Chuxia Deng

Chuxia Deng

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Chuxia Deng

Publications by authors named "Chuxia Deng"

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A novel FGFR1-binding peptide exhibits anti-tumor effect on lung cancer by inhibiting proliferation and angiogenesis.

Int J Biol Sci 2018 27;14(10):1389-1398. Epub 2018 Jul 27.

Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China.

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http://dx.doi.org/10.7150/ijbs.24739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097486PMC
August 2019

Generation of Smurf2 Conditional Knockout Mice.

Int J Biol Sci 2018 5;14(5):542-548. Epub 2018 Apr 5.

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.7150/ijbs.24303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968846PMC
July 2019

Rmrp Mutation Disrupts Chondrogenesis and Bone Ossification in Zebrafish Model of Cartilage-Hair Hypoplasia via Enhanced Wnt/β-Catenin Signaling.

J Bone Miner Res 2019 Jun 25. Epub 2019 Jun 25.

Laboratory of Wound Repair and Rehabilitation, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China.

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http://dx.doi.org/10.1002/jbmr.3820DOI Listing
June 2019

Non-classical estrogen signaling in ovarian cancer improves chemo-sensitivity and patients outcome.

Theranostics 2019 31;9(13):3952-3965. Epub 2019 May 31.

Cancer Center, Faculty of health Sciences, University of Macau, Macau, SAR of the People's Republic of China.

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http://dx.doi.org/10.7150/thno.30814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587348PMC
May 2019

Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model.

Mol Ther Nucleic Acids 2018 Dec 22;13:291-302. Epub 2018 Sep 22.

Laboratory for the Rehabilitation of Traumatic Injuries, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2018.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197781PMC
December 2018

The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism.

J Exp Clin Cancer Res 2018 Dec 13;37(1):313. Epub 2018 Dec 13.

Chongqing Key Laboratory of Molecular Oncology and Epigenetics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-
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http://dx.doi.org/10.1186/s13046-018-0979-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293581PMC
December 2018

Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice.

J Cell Physiol 2018 01 5;234(1):595-605. Epub 2018 Aug 5.

Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China.

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http://dx.doi.org/10.1002/jcp.26802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436632PMC
January 2018

Partial Müllerian Duct Retention in Smad4 Conditional Mutant Male Mice.

Int J Biol Sci 2016 21;12(6):667-76. Epub 2016 Apr 21.

1. Institut National de la Santé et de la Recherche Médicale, Institut de Recherche en Santé, Environnement et Travail, UMR1085, Université de Rennes 1, Rennes, France;; 2. Institut National de la Santé et de la Recherche Médicale, U782, Clamart, France.

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http://dx.doi.org/10.7150/ijbs.12300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870710PMC
November 2017

Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation.

J Bone Miner Res 2017 Nov 12;32(11):2194-2206. Epub 2017 Sep 12.

Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China.

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http://dx.doi.org/10.1002/jbmr.3204DOI Listing
November 2017

Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism.

Mol Metab 2017 11 15;6(11):1540-1550. Epub 2017 Sep 15.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778173057
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http://dx.doi.org/10.1016/j.molmet.2017.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681273PMC
November 2017

Transforming growth factor-β in liver cancer stem cells and regeneration.

Hepatol Commun 2017 08 21;1(6):477-493. Epub 2017 Jul 21.

Center for Translational Medicine Department of Surgery, George Washington University Washington DC.

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http://doi.wiley.com/10.1002/hep4.1062
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http://dx.doi.org/10.1002/hep4.1062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678904PMC
August 2017

Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy.

Sci Rep 2017 06 22;7(1):4035. Epub 2017 Jun 22.

Cancer Center, Faculty of Health Sciences, University of Macau, Macau, China.

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http://dx.doi.org/10.1038/s41598-017-04406-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481380PMC
June 2017

Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes.

Hum Mol Genet 2015 Mar 28;24(6):1764-73. Epub 2014 Nov 28.

Shriners Hospitals for Children, 3101 SW Sam Jackson Park Road, Portland, OR 97239, USA, Department of Cell and Developmental Biology and Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA

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http://dx.doi.org/10.1093/hmg/ddu594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351382PMC
March 2015

Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.

Cell 2014 Jul;158(3):659-72

Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA 92697, USA; INSERM U904, Sprague Hall, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674140088
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http://dx.doi.org/10.1016/j.cell.2014.06.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472354PMC
July 2014

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks.

Nature 2014 Jun 28;510(7506):556-9. Epub 2014 Apr 28.

Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

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http://www.nature.com/articles/nature13295
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http://dx.doi.org/10.1038/nature13295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118467PMC
June 2014

APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.

Cell Rep 2014 May 10;7(4):1227-38. Epub 2014 May 10.

Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA; The Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380268PMC
May 2014

Diethylstilbestrol induces vaginal adenosis by disrupting SMAD/RUNX1-mediated cell fate decision in the Müllerian duct epithelium.

Dev Biol 2013 Sep 4;381(1):5-16. Epub 2013 Jul 4.

Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.ydbio.2013.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947918PMC
September 2013

Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells.

Hepatology 2013 Jun;57(6):2458-68

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://doi.wiley.com/10.1002/hep.26237
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http://dx.doi.org/10.1002/hep.26237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633649PMC
June 2013

Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis.

Cell Res 2013 Feb 13;23(2):254-73. Epub 2012 Nov 13.

Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.

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http://dx.doi.org/10.1038/cr.2012.150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567820PMC
February 2013

Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia.

Hum Mol Genet 2012 Sep 24;21(18):3941-55. Epub 2012 May 24.

State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.

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http://hmg.oxfordjournals.org/content/early/2012/06/27/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/dds181
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http://dx.doi.org/10.1093/hmg/dds181DOI Listing
September 2012

TGF-β and BMP signaling in osteoblast differentiation and bone formation.

Int J Biol Sci 2012 21;8(2):272-88. Epub 2012 Jan 21.

Institute of Genetics, Life Science College, Zhejiang University, 388 Yuhang Road, Hangzhou 310058, China.

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http://dx.doi.org/10.7150/ijbs.2929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269610PMC
May 2012

CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.

Cancer Prev Res (Phila) 2012 Jan 20;5(1):89-97. Epub 2011 Sep 20.

Department of Medicine, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252488PMC
January 2012

Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes.

Mol Cancer Res 2011 Dec 18;9(12):1708-17. Epub 2011 Oct 18.

Department of Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, Los Angeles, California 90089, USA.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-11
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http://dx.doi.org/10.1158/1541-7786.MCR-11-0299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351767PMC
December 2011

Hidden malignant cells within leukocyte aggregates: seeds for invasive and metastatic cancer?

Cancer Epidemiol 2011 Oct 2;35(5):475-9. Epub 2011 Feb 2.

Institute of Medicine, Chung Shan Medical University, Taiwan.

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http://dx.doi.org/10.1016/j.canep.2010.11.010DOI Listing
October 2011

Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage.

Genome Biol 2011 Aug 16;12(8):R77. Epub 2011 Aug 16.

Transgenic Oncogenesis and Genomics Section, Laboratory of Cell Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/gb-2011-12-8-r77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245617PMC
August 2011

Extracellular domain of CD98hc is required for early murine development.

Cell Biosci 2011 Feb 25;1(1). Epub 2011 Feb 25.

Section on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, Program in Cellular Regulation and Metabolism (PCRM), NICHD, NIH, Bethesda, Maryland, 20892, USA.

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http://www.springerlink.com/index/y54853v0vl86p657.pdf
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http://cellandbioscience.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/2045-3701-1-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125211PMC
February 2011

Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR.

J Biol Chem 2010 Nov 17;285(47):36387-94. Epub 2010 Sep 17.

Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA.

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http://dx.doi.org/10.1074/jbc.M110.169284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978567PMC
November 2010

Inactivation of Smad4 leads to impaired ocular development and cataract formation.

Biochem Biophys Res Commun 2010 Oct 22;400(4):476-82. Epub 2010 Aug 22.

Department of Ophthalmology and Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/j.bbrc.2010.08.065DOI Listing
October 2010

BP1, an isoform of DLX4 homeoprotein, negatively regulates BRCA1 in sporadic breast cancer.

Int J Biol Sci 2010 Sep 10;6(5):513-24. Epub 2010 Sep 10.

Department of Medicine, Division of Genomic Medicine, George Washington University Medical Center, Washington, DC, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945279PMC
http://dx.doi.org/10.7150/ijbs.6.513DOI Listing
September 2010

Myocardial deletion of Smad4 using a novel α skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract.

Int J Biol Sci 2010 Sep 20;6(6):546-55. Epub 2010 Sep 20.

BIO5 Institute, and Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945925PMC
http://dx.doi.org/10.7150/ijbs.6.546DOI Listing
September 2010

Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection.

Proc Natl Acad Sci U S A 2010 Jun 1;107(24):11056-61. Epub 2010 Jun 1.

Molecular and Clinical Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1001269107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890768PMC
June 2010

Generation of Fgfr3 conditional knockout mice.

Int J Biol Sci 2010 Jun 15;6(4):327-32. Epub 2010 Jun 15.

State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892296PMC
http://dx.doi.org/10.7150/ijbs.6.327DOI Listing
June 2010

Smad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling.

Hypertension 2010 May 15;55(5):1165-71. Epub 2010 Mar 15.

Department of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, NT, Hong Kong.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.109.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.147611DOI Listing
May 2010

An unknown piece of early work of nuclear reprogramming in fish eggs.

