Claes B Wollheim

Claes B Wollheim

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Claes B Wollheim

Claes B Wollheim

Publications by authors named "Claes B Wollheim"

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Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells.

Mol Cell Endocrinol 2018 09 8;472:10-17. Epub 2018 Jun 8.

Lund University Diabetes Center, Malmoe, Lund University, Sweden; Department of Cell Physiology and Metabolism, University Medical Center. Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.mce.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559235PMC
September 2018

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.

Diabetes 2018 03 11;67(3):372-384. Epub 2017 Dec 11.

Unit of Molecular Metabolism, Department of Clinical Sciences, Lund University Diabetes Centre, Clinical Research Centre, Skåne University Hospital, Malmö, Sweden

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http://dx.doi.org/10.2337/db16-1441DOI Listing
March 2018

Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production.

Mol Cell Endocrinol 2018 02 18;461:205-214. Epub 2017 Sep 18.

Lund University Diabetes Centre, Jan Waldenströms Gata 35, SE-20502 Malmö, Sweden; Department of Neuroscience and Physiology, University of Gothenburg, Medicinaregatan 11, SE-41390 Göteborg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.09.016DOI Listing
February 2018

Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

Int J Biochem Cell Biol 2017 07 27;88:220-225. Epub 2017 Jan 27.

Department of Cell Physiology and Metabolism, University of Geneva Medical Center, 1 rue Michel-Servet, 1206 Geneva, Switzerland; Faculty Diabetes Center, University of Geneva Medical Center, 1 rue Michel-Servet, 1206 Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2017.01.012DOI Listing
July 2017

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes.

Exp Mol Med 2017 02 3;49(2):e291. Epub 2017 Feb 3.

Department of Physiology, Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Gangwon-Do, Republic of Korea.

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http://dx.doi.org/10.1038/emm.2016.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336562PMC
February 2017

Is zinc an intra-islet regulator of glucagon secretion?

Diabetol Int 2016 Jun 27;7(2):106-110. Epub 2016 Feb 27.

2Department of Cell Physiology and Metabolism, University Medical Centre, rue Michel-Servet 1, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1007/s13340-016-0259-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225009PMC
June 2016

Physiology: Microbial signals to the brain control weight.

Nature 2016 06;534(7606):185-7

Department of Cell Physiology and Metabolism, Centre Médical Universitaire, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

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http://dx.doi.org/10.1038/534185aDOI Listing
June 2016

Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function.

J Biol Chem 2016 Mar 20;291(12):6146-57. Epub 2016 Jan 20.

From the Division of Gastroenterology, Departments of Medicine, Pathology & Immunology, and Developmental Biology, Washington University, St. Louis, Missouri 63110,

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http://dx.doi.org/10.1074/jbc.M115.685750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813565PMC
March 2016

Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells.

Am J Physiol Endocrinol Metab 2015 Jun 7;308(11):E933-41. Epub 2015 Apr 7.

Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea;

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http://dx.doi.org/10.1152/ajpendo.00009.2015DOI Listing
June 2015

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.

Biochem J 2015 May;468(1):49-63

*Unit of Molecular Metabolism, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, CRC, Lund University, Skåne University Hospital, Malmö 205 02, Sweden.

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http://dx.doi.org/10.1042/BJ20140697DOI Listing
May 2015

Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia.

Hum Mol Genet 2015 Apr 8;24(7):1945-55. Epub 2014 Dec 8.

Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Skåne University Hospital, Lund University, 205 02 Malmö, Sweden.

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http://hmg.oxfordjournals.org/content/early/2014/12/08/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu610
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http://dx.doi.org/10.1093/hmg/ddu610DOI Listing
April 2015

Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?

Nat Med 2015 Apr;21(4):310-1

Department of Cell Physiology and Metabolism, Geneva University Medical Center, Geneva, Switzerland.

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http://dx.doi.org/10.1038/nm.3835DOI Listing
April 2015

Mitochondrial phosphate transport during nutrient stimulation of INS-1E insulinoma cells.

Mol Cell Endocrinol 2013 Dec 9;381(1-2):198-209. Epub 2013 Aug 9.

Department of Physiology and Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

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http://dx.doi.org/10.1016/j.mce.2013.08.003DOI Listing
December 2013

DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets.

BMC Med Genet 2013 Jul 23;14:76. Epub 2013 Jul 23.

Department of Clinical Sciences, Lund University Diabetes Centre, CRC, Lund University, Scania University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1186/1471-2350-14-76DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727960PMC
July 2013

Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.

Biochem J 2013 Mar;450(3):595-605

Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Scania University Hospital, 205 02 Malmö, Sweden.

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http://dx.doi.org/10.1042/BJ20121349DOI Listing
March 2013

Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box.

