017

Orphan diseases: state of the drug discovery art.

Wien Med Wochenschr 2017 Jun 27;167(9-10):197-204. Epub 2016 Jan 27.

Center for Therapeutic Innovation (CTI), Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1501 NW 10th Ave, BRB #416 (M860), 33136, Miami, FL, USA.

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June 2017

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.

Mol Neurodegener 2017 06 12;12(1):46. Epub 2017 Jun 12.

Department of Psychiatry & Behavioral Sciences, Center for Therapeutic Innovation, University of Miami Miller School of Medicine, 1501 NW 10th Ave, BRB-413, Miami, FL, 33136, USA.

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June 2017

Oxytocin and social functioning.

Dialogues Clin Neurosci 2017 06;19(2):193-201

University of Miami Department of Psychiatry and Behavioral Sciences, Miami, Florida, USA.

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June 2017

Oligonucleotide therapies for disorders of the nervous system.

Nat Biotechnol 2017 03 27;35(3):249-263. Epub 2017 Feb 27.

Center for Therapeutic Innovation and the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.

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March 2017

Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets.

Authors:
Claes Wahlestedt

Neuropsychopharmacology 2017 01;42(1):374

Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.

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January 2017

The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients.

Hum Mol Genet 2016 11;25(22):4870-4880

Department of Psychiatry & Behavioral Sciences, Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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November 2016

The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models.

Psychopharmacology (Berl) 2016 10 11;233(19-20):3553-63. Epub 2016 Aug 11.

Center for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine (IKE), Linköping University, SE-581 83, Linköping, Sweden.

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October 2016

Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring.

Genome Med 2016 09 8;8(1):93. Epub 2016 Sep 8.

Department of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.

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September 2016

MicroScope: ChIP-seq and RNA-seq software analysis suite for gene expression heatmaps.

BMC Bioinformatics 2016 Sep 22;17(1):390. Epub 2016 Sep 22.

Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1120 NW 14th ST, Miami, 33136, FL, USA.

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September 2016

The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans.

Mol Cell Neurosci 2016 07 19;74:49-57. Epub 2016 Mar 19.

Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1501 NW 10th Ave, Biomedical Research Building (M-860), Miami, FL 33136, USA. Electronic address:

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July 2016

Functional annotation of the vlinc class of non-coding RNAs using systems biology approach.

Nucleic Acids Res 2016 Apr 21;44(7):3233-52. Epub 2016 Mar 21.

Institute of Genomics, School of Biomedical Sciences, Huaqiao University, 668 Jimei Road, Xiamen 361021, China St. Laurent Institute, 317 New Boston St., Suite 201, Woburn, MA 01801, USA

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April 2016

C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.

Exp Neurol 2016 Mar 31;277:171-177. Epub 2015 Dec 31.

Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:

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March 2016

Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity.

J Neurosci 2015 Nov;35(45):15062-72

Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida 33136

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November 2015

Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen.

J Biomol Screen 2015 Oct 14;20(9):1132-41. Epub 2015 Jul 14.

Department of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, FL, USA Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA

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October 2015

Bromodomain inhibitors regulate the C9ORF72 locus in ALS.

Exp Neurol 2015 Sep 20;271:241-50. Epub 2015 Jun 20.

Center for Therapeutic Innovation and Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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September 2015

Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells.

Front Genet 2015 10;6:263. Epub 2015 Aug 10.

Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami Miami, FL, USA.

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August 2015

The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.

Proc Natl Acad Sci U S A 2015 Jul 25;112(27):8326-31. Epub 2015 Jun 25.

Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL 33136;

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July 2015

The Landscape of long noncoding RNA classification.

Trends Genet 2015 May 10;31(5):239-51. Epub 2015 Apr 10.

Institute of Genomics, School of Biomedical Sciences, Huaqiao Univerisity, 668 Jimei Road, Xiamen, China 361021; St. Laurent Institute, 317 New Boston St., Suite 201, Woburn, MA 01801 USA. Electronic address:

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May 2015

Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2.

Cell Rep 2015 May 30;11(6):967-976. Epub 2015 Apr 30.

Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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May 2015

The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.

J Biol Chem 2014 Dec 29;289(51):35494-502. Epub 2014 Oct 29.

From the Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery and the Sylvester Cancer Center and Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida 33136

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December 2014

HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline.

Source Code Biol Med 2014 24;9(1):30. Epub 2014 Dec 24.

Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1120 NW 14th ST, Miami, 33136 FL USA.

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December 2014

Emerging treatment strategies for glioblastoma multiforme.

EMBO Mol Med 2014 Nov;6(11):1359-70

Department of Psychiatry and Behavioral Sciences, Center for Therapeutic Innovation University of Miami Miller School of Medicine, Miami, FL, USA

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November 2014

Natural antisense transcripts.

