Ciriaco Piccirillo

Ciriaco Piccirillo

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Ciriaco Piccirillo

Publications by authors named "Ciriaco Piccirillo"

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Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes.

Diabetes 2020 Apr 31;69(4):784-795. Epub 2020 Jan 31.

Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada

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http://dx.doi.org/10.2337/db19-0831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085253PMC
April 2020

Mechanisms of T cell adaptation to inflammation.

J Leukoc Biol 2020 Mar 23. Epub 2020 Mar 23.

Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1002/JLB.1MR0120-196RDOI Listing
March 2020

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome: A systematic review.

Autoimmun Rev 2020 Mar 29:102526. Epub 2020 Mar 29.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2020.102526DOI Listing
March 2020

Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3 Regulatory T Cells.

Cell Rep 2020 Feb;30(5):1515-1529.e4

Department of Microbiology and Immunology, McGill University, Montréal, QC H3A 2B4, Canada; Program in Infectious Diseases and Immunology in Global Health, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada; Centre of Excellence in Translational Immunology (CETI), Montréal, QC H4A 3J1, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, QC H4A 3J1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.01.002DOI Listing
February 2020

PD-1/PD-L1 Immune Checkpoint Inhibition with Radiation in Bladder Cancer: and Abscopal Effects.

Mol Cancer Ther 2020 01 18;19(1):211-220. Epub 2019 Sep 18.

Urologic Oncology Research Program, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0986DOI Listing
January 2020

The Deubiquitinating Enzyme Ubiquitin-Specific Peptidase 11 Potentiates TGF-β Signaling in CD4 T Cells to Facilitate Foxp3 Regulatory T and T17 Cell Differentiation.

J Immunol 2019 Nov 25;203(9):2388-2400. Epub 2019 Sep 25.

Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada;

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http://dx.doi.org/10.4049/jimmunol.1801689DOI Listing
November 2019

Rebalancing Immune Homeostasis to Treat Autoimmune Diseases.

Trends Immunol 2019 Oct 7;40(10):888-908. Epub 2019 Oct 7.

Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.it.2019.08.003DOI Listing
October 2019

Foxp3 Post-translational Modifications and Treg Suppressive Activity.

Front Immunol 2019 18;10:2486. Epub 2019 Oct 18.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.02486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813729PMC
October 2019

Signaling Through gp130 Compromises Suppressive Function in Human FOXP3 Regulatory T Cells.

Front Immunol 2019 18;10:1532. Epub 2019 Jul 18.

Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fimmu.2019.01532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657659PMC
July 2019

The immune mediated role of extracellular HMGB1 in a heterotopic model of bladder cancer radioresistance.

Sci Rep 2019 04 23;9(1):6348. Epub 2019 Apr 23.

Urologic Oncology Research Division, Research Institute of McGill University Health Centre, Montréal, H4A 3J1, Canada.

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http://dx.doi.org/10.1038/s41598-019-42864-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478679PMC
April 2019

AS Infection Induces CD4 Th1 Cells and Foxp3T-bet Regulatory T Cells That Express CXCR3 and Migrate to CXCR3 Ligands.

Front Immunol 2019 11;10:425. Epub 2019 Mar 11.

Centre for Host-Parasite Interactions, Institute of Parasitology, McGill University, Ste-Anne de Bellevue, QC, Canada.

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http://dx.doi.org/10.3389/fimmu.2019.00425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422055PMC
March 2019

Pleiotropic Effects of IL-33 on CD4 T Cell Differentiation and Effector Functions.

Front Immunol 2019 20;10:522. Epub 2019 Mar 20.

Department of Microbiology and Immunology, McGill University, Montréal, QC, Canada.

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00522
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http://dx.doi.org/10.3389/fimmu.2019.00522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435597PMC
March 2019

The Microbiota and Immune System Crosstalk in Health and Disease.

Mediators Inflamm 2018 22;2018:2912539. Epub 2018 Apr 22.

Institute of Internal Medicine, "A. Gemelli Hospital", Catholic University of the Sacred Heart, Rome, Italy.

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http://dx.doi.org/10.1155/2018/2912539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937375PMC
January 2019

The Intricate Link among Gut "Immunological Niche," Microbiota, and Xenobiotics in Intestinal Pathology.

Mediators Inflamm 2017 8;2017:8390595. Epub 2017 Oct 8.

Department of Internal Medicine and Medical Sciences, "A. Gemelli Hospital", Catholic University of the Sacred Heart, Rome, Italy.

