Cinzia Rinaldo

Cinzia Rinaldo

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Cinzia Rinaldo

Cinzia Rinaldo

Publications by authors named "Cinzia Rinaldo"

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Extrachromosomal Histone H2B Contributes to the Formation of the Abscission Site for Cell Division.

Authors:
Laura Monteonofrio Davide Valente Cinzia Rinaldo Silvia Soddu

Cells 2019 Nov 5;8(11). Epub 2019 Nov 5.

Unit of Cellular Networks and Molecular Therapeutic Targets, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.

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http://dx.doi.org/10.3390/cells8111391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912571PMC
November 2019

p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway.

Authors:
Claudia Contadini Laura Monteonofrio Ilaria Virdia Andrea Prodosmo Davide Valente Luciana Chessa Antonio Musio Luca L Fava Cinzia Rinaldo Giuliana Di Rocco Silvia Soddu

Cell Death Dis 2019 Nov 7;10(11):850. Epub 2019 Nov 7.

Unit of Cellular Networks and Molecular Therapeutic Targets, IRCCS-Regina Elena National Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.1038/s41419-019-2076-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838180PMC
November 2019

HIPK2 Phosphorylates the Microtubule-Severing Enzyme Spastin at S268 for Abscission.

Authors:
Alessandra Pisciottani Loredana Biancolillo Manuela Ferrara Davide Valente Francesca Sardina Laura Monteonofrio Serena Camerini Marco Crescenzi Silvia Soddu Cinzia Rinaldo

Cells 2019 07 5;8(7). Epub 2019 Jul 5.

Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), c/o Sapienza University, 00185 Rome, Italy.

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http://dx.doi.org/10.3390/cells8070684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678495PMC
July 2019

ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage.

Authors:
Jessica Willan Alexa J Cleasby Neftali Flores-Rodriguez Flavia Stefani Cinzia Rinaldo Alessandra Pisciottani Emma Grant Philip Woodman Helen E Bryant Barbara Ciani

Oncogenesis 2019 Apr 15;8(5):29. Epub 2019 Apr 15.

Department of Chemistry, Centre for Membrane Interactions and Dynamics (CMIAD), Krebs Institute, University of Sheffield, Brook Hill, Sheffield, S3 7HF, United Kingdom.

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http://www.nature.com/articles/s41389-019-0136-0
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http://dx.doi.org/10.1038/s41389-019-0136-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465242PMC
April 2019

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.

Authors:
Laura Monteonofrio Davide Valente Manuela Ferrara Serena Camerini Roberta Miscione Marco Crescenzi Cinzia Rinaldo Silvia Soddu

Oncogene 2018 06 22;37(26):3562-3574. Epub 2018 Mar 22.

Unit of Cellular Networks and Molecular Therapeutic Targets, Regina Elena National Cancer Institute-IRCCS, Rome, 00144, Italy.

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http://dx.doi.org/10.1038/s41388-018-0191-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021368PMC
June 2018

Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain.

Authors:
Antonella Scaglione Laura Monteonofrio Giacomo Parisi Cristina Cecchetti Francesca Siepi Cinzia Rinaldo Alessandra Giorgi Daniela Verzili Carlotta Zamparelli Carmelinda Savino Silvia Soddu Beatrice Vallone Linda Celeste Montemiglio

Protein Sci 2018 03 28;27(3):725-737. Epub 2017 Dec 28.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, P.le A. Moro 5, 00185, Italy, Rome.

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http://doi.wiley.com/10.1002/pro.3367
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http://dx.doi.org/10.1002/pro.3367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818748PMC
March 2018

CDKL5 localizes at the centrosome and midbody and is required for faithful cell division.

Authors:
Isabella Barbiero Davide Valente Chetan Chandola Fiorenza Magi Anna Bergo Laura Monteonofrio Marco Tramarin Maria Fazzari Silvia Soddu Nicoletta Landsberger Cinzia Rinaldo Charlotte Kilstrup-Nielsen

Sci Rep 2017 07 24;7(1):6228. Epub 2017 Jul 24.

Department of Biotechnology and Life Sciences, University of Insubria, 21052, Busto Arsizio, Italy.

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http://dx.doi.org/10.1038/s41598-017-05875-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524905PMC
July 2017

Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities.

Authors:
Giovanna Maria Pierantoni Andrea Conte Cinzia Rinaldo Mara Tornincasa Raffaele Gerlini Davide Valente Antonella Izzo Alfredo Fusco

Cell Cycle 2016 ;15(6):812-8

a Istituto di Endocrinologia ed Oncologia Sperimentale del CNR and Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli "Federico II" , Naples , Italy.

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http://www.tandfonline.com/doi/full/10.1080/15384101.2016.11
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http://dx.doi.org/10.1080/15384101.2016.1146835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845974PMC
December 2016

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia.

