Publications by authors named "Ciro Leonardo Pierri"

41Publications

Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers.

Authors:
Lucia Trisolini Luna Laera Maria Favia Antonella Muscella Alessandra Castegna Vito Pesce Lorenzo Guerra Anna De Grassi Mariateresa Volpicella Ciro Leonardo Pierri

Biomolecules 2020 Dec 30;11(1). Epub 2020 Dec 30.

Department of Biosciences, Biotechnologies, Biopharmaceutics, University "Aldo Moro" of Bari, Via E. Orabona, 4, 70125 Bari, Italy.

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December 2020

Targeting GMC Oxidoreductase with High Affinity Small Molecules for Reducing Patulin Production.

Authors:
Vincenzo Tragni Pietro Cotugno Anna De Grassi Maria Maddalena Cavalluzzi Annamaria Mincuzzi Giovanni Lentini Simona Marianna Sanzani Antonio Ippolito Ciro Leonardo Pierri

Biology (Basel) 2020 Dec 31;10(1). Epub 2020 Dec 31.

Laboratory of Biochemistry, Molecular and Structural Biology, Department of Biosciences, Biotechnologies, Biopharmaceutics, University of Bari, Via E. Orabona, 4, 70125 Bari, Italy.

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December 2020

Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas.

Authors:
Nivea Dias Amoedo Saharnaz Sarlak Emilie Obre Pauline Esteves Hugues Bégueret Yann Kieffer Benoît Rousseau Alexis Dupis Julien Izotte Nadège Bellance Laetitia Dard Isabelle Redonnet-Vernhet Giuseppe Punzi Mariana Figueiredo Rodrigues Elodie Dumon Walid Mafhouf Véronique Guyonnet-Dupérat Lara Gales Tony Palama Floriant Bellvert Nathalie Dugot-Senan Stéphane Claverol Jean-Marc Baste Didier Lacombe Hamid Reza Rezvani Ciro Leonardo Pierri Fatima Mechta-Grigoriou Matthieu Thumerel Rodrigue Rossignol

J Clin Invest 2021 Jan;131(1)

CELLOMET, Bordeaux, France.

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January 2021

Mitochondrial Membranes of Human SH-SY5Y Neuroblastoma Cells Express Serotonin 5-HT Receptor.

Authors:
Alessandra Tempio Mauro Niso Luna Laera Lucia Trisolini Maria Favia Lucia Ciranna Domenico Marzulli Giuseppe Petrosillo Ciro Leonardo Pierri Enza Lacivita Marcello Leopoldo

Int J Mol Sci 2020 Dec 17;21(24). Epub 2020 Dec 17.

Biofordrug srl, via Dante 99, 70019 Triggiano (Bari), Italy.

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December 2020

Targeting mitochondrial metabolite transporters in Penicillium expansum for reducing patulin production.

Authors:
Vincenzo Tragni Pietro Cotugno Anna De Grassi Federica Massari Francesco Di Ronzo Antonella Maria Aresta Carlo Zambonin Simona Marianna Sanzani Antonio Ippolito Ciro Leonardo Pierri

Plant Physiol Biochem 2021 Jan 28;158:158-181. Epub 2020 Jul 28.

Laboratory of Biochemistry, Molecular and Structural Biology, Department of Biosciences, Biotechnologies, Biopharmaceutics, University of Bari, Via E. Orabona, 4, 70125, Bari, Italy; BROWSer S.r.l. (https://browser-bioinf.com/) c/o, Department of Biosciences, Biotechnologies, Biopharmaceutics, University "Aldo Moro" of Bari, Via E. Orabona, 4, 70126, Bari, Italy. Electronic address:

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January 2021

Sweet as honey, bitter as bile: Mitochondriotoxic peptides and other therapeutic proteins isolated from animal tissues, for dealing with mitochondrial apoptosis.

Authors:
Francesco Colella Giovanni Scillitani Ciro Leonardo Pierri

Toxicology 2021 01 7;447:152612. Epub 2020 Nov 7.

Laboratory of Biochemistry, Molecular and Structural Biology, Department of Biosciences, Biotechnologies, Biopharmaceutics, University of Bari, Via E. Orabona, 4, 70125, Bari, Italy; BROWSer S.r.l. (https://browser-bioinf.com/) c/o Department of Biosciences, Biotechnologies, Biopharmaceutics, University "Aldo Moro" of Bari, Via E. Orabona, 4, 70126, Bari, Italy. Electronic address:

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January 2021

SARS-CoV-2 spike protein: flexibility as a new target for fighting infection.