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https://www.hindawi.com/journals/mi/2017/8390595/
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http://dx.doi.org/10.1155/2017/8390595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651127PMC
July 2018

KLRG1 expression identifies short-lived Foxp3 T effector cells with functional plasticity in islets of NOD mice.

Autoimmunity 2017 Sep 29;50(6):354-362. Epub 2017 Aug 29.

a Department of Microbiology and Immunology , McGill University , Montréal , Québec , Canada.

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http://dx.doi.org/10.1080/08916934.2017.1364368DOI Listing
September 2017

Suppression by human FOXP3 regulatory T cells requires FOXP3-TIP60 interactions.

Sci Immunol 2017 Jun;2(12)

Department of Microbiology and Immunology, McGill University and Research Institute of McGill University Health Centre, Montréal, Québec H3A 2B4, Canada.

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http://dx.doi.org/10.1126/sciimmunol.aai9297DOI Listing
June 2017

The common, autoimmunity-predisposing 620Arg > Trp variant of PTPN22 modulates macrophage function and morphology.

J Autoimmun 2017 May 22;79:74-83. Epub 2017 Feb 22.

Research Institute of McGill University Health Centre, Child Health and Human Development Program, 1001 Decarie Boulevard, Montreal, QC H4A 3J1, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411163032
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http://dx.doi.org/10.1016/j.jaut.2017.01.009DOI Listing
May 2017

Peripherally Generated Foxp3 Regulatory T Cells Mediate the Immunomodulatory Effects of IVIg in Allergic Airways Disease.

J Immunol 2017 04 20;198(7):2760-2771. Epub 2017 Feb 20.

Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada;

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http://dx.doi.org/10.4049/jimmunol.1502361DOI Listing
April 2017

Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice.

PLoS One 2015 6;10(5):e0126311. Epub 2015 May 6.

Department of Microbiology and Immunology, McGill University, Montréal, QC, Canada, H3A 2B4; Microbiome and Disease Tolerance Centre, McGill University, Montreal, QC, Canada, H3A 2B4; FOCIS Center of Excellence in Translational Immunology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, H3G 1A4.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126311PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422433PMC
April 2016

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes.

Diabetes 2016 04 19;65(4):1031-9. Epub 2016 Jan 19.

Department of Surgery, The University of British Columbia, and Child & Family Research Institute, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.2337/db15-0572DOI Listing
April 2016

The Interactions between Innate Immunity and Microbiota in Gastrointestinal Diseases.

J Immunol Res 2015 20;2015:898297. Epub 2015 May 20.

Department of Medical Sciences, Catholic University of Rome, Largo A. Gemelli 8, 00168 Rome, Italy.

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http://dx.doi.org/10.1155/2015/898297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452856PMC
March 2016

Posttranscriptional and Translational Control of Gene Regulation in CD4+ T Cell Subsets.

J Immunol 2016 Jan;196(2):533-40

Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada;Translational Immunology Unit, Program in Infectious Disease and Immunity in Global Health, Research Institute of the McGill University Health Center, Montreal, Quebec H4A 3J1, Canada; andFederation of Clinical Immunology Societies Center of Excellence, McGill University and the Research Institute of the McGill University Health Center, Montreal, Quebec H3H 2R9, Canada

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http://dx.doi.org/10.4049/jimmunol.1501337DOI Listing
January 2016

The immunological and genetic basis of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.

Curr Opin Allergy Clin Immunol 2015 Dec;15(6):525-32

aDepartment of Microbiology and Immunology, FOCIS Centre of Excellence, McGill University, Research Institute of the McGill University Health Centre bProgram in Infectious Diseases and Immunology in Global Health, the Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.

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http://dx.doi.org/10.1097/ACI.0000000000000214DOI Listing
December 2015

Induction of Regulatory T Cells by Intravenous Immunoglobulin: A Bridge between Adaptive and Innate Immunity.

Front Immunol 2015 11;6:469. Epub 2015 Sep 11.

Translational Research in Respiratory Diseases Program, The Research Institute of the McGill University Health Centre , Montreal, QC , Canada ; Department of Pediatrics, Faculty of Medicine, McGill University , Montreal, QC , Canada.

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http://dx.doi.org/10.3389/fimmu.2015.00469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566032PMC
October 2015

Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells.

J Immunol 2015 Apr 11;194(8):3687-96. Epub 2015 Mar 11.

Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3G 1A4, Canada; Federation of Clinical Immunology Centre of Excellence, Research Institute of the McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1401803
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http://dx.doi.org/10.4049/jimmunol.1401803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610024PMC
April 2015

The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo.

