Chunhua Weng

Chunhua Weng

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Chunhua Weng

Publications by authors named "Chunhua Weng"

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100Publications

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A Method for Harmonization of Clinical Abbreviation and Acronym Sense Inventories.

J Biomed Inform 2018 Nov 7. Epub 2018 Nov 7.

Department of Biomedical Informatics, Columbia University, New York, NY, USA; Value Institute, NewYork-Presbyterian Hospital, New York, NY, USA.

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November 2018

Call for Papers: Deep Phenotyping for Precision Medicine.

J Biomed Inform 2018 Sep 29. Epub 2018 Sep 29.

Department of Biomedical Informatics, Columbia University, New York, NY, USA. Electronic address:

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September 2018

Urinary C‑X‑C motif chemokine 13 is a noninvasive biomarker of antibody‑mediated renal allograft rejection.

Mol Med Rep 2018 Aug 22;18(2):2399-2406. Epub 2018 Jun 22.

Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.

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August 2018

Post-publication peer review and evidence appraisals in primary care.

Lancet 2018 08;392(10145):386

Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA.

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August 2018

Deep Phenotyping on Electronic Health Records Facilitates Genetic Diagnosis by Clinical Exomes.

Am J Hum Genet 2018 Jul 28;103(1):58-73. Epub 2018 Jun 28.

Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA; Institute for Genomic Medicine, Columbia University, New York, NY 10032, USA; Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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July 2018

An OMOP CDM-Based Relational Database of Clinical Research Eligibility Criteria.

Stud Health Technol Inform 2017 ;245:950-954

Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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June 2018

The Data Gap in the EHR for Clinical Research Eligibility Screening.

AMIA Jt Summits Transl Sci Proc 2018 18;2017:320-329. Epub 2018 May 18.

Department of Biomedical Informatics, Columbia University, New York City, New York.

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May 2018

Exploration of Temporal ICD Coding Bias Related to Acute Diabetic Conditions.

AMIA Annu Symp Proc 2015 5;2015:2005-14. Epub 2015 Nov 5.

Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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April 2018

Desiderata for Major Eligibility Criteria in Breast Cancer Clinical Trials.

AMIA Annu Symp Proc 2015 5;2015:2025-34. Epub 2015 Nov 5.

Department of Biomedical Informatics, Columbia University, New York, NY.

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April 2018

The ranking of scientists.

J Biomed Inform 2018 Mar 15;79:145-146. Epub 2018 Feb 15.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY USA.

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March 2018

Simulation-based Evaluation of the Generalizability Index for Study Traits.

AMIA Annu Symp Proc 2015 5;2015:594-603. Epub 2015 Nov 5.

Department of Biomedical Informatics, Columbia University, New York, NY USA.

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January 2018

Quality Assurance of Cancer Study Common Data Elements Using A Post-Coordination Approach.

AMIA Annu Symp Proc 2015 5;2015:659-68. Epub 2015 Nov 5.

Johns Hopkins University, Baltimore, MN.

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January 2018

Initial Readability Assessment of Clinical Trial Eligibility Criteria.

AMIA Annu Symp Proc 2015 5;2015:687-96. Epub 2015 Nov 5.

Department of Biomedical Informatics, Columbia University, New York, NY 10032.

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January 2018

Systematic data ingratiation of clinical trial recruitment locations for geographic-based query and visualization.

Int J Med Inform 2017 12 4;108:85-91. Epub 2017 Oct 4.

Department of Biomedical Informatics, Columbia University, New York City, NY, United States.

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December 2017

EliIE: An open-source information extraction system for clinical trial eligibility criteria.

J Am Med Inform Assoc 2017 Nov;24(6):1062-1071

Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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November 2017

Evidence appraisal: a scoping review, conceptual framework, and research agenda.

J Am Med Inform Assoc 2017 Nov;24(6):1192-1203

Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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November 2017

Assessing the readiness of precision medicine interoperabilty: An exploratory study of the National Institutes of Health genetic testing registry.

J Innov Health Inform 2017 Nov 17;24(4):918. Epub 2017 Nov 17.

Massachusetts General Hospital Harvard Medical School.

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November 2017

A conceptual framework for evaluating data suitability for observational studies.

J Am Med Inform Assoc 2017 Sep 8. Epub 2017 Sep 8.

Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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September 2017

The representativeness of eligible patients in type 2 diabetes trials: a case study using GIST 2.0.

J Am Med Inform Assoc 2017 Sep 13. Epub 2017 Sep 13.

Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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September 2017

A Data Quality Assessment Guideline for Electronic Health Record Data Reuse.

EGEMS (Wash DC) 2017 Sep 4;5(1):14. Epub 2017 Sep 4.