Authors:
Stefano Iacovelli Maria Rosaria Ricciardi Matteo Allegretti Simone Mirabilii Roberto Licchetta Paola Bergamo Cinzia Rinaldo Ann Zeuner Robin Foà Michele Milella James A McCubrey Alberto M Martelli Agostino Tafuri

Oncotarget 2015 Oct;6(31):32089-103

Hematology, "Sant'Andrea" Hospital - Sapienza University of Rome, Department of Clinical and Molecular Medicine, Rome, Italy.

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http://dx.doi.org/10.18632/oncotarget.5156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741661PMC
October 2015

Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes.

Authors:
Giovanna Maria Pierantoni Andrea Conte Cinzia Rinaldo Mara Tornincasa Raffaele Gerlini Antonella Federico Davide Valente Enzo Medico Alfredo Fusco

Oncotarget 2015 Jul;6(19):17342-53

Istituto di Endocrinologia ed Oncologia Sperimentale del CNR and Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli "Federico II", 80131, Naples, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627312PMC
http://dx.doi.org/10.18632/oncotarget.3944DOI Listing
July 2015

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity.

Authors:
Davide Valente Gianluca Bossi Alice Moncada Mara Tornincasa Stefania Indelicato Salvatore Piscuoglio Eva Diamantis Karamitopoulou Armando Bartolazzi Giovanna Maria Pierantoni Alfredo Fusco Silvia Soddu Cinzia Rinaldo

Oncotarget 2015 Apr;6(12):10320-34

Experimental Oncology Laboratory, Regina Elena National Cancer Institute, Rome, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496358PMC
http://dx.doi.org/10.18632/oncotarget.3583DOI Listing
April 2015

Homeodomain-interacting protein kinase-2 stabilizes p27kip1 by its phosphorylation at serine 10 and contributes to cell motility.

Authors:
Giovanna Maria Pierantoni Francesco Esposito Mara Tornincasa Cinzia Rinaldo Giuseppe Viglietto Silvia Soddu Alfredo Fusco

J Biol Chem 2014 06;289(25):17426

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http://www.jbc.org/lookup/doi/10.1074/jbc.A111.230854
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http://dx.doi.org/10.1074/jbc.A111.230854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067179PMC
June 2014

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer.

Authors:
Gabriella D'Orazi Cinzia Rinaldo Silvia Soddu

J Exp Clin Cancer Res 2012 Aug 13;31:63. Epub 2012 Aug 13.

Department of Medical, Oral, and Biotechnological Sciences, University "G, d'Annunzio", Chieti 66013, Italy.

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http://dx.doi.org/10.1186/1756-9966-31-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432601PMC
August 2012

HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody.

Authors:
Cinzia Rinaldo Alice Moncada Alessandra Gradi Laura Ciuffini Donatella D'Eliseo Francesca Siepi Andrea Prodosmo Alessandra Giorgi Giovanna M Pierantoni Francesco Trapasso Giulia Guarguaglini Armando Bartolazzi Enrico Cundari M Eugenia Schininà Alfredo Fusco Silvia Soddu

Mol Cell 2012 Jul 31;47(1):87-98. Epub 2012 May 31.

Laboratorio di Oncogenesi Molecolare, Dipartimento di Oncologia Sperimentale, Istituto Nazionale dei Tumori Regina Elena, 00158 Rome, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765120035
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http://dx.doi.org/10.1016/j.molcel.2012.04.029DOI Listing
July 2012

The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas.

Authors:
Luca Lavra Cinzia Rinaldo Alessandra Ulivieri Emidio Luciani Paolo Fidanza Laura Giacomelli Carlo Bellotti Alberto Ricci Maria Trovato Silvia Soddu Armando Bartolazzi Salvatore Sciacchitano

PLoS One 2011 17;6(6):e20665. Epub 2011 Jun 17.

Research Center, St. Pietro Fatebenefratelli Hospital, Rome, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020665PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117790PMC
November 2011

Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility.

Authors:
Giovanna Maria Pierantoni Francesco Esposito Mara Tornincasa Cinzia Rinaldo Giuseppe Viglietto Silvia Soddu Alfredo Fusco

J Biol Chem 2011 08 29;286(33):29005-13. Epub 2011 Jun 29.

Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II, via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1074/jbc.M111.230854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190708PMC
August 2011

MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.

Authors:
Marialaura Petroni Veronica Veschi Andrea Prodosmo Cinzia Rinaldo Isabella Massimi Maurizio Carbonari Carlo Dominici Heather P McDowell Christian Rinaldi Isabella Screpanti Luigi Frati Armando Bartolazzi Alberto Gulino Silvia Soddu Giuseppe Giannini

Mol Cancer Res 2011 Jan 20;9(1):67-77. Epub 2010 Dec 20.

Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena, 324, 00161, Rome, Italy.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0227DOI Listing
January 2011

Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.

Authors:
Rosario Amato Lucia D'Antona Giovanni Porciatti Valter Agosti Miranda Menniti Cinzia Rinaldo Nicola Costa Emanuele Bellacchio Stefano Mattarocci Giorgio Fuiano Silvia Soddu Marco G Paggi Florian Lang Nicola Perrotti

J Mol Med (Berl) 2009 Dec 11;87(12):1221-39. Epub 2009 Sep 11.