Immunity 2015 Jan 2;42(1):41-54. Epub 2015 Jan 2.

Goodman Cancer Research Centre, McGill University, Montreal, QC, H3G 1Y6, Canada; Department of Physiology, McGill University, Montreal, QC, H3G 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.12.030DOI Listing
January 2015

Reply: To PMID 24210883.

J Allergy Clin Immunol 2014 Dec 28;134(6):1469-1470. Epub 2014 Oct 28.

McGill University Health Center Research Institute, Meakins Christie Laboratories, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.08.050DOI Listing
December 2014

Translational control of immune responses: from transcripts to translatomes.

Nat Immunol 2014 Jun;15(6):503-11

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/ni.2891DOI Listing
June 2014

Functional dynamics of Foxp3⁺ regulatory T cells in mice and humans.

Immunol Rev 2014 May;259(1):140-58

Department of Microbiology and Immunology, FOCIS Center of Excellence in Translational Immunology, Microbiome and Disease Tolerance Centre, McGill University and the Research Institute of the McGill University Health Centre, Montreal, QC, Canada.

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http://doi.wiley.com/10.1111/imr.12168
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http://dx.doi.org/10.1111/imr.12168DOI Listing
May 2014

Dendritic cell immunoreceptor: a novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells.

J Allergy Clin Immunol 2014 Mar 8;133(3):853-63.e5. Epub 2013 Nov 8.

Meakins Christie Laboratories, the Department of Pediatrics, Division of Allergy and Immunology, The Research Institute of the McGill University Health Center, and the Department of Medicine, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.09.029DOI Listing
March 2014

Altered T helper 17 responses in children with food allergy.

Int Arch Allergy Immunol 2013 25;162(4):318-22. Epub 2013 Oct 25.

Department of Microbiology and Immunology and FOCIS Center of Excellence, McGill University and the Research Institute of the McGill University Health Center, Montreal, Que., Canada.

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http://dx.doi.org/10.1159/000354028DOI Listing
February 2014

Developmental plasticity of murine and human Foxp3(+) regulatory T cells.

Adv Immunol 2013 ;119:85-106

Autoimmune Genetics Laboratory, VIB and University of Leuven, Campus Gasthuisberg, Leuven, Belgium.

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http://dx.doi.org/10.1016/B978-0-12-407707-2.00003-5DOI Listing
October 2013

Environmental sensing and regulation of gene expression in CD4+ T cell subsets.

Curr Opin Immunol 2013 Oct 17;25(5):564-70. Epub 2013 Oct 17.

Department of Microbiology and Immunology, FOCIS Center of Excellence in Translational Immunology, Microbiome and Disease Tolerance Centre, McGill University and the Research Institute of the McGill University Health Centre, Montreal, QC, Canada H3G 1A4. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2013.09.006DOI Listing
October 2013

Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice.

Autoimmunity 2013 Jun 4;46(4):259-68. Epub 2013 Feb 4.

Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.3109/08916934.2012.752462DOI Listing
June 2013

Immune Regulation in T1D and T2D: Prospective Role of Foxp3+ Treg Cells in Disease Pathogenesis and Treatment.

Front Endocrinol (Lausanne) 2013 25;4:76. Epub 2013 Jun 25.

Department of Microbiology and Immunology, McGill University , Montreal, QC , Canada ; FOCIS Center of Excellence, Research Institute of the McGill University Health Center , Montreal, QC , Canada.

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http://dx.doi.org/10.3389/fendo.2013.00076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691561PMC
June 2013

Distinct translational control in CD4+ T cell subsets.

PLoS Genet 2013 May 2;9(5):e1003494. Epub 2013 May 2.

Department of Microbiology and Immunology, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1003494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642068PMC
May 2013

Reply: To PMID 22564681.

J Allergy Clin Immunol 2013 Apr 1;131(4):1257-8. Epub 2013 Mar 1.

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http://dx.doi.org/10.1016/j.jaci.2013.01.032DOI Listing
April 2013

Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance.

Front Immunol 2012 22;3:165. Epub 2012 Jun 22.

Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fimmu.2012.00165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381230PMC
August 2012

Functional stability of Foxp3+ regulatory T cells.

Trends Mol Med 2012 Aug 6;18(8):454-62. Epub 2012 Jul 6.

Department of Microbiology and Immunology, McGill University, Montreal, Quebec, H3A 2B4, Canada.