Hum Mol Genet 2014 Sep 16;23(R1):R54-63. Epub 2014 May 16.

Department of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami, FL 33136, USA

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September 2014

I-BET151 selectively regulates IL-6 production.

Biochim Biophys Acta 2014 Sep 22;1842(9):1549-55. Epub 2014 May 22.

Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Electronic address:

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September 2014

Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs.

Breast Cancer Res Treat 2014 Sep 17;147(2):249-63. Epub 2014 Aug 17.

Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, 1501 NW 10th Ave., Miami, FL, 33136, USA.

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September 2014

BET bromodomain proteins are required for glioblastoma cell proliferation.

Epigenetics 2014 Apr 19;9(4):611-20. Epub 2014 Feb 19.

Center For Therapeutic Innovation; Department of Psychiatry and Behavioral Sciences; University of Miami Miller School of Medicine; Miami, FL USA.

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April 2014

Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome.

Hum Genet 2014 Jan 5;133(1):59-67. Epub 2013 Sep 5.

Department of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL, 33136, USA,

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January 2014

Regulation of the apolipoprotein gene cluster by a long noncoding RNA.

Cell Rep 2014 Jan 2;6(1):222-30. Epub 2014 Jan 2.

Center for Therapeutic Innovation, University of Miami, Miller School of Medicine, NW 10(th) Avenue, Miami, FL 33136, USA; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, NW 10(th) Avenue, Miami, FL 33136, USA. Electronic address:

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January 2014

Non-coding RNAs as direct and indirect modulators of epigenetic regulation.

Epigenetics 2014 Jan;9(1):3-12

Center for Therapeutic Innovation & Department of Psychiatry and Behavioral Sciences; University of Miami; Miller School of Medicine; Miami, FL USA.

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January 2014

Epigenetic pathways and glioblastoma treatment.

Epigenetics 2013 Aug 27;8(8):785-95. Epub 2013 Jun 27.

Division of Biostatistics; Department of Epidemiology and Public Health; University of Miami Miller School of Medicine; Miami, FL USA.

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August 2013

Targeting long non-coding RNA to therapeutically upregulate gene expression.

Authors:
Claes Wahlestedt

Nat Rev Drug Discov 2013 Jun;12(6):433-46

Center for Therapeutic Innovation and the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami 33136, Florida, USA.

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June 2013

Personalized medicine in psychiatry: problems and promises.

BMC Med 2013 May 16;11:132. Epub 2013 May 16.

University of Miami, Leonard M, Miller School of Medicine, Miami, FL, USA.

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May 2013

Oligonucleotides for upregulating gene expression.

Pharm Pat Anal 2013 Mar;2(2):215-29

OPKO-CURNA 10320 USA Today way, Miramar, FL, USA.

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March 2013

Natural antisense transcripts as therapeutic targets.

Drug Discov Today Ther Strateg 2013 ;10(3):e119-e125

Department of Psychiatry and Behavioral Sciences, and Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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January 2013

RNAi joins the "Singles Club".

Mol Ther 2012 Nov;20(11):2010-1

Department of Psychiatry and Behavioral Sciences, Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, Florida, USA.

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November 2012

The Emerging Role of Non-Coding RNAs in Drug Addiction.

Front Genet 2012 22;3:106. Epub 2012 Jun 22.

Hussman Institute for Human Genomics, University of Miami Miller School of Medicine Miami, FL, USA.

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October 2012

Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts.

Trends Genet 2012 Aug 26;28(8):389-96. Epub 2012 Apr 26.

Department of Psychiatry and Behavioral Sciences, and Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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August 2012

Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists.

Bioorg Med Chem Lett 2012 Jun 30;22(12):3916-20. Epub 2012 Apr 30.

Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA.

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June 2012

Involvement of long noncoding RNAs in diseases affecting the central nervous system.

RNA Biol 2012 Jun 1;9(6):860-70. Epub 2012 Jun 1.

Department of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.

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June 2012

Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation.

Nat Biotechnol 2012 Mar 25;30(5):453-9. Epub 2012 Mar 25.

Department of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.

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March 2012

MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.

Proc Natl Acad Sci U S A 2012 Feb 6;109(8):3125-30. Epub 2012 Feb 6.

Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, Jupiter, FL 33458, USA.

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February 2012

Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis.

Int J Alzheimers Dis 2011 9;2011:929042. Epub 2011 Jul 9.

Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1501 NW 10th Avenue Miami, FL 33136, USA.

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November 2011

The reality of pervasive transcription.

PLoS Biol 2011 Jul 12;9(7):e1000625; discussion e1001102. Epub 2011 Jul 12.