Int J Biol Sci 2010 Apr 21;6(2):190-1. Epub 2010 Apr 21.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862325PMC
http://dx.doi.org/10.7150/ijbs.6.190DOI Listing
April 2010

Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice.

Diabetes 2009 Dec 14;58(12):2776-87. Epub 2009 Sep 14.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://diabetes.diabetesjournals.org/content/early/2009/09/1
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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db09-05
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http://dx.doi.org/10.2337/db09-0522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780871PMC
December 2009

BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways.

Development 2009 Nov 30;136(21):3575-84. Epub 2009 Sep 30.

Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA.

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http://dx.doi.org/10.1242/dev.038133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761108PMC
November 2009

Sirt1, notch and stem cell "age asymmetry".

Cell Cycle 2008 Sep 26;7(18):2821-5. Epub 2008 Sep 26.

Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202-5181, USA.

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http://dx.doi.org/10.4161/cc.7.18.6517DOI Listing
September 2008

Metabolic roles of the M3 muscarinic acetylcholine receptor studied with M3 receptor mutant mice: a review.

J Recept Signal Transduct Res 2008 ;28(1-2):93-108

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892-0810, USA.

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http://www.tandfonline.com/doi/full/10.1080/1079989080194200
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http://dx.doi.org/10.1080/10799890801942002 DOI Listing
August 2008

Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development.

Dev Cell 2008 Aug;15(2):322-9

Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S153458070800245
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http://dx.doi.org/10.1016/j.devcel.2008.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610417PMC
August 2008

Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-beta1 pathway.

Am J Physiol Renal Physiol 2008 Jul 23;295(1):F128-36. Epub 2008 Apr 23.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032-3784, USA.

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http://dx.doi.org/10.1152/ajprenal.00577.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494502PMC
July 2008

A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis.

Bone 2008 Apr 31;42(4):631-43. Epub 2008 Jan 31.

State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.

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http://dx.doi.org/10.1016/j.bone.2007.11.019DOI Listing
April 2008

A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation.

Nat Cell Biol 2008 Feb 23;10(2):186-93. Epub 2007 Dec 23.

Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

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http://dx.doi.org/10.1038/ncb1679DOI Listing
February 2008

Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation.

Cell 2008 Jan;132(1):137-48

Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 35, Room 3B203, 35 Convent Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cell.2007.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259239PMC
January 2008

Smad4 is required to regulate the fate of cranial neural crest cells.

Dev Biol 2007 Dec 4;312(1):435-47. Epub 2007 Oct 4.

Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/j.ydbio.2007.09.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704603PMC
December 2007

Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects.

Dev Biol 2007 Nov 31;311(1):172-84. Epub 2007 Aug 31.

Renal Division, Department of Internal Medicine, Department of Cell Biology and Physiology, Campus Box 8126, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ydbio.2007.08.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692609PMC
November 2007

FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis.

Development 2007 Nov;134(22):4033-41

Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

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http://dx.doi.org/10.1242/dev.009167DOI Listing
November 2007

Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice.

Blood 2007 Oct 16;110(8):3049-55. Epub 2007 Jul 16.

Department of Research, Experimental Hematology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2007-02-074393DOI Listing
October 2007

In celebration of Dr. Mario R. Capecchi's Nobel Prize.

Authors:
Chuxia Deng

Int J Biol Sci 2007 Oct 17;3(7):417-9. Epub 2007 Oct 17.

International Journal of Biological Sciences, NIDDK, National Institutes of Health, 10/9N105, 10 Center Drive, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043165PMC
http://dx.doi.org/10.7150/ijbs.3.417DOI Listing
October 2007

Smad3 signal transducer regulates skin inflammation and specific IgE response in murine model of atopic dermatitis.

J Invest Dermatol 2007 Aug 12;127(8):1923-9. Epub 2007 Apr 12.

Unit of Excellence in Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland.

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http://dx.doi.org/10.1038/sj.jid.5700809DOI Listing
August 2007

Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development.

J Clin Invest 2007 May 5;117(5):1314-23. Epub 2007 Apr 5.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1172/JCI31222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838927PMC
May 2007

Elovl4 haploinsufficiency does not induce early onset retinal degeneration in mice.

Vision Res 2007 Mar 24;47(5):714-22. Epub 2007 Jan 24.

Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.visres.2006.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583245PMC
March 2007

M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes.

J Mol Neurosci 2006 ;30(1-2):157-60

Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1385/JMN:30:1:157DOI Listing
February 2007

Renal function in mice with targeted disruption of the A isoform of the Na-K-2Cl co-transporter.

J Am Soc Nephrol 2007 Feb 10;18(2):440-8. Epub 2007 Jan 10.