Mol Cell Endocrinol 2012 Nov 16;363(1-2):20-6. Epub 2012 Jul 16.

Division of Endocrinology and Diabetology, Department of Internal Medicine II, University Hospital of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.mce.2012.07.003DOI Listing
November 2012

Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells.

Biochim Biophys Acta 2012 Oct 15;1823(10):1815-24. Epub 2012 Jul 15.

Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.bbamcr.2012.07.005DOI Listing
October 2012

Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress.

Mol Cell Proteomics 2012 Aug 16;11(8):244-54. Epub 2012 Mar 16.

Biomedical Proteomics Research Group, Department of Human Protein Sciences, University Medical Center, Geneva 1211, Switzerland.

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http://www.mcponline.org/lookup/doi/10.1074/mcp.M112.018051
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http://dx.doi.org/10.1074/mcp.M112.018051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412959PMC
August 2012

Improved characterization of the insulin secretory granule proteomes.

J Proteomics 2012 Aug 27;75(15):4620-31. Epub 2012 Apr 27.

Biomedical Proteomics Research Group, Department of Human Protein Sciences, University Medical Center, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.jprot.2012.04.023DOI Listing
August 2012

Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes.

Mol Endocrinol 2012 Jul 8;26(7):1203-12. Epub 2012 May 8.

Department of Clinical Sciences, Unit of Epigenetics and Diabetes, Lund University Diabetes Centre, Scania University Hospital, 205 02 Malmoe, Sweden.

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http://dx.doi.org/10.1210/me.2012-1004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416998PMC
July 2012

Mitochondrial signals drive insulin secretion in the pancreatic β-cell.

Mol Cell Endocrinol 2012 Apr 19;353(1-2):128-37. Epub 2011 Jul 19.

Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.mce.2011.07.016DOI Listing
April 2012

Defective mitochondrial function and motility due to mitofusin 1 overexpression in insulin secreting cells.

Korean J Physiol Pharmacol 2012 Feb 28;16(1):71-7. Epub 2012 Feb 28.

Department of Physiology, Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Wonju 220-701, Korea.

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http://dx.doi.org/10.4196/kjpp.2012.16.1.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298829PMC
February 2012

Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.

Diabetes 2011 Nov 16;60(11):2872-82. Epub 2011 Sep 16.

Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.2337/db11-0876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198058PMC
November 2011

Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.

J Biol Chem 2011 Sep 22;286(37):32300-12. Epub 2011 Jul 22.

Department of Cell Physiology and Metabolism, Centre Médical Universitaire, Université de Genève, 1 Rue Michel-Servet, 1211 Genève 4, Switzerland.

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http://dx.doi.org/10.1074/jbc.M111.247866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173152PMC
September 2011

Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells.

Mol Cell Endocrinol 2011 May 1;338(1-2):46-57. Epub 2011 Mar 1.

Department of Cell Physiology and Metabolism, University Medical Centre, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.mce.2011.02.019DOI Listing
May 2011

Mitochondrial matrix calcium is an activating signal for hormone secretion.

Cell Metab 2011 May;13(5):601-11

Department of Cell Physiology and Metabolism, University of Geneva, University Medical Center, Switzerland.

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http://dx.doi.org/10.1016/j.cmet.2011.03.015DOI Listing
May 2011

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells.

FASEB J 2010 Nov 20;24(11):4613-26. Epub 2010 Jul 20.

Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1096/fj.10-162222DOI Listing
November 2010

Evidence against a direct role of klotho in insulin resistance.

Pflugers Arch 2010 Feb 13;459(3):465-73. Epub 2009 Sep 13.

Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1007/s00424-009-0735-2DOI Listing
February 2010

Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation.

Biochim Biophys Acta 2010 Feb 18;1801(2):191-7. Epub 2009 Nov 18.

Karolinska Institutet, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital M1:03, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbalip.2009.11.002DOI Listing
February 2010

Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cells.

Proteomics 2010 Jan;10(1):59-71

Biomedical Proteomics Research Group, Structural Biology and Bioinformatics Department, Centre Médical Universitaire, Geneva, Switzerland.

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http://dx.doi.org/10.1002/pmic.200900080DOI Listing
January 2010

Linking fatty acid stress to beta-cell mitochondrial dynamics.

Diabetes 2009 Oct;58(10):2185-6

Department of Cell Physiology and Metabolism, University Medical Center, Geneva, Switzerland.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db09-09
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http://dx.doi.org/10.2337/db09-0967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750214PMC
October 2009

Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

J Biol Chem 2009 Jun 17;284(25):16808-21. Epub 2009 Apr 17.

Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1074/jbc.M807723200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719317PMC
June 2009

Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis.

Int J Biochem Cell Biol 2009 Apr 2;41(4):879-90. Epub 2008 Sep 2.

Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, PR China.

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http://dx.doi.org/10.1016/j.biocel.2008.08.031DOI Listing
April 2009

Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation.

EMBO J 2009 Feb 22;28(4):417-28. Epub 2009 Jan 22.

Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1038/emboj.2008.302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646158PMC
February 2009

Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells.

J Biol Chem 2009 Jan 7;284(1):515-24. Epub 2008 Nov 7.

Departamento de Biología Molecular, CIBER de Enfermedades Raras (CIBERER), Universidad Autónoma, 28049 Madrid, Spain.

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http://dx.doi.org/10.1074/jbc.M806729200DOI Listing
January 2009

Synaptotagmins bind calcium to release insulin.

Am J Physiol Endocrinol Metab 2008 Dec 19;295(6):E1279-86. Epub 2008 Aug 19.

Dept. of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1152/ajpendo.90568.2008DOI Listing
December 2008

TRIB3 [corrected] is implicated in glucotoxicity- and endoplasmic reticulum-stress-induced [corrected] beta-cell apoptosis.

J Endocrinol 2008 Dec 25;199(3):407-16. Epub 2008 Sep 25.

Graduate School of Peking Union Medical College, Beijing 100730, People's Republic of China.

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http://dx.doi.org/10.1677/JOE-08-0331DOI Listing
December 2008

Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells.

J Biol Chem 2008 Nov 2;283(48):33347-56. Epub 2008 Oct 2.

Department of Cell Physiology and Metabolism, University of Geneva, CH-1211, Geneva 4, Switzerland.

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http://dx.doi.org/10.1074/jbc.M806251200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662262PMC
November 2008

Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell.

Cell Calcium 2008 Jul 8;44(1):64-76. Epub 2008 Jan 8.

Department of Cell Physiology and Metabolism, University Medical Center, 1 rue Michel-Servet, Geneva 4, Switzerland.

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http://milne.ruc.dk/~booss/betasys/exocytosis/rexworkshop200
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http://linkinghub.elsevier.com/retrieve/pii/S014341600700192
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http://dx.doi.org/10.1016/j.ceca.2007.11.004DOI Listing
July 2008

The MODY1 gene for hepatocyte nuclear factor 4alpha and a feedback loop control COUP-TFII expression in pancreatic beta cells.

Mol Cell Biol 2008 Jul 12;28(14):4588-97. Epub 2008 May 12.

Department of Endocrinology, Metabolism and Cancer, Institut Cochin, Université Paris Descartes, CNRS, UMR 8104, Paris, France.

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http://dx.doi.org/10.1128/MCB.01191-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447131PMC
July 2008

Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion.

Endocrinology 2008 May 24;149(5):2494-505. Epub 2008 Jan 24.

Department of Genetic Medicine and Development, University of Geneva Medical Center, 1211 Geneva-4, Switzerland.

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http://dx.doi.org/10.1210/en.2007-0974DOI Listing
May 2008

Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis.

FASEB J 2008 Jan 20;22(1):194-206. Epub 2007 Aug 20.

Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1096/fj.07-8333comDOI Listing
January 2008

Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy.

J Biol Chem 2007 Nov 30;282(44):32084-92. Epub 2007 Aug 30.

Vollum Institute, and Division of Biostatistics, Department of Public Health and Preventative Medicine, Oregon Health & Science University, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1074/jbc.M700899200DOI Listing
November 2007

Proteomics analysis of insulin secretory granules.

Mol Cell Proteomics 2007 Jun 22;6(6):1007-17. Epub 2007 Feb 22.

Biomedical Proteomics Research Group, University Medical Center, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1074/mcp.M600443-MCP200DOI Listing
June 2007

Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains.

Endocr Rev 2007 Feb 16;28(1):84-116. Epub 2007 Jan 16.

Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1210/er.2006-0007DOI Listing
February 2007

Minireview: implication of mitochondria in insulin secretion and action.

Endocrinology 2006 Jun 23;147(6):2643-9. Epub 2006 Mar 23.

Department of Cell Physiology and Metabolism, University Medical Center, Geneva, Switzerland.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2006-0057DOI Listing
June 2006

[Glucose homeostasis ribo-regulated by microRNA].

Med Sci (Paris) 2006 May;22(5):463-5

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http://dx.doi.org/10.1051/medsci/2006225463DOI Listing
May 2006

MicroRNAs: 'ribo-regulators' of glucose homeostasis.

Nat Med 2006 Jan;12(1):36-8

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http://dx.doi.org/10.1038/nm0106-36DOI Listing
January 2006

SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment.

J Cell Sci 2005 Dec;118(Pt 23):5647-60

Department of Cell Physiology and Metabolism, University Medical Center, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1242/jcs.02658DOI Listing
December 2005

Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells.