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http://dx.doi.org/10.1016/j.molmed.2012.06.001DOI Listing
August 2012

Functional plasticity in human FOXP3(+) regulatory T cells: implications for cell-based immunotherapy.

Hum Vaccin Immunother 2012 Jul 1;8(7):1001-5. Epub 2012 Jul 1.

Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.4161/hv.20203DOI Listing
July 2012

Intravenous immunoglobulin attenuates airway inflammation through induction of forkhead box protein 3-positive regulatory T cells.

J Allergy Clin Immunol 2012 Jun 5;129(6):1656-65.e3. Epub 2012 May 5.

Meakins Christie Laboratories, McGill University Health Center-Research Institute, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jaci.2012.02.050DOI Listing
June 2012

The immunogenetics of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome.

J Med Genet 2012 May;49(5):291-302

Department of Microbiologyand Immunology, McGill University, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1136/jmedgenet-2012-100759DOI Listing
May 2012

ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic mice.

J Immunol 2012 Feb 6;188(3):1064-74. Epub 2012 Jan 6.

Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada H3A 2B4.

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http://dx.doi.org/10.4049/jimmunol.1101303DOI Listing
February 2012

Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient mice.

Inflamm Bowel Dis 2012 Jan 29;18(1):85-93. Epub 2011 Oct 29.

Department of Surgery, University of British Columbia and Immunity in Health & Disease, Child and Family Research Institute, British Columbia Children's Hospital, Vancouver, Canada.

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http://dx.doi.org/10.1002/ibd.21738DOI Listing
January 2012

Acquired Omenn-like syndrome, a novel posttransplant autoaggression syndrome reversed by rapamycin.

Clin Vaccine Immunol 2012 Jan 16;19(1):109-12. Epub 2011 Nov 16.

Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.

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http://dx.doi.org/10.1128/CVI.05456-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255959PMC
January 2012

Critical co-stimulatory pathways in the stability of Foxp3+ Treg cell homeostasis in Type I diabetes.

Autoimmun Rev 2011 Dec 22;11(2):104-11. Epub 2011 Aug 22.

Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.autrev.2011.08.007DOI Listing
December 2011

CD4+ Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammation.

Eur J Immunol 2011 Dec 10;41(12):3455-66. Epub 2011 Nov 10.

Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1002/eji.201141814DOI Listing
December 2011

Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives.

Clin Cancer Res 2011 Nov 8;17(22):6985-91. Epub 2011 Nov 8.

Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Hôpital Notre-Dame, Université de Montréal and Institut du Cancer de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1331DOI Listing
November 2011

Phenotypic characterization and functional analysis of human tumor immune infiltration after mechanical and enzymatic disaggregation.

J Immunol Methods 2011 Sep 18;372(1-2):119-26. Epub 2011 Jul 18.

Research Center, Centre Hospitalier de l'Université de Montréal (CRCHUM), Hôpital Notre-Dame, Université de Montréal and Institut du Cancer de Montréal, Montréal, Québec, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S002217591100172
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http://dx.doi.org/10.1016/j.jim.2011.07.002DOI Listing
September 2011

IL-2 production by dendritic cells promotes Foxp3(+) regulatory T-cell expansion in autoimmune-resistant NOD congenic mice.

Autoimmunity 2011 Aug 19;44(5):406-14. Epub 2011 Jan 19.

Departments of Microbiology & Immunology and Medicine, FOCIS Center of Excellence, McGill University and Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.3109/08916934.2010.536795DOI Listing
August 2011

Single-cell analysis of the human T regulatory population uncovers functional heterogeneity and instability within FOXP3+ cells.

J Immunol 2011 Jun 16;186(12):6788-97. Epub 2011 May 16.

Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.4049/jimmunol.1100269DOI Listing
June 2011

Analysis of human FOXP3+ Treg cells phenotype and function.

Methods Mol Biol 2011 ;707:199-218

Center for the Study of Host Resistance, Montreal, QC, Canada.

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http://dx.doi.org/10.1007/978-1-61737-979-6_13DOI Listing
May 2011

Cardiolipin binds to CD1d and stimulates CD1d-restricted γδ T cells in the normal murine repertoire.

J Immunol 2011 Apr 9;186(8):4771-81. Epub 2011 Mar 9.

Division of Rheumatology, Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec H3G 1A4, Canada.

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http://dx.doi.org/10.4049/jimmunol.1000921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076096PMC
April 2011

IL-2 contributes to maintaining a balance between CD4+Foxp3+ regulatory T cells and effector CD4+ T cells required for immune control of blood-stage malaria infection.

