Chun-hua Huang

Chun-hua Huang

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Chun-hua Huang

Chun-hua Huang

Publications by authors named "Chun-hua Huang"

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An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine.

Free Radic Biol Med 2020 Feb 17;147:150-158. Epub 2019 Dec 17.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China; Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA; Joint Institute for Environmental Science, Research Center for Eco-Environmental Sciences and Hong Kong Baptist University, Beijing, Hong Kong, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.12.013DOI Listing
February 2020

Unexpected activation of N-alkyl hydroxamic acids to produce reactive N-centered free radicals and DNA damage by carcinogenic chlorinated quinones under normal physiological conditions.

Free Radic Biol Med 2020 Jan 15;146:70-78. Epub 2019 Oct 15.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, The Chinese Academy of Sciences, Beijing, 100085, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China; Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA; Joint Institute for Environmental Science, Research Center for Eco-Environmental Sciences and Hong Kong Baptist University, Beijing/Hong Kong, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.10.009DOI Listing
January 2020

Chiral Os(II) Polypyridyl Complexes as Enantioselective Nuclear DNA Imaging Agents Especially Suitable for Correlative High-Resolution Light and Electron Microscopy Studies.

ACS Appl Mater Interfaces 2020 Jan 8;12(3):3465-3473. Epub 2020 Jan 8.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences , Chinese Academy of Sciences , Beijing 100085 , P. R. China.

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http://dx.doi.org/10.1021/acsami.9b19776DOI Listing
January 2020

Sulfur-centered hemi-bond radicals as active intermediates in S-DNA phosphorothioate oxidation.

Nucleic Acids Res 2019 Dec;47(22):11514-11526

College of Chemistry, Beijing Normal University, Beijing 100875, China.

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http://dx.doi.org/10.1093/nar/gkz987DOI Listing
December 2019

Molecular mechanism for the activation of the anti-tuberculosis drug isoniazid by Mn(III): First detection and unequivocal identification of the critical N-centered isoniazidyl radical and its exact location.

Free Radic Biol Med 2019 Nov 15;143:232-239. Epub 2019 Jul 15.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China; Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.07.012DOI Listing
November 2019

Targeted live-cell nuclear delivery of the DNA 'light-switching' Ru(II) complex via ion-pairing with chlorophenolate counter-anions: the critical role of binding stability and lipophilicity of the ion-pairing complexes.

Nucleic Acids Res 2019 Nov;47(20):10520-10528

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences, The Chinese Academy of Sciences, Beijing 100085, P. R. China.

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http://dx.doi.org/10.1093/nar/gkz152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847114PMC
November 2019

Reactive Nitrogen Species Are Also Involved in the Transformation of Micropollutants by the UV/Monochloramine Process.

Environ Sci Technol 2019 Oct 27;53(19):11142-11152. Epub 2019 Aug 27.

Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, School of Environmental Science and Engineering , Sun Yat-Sen University , Guangzhou 510275 , China.

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http://dx.doi.org/10.1021/acs.est.9b01212DOI Listing
October 2019

Enantioselective and Differential Fluorescence Lifetime Imaging of Nucleus and Nucleolus by the Two Enantiomers of Chiral Os(II) Polypyridyl Complex.

J Phys Chem Lett 2019 Oct 20;10(19):5909-5916. Epub 2019 Sep 20.

State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences, Chinese Academy of Sciences , Beijing 100085 , People's Republic of China.

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http://dx.doi.org/10.1021/acs.jpclett.9b02075DOI Listing
October 2019

What Are the Major Physicochemical Factors in Determining the Preferential Nuclear Uptake of the DNA "Light-Switching" Ru(II)-Polypyridyl Complex in Live Cells via Ion-Pairing with Chlorophenolate Counter-Anions?

J Phys Chem Lett 2019 Jul 9;10(14):4123-4128. Epub 2019 Jul 9.

State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences, Chinese Academy of Sciences , Beijing 100085 , People's Republic of China.

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http://dx.doi.org/10.1021/acs.jpclett.9b01225DOI Listing
July 2019

An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve-agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions.

Free Radic Biol Med 2019 01 21;130:1-7. Epub 2018 Oct 21.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849183222
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http://dx.doi.org/10.1016/j.freeradbiomed.2018.10.425DOI Listing
January 2019

Mechanism of unprecedented hydroxyl radical production and site-specific oxidative DNA damage by photoactivation of the classic arylhydroxamic acid carcinogens.