NIDDK, NIH, Building 10, Room 4 D51, 10 Center Drive MSC-1370, Bethesda, MD 20892-1370, USA.

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http://dx.doi.org/10.1681/ASN.2006091070DOI Listing
February 2007

Macula densa control of renin secretion and preglomerular resistance in mice with selective deletion of the B isoform of the Na,K,2Cl co-transporter.

J Am Soc Nephrol 2006 Aug 28;17(8):2143-52. Epub 2006 Jun 28.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1370, USA.

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http://dx.doi.org/10.1681/ASN.2006040384DOI Listing
August 2006

Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members.

Cancer Res 2006 Jul;66(14):7151-7

Genetics of Development and Disease Branch and Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4570DOI Listing
July 2006

A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo.

Cell Metab 2006 Jun;3(6):449-61

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S155041310600128
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http://dx.doi.org/10.1016/j.cmet.2006.04.009DOI Listing
June 2006

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.

Nature 2006 Jun;441(7096):1015-9

Laboratory of Cell Regulation and Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature04846DOI Listing
June 2006

Essential role of Smad3 in angiotensin II-induced vascular fibrosis.

Circ Res 2006 Apr 23;98(8):1032-9. Epub 2006 Mar 23.

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1161/01.RES.0000218782.52610.dcDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450325PMC
April 2006

Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning.

Development 2005 Oct 24;132(19):4235-45. Epub 2005 Aug 24.

Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.02001
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October 2005

Disruption of Smad5 gene induces mitochondria-dependent apoptosis in cardiomyocytes.

Exp Cell Res 2005 May 17;306(1):85-93. Epub 2005 Mar 17.

Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Fengtai, Beijing 100071, PR China.

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http://dx.doi.org/10.1016/j.yexcr.2005.02.012DOI Listing
May 2005

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

Proc Natl Acad Sci U S A 2005 May 9;102(20):7386-91. Epub 2005 May 9.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0408268102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1129092PMC
May 2005

Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit.

Proc Natl Acad Sci U S A 2005 Apr 5;102(15):5513-8. Epub 2005 Apr 5.

Metabolic Diseases Branch and Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0408262102
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http://dx.doi.org/10.1073/pnas.0408262102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC556240PMC
April 2005

Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells.

Curr Biol 2005 Mar;15(6):561-5

Department of Pathology, University of Southern California/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1016/j.cub.2005.01.052DOI Listing
March 2005

Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis.

Cancer Res 2004 Nov;64(21):7836-45

Department of Otolaryngology, Oregon Health and Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-1331DOI Listing
November 2004

Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system.

Nucleic Acids Res 2004 Jun 15;32(10):e85. Epub 2004 Jun 15.

Genetics of Development and Disease Branch, 10/9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/nar/gnh083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC434461PMC
June 2004

BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition.

J Biol Chem 2004 May 27;279(19):19643-8. Epub 2004 Feb 27.

Derald H. Ruttenberg Cancer Center, The Mount Sinai School of Medicine, New York University, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1074/jbc.M311780200DOI Listing
May 2004

HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice.

Hepatology 2004 Feb;39(2):318-24

Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, China.

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http://dx.doi.org/10.1002/hep.20076DOI Listing
February 2004

Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia.

Proc Natl Acad Sci U S A 2004 Jan 29;101(2):609-14. Epub 2003 Dec 29.

Research Center, Shriners Hospital for Children, and Departmentof Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1073/pnas.2237184100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC327195PMC
January 2004

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.

Oncogene 2003 Dec;22(55):8931-8

The Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, New York University, New York, NY 10029, USA.

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http://dx.doi.org/10.1038/sj.onc.1207057DOI Listing
December 2003

Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease.

J Neurosci 2003 Jul;23(17):6956-64

Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740731PMC
July 2003

Smad3 is required for enamel biomineralization.

Biochem Biophys Res Commun 2003 Jun;305(3):684-90

Department of Orthodontics, School of Dentistry, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan.

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http://dx.doi.org/10.1016/s0006-291x(03)00806-4DOI Listing
June 2003

Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo.

Development 2003 Feb;130(3):623-33

Programmes in Cardiovascular Research and Developmental Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.

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http://dx.doi.org/10.1242/dev.00191DOI Listing
February 2003

Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development.

Dev Dyn 2002 May;224(1):69-78

Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1002/dvdy.10088DOI Listing
May 2002

Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation.

Am J Pathol 2002 Mar;160(3):1057-68

Laboratory of Cell Regulation and Carcinogenesis and Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-5055, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867194PMC
http://dx.doi.org/10.1016/S0002-9440(10)64926-7DOI Listing
March 2002

Conditional knockout of the Smad1 gene.

Genesis 2002 Feb;32(2):76-9

Laboratory of Cell Regulation and Carcinogenesis, NCI, NIH, Bethesda, Maryland 20892-5055, USA.

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February 2002