Cigall Kadoch

Cigall Kadoch

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Cigall Kadoch

Cigall Kadoch

Publications by authors named "Cigall Kadoch"

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Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling.

Cell 2019 Nov 20;179(6):1342-1356.e23. Epub 2019 Nov 20.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.10.044DOI Listing
November 2019

Diverse compositions and functions of chromatin remodeling machines in cancer.

Authors:
Cigall Kadoch

Sci Transl Med 2019 Jul;11(501)

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scitranslmed.aay1018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755912PMC
July 2019

Chromatin regulatory mechanisms and therapeutic opportunities in cancer.

Nat Cell Biol 2019 02 2;21(2):152-161. Epub 2019 Jan 2.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41556-018-0258-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755910PMC
February 2019

Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes.

Cell 2018 11 18;175(5):1272-1288.e20. Epub 2018 Oct 18.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183124
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http://dx.doi.org/10.1016/j.cell.2018.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791824PMC
November 2018

The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma.

Cancer Cell 2018 06 31;33(6):1128-1141.e7. Epub 2018 May 31.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA; Epigenomics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791822PMC
June 2018

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens.

Cell Syst 2018 05 16;6(5):555-568.e7. Epub 2018 May 16.

Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054712183018
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http://dx.doi.org/10.1016/j.cels.2018.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152908PMC
May 2018

Disruption of mammalian SWI/SNF and polycomb complexes in human sarcomas: mechanisms and therapeutic opportunities.

J Pathol 2018 04 6;244(5):638-649. Epub 2018 Mar 6.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/path.5042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755911PMC
April 2018

Composition and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease.

Cold Spring Harb Symp Quant Biol 2016 13;81:53-60. Epub 2017 Apr 13.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1101/sqb.2016.81.031021DOI Listing
February 2018

A Two-Faced mSWI/SNF Subunit: Dual Roles for ARID1A in Tumor Suppression and Oncogenicity in the Liver.

Cancer Cell 2017 11;32(5):542-543

Chemical Biology Program, Harvard University, Cambridge, MA 02138, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.10.014DOI Listing
November 2017

Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain.

Cell 2017 Sep 24;171(1):163-178.e19. Epub 2017 Aug 24.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.07.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791823PMC
September 2017

A SMARCD2-containing mSWI/SNF complex is required for granulopoiesis.

Nat Genet 2017 Apr;49(5):655-657

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA, and at the Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://www.nature.com/doifinder/10.1038/ng.3853
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http://dx.doi.org/10.1038/ng.3853DOI Listing
April 2017

Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin.

Nat Genet 2017 Feb 12;49(2):282-288. Epub 2016 Dec 12.

Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/ng.3735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373480PMC
February 2017

Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities.

Curr Opin Genet Dev 2017 Feb 6;42:56-67. Epub 2017 Apr 6.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777332PMC
February 2017

Polycomb and trithorax opposition in development and disease.

Wiley Interdiscip Rev Dev Biol 2016 11 1;5(6):659-688. Epub 2016 Sep 1.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1002/wdev.244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518792PMC
November 2016

Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis.

Authors:
Cigall Kadoch

Cancer Discov 2016 Apr;6(4):350-2

Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts. Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764754PMC
April 2016

PRC2 and SWI/SNF Chromatin Remodeling Complexes in Health and Disease.

Biochemistry 2016 Mar 17;55(11):1600-14. Epub 2016 Feb 17.

Epizyme Inc. , 400 Technology Square, 4th floor, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.biochem.5b01191DOI Listing
March 2016

Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.

Sci Adv 2015 Jun 12;1(5):e1500447. Epub 2015 Jun 12.

Howard Hughes Medical Institute, Departments of Pathology and Developmental Biology, Stanford University, Stanford, CA 94305, USA.

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.150
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http://dx.doi.org/10.1126/sciadv.1500447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640607PMC
June 2015

Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma.

Clin Cancer Res 2014 Feb 4;20(4):1029-41. Epub 2013 Nov 4.

Authors' Affiliations: Division of Hematology/Oncology, Genentech, South San Francisco; Helen Diller Comprehensive Cancer Center; and Department of Radiology, Laboratory Medicine, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944388PMC
February 2014

Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma.

Cell 2013 Mar;153(1):71-85

Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674130026
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http://dx.doi.org/10.1016/j.cell.2013.02.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655887PMC
March 2013

Biology and treatment of primary central nervous system lymphoma.

Neurotherapeutics 2009 Jul;6(3):587-97

Division of Hematology and Oncology, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1016/j.nurt.2009.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942275PMC
July 2009

Alcohol as a potential contributing factor in radiation complications.

Clin Adv Hematol Oncol 2009 Apr;7(4):257-62

Department of Radiation Oncology, Beth Israel/Deaconess Medical Center, Harvard Medical School, and Boston Veterans Health Affairs Medical Centers, Boston, MA 02118, USA.

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April 2009

Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.

Clin Cancer Res 2009 Mar 10;15(6):1989-97. Epub 2009 Mar 10.

Division of Hematology/Oncology, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-08-2054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372389PMC
March 2009

Molecular pathogenesis of primary central nervous system lymphoma.

Neurosurg Focus 2006 Nov 15;21(5):E1. Epub 2006 Nov 15.

Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.

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http://dx.doi.org/10.3171/foc.2006.21.5.2DOI Listing
November 2006

When prostate brachytherapy fails: a case report and discussion.

Oncologist 2005 Nov-Dec;10(10):799-805

University of California, Berkeley, California, USA.

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http://theoncologist.alphamedpress.org/cgi/doi/10.1634/theon
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http://dx.doi.org/10.1634/theoncologist.10-10-799DOI Listing
January 2006