J Immunol 2011 Apr 9;186(8):4862-71. Epub 2011 Mar 9.

Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, H3G 1A4 Canada.

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http://dx.doi.org/10.4049/jimmunol.1003777DOI Listing
April 2011

Human CD4+ FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils.

Eur J Immunol 2011 Feb 11;41(2):306-12. Epub 2011 Jan 11.

Department of Surgery, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/eji.201040459DOI Listing
February 2011

Treg's alter ego: an accessory in tumor killing.

Immunity 2010 Dec;33(6):838-40

Department of Microbiology & Immunology and Medicine, Montreal General Hospital, McGill University and Research Institute of McGill University Health Center (MUHC), 1650 Cedar Avenue Room L11-132, Montreal, Quebec H3G 1A4, Canada.

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http://dx.doi.org/10.1016/j.immuni.2010.12.005DOI Listing
December 2010

IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease.

J Transl Med 2010 Nov 8;8:113. Epub 2010 Nov 8.

Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, H3A 2B4, Qc, Quebec, Canada.

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http://dx.doi.org/10.1186/1479-5876-8-113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994816PMC
November 2010

Control of type 1 diabetes by CD4+Foxp3+ regulatory T cells: lessons from mouse models and implications for human disease.

Diabetes Metab Res Rev 2009 Mar;25(3):208-18

Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada, H3A 2B4.

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http://dx.doi.org/10.1002/dmrr.945DOI Listing
March 2009

CD4+Foxp3+ regulatory T cells in the control of autoimmunity: in vivo veritas.

Curr Opin Immunol 2008 Dec 28;20(6):655-62. Epub 2008 Oct 28.

Department of Microbiology and Immunology, and Center for the Study of Host Resistance, McGill University and the Research Institute of the McGill University Health Center, Montreal, QC, Canada H3A 2B4.

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http://dx.doi.org/10.1016/j.coi.2008.09.006DOI Listing
December 2008

Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice.

J Immunol 2008 Nov;181(9):6283-92

Department of Microbiology and Immunology, and McGill Center for the Study of Host Resistance, McGill University, Montreal, Québec, Canada.

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http://dx.doi.org/10.4049/jimmunol.181.9.6283DOI Listing
November 2008

The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease.

Immunology 2008 Oct;125(2):145-53

Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, Canada.

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http://dx.doi.org/10.1111/j.1365-2567.2008.02939.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561137PMC
October 2008

Regulatory T cells in health and disease.

Cytokine 2008 Sep 22;43(3):395-401. Epub 2008 Aug 22.

Department of Microbiology and Immunology, Center for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.cyto.2008.07.469DOI Listing
September 2008

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.

Immunity 2008 May 8;28(5):687-97. Epub 2008 May 8.

Department of Surgery, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, San Francisco, CA 94143-0540, USA.

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http://dx.doi.org/10.1016/j.immuni.2008.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394854PMC
May 2008

Cell line-dependent internalization pathways and intracellular trafficking determine transfection efficiency of nanoparticle vectors.

Eur J Pharm Biopharm 2008 Mar 15;68(3):676-87. Epub 2007 Sep 15.

Department of Biomedical Engineering, McGill University, Montreal, Que., Canada.

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http://dx.doi.org/10.1016/j.ejpb.2007.09.002DOI Listing
March 2008

Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.

Diabetes 2008 Jan 10;57(1):113-23. Epub 2007 Oct 10.

Department of Microbiology and Immunology, McGill Center for the Study of Host Resistance, McGill University, 3775 University St., Room 510, Lyman Duff Medical Building, Montreal, QC, Canada.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db06-17
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http://dx.doi.org/10.2337/db06-1700DOI Listing
January 2008

T regulatory cells control numbers of NK cells and CD8alpha+ immature dendritic cells in the lymph node paracortex.

J Immunol 2007 Oct;179(7):4492-502

Institute of Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.4049/jimmunol.179.7.4492DOI Listing
October 2007

Impairment of dendritic cell function by excretory-secretory products: a potential mechanism for nematode-induced immunosuppression.

Eur J Immunol 2007 Jul;37(7):1887-904

Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, McGill University, Montreal, Québec, Canada.

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http://dx.doi.org/10.1002/eji.200636553DOI Listing
July 2007

Ubiquitous expression of mRFP-1 in vivo by site-directed transgenesis.

Transgenic Res 2007 Feb 1;16(1):29-40. Epub 2006 Nov 1.

