Publications by authors named "Cinzia Rinaldo"

31Publications

Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation.

Authors:
Francesca Sardina Alessandra Pisciottani Manuela Ferrara Davide Valente Marialuisa Casella Marco Crescenzi Angelo Peschiaroli Carlo Casali Silvia Soddu Andrew J Grierson Cinzia Rinaldo

Life Sci Alliance 2020 12 26;3(12). Epub 2020 Oct 26.

Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), c/o Sapienza University, Rome, Italy

View Article and Find Full Text PDF
December 2020

HIPK2 Is Required for Midbody Remnant Removal Through Autophagy-Mediated Degradation.

Authors:
Francesca Sardina Laura Monteonofrio Manuela Ferrara Fiorenza Magi Silvia Soddu Cinzia Rinaldo

Front Cell Dev Biol 2020 15;8:572094. Epub 2020 Sep 15.

Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), c/o Sapienza University of Rome, Rome, Italy.

View Article and Find Full Text PDF
September 2020

An Alternative Splice Variant of HIPK2 with Intron Retention Contributes to Cytokinesis.

Authors:
Veronica Gatti Manuela Ferrara Ilaria Virdia Silvia Matteoni Laura Monteonofrio Simona di Martino Maria Grazia Diodoro Giuliana Di Rocco Cinzia Rinaldo Silvia Soddu

Cells 2020 02 20;9(2). Epub 2020 Feb 20.

Unit of Cellular Networks and Molecular Therapeutic Targets; IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.

View Article and Find Full Text PDF
February 2020

p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway.

Authors:
Claudia Contadini Laura Monteonofrio Ilaria Virdia Andrea Prodosmo Davide Valente Luciana Chessa Antonio Musio Luca L Fava Cinzia Rinaldo Giuliana Di Rocco Silvia Soddu

Cell Death Dis 2019 11 7;10(11):850. Epub 2019 Nov 7.

Unit of Cellular Networks and Molecular Therapeutic Targets, IRCCS-Regina Elena National Cancer Institute, Rome, Italy.

View Article and Find Full Text PDF
November 2019

Extrachromosomal Histone H2B Contributes to the Formation of the Abscission Site for Cell Division.

Authors:
Laura Monteonofrio Davide Valente Cinzia Rinaldo Silvia Soddu

Cells 2019 11 5;8(11). Epub 2019 Nov 5.

Unit of Cellular Networks and Molecular Therapeutic Targets, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.

View Article and Find Full Text PDF
November 2019

HIPK2 Phosphorylates the Microtubule-Severing Enzyme Spastin at S268 for Abscission.

Authors:
Alessandra Pisciottani Loredana Biancolillo Manuela Ferrara Davide Valente Francesca Sardina Laura Monteonofrio Serena Camerini Marco Crescenzi Silvia Soddu Cinzia Rinaldo

Cells 2019 07 5;8(7). Epub 2019 Jul 5.

Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), c/o Sapienza University, 00185 Rome, Italy.

View Article and Find Full Text PDF
July 2019

ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage.

Authors:
Jessica Willan Alexa J Cleasby Neftali Flores-Rodriguez Flavia Stefani Cinzia Rinaldo Alessandra Pisciottani Emma Grant Philip Woodman Helen E Bryant Barbara Ciani

Oncogenesis 2019 Apr 15;8(5):29. Epub 2019 Apr 15.

Department of Chemistry, Centre for Membrane Interactions and Dynamics (CMIAD), Krebs Institute, University of Sheffield, Brook Hill, Sheffield, S3 7HF, United Kingdom.

View Article and Find Full Text PDF
April 2019

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.

Authors:
Laura Monteonofrio Davide Valente Manuela Ferrara Serena Camerini Roberta Miscione Marco Crescenzi Cinzia Rinaldo Silvia Soddu

Oncogene 2018 06 22;37(26):3562-3574. Epub 2018 Mar 22.

Unit of Cellular Networks and Molecular Therapeutic Targets, Regina Elena National Cancer Institute-IRCCS, Rome, 00144, Italy.

View Article and Find Full Text PDF
June 2018

Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain.

Authors:
Antonella Scaglione Laura Monteonofrio Giacomo Parisi Cristina Cecchetti Francesca Siepi Cinzia Rinaldo Alessandra Giorgi Daniela Verzili Carlotta Zamparelli Carmelinda Savino Silvia Soddu Beatrice Vallone Linda Celeste Montemiglio

Protein Sci 2018 03 28;27(3):725-737. Epub 2017 Dec 28.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, P.le A. Moro 5, 00185, Italy, Rome.

View Article and Find Full Text PDF
March 2018

CDKL5 localizes at the centrosome and midbody and is required for faithful cell division.

Authors:
Isabella Barbiero Davide Valente Chetan Chandola Fiorenza Magi Anna Bergo Laura Monteonofrio Marco Tramarin Maria Fazzari Silvia Soddu Nicoletta Landsberger Cinzia Rinaldo Charlotte Kilstrup-Nielsen

Sci Rep 2017 07 24;7(1):6228. Epub 2017 Jul 24.