Carcinogenesis 2019 Jan 8. Epub 2019 Jan 8.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, The Chinese Academy of Sciences, Beijing, P.R. China.

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http://dx.doi.org/10.1093/carcin/bgz021DOI Listing
January 2019

The Expensive-Tissue Hypothesis in Vertebrates: Gut Microbiota Effect, a Review.

Int J Mol Sci 2018 Jun 17;19(6). Epub 2018 Jun 17.

Key Laboratory of Southwest China Wildlife Resources Conservation (Ministry of Education), China West Normal University, Nanchong 637009, Sichuan, China.

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http://dx.doi.org/10.3390/ijms19061792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032294PMC
June 2018

Unusual Double Beckmann Fragmentation Reaction under Physiological Conditions.

J Org Chem 2017 12 27;82(24):13084-13092. Epub 2017 Nov 27.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, University of Chinese Academy of Sciences , Beijing 100085, P. R. China.

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http://dx.doi.org/10.1021/acs.joc.7b02106DOI Listing
December 2017

Mechanism of synergistic DNA damage induced by the hydroquinone metabolite of brominated phenolic environmental pollutants and Cu(II): Formation of DNA-Cu complex and site-specific production of hydroxyl radicals.

Free Radic Biol Med 2017 03 3;104:54-63. Epub 2017 Jan 3.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences and University of Chinese Academy of Sciences, The Chinese Academy of Sciences, Beijing 100085, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.12.050DOI Listing
March 2017

Mechanism of Intrinsic Chemiluminescence Production from the Degradation of Persistent Chlorinated Phenols by the Fenton System: A Structure-Activity Relationship Study and the Critical Role of Quinoid and Semiquinone Radical Intermediates.

Environ Sci Technol 2017 03 17;51(5):2934-2943. Epub 2017 Feb 17.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences and University of Chinese Academy of Sciences, Chinese Academy of Sciences , Beijing, P.R. China 100085.

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http://dx.doi.org/10.1021/acs.est.6b04664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806603PMC
March 2017

A series of pure-blue-light emitting Cu(i) complexes with thermally activated delayed fluorescence: structural, photophysical, and computational studies.

Dalton Trans 2017 Jan;46(5):1413-1419

Institute of Optical Crystalline Materials, College of Chemistry, Fuzhou University, Fuzhou 350116, P. R. China.

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http://dx.doi.org/10.1039/c6dt03965kDOI Listing
January 2017

An Exceptionally Facile Two-Step Structural Isomerization and Detoxication via a Water-Assisted Double Lossen Rearrangement.

Sci Rep 2016 12 23;6:39207. Epub 2016 Dec 23.

State Key Laboratory of Environmental Chemistry and Eco-toxicology, Research Centre for Eco-environmental Sciences, the Chinese Academy of Sciences, Beijing 100085, PR China.

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http://dx.doi.org/10.1038/srep39207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180244PMC
December 2016

Why Does 2,3,5,6-Tetrachlorophenol Generate the Strongest Intrinsic Chemiluminescence among All Nineteen Chlorophenolic Persistent Organic Pollutants during Environmentally-friendly Advanced Oxidation Process?

Sci Rep 2016 10 17;6:33159. Epub 2016 Oct 17.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P. R. China.

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http://dx.doi.org/10.1038/srep33159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066286PMC
October 2016

Delivering the cell-impermeable DNA 'light-switching' Ru(ii) complexes preferentially into live-cell nucleus an unprecedented ion-pairing method.

Chem Sci 2016 Jul 5;7(7):4016-4023. Epub 2016 Apr 5.

State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research Center for Eco-Environmental Sciences , The Chinese Academy of Sciences , P.O. Box 2871 , Beijing , P. R. China 100085 . Email: ; ; Tel: +86-10-62849030.

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http://dx.doi.org/10.1039/c5sc03796dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013783PMC
July 2016

Intrinsic Chemiluminescence Generation during Advanced Oxidation of Persistent Halogenated Aromatic Carcinogens.

Environ Sci Technol 2015 Jul 11;49(13):7940-7. Epub 2015 Jun 11.

†State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, The Chinese Academy of Sciences, Beijing, P. R. China 100085.

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http://dx.doi.org/10.1021/acs.est.5b01227DOI Listing
July 2015

Molecular mechanism of metal-independent decomposition of organic hydroperoxides by halogenated quinoid carcinogens and the potential biological implications.