Department of Microbiology and Immunology, McGill University, Montreal, H3A 2B4, Canada.

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http://dx.doi.org/10.1007/s11248-006-9030-6DOI Listing
February 2007

Functional dynamics of naturally occurring regulatory T cells in health and autoimmunity.

Adv Immunol 2006 ;92:119-55

Department of Surgery, University of British Columbia and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver V6H 3Z6, Canada.

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http://dx.doi.org/10.1016/S0065-2776(06)92003-3DOI Listing
December 2006

Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles.

J Control Release 2006 Oct 6;115(3):354-61. Epub 2006 Sep 6.

Department of Biomedical Engineering, McGill University, 3775 University St., Montreal, QC, Canada H3A 2B4.

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http://dx.doi.org/10.1016/j.jconrel.2006.08.021DOI Listing
October 2006

Development and function of naturally occurring CD4+CD25+ regulatory T cells.

J Leukoc Biol 2006 Sep 29;80(3):458-70. Epub 2006 Jun 29.

Department fo Microbiology and Immunology, McGill University, Montreal, Canada, H3A 2B4.

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http://dx.doi.org/10.1189/jlb.0206095DOI Listing
September 2006

The TGF-beta1/Foxp3 regulatory axis in immune self-tolerance: implications for health and disease.

Inflamm Allergy Drug Targets 2006 Sep;5(3):167-77

Department of Microbiology and Immunology and Strategic Training Centre in Infectious Diseases and Autoimmunity, McGill University, Montreal, QC, Canada, H3A 2B4.

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http://dx.doi.org/10.2174/187152806778256089DOI Listing
September 2006

Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C.

Blood 2006 Jun 14;107(11):4424-32. Epub 2006 Feb 14.

Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-09-39
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http://dx.doi.org/10.1182/blood-2005-09-3903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895795PMC
June 2006

Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens.

J Exp Med 2006 Mar 13;203(3):777-88. Epub 2006 Mar 13.

Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1084/jem.20052056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118233PMC
March 2006

TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.

Eur J Immunol 2005 Oct;35(10):2886-95

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/eji.200526106DOI Listing
October 2005

Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells.

Trends Immunol 2004 Jul;25(7):374-80

Host Resistance Laboratory, Department of Microbiology and Immunology, McGill University, Montreal, H3A 2B4, Canada.

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http://dx.doi.org/10.1016/j.it.2004.04.009DOI Listing
July 2004

Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function.

J Immunol 2004 Jun;172(11):6519-23

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.172.11.6519DOI Listing
June 2004

Control of T cell activation by CD4+CD25+ suppressor T cells.

Novartis Found Symp 2003 ;252:24-36; discussion 36-44, 106-14

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1892, USA.

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April 2004

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance.

Semin Immunol 2004 Apr;16(2):81-8

Department of Microbiology and Immunology, Host Resistance Laboratory, McGill University, Montreal, Que., Canada H3A 2B4.

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http://linkinghub.elsevier.com/retrieve/pii/S104453230300107
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http://dx.doi.org/10.1016/j.smim.2003.12.003DOI Listing
April 2004

The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells.

J Immunol 2004 Mar;172(5):3157-66

Laboratories of Parasitic Diseases and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.172.5.3157DOI Listing
March 2004

Activation requirements for the induction of CD4+CD25+ T cell suppressor function.

Eur J Immunol 2004 Feb;34(2):366-76

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 20892-1892, USA.

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http://doi.wiley.com/10.1002/eji.200324455
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http://dx.doi.org/10.1002/eji.200324455DOI Listing
February 2004

Gene therapy with plasmids encoding cytokine- or cytokine receptor--IgG chimeric proteins.

Methods Mol Biol 2003 ;215:153-70

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1385/1-59259-345-3:153DOI Listing
June 2003

Immune modulation by plasmid DNA-mediated cytokine gene transfer.

Curr Pharm Des 2003 ;9(1):83-94

Department of Pathology, McGill University, Room B13, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada.

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http://dx.doi.org/10.2174/1381612033392404DOI Listing
May 2003

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity.

Nature 2002 Dec;420(6915):502-7

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature01152DOI Listing
December 2002

CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness.

J Exp Med 2002 Jul;196(2):237-46

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193919PMC
http://dx.doi.org/10.1084/jem.20020590DOI Listing
July 2002

CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.

Immunity 2002 Feb;16(2):311-23

Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/s1074-7613(02)00280-7DOI Listing
February 2002