Department of Biomedical Informatics, Columbia University.

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September 2017

SMASH: A Data-driven Informatics Method to Assist Experts in Characterizing Semantic Heterogeneity among Data Elements.

AMIA Annu Symp Proc 2016 10;2016:1717-1726. Epub 2017 Feb 10.

Department of Biomedical Informatics, Columbia University, New York, NY; School of Nursing, Columbia University, New York, NY.

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August 2017

A survey of practices for the use of electronic health records to support research recruitment.

J Clin Transl Sci 2017 Aug;1(4):246-252

NC Translational and Clinical Sciences Institute, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

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August 2017

Pathogenic Mutations in Cancer-Predisposing Genes: A Survey of 300 Patients with Whole-Genome Sequencing and Lifetime Electronic Health Records.

PLoS One 2016 8;11(12):e0167847. Epub 2016 Dec 8.

Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America.

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July 2017

Evaluation of crescent formation as a predictive marker in immunoglobulin A nephropathy: a systematic review and meta-analysis.

Oncotarget 2017 Jul;8(28):46436-46448

Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

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July 2017

Correlating Lab Test Results in Clinical Notes with Structured Lab Data: A Case Study in HbA1c and Glucose.

AMIA Jt Summits Transl Sci Proc 2017 26;2017:221-228. Epub 2017 Jul 26.

Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.

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July 2017

Building a semantic web-based metadata repository for facilitating detailed clinical modeling in cancer genome studies.

J Biomed Semantics 2017 Jun 5;8(1):19. Epub 2017 Jun 5.

Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

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June 2017

An Interoperable Similarity-based Cohort Identification Method Using the OMOP Common Data Model version 5.0.

J Healthc Inform Res 2017 Jun 8;1(1):1-18. Epub 2017 Jun 8.

Department of Biomedical Informatics, Columbia University, New York NY 10032.

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June 2017

Similarity-Based Recommendation of New Concepts to a Terminology.

AMIA Annu Symp Proc 2015;2015:386-95. Epub 2015 Nov 5.

Department of Biomedical Informatics, Columbia University, New York, NY USA.

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February 2017

Correlating eligibility criteria generalizability and adverse events using Big Data for patients and clinical trials.

Ann N Y Acad Sci 2017 01 6;1387(1):34-43. Epub 2016 Sep 6.

Department of Biomedical Informatics, Columbia University, New York, New York.

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January 2017

Assessing the Collective Population Representativeness of Related Type 2 Diabetes Trials by Combining Public Data from ClinicalTrials.gov and NHANES.

Stud Health Technol Inform 2015 ;216:569-73

Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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December 2016

Use of Self-Service Query Tools Varies by Experience and Research Knowledge.

Stud Health Technol Inform 2015 ;216:1023

Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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December 2016

IDENTIFICATION OF QUESTIONABLE EXCLUSION CRITERIA IN MENTAL DISORDER CLINICAL TRIALS USING A MEDICAL ENCYCLOPEDIA.

Pac Symp Biocomput 2016 ;21:219-30

Department of Biomedical Informatics, Columbia University, 622 West 168 Street, PH-20, New York, NY, 10032, USA,

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October 2016

NMDA receptors participate in the progression of diabetic kidney disease by decreasing Cdc42-GTP activation in podocytes.

J Pathol 2016 10 24;240(2):149-60. Epub 2016 Aug 24.

Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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October 2016

Automated learning of domain taxonomies from text using background knowledge.

J Biomed Inform 2016 10 3;63:295-306. Epub 2016 Sep 3.

Department of Biomedical Informatics, Columbia University, New York, NY, USA. Electronic address:

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October 2016

GIST 2.0: A scalable multi-trait metric for quantifying population representativeness of individual clinical studies.

J Biomed Inform 2016 10 4;63:325-336. Epub 2016 Sep 4.

Department of Biomedical Informatics, Columbia University, New York, NY 10032, United States. Electronic address:

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October 2016

Learning Optimal Individualized Treatment Rules from Electronic Health Record Data.

IEEE Int Conf Healthc Inform 2016 Oct 8;2016:65-71. Epub 2016 Dec 8.

Department of Biostatistics, University at North Carolina at Chapel Hill.

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October 2016

A multi-site cognitive task analysis for biomedical query mediation.

Int J Med Inform 2016 09 16;93:74-84. Epub 2016 Jun 16.

Department of Biomedical Informatics, Columbia University, New York, NY, USA. Electronic address:

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September 2016

Bacterial clinical infectious diseases ontology (BCIDO) dataset.

Data Brief 2016 Sep 16;8:881-4. Epub 2016 Jul 16.