Endocrinology 2005 Nov 4;146(11):4861-70. Epub 2005 Aug 4.

Lilly Research Laboratories, Essener Bogen 7, D-22419 Hamburg, Germany.

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http://dx.doi.org/10.1210/en.2005-0800DOI Listing
November 2005

ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity.

J Cell Sci 2005 Sep 9;118(Pt 17):3905-15. Epub 2005 Aug 9.

Department of Cell Physiology and Metabolism, University Medical Center, Geneva, CH-1211, Switzerland.

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http://dx.doi.org/10.1242/jcs.02513DOI Listing
September 2005

Adenovirus-mediated silencing of synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets.

FEBS Lett 2005 Sep;579(23):5241-6

Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland.

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http://doi.wiley.com/10.1016/j.febslet.2005.08.047
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http://dx.doi.org/10.1016/j.febslet.2005.08.047DOI Listing
September 2005

Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release.

Diabetes 2005 Jun;54(6):1808-15

Department of Cell PhysiologyMetabolism, University Medical Centre, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.2337/diabetes.54.6.1808DOI Listing
June 2005

Does chasing selected 'Fox' to the nucleus prevent diabetes?

Trends Mol Med 2005 Jun;11(6):262-5

Department of Cell Physiology and Metabolism, University Medical Center, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.molmed.2005.04.003DOI Listing
June 2005

[Pax4, islet plasticity and diabetes].

Med Sci (Paris) 2005 Apr;21(4):358-9

Département de Physiologie cellulaire et métabolisme, Centre Médical Universitaire, 1, rue Michel Servet, 1211 Genève 4, Suisse. thierry.brun@ medecine.unige.ch

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http://dx.doi.org/10.1051/medsci/2005214358DOI Listing
April 2005

The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets.

J Cell Biol 2004 Dec 13;167(6):1123-35. Epub 2004 Dec 13.

Department of Cell Physiology and Metabolism, University Medical Center, Geneva, Switzerland.

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http://dx.doi.org/10.1083/jcb.200405148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172618PMC
December 2004

Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets.

J Biol Chem 2004 Jul 19;279(30):31121-30. Epub 2004 May 19.

Department of Cell Physiology and Metabolism and Genomics Platform, National Center of Competence in Research Frontiers in Genetics, University of Geneva, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1074/jbc.M405030200DOI Listing
July 2004

Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis.

J Cell Sci 2004 Jul 9;117(Pt 15):3119-27. Epub 2004 Jun 9.

Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1242/jcs.01179DOI Listing
July 2004

GABA in the endocrine pancreas: its putative role as an islet cell paracrine-signalling molecule.

J Gen Physiol 2004 Mar 9;123(3):185-90. Epub 2004 Feb 9.

Experimental Diabetology Group, Department of Cell Physiology and Metabolism, University Medical Center, Geneva, Switzerland.

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http://dx.doi.org/10.1085/jgp.200409016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217445PMC
March 2004

Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.

Endocrinology 2004 Feb 30;145(2):667-78. Epub 2003 Oct 30.

Division of Clinical Biochemistry, Department of Internal Medicine, DBC-9100, University Medical Center, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1210/en.2003-1099DOI Listing
February 2004

The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction.

J Biol Chem 2003 May 24;278(19):16622-9. Epub 2003 Feb 24.

Department of Internal Medicine, University Medical Centre, Geneva-4 CH-1211, Switzerland.

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http://dx.doi.org/10.1074/jbc.M212488200DOI Listing
May 2003

Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.

Nat Cell Biol 2003 Apr;5(4):330-5

Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1038/ncb951DOI Listing
April 2003

Experimental models of transcription factor-associated maturity-onset diabetes of the young.

Diabetes 2002 Dec;51 Suppl 3:S333-42

Department of Internal Medicine, Division of Clinical Biochemistry, University Medical Centre, Geneva, Switzerland.

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http://dx.doi.org/10.2337/diabetes.51.2007.s333DOI Listing
December 2002

Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells.

FEBS Lett 2002 Nov;531(2):199-203

Islet Discovery Research, Novo Nordisk A/S, Novo Alle, Bagsvaerd, Denmark.

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http://dx.doi.org/10.1016/s0014-5793(02)03500-7DOI Listing
November 2002

ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells.

J Biol Chem 2002 Sep 26;277(36):32746-52. Epub 2002 Jun 26.

Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1074/jbc.M201635200DOI Listing
September 2002

Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha.

J Biol Chem 2002 Jul 6;277(29):25914-9. Epub 2002 May 6.

Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1074/jbc.M201582200DOI Listing
July 2002

Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release.

J Biol Chem 2002 May 1;277(20):17564-70. Epub 2002 Mar 1.

Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1074/jbc.M111037200DOI Listing
May 2002