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.

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July 2011

Therapeutic potential of neuropeptide Y (NPY) receptor ligands.

EMBO Mol Med 2010 Nov;2(11):429-39

Department of Neuroscience, The Scripps Research Institute, Jupiter, FL, USA.

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November 2010

RNAi screen indicates widespread biological function for human natural antisense transcripts.

PLoS One 2010 Oct 4;5(10). Epub 2010 Oct 4.

Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida, United States of America.

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October 2010

Adult neurogenesis: a potential tool for early diagnosis in Alzheimer's disease?

J Alzheimers Dis 2010 ;20(2):395-408

Department of Neuroscience, The Scripps Research Institute, Jupiter, FL, USA.

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September 2010

Evidence for natural antisense transcript-mediated inhibition of microRNA function.

Genome Biol 2010 27;11(5):R56. Epub 2010 May 27.

Department of Neuroscience, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA.

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September 2010

Role of Sirtuin 1 in metabolic regulation.

Drug Discov Today 2010 Sep 16;15(17-18):781-91. Epub 2010 Jul 16.

Department of Neuroscience, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.

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September 2010

Striatal microRNA controls cocaine intake through CREB signalling.

Nature 2010 Jul;466(7303):197-202

Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA.

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July 2010

MicroRNA dysregulation in psychiatric disease.

Brain Res 2010 Jun 18;1338:89-99. Epub 2010 Mar 18.

Department of Neuroscience, Scripps Florida, Jupiter, FL 33458, USA.

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June 2010

RNA mechanisms in CNS systems and disorders.

Brain Res 2010 Jun 7;1338:1-2. Epub 2010 Apr 7.

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June 2010

Navigating genomic maps of cancer cells.

Nat Biotechnol 2010 Mar;28(3):241-2

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March 2010

microRNAs in CNS disorders.

Neuromolecular Med 2009 18;11(3):162-72. Epub 2009 Jun 18.

Department of Molecular and Integrative Neurosciences, Scripps Research Institute, Jupiter, FL 33458, USA.

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December 2009

Non-coding RNA transcripts: sensors of neuronal stress, modulators of synaptic plasticity, and agents of change in the onset of Alzheimer's disease.

Neurosci Lett 2009 Dec 20;466(2):81-8. Epub 2009 Aug 20.

Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037, USA.

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December 2009

Regulatory roles of natural antisense transcripts.

Nat Rev Mol Cell Biol 2009 Sep 29;10(9):637-43. Epub 2009 Jul 29.

Molecular and Integrative Neurosciences Department, The Scripps Research Institute, Jupiter, Florida 33458, USA.

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September 2009

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

Authors:
Harukazu Suzuki Alistair R R Forrest Erik van Nimwegen Carsten O Daub Piotr J Balwierz Katharine M Irvine Timo Lassmann Timothy Ravasi Yuki Hasegawa Michiel J L de Hoon Shintaro Katayama Kate Schroder Piero Carninci Yasuhiro Tomaru Mutsumi Kanamori-Katayama Atsutaka Kubosaki Altuna Akalin Yoshinari Ando Erik Arner Maki Asada Hiroshi Asahara Timothy Bailey Vladimir B Bajic Denis Bauer Anthony G Beckhouse Nicolas Bertin Johan Björkegren Frank Brombacher Erika Bulger Alistair M Chalk Joe Chiba Nicole Cloonan Adam Dawe Josee Dostie Pär G Engström Magbubah Essack Geoffrey J Faulkner J Lynn Fink David Fredman Ko Fujimori Masaaki Furuno Takashi Gojobori Julian Gough Sean M Grimmond Mika Gustafsson Megumi Hashimoto Takehiro Hashimoto Mariko Hatakeyama Susanne Heinzel Winston Hide Oliver Hofmann Michael Hörnquist Lukasz Huminiecki Kazuho Ikeo Naoko Imamoto Satoshi Inoue Yusuke Inoue Ryoko Ishihara Takao Iwayanagi Anders Jacobsen Mandeep Kaur Hideya Kawaji Markus C Kerr Ryuichiro Kimura Syuhei Kimura Yasumasa Kimura Hiroaki Kitano Hisashi Koga Toshio Kojima Shinji Kondo Takeshi Konno Anders Krogh Adele Kruger Ajit Kumar Boris Lenhard Andreas Lennartsson Morten Lindow Marina Lizio Cameron Macpherson Norihiro Maeda Christopher A Maher Monique Maqungo Jessica Mar Nicholas A Matigian Hideo Matsuda John S Mattick Stuart Meier Sei Miyamoto Etsuko Miyamoto-Sato Kazuhiko Nakabayashi Yutaka Nakachi Mika Nakano Sanne Nygaard Toshitsugu Okayama Yasushi Okazaki Haruka Okuda-Yabukami Valerio Orlando Jun Otomo Mikhail Pachkov Nikolai Petrovsky Charles Plessy John Quackenbush Aleksandar Radovanovic Michael Rehli Rintaro Saito Albin Sandelin Sebastian Schmeier Christian Schönbach Ariel S Schwartz Colin A Semple Miho Sera Jessica Severin Katsuhiko Shirahige Cas Simons George St Laurent Masanori Suzuki Takahiro Suzuki Matthew J Sweet Ryan J Taft Shizu Takeda Yoichi Takenaka Kai Tan Martin S Taylor Rohan D Teasdale Jesper Tegnér Sarah Teichmann Eivind Valen Claes Wahlestedt Kazunori Waki Andrew Waterhouse Christine A Wells Ole Winther Linda Wu Kazumi Yamaguchi Hiroshi Yanagawa Jun Yasuda Mihaela Zavolan David A Hume Takahiro Arakawa Shiro Fukuda Kengo Imamura Chikatoshi Kai Ai Kaiho Tsugumi Kawashima Chika Kawazu Yayoi Kitazume Miki Kojima Hisashi Miura Kayoko Murakami Mitsuyoshi Murata Noriko Ninomiya Hiromi Nishiyori Shohei Noma Chihiro Ogawa Takuma Sano Christophe Simon Michihira Tagami Yukari Takahashi Jun Kawai Yoshihide Hayashizaki