Authors:
Ciro Leonardo Pierri

Signal Transduct Target Ther 2020 10 30;5(1):254. Epub 2020 Oct 30.

Laboratory of Biochemistry; Molecular and Structural Biology; Department of Biosciences, Biotechnologies, Biopharmaceutics, University of Bari, Via E. Orabona, 4, 70125, Bari, Italy.

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October 2020

Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies.

Authors:
Ivan Mercurio Vincenzo Tragni Francesco Busto Anna De Grassi Ciro Leonardo Pierri

Cell Mol Life Sci 2020 Jul 4. Epub 2020 Jul 4.

Laboratory of Biochemistry, Molecular and Structural Biology, Department of Biosciences, Biotechnologies, Biopharmaceutics, University of Bari, Via E. Orabona, 4, 70125, Bari, Italy.

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July 2020

Targeting Human Lung Adenocarcinoma with a Suppressor of Mitochondrial Superoxide Production.

Authors:
Nivea Dias Amoedo Laetitia Dard Saharnaz Sarlak Walid Mahfouf Wendy Blanchard Benoît Rousseau Julien Izotte Stéphane Claverol Didier Lacombe Hamid Reza Rezvani Ciro Leonardo Pierri Rodrigue Rossignol

Antioxid Redox Signal 2020 11 29;33(13):883-902. Epub 2020 Jun 29.

CELLOMET, Functional Genomics Center (CGFB), Bordeaux, France.

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November 2020

FAD/NADH Dependent Oxidoreductases: From Different Amino Acid Sequences to Similar Protein Shapes for Playing an Ancient Function.

Authors:
Lucia Trisolini Nicola Gambacorta Ruggiero Gorgoglione Michele Montaruli Luna Laera Francesco Colella Mariateresa Volpicella Anna De Grassi Ciro Leonardo Pierri

J Clin Med 2019 Dec 2;8(12). Epub 2019 Dec 2.

Laboratory of Biochemistry; Molecular and Structural Biology; Department of Biosciences, Biotechnologies, Biopharmaceutics; University of Bari; Via E. Orabona 4; 70125 Bari, Italy.

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December 2019

Beyond the Big Five: Investigating Myostatin Structure, Polymorphism and Expression in .

Authors:
Maria Favia Robert Fitak Lorenzo Guerra Ciro Leonardo Pierri Bernard Faye Ahmad Oulmouden Pamela Anna Burger Elena Ciani

Front Genet 2019 7;10:502. Epub 2019 Jun 7.

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", Bari, Italy.

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June 2019

Pathogenic Variants in NUP214 Cause "Plugged" Nuclear Pore Channels and Acute Febrile Encephalopathy.

Authors:
Boris Fichtman Tamar Harel Nitzan Biran Fadia Zagairy Carolyn D Applegate Yuval Salzberg Tal Gilboa Somaya Salah Avraham Shaag Natalia Simanovsky Houriya Ayoubieh Nara Sobreira Giuseppe Punzi Ciro Leonardo Pierri Ada Hamosh Orly Elpeleg Amnon Harel Simon Edvardson

Am J Hum Genet 2019 07 6;105(1):48-64. Epub 2019 Jun 6.

Pediatric Neurology Unit, Hadassah-Hebrew University Medical Center, Jerusalem 91240, Israel; Monique and Jacques Roboh Department of Genetic Research, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.

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July 2019

A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent.

Authors:
Yulia Itkis Tatiana Krylova Natalia L Pechatnikova Anna De Grassi Vyacheslav Yu Tabakov Ciro Leonardo Pierri Vasily Aleshin Alexandra Boyko Victoria I Bunik Ekaterina Yu Zakharova

Mitochondrion 2019 07 19;47:10-17. Epub 2019 Apr 19.

Department of Inborn Errors of Metabolism, FSBI 'Research Centre for Medical Genetics', Moscow, Russia.

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July 2019

Heterozygous RNF13 Gain-of-Function Variants Are Associated with Congenital Microcephaly, Epileptic Encephalopathy, Blindness, and Failure to Thrive.