Chem Res Toxicol 2015 May 17;28(5):831-7. Epub 2015 Apr 17.

†State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences, CAS, Beijing 100085, China.

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http://dx.doi.org/10.1021/tx500486zDOI Listing
May 2015

A combined experimental and computational investigation on the unusual molecular mechanism of the Lossen rearrangement reaction activated by carcinogenic halogenated quinones.

J Org Chem 2015 Jan 17;80(1):180-9. Epub 2014 Dec 17.

†State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

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http://dx.doi.org/10.1021/jo5022713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285140PMC
January 2015

Effect of small interfering RNAs on matrix metalloproteinase 1 expression.

Biotechnol Rep (Amst) 2014 Dec 20;4:5-13. Epub 2014 Jul 20.

Department of Food & Nutrition, Providence University, Taiwan.

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http://dx.doi.org/10.1016/j.btre.2014.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466121PMC
December 2014

Detoxifying polyhalogenated catechols through a copper-chelating agent by forming stable and redox-inactive hydrogen-bonded complexes with an unusual perpendicular structure.

Chemistry 2014 Sep 14;20(40):13028-33. Epub 2014 Aug 14.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, The Chinese Academy of Sciences, Beijing 100085 (P.R. China).

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http://doi.wiley.com/10.1002/chem.201402833
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http://dx.doi.org/10.1002/chem.201402833DOI Listing
September 2014

Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens.

Free Radic Biol Med 2013 Oct 14;63:459-66. Epub 2013 May 14.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806606PMC
October 2013

Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism.

Free Radic Biol Med 2013 Jul 30;60:177-82. Epub 2013 Jan 30.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476646PMC
July 2013

The first purification and unequivocal characterization of the radical form of the carbon-centered quinone ketoxy radical adduct.

Chem Commun (Camb) 2013 Jul;49(57):6436-8

State Key Lab of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, CAS, Beijing 100085, China.

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http://dx.doi.org/10.1039/c3cc42732cDOI Listing
July 2013

[Post-stroke depression treated with acupuncture and moxibustion: an evaluation of therapeutic effect and safety].

Zhongguo Zhen Jiu 2013 Jun;33(6):490-4

Department of TCM, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Province, China.

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June 2013

Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2.

Proc Natl Acad Sci U S A 2012 Oct 17;109(40):16046-51. Epub 2012 Sep 17.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People's Republic of China.

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http://dx.doi.org/10.1073/pnas.1204479109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479549PMC
October 2012

[Observation of therapeutic effect on post stroke depression treated by differentiation of spleen and stomach].

Zhongguo Zhen Jiu 2011 Apr;31(4):325-8

The Second Clinical College of Guangzhou University of TCM, Guangzhou 510405, Guangdong Province, China.

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April 2011

[Observation on relations between onset seasons of peripheral facial paralysis and therapeutic courses and effect of acupuncture].

Zhongguo Zhen Jiu 2011 Mar;31(3):209-12

Acupuncture and Rehabilitation Department, The Affiliated Hospital of Jiangxi College of TCM, Nanchang 330006, China.

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March 2011

Nuclear expression of dynamin-related protein 1 in lung adenocarcinomas.

Mod Pathol 2009 Sep 12;22(9):1139-50. Epub 2009 Jun 12.

Department of Dental Laboratory Technology, Central Taiwan University of Science and Technology, Taichung, Taiwan.

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http://dx.doi.org/10.1038/modpathol.2009.83DOI Listing
September 2009

Metal-independent decomposition of hydroperoxides by halogenated quinones: detection and identification of a quinone ketoxy radical.

Proc Natl Acad Sci U S A 2009 Jul 25;106(28):11466-71. Epub 2009 Jun 25.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People's Republic of China. mail:

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http://dx.doi.org/10.1073/pnas.0900065106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710671PMC
July 2009

[A case-control study of factors associated with primary angle-closure glaucoma].

Zhonghua Yan Ke Za Zhi 2008 Jun;44(6):503-6

Department of Public Health, Nantong University, Nantong 226001, China.

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June 2008

[Prokaryotic expression of SARS coronavirus spike protein and construction of its DNA vaccine].

Di Yi Jun Yi Da Xue Xue Bao 2005 Jan;25(1):33-6

Southern China University of Tropical Agriculture, Danzhou 571737, China.

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January 2005