Department of Biotechnology and Life Sciences, University of Insubria, 21052, Busto Arsizio, Italy.

View Article and Find Full Text PDF
July 2017

Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities.

Authors:
Giovanna Maria Pierantoni Andrea Conte Cinzia Rinaldo Mara Tornincasa Raffaele Gerlini Davide Valente Antonella Izzo Alfredo Fusco

Cell Cycle 2016 ;15(6):812-8

a Istituto di Endocrinologia ed Oncologia Sperimentale del CNR and Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli "Federico II" , Naples , Italy.

View Article and Find Full Text PDF
December 2016

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia.

Authors:
Stefano Iacovelli Maria Rosaria Ricciardi Matteo Allegretti Simone Mirabilii Roberto Licchetta Paola Bergamo Cinzia Rinaldo Ann Zeuner Robin Foà Michele Milella James A McCubrey Alberto M Martelli Agostino Tafuri

Oncotarget 2015 Oct;6(31):32089-103

Hematology, "Sant'Andrea" Hospital - Sapienza University of Rome, Department of Clinical and Molecular Medicine, Rome, Italy.

View Article and Find Full Text PDF
October 2015

Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes.

Authors:
Giovanna Maria Pierantoni Andrea Conte Cinzia Rinaldo Mara Tornincasa Raffaele Gerlini Antonella Federico Davide Valente Enzo Medico Alfredo Fusco

Oncotarget 2015 Jul;6(19):17342-53

Istituto di Endocrinologia ed Oncologia Sperimentale del CNR and Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli "Federico II", 80131, Naples, Italy.

View Article and Find Full Text PDF
July 2015

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity.

Authors:
Davide Valente Gianluca Bossi Alice Moncada Mara Tornincasa Stefania Indelicato Salvatore Piscuoglio Eva Diamantis Karamitopoulou Armando Bartolazzi Giovanna Maria Pierantoni Alfredo Fusco Silvia Soddu Cinzia Rinaldo

Oncotarget 2015 Apr;6(12):10320-34

Experimental Oncology Laboratory, Regina Elena National Cancer Institute, Rome, Italy.

View Article and Find Full Text PDF
April 2015

Homeodomain-interacting protein kinase-2 stabilizes p27kip1 by its phosphorylation at serine 10 and contributes to cell motility.

Authors:
Giovanna Maria Pierantoni Francesco Esposito Mara Tornincasa Cinzia Rinaldo Giuseppe Viglietto Silvia Soddu Alfredo Fusco

J Biol Chem 2014 06;289(25):17426

View Article and Find Full Text PDF
June 2014

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer.

Authors:
Gabriella D'Orazi Cinzia Rinaldo Silvia Soddu

J Exp Clin Cancer Res 2012 Aug 13;31:63. Epub 2012 Aug 13.

Department of Medical, Oral, and Biotechnological Sciences, University "G, d'Annunzio", Chieti 66013, Italy.

View Article and Find Full Text PDF
August 2012

HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody.

Authors:
Cinzia Rinaldo Alice Moncada Alessandra Gradi Laura Ciuffini Donatella D'Eliseo Francesca Siepi Andrea Prodosmo Alessandra Giorgi Giovanna M Pierantoni Francesco Trapasso Giulia Guarguaglini Armando Bartolazzi Enrico Cundari M Eugenia Schininà Alfredo Fusco Silvia Soddu

Mol Cell 2012 Jul 31;47(1):87-98. Epub 2012 May 31.

Laboratorio di Oncogenesi Molecolare, Dipartimento di Oncologia Sperimentale, Istituto Nazionale dei Tumori Regina Elena, 00158 Rome, Italy.

View Article and Find Full Text PDF
July 2012

Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility.

Authors:
Giovanna Maria Pierantoni Francesco Esposito Mara Tornincasa Cinzia Rinaldo Giuseppe Viglietto Silvia Soddu Alfredo Fusco

J Biol Chem 2011 08 29;286(33):29005-13. Epub 2011 Jun 29.

Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II, via Pansini 5, 80131 Naples, Italy.

View Article and Find Full Text PDF
August 2011

The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas.

Authors:
Luca Lavra Cinzia Rinaldo Alessandra Ulivieri Emidio Luciani Paolo Fidanza Laura Giacomelli Carlo Bellotti Alberto Ricci Maria Trovato Silvia Soddu Armando Bartolazzi Salvatore Sciacchitano

PLoS One 2011 17;6(6):e20665. Epub 2011 Jun 17.

Research Center, St. Pietro Fatebenefratelli Hospital, Rome, Italy.

View Article and Find Full Text PDF
November 2011

MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.

Authors:
Marialaura Petroni Veronica Veschi Andrea Prodosmo Cinzia Rinaldo Isabella Massimi Maurizio Carbonari Carlo Dominici Heather P McDowell Christian Rinaldi Isabella Screpanti Luigi Frati Armando Bartolazzi Alberto Gulino Silvia Soddu Giuseppe Giannini

Mol Cancer Res 2011 Jan 20;9(1):67-77. Epub 2010 Dec 20.

Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena, 324, 00161, Rome, Italy.

View Article and Find Full Text PDF
January 2011