Authors:
Simon Edvardson Claudia M Nicolae Grace J Noh Jennifer E Burton Giuseppe Punzi Avraham Shaag Jessica Bischetsrieder Anna De Grassi Ciro Leonardo Pierri Orly Elpeleg George-Lucian Moldovan

Am J Hum Genet 2019 01 27;104(1):179-185. Epub 2018 Dec 27.

Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA. Electronic address:

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January 2019

The Bacterial Protein CNF1 as a Potential Therapeutic Strategy against Mitochondrial Diseases: A Pilot Study.

Authors:
Alessia Fabbri Sara Travaglione Zaira Maroccia Marco Guidotti Ciro Leonardo Pierri Guido Primiano Serenella Servidei Stefano Loizzo Carla Fiorentini

Int J Mol Sci 2018 06 21;19(7). Epub 2018 Jun 21.

Italian Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy.

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June 2018

Metabolic Routes in Inflammation: The Citrate Pathway and its Potential as Therapeutic Target.

Authors:
Vittoria Infantino Ciro Leonardo Pierri Vito Iacobazzi

Curr Med Chem 2019 ;26(40):7104-7116

Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari, Bari, Italy.

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February 2020

Effect of cariporide on ram sperm pH regulation and motility: possible role of NHE1.

Authors:
Stefania Muzzachi Lorenzo Guerra Nicola Antonio Martino Maria Favia Giuseppe Punzi Fabio Silvestre Antonio Ciro Guaricci Maria Teresa Roscino Ciro Leonardo Pierri Maria Elena Dell'Aquila Valeria Casavola Giovanni Michele Lacalandra Elena Ciani

Reproduction 2018 05 28;155(5):433-445. Epub 2018 Feb 28.

Department of BiosciencesBiotechnologies and Biopharmaceutics, University of Bari 'Aldo Moro', Bari, Italy.

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May 2018

Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition.

Authors:
Cinzia Tavani Lara Bianchi Annalisa De Palma Giovanna Ilaria Passeri Giuseppe Punzi Ciro Leonardo Pierri Angelo Lovece Maria Maddalena Cavalluzzi Carlo Franchini Giovanni Lentini Giovanni Petrillo

Bioorg Med Chem Lett 2017 09 27;27(17):3980-3986. Epub 2017 Jul 27.

Department of Chemistry and Industrial Chemistry, University of Genoa, Via Dodecaneso 31, I-16146 Genoa, Italy.

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September 2017

Biochemical characterization of a new mitochondrial transporter of dephosphocoenzyme A in Drosophila melanogaster.

Authors:
Angelo Vozza Francesco De Leonardis Eleonora Paradies Anna De Grassi Ciro Leonardo Pierri Giovanni Parisi Carlo Marya Thomas Marobbio Francesco Massimo Lasorsa Luigina Muto Loredana Capobianco Vincenza Dolce Susanna Raho Giuseppe Fiermonte

Biochim Biophys Acta Bioenerg 2017 Feb 9;1858(2):137-146. Epub 2016 Nov 9.

Department of Biosciences, Biotechnologies and Biopharmaceutics, Laboratory of Biochemistry and Molecular Biology, University of Bari, via Orabona 4, 70125 Bari, Italy. Electronic address:

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February 2017

Dataset of the AAC2 conformations in the c-, intermediate- and m-states obtained from free-energy simulations.

Authors:
Adriana Pietropaolo Ciro Leonardo Pierri Ferdinando Palmieri Martin Klingenberg

Data Brief 2016 Jun 13;7:1355-7. Epub 2016 Apr 13.

Institut für Physiologische Chemie, Schillerstr.44, 80336 München, Germany.

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June 2016

Molecular modeling of antibodies for the treatment of TNFα-related immunological diseases.

Authors:
Ciro Leonardo Pierri Fabrizio Bossis Giuseppe Punzi Anna De Grassi Michela Cetrone Giovanni Parisi Domenico Tricarico

Pharmacol Res Perspect 2016 Feb 15;4(1):e00197. Epub 2016 Jan 15.

Department of Pharmacy - Drug Science University of Bari Bari Italy.

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February 2016

The switching mechanism of the mitochondrial ADP/ATP carrier explored by free-energy landscapes.

Authors:
Adriana Pietropaolo Ciro Leonardo Pierri Ferdinando Palmieri Martin Klingenberg

Biochim Biophys Acta 2016 Jun 10;1857(6):772-81. Epub 2016 Feb 10.