Department of Biomedical Informatics, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA.

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September 2016

Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models.

Sci Rep 2016 09 1;6:32087. Epub 2016 Sep 1.

Kidney Disease Center, First Affiliated Hospital, Zhejiang University, School of Medicine; Key Laboratory of Nephropathy, Zhejiang Province, Hangzhou, Zhejiang, China.

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September 2016

How Have Cancer Clinical Trial Eligibility Criteria Evolved Over Time?

AMIA Jt Summits Transl Sci Proc 2016 20;2016:269-78. Epub 2016 Jul 20.

Department of Biomedical Informatics, Columbia University, New York, NY USA.

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August 2016

A data-driven concept schema for defining clinical research data needs.

Int J Med Inform 2016 Jul 2;91:1-9. Epub 2016 Apr 2.

Department of Biomedical Informatics, Columbia University, NY, New York, USA. Electronic address:

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July 2016

Leveraging dialog systems research to assist biomedical researchers' interrogation of Big Clinical Data.

J Biomed Inform 2016 06 8;61:176-84. Epub 2016 Apr 8.

Department of Biomedical Informatics, Columbia University, 622 W. 168th Street, New York, NY, USA. Electronic address:

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June 2016

Valx: A System for Extracting and Structuring Numeric Lab Test Comparison Statements from Text.

Methods Inf Med 2016 May 4;55(3):266-75. Epub 2016 Mar 4.

Chunhua Weng, Ph.D., Department of Biomedical Informatics, Columbia University, New York City, 622 W 168th Street, PH-20, New York, NY 10032, USA, E-mail:

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May 2016

Multivariate analysis of the population representativeness of related clinical studies.

J Biomed Inform 2016 Apr 25;60:66-76. Epub 2016 Jan 25.

Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA; Observational Health Data Sciences and Informatics, New York, NY 10032, USA.

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April 2016

Prediction of black box warning by mining patterns of Convergent Focus Shift in clinical trial study populations using linked public data.

J Biomed Inform 2016 Apr 3;60:132-44. Epub 2016 Feb 3.

Department of Biomedical Informatics, Columbia University, New York, NY, USA. Electronic address:

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April 2016

Facilitating biomedical researchers' interrogation of electronic health record data: Ideas from outside of biomedical informatics.

J Biomed Inform 2016 Apr 10;60:376-84. Epub 2016 Mar 10.

Department of Biomedical Informatics, Columbia University, New York, NY, USA. Electronic address:

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April 2016

DREAM: Classification scheme for dialog acts in clinical research query mediation.

J Biomed Inform 2016 Feb 30;59:89-101. Epub 2015 Nov 30.

Department of Biomedical Informatics, Columbia University, New York, NY, USA. Electronic address:

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February 2016

MicroRNA-409-3p suppresses colorectal cancer invasion and metastasis partly by targeting GAB1 expression.

Int J Cancer 2015 Nov 4;137(10):2310-22. Epub 2015 Jun 4.

Institute of Environmental Health, Zhejiang University School of Public Health, Hangzhou, China.

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November 2015

Optimizing Clinical Research Participant Selection with Informatics.

Authors:
Chunhua Weng

Trends Pharmacol Sci 2015 Nov;36(11):706-709

Department of Biomedical Informatics, Columbia University, 622 W 168 Street, PH-20, Room 407, New York, NY 10032, USA. Electronic address:

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November 2015

Combining expert knowledge and knowledge automatically acquired from electronic data sources for continued ontology evaluation and improvement.

J Biomed Inform 2015 Oct 23;57:42-52. Epub 2015 Jul 23.

Department of Biomedical Informatics, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA. Electronic address:

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October 2015

Could Patient Self-reported Health Data Complement EHR for Phenotyping?

AMIA Annu Symp Proc 2014 14;2014:1738-47. Epub 2014 Nov 14.

Department of Biomedical Informatics, Columbia University, New York City, NY.

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September 2015

A method for analyzing commonalities in clinical trial target populations.

AMIA Annu Symp Proc 2014 14;2014:1777-86. Epub 2014 Nov 14.

Department of Biomedical Informatics, Columbia University, New York, NY.

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September 2015

What Is Asked in Clinical Data Request Forms? A Multi-site Thematic Analysis of Forms Towards Better Data Access Support.

AMIA Annu Symp Proc 2014 14;2014:616-25. Epub 2014 Nov 14.

Dept. of Biomedical Informatics, Columbia University, New York, NY.

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August 2015

Research Data Explorer: Lessons Learned in Design and Development of Context-based Cohort Definition and Selection.