Nat Genet 2009 May 19;41(5):553-62. Epub 2009 Apr 19.

RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa, Japan.

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May 2009

MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction.

Proc Natl Acad Sci U S A 2009 Mar 5;106(9):3507-12. Epub 2009 Feb 5.

Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.

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March 2009

A small molecule enhances RNA interference and promotes microRNA processing.

Nat Biotechnol 2008 Aug 20;26(8):933-40. Epub 2008 Jul 20.

Department of Human Genetics, Emory University School of Medicine, 615 Michael St, Atlanta, Georgia 30322, USA.

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August 2008

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase.

Nat Med 2008 Jul 29;14(7):723-30. Epub 2008 Jun 29.

Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, Florida 33458, USA.

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July 2008

Epigenetic mechanisms of gene regulation during mammalian spermatogenesis.

Epigenetics 2008 Jan-Feb;3(1):21-8

Molecular and Integrative Neurosciences Department (MIND, Jupiter, Florida, USA.

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June 2008

Analysis of siRNA specificity on targets with double-nucleotide mismatches.

Nucleic Acids Res 2008 May 17;36(9):e53. Epub 2008 Apr 17.

Department of Molecular Medicine and Surgery, Karolinska Institutet, CMM L8:01, 171 76 Stockholm, Sweden.

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May 2008

Focusing on RISC assembly in mammalian cells.

Biochem Biophys Res Commun 2008 Apr 4;368(3):703-8. Epub 2008 Feb 4.

Institute of Molecular Medicine, Peking University, 100871 Beijing, PR China.

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April 2008

Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence.

Addict Biol 2008 Mar;13(1):88-94

Molecular and Integrative Neurosciences Department, The Scripps Research Institute, Jupiter, FL 33458, USA.

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March 2008

Gene characterization index: assessing the depth of gene annotation.

PLoS One 2008 Jan 23;3(1):e1440. Epub 2008 Jan 23.

Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden.

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January 2008

A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome.

PLoS One 2008 Jan 23;3(1):e1486. Epub 2008 Jan 23.

Molecular and Integrative Neurosciences Department (MIND), The Scripps Research Institute, Jupiter, Florida, USA.

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January 2008

Noncoding RNAs: couplers of analog and digital information in nervous system function?

Trends Neurosci 2007 Dec 8;30(12):612-21. Epub 2007 Nov 8.

The George Washington University Medical Center, Department of Biochemistry and Molecular Biology, 2300 I Street NW, Washington, D.C. 20037, USA.

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December 2007

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

Proc Natl Acad Sci U S A 2007 Mar 5;104(11):4401-6. Epub 2007 Mar 5.

Wenner-Gren Institute, Arrhenius Laboratories, Stockholm University, SE-106 91 Stockholm, Sweden.

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March 2007

The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function.

BMC Genomics 2007 Mar 15;8:74. Epub 2007 Mar 15.

Department of Cellular and Molecular Biology, Program for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden.

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March 2007

RNA Interference with chemically modified siRNA.

Curr Top Med Chem 2006 ;6(9):893-900

Center for Molecular Medicine, Karolinska Institutet, 171 77 Sotckholm, Sweden.

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August 2006