Institut für Physiologische Chemie, Schillerstr.44, 80336 München, Germany. Electronic address:

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June 2016

Identification of new highly selective inhibitors of the human ADP/ATP carriers by molecular docking and in vitro transport assays.

Authors:
Simona Todisco Maria Antonietta Di Noia Angelo Onofrio Giovanni Parisi Giuseppe Punzi Giandomenico Redavid Anna De Grassi Ciro Leonardo Pierri

Biochem Pharmacol 2016 Jan 23;100:112-32. Epub 2015 Nov 23.

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, 70125 Bari, Italy. Electronic address:

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January 2016

Truncating mutation in the nitric oxide synthase 1 gene is associated with infantile achalasia.

Authors:
Eyal Shteyer Simon Edvardson Sarah L Wynia-Smith Ciro Leonardo Pierri Tzili Zangen Saar Hashavya Michal Begin Barak Yaacov Yuval Cinamon Benjamin Z Koplewitz Amos Vromen Orly Elpeleg Brian C Smith

Gastroenterology 2015 Mar 3;148(3):533-536.e4. Epub 2014 Dec 3.

Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin.

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March 2015

Riboflavin responsive mitochondrial myopathy is a new phenotype of dihydrolipoamide dehydrogenase deficiency. The chaperon-like effect of vitamin B2.

Authors:
Rosalba Carrozzo Alessandra Torraco Giuseppe Fiermonte Diego Martinelli Michela Di Nottia Teresa Rizza Angelo Vozza Daniela Verrigni Daria Diodato Giovanni Parisi Arianna Maiorana Cristiano Rizzo Ciro Leonardo Pierri Stefania Zucano Fiorella Piemonte Enrico Bertini Carlo Dionisi-Vici

Mitochondrion 2014 Sep 22;18:49-57. Epub 2014 Sep 22.

Division of Metabolism, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Electronic address:

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September 2014

Sirtuin 3 interacts with Lon protease and regulates its acetylation status.

Authors:
Lara Gibellini Marcello Pinti Francesca Beretti Ciro Leonardo Pierri Angelo Onofrio Massimo Riccio Gianluca Carnevale Sara De Biasi Milena Nasi Francesca Torelli Federica Boraldi Anto De Pol Andrea Cossarizza

Mitochondrion 2014 Sep 13;18:76-81. Epub 2014 Aug 13.

Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena, Italy.

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September 2014

Distance-dependent hydrophobic-hydrophobic contacts in protein folding simulations.

Authors:
Angelo Onofrio Giovanni Parisi Giuseppe Punzi Simona Todisco Maria Antonietta Di Noia Fabrizio Bossis Antonio Turi Anna De Grassi Ciro Leonardo Pierri

Phys Chem Chem Phys 2014 Sep;16(35):18907-17

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, 70125, Bari, Italy.

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September 2014

Prediction of high- and low-affinity quinol-analogue-binding sites in the aa3 and bo3 terminal oxidases from Bacillus subtilis and Escherichia coli1.

Authors:
Fabrizio Bossis Anna De Grassi Luigi Leonardo Palese Ciro Leonardo Pierri

Biochem J 2014 Jul;461(2):305-14

†Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, 70125 Bari, Italy.

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July 2014

Isolated truncus arteriosus associated with a mutation in the plexin-D1 gene.

Authors:
Asaf Ta-Shma Ciro Leonardo Pierri Polina Stepensky Avraham Shaag Shamir Zenvirt Orly Elpeleg Azaria J J T Rein

Am J Med Genet A 2013 Dec 29;161A(12):3115-20. Epub 2013 Oct 29.

Department of Pediatric Cardiology, Hadassah, Hebrew University Medical Center, Jerusalem, Israel.

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December 2013

Mitochondrial glutamate carriers from Drosophila melanogaster: biochemical, evolutionary and modeling studies.

Authors:
Paola Lunetti Anna Rita Cappello René Massimiliano Marsano Ciro Leonardo Pierri Chiara Carrisi Emanuela Martello Corrado Caggese Vincenza Dolce Loredana Capobianco

Biochim Biophys Acta 2013 Oct 11;1827(10):1245-55. Epub 2013 Jul 11.

Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy.

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October 2013

Single-nucleotide evolution quantifies the importance of each site along the structure of mitochondrial carriers.

Authors:
Ciro Leonardo Pierri Ferdinando Palmieri Anna De Grassi

Cell Mol Life Sci 2014 Jan 26;71(2):349-64. Epub 2013 Jun 26.