Department of Experimental and clinical Medicine G. Salvatore, Faculty of Medicine, University Magna Graecia at Catanzaro, Catanzaro, Italy.

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http://link.springer.com/content/pdf/10.1007/s00109-009-0525
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http://link.springer.com/10.1007/s00109-009-0525-5
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http://dx.doi.org/10.1007/s00109-009-0525-5DOI Listing
December 2009

HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA.

Authors:
Cinzia Rinaldo Andrea Prodosmo Francesca Siepi Alice Moncada Ada Sacchi Galina Selivanova Silvia Soddu

Cancer Res 2009 Aug 28;69(15):6241-8. Epub 2009 Jul 28.

Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome, Italy.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-0337DOI Listing
August 2009

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.

Authors:
Francesca Mancini Giusy Di Conza Marsha Pellegrino Cinzia Rinaldo Andrea Prodosmo Simona Giglio Igea D'Agnano Fulvio Florenzano Lara Felicioni Fiamma Buttitta Antonio Marchetti Ada Sacchi Alfredo Pontecorvi Silvia Soddu Fabiola Moretti

EMBO J 2009 Jul 11;28(13):1926-39. Epub 2009 Jun 11.

Institute of Neurobiology and Molecular Medicine, National Council of Research, Rome, Italy.

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http://dx.doi.org/10.1038/emboj.2009.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711189PMC
July 2009

Gal-3 is stimulated by gain-of-function p53 mutations and modulates chemoresistance in anaplastic thyroid carcinomas.

Authors:
Luca Lavra Alessandra Ulivieri Cinzia Rinaldo Roberto Dominici Marco Volante Emidio Luciani Armando Bartolazzi Francesco Frasca Silvia Soddu Salvatore Sciacchitano

J Pathol 2009 May;218(1):66-75

S. Pietro Fatebenefratelli Hospital, Rome, Italy.

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http://dx.doi.org/10.1002/path.2510DOI Listing
May 2009

HIPKs: Jack of all trades in basic nuclear activities.

Authors:
Cinzia Rinaldo Francesca Siepi Andrea Prodosmo Silvia Soddu

Biochim Biophys Acta 2008 Nov 18;1783(11):2124-9. Epub 2008 Jun 18.

Department of Experimental Oncology, Regina Elena Cancer Institute, 00158 Rome, Italy.

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http://dx.doi.org/10.1016/j.bbamcr.2008.06.006DOI Listing
November 2008

HIPK2: a multitalented partner for transcription factors in DNA damage response and development.

Authors:
Cinzia Rinaldo Andrea Prodosmo Francesca Siepi Silvia Soddu

Biochem Cell Biol 2007 Aug;85(4):411-8

Department of Experimental Oncology, Regina Elena Cancer Institute, 00158 Rome, Italy.

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http://dx.doi.org/10.1139/O07-071DOI Listing
August 2007

High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

Authors:
Giovanna Maria Pierantoni Cinzia Rinaldo Marcella Mottolese Anna Di Benedetto Francesco Esposito Silvia Soddu Alfredo Fusco

J Clin Invest 2007 Mar 8;117(3):693-702. Epub 2007 Feb 8.

Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, Naples, Italy.

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http://dx.doi.org/10.1172/JCI29852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784001PMC
March 2007

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

Authors:
Cinzia Rinaldo Andrea Prodosmo Francesca Mancini Stefano Iacovelli Ada Sacchi Fabiola Moretti Silvia Soddu

Mol Cell 2007 Mar;25(5):739-50

Department of Experimental Oncology, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy.

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http://dx.doi.org/10.1016/j.molcel.2007.02.008DOI Listing
March 2007

Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis.

Authors:
Barbara Cecchinelli Luca Lavra Cinzia Rinaldo Stefano Iacovelli Aymone Gurtner Alessandra Gasbarri Alessandra Ulivieri Fabrizio Del Prete Maria Trovato Giulia Piaggio Armando Bartolazzi Silvia Soddu Salvatore Sciacchitano

Mol Cell Biol 2006 Jun;26(12):4746-57

Department of Experimental Oncology, Regina Elena Cancer Institute, 00158 Rome, Italy.

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http://dx.doi.org/10.1128/MCB.00959-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489111PMC
June 2006

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis.

Authors:
Valeria Di Stefano Cinzia Rinaldo Ada Sacchi Silvia Soddu Gabriella D'Orazi

Exp Cell Res 2004 Feb;293(2):311-20

Deparment of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, via delle Messi d'Oro 156, 00158 Rome, Italy.

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http://dx.doi.org/10.1016/j.yexcr.2003.09.032DOI Listing
February 2004

Roles for Caenorhabditis elegans rad-51 in meiosis and in resistance to ionizing radiation during development.

Authors:
Cinzia Rinaldo Paolo Bazzicalupo Sara Ederle Massimo Hilliard Adriana La Volpe

Genetics 2002 Feb;160(2):471-9

Istituto di Genetica e Biofisica Adriano Buzzati-Traverso-CNR, 80125 Naples, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461995PMC
February 2002