AMIA Jt Summits Transl Sci Proc 2015 25;2015:194-8. Epub 2015 Mar 25.

Columbia University, New York, NY.

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August 2015

Predicting New Target Conditions for Drug Retesting Using Temporal Patterns in Clinical Trials: A Proof of Concept.

Authors:
Zhe He Chunhua Weng

AMIA Jt Summits Transl Sci Proc 2015 25;2015:445-9. Epub 2015 Mar 25.

Department of Biomedical Informatics, Columbia University, New York, NY.

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August 2015

Enhancing electronic health records to support clinical research.

AMIA Jt Summits Transl Sci Proc 2014 7;2014:102-8. Epub 2014 Apr 7.

Laboratory for Informatics Development, NIH Clinical Center, Bethesda, MD ; Columbia University Department of Biomedical Informatics, New York, NY.

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May 2015

Temporal analysis of the usage log of a research networking system.

AMIA Jt Summits Transl Sci Proc 2014 7;2014:116-22. Epub 2014 Apr 7.

The Irving Institute for Clinical and Translational Research, Columbia University, New York, New York, USA ; Department of Biomedical Informatics, Columbia University, New York, New York, USA.

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May 2015

Toward a cognitive task analysis for biomedical query mediation.

AMIA Jt Summits Transl Sci Proc 2014 7;2014:218-22. Epub 2014 Apr 7.

Department of Biomedical Informatics, Columbia University, New York City.

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May 2015

Cross-system evaluation of clinical trial search engines.

AMIA Jt Summits Transl Sci Proc 2014 7;2014:223-9. Epub 2014 Apr 7.

Department of Biomedical Informatics, Columbia University, New York, NY 10032.

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May 2015

A method for probing disease relatedness using common clinical eligibility criteria.

Stud Health Technol Inform 2013 ;192:481-5

Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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April 2015

Extending VIVO ontology to represent research and educational resources in an academic biomedical informatics department.

Stud Health Technol Inform 2013 ;192:1206

Department of Biomedical Informatics, Columbia University, New York, NY, USA 10032.

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April 2015

Visual aggregate analysis of eligibility features of clinical trials.

J Biomed Inform 2015 Apr 20;54:241-55. Epub 2015 Jan 20.

Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA. Electronic address:

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April 2015

Case-based reasoning using electronic health records efficiently identifies eligible patients for clinical trials.

J Am Med Inform Assoc 2015 Apr 13;22(e1):e141-50. Epub 2015 Mar 13.

Department of Biomedical Informatics The Irving Institute for Clinical and Translational Research, Columbia University, New York, NY 10032, USA

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April 2015

Considerations for using research data to verify clinical data accuracy.

AMIA Jt Summits Transl Sci Proc 2014 7;2014:211-7. Epub 2014 Apr 7.

Intermountain Healthcare, Salt Lake City, UT.

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February 2015

From expert-derived user needs to user-perceived ease of use and usefulness: a two-phase mixed-methods evaluation framework.

J Biomed Inform 2014 Dec 12;52:141-50. Epub 2013 Dec 12.

Department of Biomedical Informatics, Columbia University, New York, NY, USA; The Irving Institute for Clinical and Translational Research, Columbia University, New York, NY, USA. Electronic address:

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December 2014

Clustering clinical trials with similar eligibility criteria features.

J Biomed Inform 2014 Dec 1;52:112-20. Epub 2014 Feb 1.

Department of Biomedical Informatics, Columbia University, New York, NY, United States. Electronic address:

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December 2014

Associating co-authorship patterns with publications in high-impact journals.

J Biomed Inform 2014 Dec 19;52:311-8. Epub 2014 Jul 19.

Department of Biomedical Informatics, Columbia University, New York City, United States; The Irving Institute for Clinical and Translational Research, Columbia University, New York City, United States. Electronic address:

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December 2014

Impact of cervical effacement and fetal station on progress during the first stage of labor: a biexponential model.

Am J Perinatol 2014 Oct 11;31(9):745-51. Epub 2013 Dec 11.

Department of Obstetrics and Gynecology, American University of Beirut, Beirut, Lebanon.

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October 2014

Automatic generation of investigator bibliographies for institutional research networking systems.

J Biomed Inform 2014 Oct 30;51:8-14. Epub 2014 Mar 30.

Department of Biomedical Informatics, Columbia University, New York, United States; The Irving Institute for Clinical and Translational Research, Columbia University, New York, United States.

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October 2014

Absence of pancreatic intraepithelial neoplasia predicts poor survival after resection of pancreatic cancer.