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, 70125, Bari, Italy.

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January 2014

Agenesis of corpus callosum and optic nerve hypoplasia due to mutations in SLC25A1 encoding the mitochondrial citrate transporter.

Authors:
Simon Edvardson Vito Porcelli Chaim Jalas Devorah Soiferman Yuval Kellner Avraham Shaag Stanley H Korman Ciro Leonardo Pierri Pasquale Scarcia Nitay D Fraenkel Reeval Segel Abraham Schechter Ayala Frumkin Ophry Pines Ann Saada Luigi Palmieri Orly Elpeleg

J Med Genet 2013 Apr 7;50(4):240-5. Epub 2013 Feb 7.

Monique and Jacques Roboh Department of Genetic Research, Hadassah, Hebrew University Medical Center, Jerusalem, Israel.

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April 2013

Characterization of mitochondrial dicarboxylate/tricarboxylate transporters from grape berries.

Authors:
Ana Regalado Ciro Leonardo Pierri Maria Bitetto Valentina Liliana Laera Catarina Pimentel Rita Francisco José Passarinho Maria M Chaves Gennaro Agrimi

Planta 2013 Mar 25;237(3):693-703. Epub 2012 Oct 25.

Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República-EAN, 2780-157, Oeiras, Portugal.

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March 2013

Isolation and characterization of novel variants of BBI coding genes from the legume Lathyrus sativus.

Authors:
Domenico De Paola Emanuela Blanco Ciro Leonardo Pierri Gabriella Sonnante

Plant Physiol Biochem 2012 Aug 12;57:45-53. Epub 2012 May 12.

Institute of Plant Genetics (IGV), National Research Council (CNR), Bari, Italy.

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August 2012

The peroxisomal NAD+ carrier of Arabidopsis thaliana transports coenzyme A and its derivatives.

Authors:
Gennaro Agrimi Annamaria Russo Ciro Leonardo Pierri Ferdinando Palmieri

J Bioenerg Biomembr 2012 Jun 4;44(3):333-40. Epub 2012 May 4.

Department of Biosciences, Biotechnology and Pharmacological Sciences, University of Bari, Via Orabona 4, 70125 Bari, Italy.

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June 2012

A new Caucasian case of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD): a clinical, molecular, and functional study.

Authors:
Giuseppe Fiermonte Giovanni Parisi Diego Martinelli Francesco De Leonardis Giuliano Torre Ciro Leonardo Pierri Alessia Saccari Francesco Massimo Lasorsa Angelo Vozza Ferdinando Palmieri Carlo Dionisi-Vici

Mol Genet Metab 2011 Dec 25;104(4):501-6. Epub 2011 Aug 25.

Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy.

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December 2011

Mitochondrial metabolite transport.

Authors:
Ferdinando Palmieri Ciro Leonardo Pierri

Essays Biochem 2010 ;47:37-52

Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, 70125 Bari, Italy.

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December 2010

Computational approaches for protein function prediction: a combined strategy from multiple sequence alignment to molecular docking-based virtual screening.

Authors:
Ciro Leonardo Pierri Giovanni Parisi Vito Porcelli

Biochim Biophys Acta 2010 Sep 28;1804(9):1695-712. Epub 2010 Apr 28.

Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Va E. Orabona, 4 - 70125 Bari, Italy.

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September 2010

Structure and function of mitochondrial carriers - role of the transmembrane helix P and G residues in the gating and transport mechanism.

Authors:
Ferdinando Palmieri Ciro Leonardo Pierri

FEBS Lett 2010 May 25;584(9):1931-9. Epub 2009 Oct 25.

Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy.

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May 2010

Lattices for ab initio protein structure prediction.

Authors:
Ciro Leonardo Pierri Anna De Grassi Antonio Turi

Proteins 2008 Nov;73(2):351-61

Department of Pharmaco-Biology, University of Bari, Va E. Orabona, Bari, Italy.

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November 2008

Structural-dynamical properties of the transmembrane segment VI of the mitochondrial oxoglutarate carrier studied by site directed spin-labeling.

Authors:
Graziantonio Lauria Paloma Sanchez Blasco Morozzo Della Rocca Ciro Leonardo Pierri Francesca Polizio Italo Stipani Alessandro Desideri

Mol Membr Biol 2008 Apr;25(3):236-44

Department of Pharmaco-Biology, University of Bari, Italy.

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April 2008