Pancreas 2014 Oct;43(7):1073-7

From the *Department of Medicine, Columbia University, New York, NY; †Department of Medicine, Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY; Departments of ‡Pathology and Cell Biology and §Biomedical Informatics, Columbia University, New York, NY; ∥Department of Medicine, Stanford University, Stanford, CA; ¶Department of Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA; and #Department of Surgery, Columbia University, New York, NY.

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October 2014

Trend and Network Analysis of Common Eligibility Features for Cancer Trials in ClinicalTrials.gov.

Smart Health (2014) 2014 Jul;8549:130-141

Department of Biomedical Informatics, Columbia University, New York City, USA.

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July 2014

Hidden in plain sight: bias towards sick patients when sampling patients with sufficient electronic health record data for research.

BMC Med Inform Decis Mak 2014 Jun 11;14:51. Epub 2014 Jun 11.

Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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June 2014

Design and evaluation of a bacterial clinical infectious diseases ontology.

AMIA Annu Symp Proc 2013 16;2013:502-11. Epub 2013 Nov 16.

Department of Biomedical Informatics, Columbia University, New York.

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May 2014

Sick patients have more data: the non-random completeness of electronic health records.

AMIA Annu Symp Proc 2013 16;2013:1472-7. Epub 2013 Nov 16.

Columbia University, New York, NY.

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May 2014

eTACTS: a method for dynamically filtering clinical trial search results.

J Biomed Inform 2013 Dec 3;46(6):1060-7. Epub 2013 Aug 3.

Department of Biomedical Informatics, Columbia University, New York, NY 10032, United States.

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December 2013

Defining a comprehensive verotype using electronic health records for personalized medicine.

J Am Med Inform Assoc 2013 Dec 3;20(e2):e232-8. Epub 2013 Sep 3.

Department of Biomedical Informatics, Columbia University, New York, New York, USA.

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December 2013

Unsupervised mining of frequent tags for clinical eligibility text indexing.

J Biomed Inform 2013 Dec 10;46(6):1145-51. Epub 2013 Sep 10.

Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA.

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December 2013

Characterization of the biomedical query mediation process.

AMIA Jt Summits Transl Sci Proc 2013 18;2013:89-93. Epub 2013 Mar 18.

Department of Biomedical Informatics, Columbia University, New York, NY 10032.

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December 2013

Towards dynamic and interactive retrieval of clinical trials using common eligibility features.

AMIA Jt Summits Transl Sci Proc 2013 18;2013:182. Epub 2013 Mar 18.

Department of Biomedical Informatics, Columbia University, New York, NY.

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December 2013

Evaluation considerations for EHR-based phenotyping algorithms: A case study for drug-induced liver injury.

AMIA Jt Summits Transl Sci Proc 2013 18;2013:130-4. Epub 2013 Mar 18.

Department of Biomedical Informatics, Columbia University, New York, NY.

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December 2013

Defining and measuring completeness of electronic health records for secondary use.

J Biomed Inform 2013 Oct 29;46(5):830-6. Epub 2013 Jun 29.

Department of Biomedical Informatics, Columbia University, New York, NY 10032, United States. Electronic address:

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October 2013

Opportunities for genomic clinical decision support interventions.

Genet Med 2013 Oct 19;15(10):817-23. Epub 2013 Sep 19.

1] Department of Biomedical Informatics, Columbia University, New York, New York, USA [2] Program for Personalized & Genomic Medicine and Center for Health-Related Informatics and Bioimaging, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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October 2013

A centralized research data repository enhances retrospective outcomes research capacity: a case report.

J Am Med Inform Assoc 2013 May 15;20(3):563-7. Epub 2013 Jan 15.

Department of Urology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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May 2013

A human-computer collaborative approach to identifying common data elements in clinical trial eligibility criteria.

J Biomed Inform 2013 Feb 27;46(1):33-9. Epub 2012 Jul 27.

Department of Biomedical Informatics, Columbia University, New York, NY 10032, United States.

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February 2013

Using EHRs to integrate research with patient care: promises and challenges.

J Am Med Inform Assoc 2012 Sep-Oct;19(5):684-7. Epub 2012 Apr 29.

Department of Biomedical Informatics, Columbia University, New York, New York 10032, USA.

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January 2013

Methods and dimensions of electronic health record data quality assessment: enabling reuse for clinical research.

J Am Med Inform Assoc 2013 Jan 25;20(1):144-51. Epub 2012 Jun 25.

Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA.

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January 2013

An initial log analysis of usage patterns on a research networking system.

Clin Transl Sci 2012 Aug 1;5(4):340-7. Epub 2012 Jun 1.

The Irving Institute for Clinical and Translational Research, Columbia University, New York, New York, USA.

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August 2012