Chun-Jen Liu

Chun-Jen Liu

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Antiviral therapy against chronic hepatitis C is associated with a reduced risk of oral cancer.

Int J Cancer 2020 Aug 2;147(3):901-908. Epub 2020 Jan 2.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1002/ijc.32840DOI Listing
August 2020

2020 Taiwan consensus statement on the management of hepatitis C: Part (II) special populations.

J Formos Med Assoc 2020 Jul 27;119(7):1135-1157. Epub 2020 Apr 27.

Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine and Hepatitis Research Center, College of Medicine, Center for Cancer Research and Center for Liquid Biopsy, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1016/j.jfma.2020.04.002DOI Listing
July 2020

Glecaprevir/pibrentasvir for patients with chronic hepatitis C virus infection and severe renal impairment.

J Viral Hepat 2020 Jun 6;27(6):568-575. Epub 2020 Feb 6.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jvh.13265DOI Listing
June 2020

HEV superinfection accelerates disease progression in patients with chronic HBV infection and increases mortality in those with cirrhosis.

J Hepatol 2020 Jun 12;72(6):1105-1111. Epub 2020 Mar 12.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2020.01.012DOI Listing
June 2020

Permanent Inactivation of HBV Genomes by CRISPR/Cas9-Mediated Non-cleavage Base Editing.

Mol Ther Nucleic Acids 2020 Jun 19;20:480-490. Epub 2020 Mar 19.

Department of Microbiology, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2020.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150432PMC
June 2020

2020 Taiwan consensus statement on the management of hepatitis C: part (I) general population.

J Formos Med Assoc 2020 Jun 29;119(6):1019-1040. Epub 2020 Apr 29.

Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine and Hepatitis Research Center, College of Medicine, Center for Cancer Research and Center for Liquid Biopsy, Kaohsiung Medical University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1016/j.jfma.2020.04.003DOI Listing
June 2020

Pathologic findings of patients with nonalcoholic fatty liver disease and the impact of concurrent hepatitis B virus infection in Taiwan.

J Formos Med Assoc 2020 Jun 1. Epub 2020 Jun 1.

Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei City, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and Hospital, Taipei City, Taiwan; Hepatitis Research Center, National Taiwan University College of Medicine and Hospital, Taipei City, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2020.05.027DOI Listing
June 2020

Sofosbuvir/velpatasvir/voxilaprevir plus ribavirin for chronic hepatitis C patients with direct acting antiviral failures: Implications for viral elimination in Taiwan.

J Formos Med Assoc 2020 Jun 14. Epub 2020 Jun 14.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2020.06.013DOI Listing
June 2020

Limited drug-drug interaction of elbasvir/grazoprevir for chronic hepatitis C.

J Formos Med Assoc 2020 May 5;119(5):933-940. Epub 2019 Oct 5.

Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.09.011DOI Listing
May 2020

Evolution of eGFR in chronic HCV patients receiving sofosbuvir-based or sofosbuvir-free direct-acting antivirals.

J Hepatol 2020 May 29;72(5):839-846. Epub 2019 Nov 29.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.11.014DOI Listing
May 2020

Elbasvir/grazoprevir is effective and tolerable for the treatment of HCV GT1-infected patients: A real world multicenter observatory study in Taiwan.

J Microbiol Immunol Infect 2020 May 22. Epub 2020 May 22.

Department of Internal Medicine and Hepatitis Research Center, National Taiwan University College of Medicine and Hospital, Taipei City, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2020.05.004DOI Listing
May 2020

Effects and safety of body positioning on back pain after transcatheter arterial chemoembolization in people with hepatocellular carcinoma: A randomized controlled study.

Int J Nurs Stud 2020 May 16;109:103641. Epub 2020 May 16.

School of Nursing, College of Nursing, National Yang-Ming University, No.155, Sec.2, Li-Nong Street, Taipei City, 112, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijnurstu.2020.103641DOI Listing
May 2020

Glecaprevir/pibrentasvir for patients with chronic hepatitis C virus infection: Real-world effectiveness and safety in Taiwan.

Liver Int 2020 Apr 11;40(4):758-768. Epub 2019 Nov 11.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/liv.14295DOI Listing
April 2020

Serum Mac-2-Binding Protein Glycosylation Isomer at Virological Remission Predicts Hepatocellular Carcinoma and Death in Chronic Hepatitis B-Related Cirrhosis.

J Infect Dis 2020 Feb;221(4):589-597

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1093/infdis/jiz496DOI Listing
February 2020

NIACE score refines the overall survival of hepatocellular carcinoma by Barcelona clinic liver cancer staging.

J Gastroenterol Hepatol 2019 Dec 18;34(12):2179-2186. Epub 2019 Jun 18.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jgh.14705DOI Listing
December 2019

High Level of Hepatitis B Core-Related Antigen Associated With Increased Risk of Hepatocellular Carcinoma in Patients With Chronic HBV Infection of Intermediate Viral Load.

Gastroenterology 2019 12 27;157(6):1518-1529.e3. Epub 2019 Aug 27.

Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.08.028DOI Listing
December 2019

Antiviral Therapy in Patients With Chronic Hepatitis C Is Associated With a Reduced Risk of Parkinsonism.

Mov Disord 2019 12 10;34(12):1882-1890. Epub 2019 Sep 10.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1002/mds.27848DOI Listing
December 2019

Sofosbuvir-based direct acting antiviral therapies for patients with hepatitis C virus genotype 2 infection.

J Gastroenterol Hepatol 2019 Sep 17;34(9):1620-1625. Epub 2019 Feb 17.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jgh.14615DOI Listing
September 2019

Expression of Metastatic Tumor Antigen 1 Splice Variant Correlates With Early Recurrence and Aggressive Features of Hepatitis B Virus-Associated Hepatocellular Carcinoma.

Hepatology 2019 07 14;70(1):184-197. Epub 2019 Apr 14.

Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1002/hep.30581DOI Listing
July 2019

A simple non-invasive test for ruling out cirrhosis in chronic hepatitis B.

Lancet Gastroenterol Hepatol 2019 07 9;4(7):495-496. Epub 2019 Apr 9.

Department of Internal Medicine and Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/S2468-1253(19)30118-9DOI Listing
July 2019

Smoking and Hepatitis B Virus-Related Hepatocellular Carcinoma Risk: The Mediating Roles of Viral Load and Alanine Aminotransferase.

Hepatology 2019 04 19;69(4):1412-1425. Epub 2019 Feb 19.

Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

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http://doi.wiley.com/10.1002/hep.30339
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http://dx.doi.org/10.1002/hep.30339DOI Listing
April 2019

Chronic hepatitis B is associated with an increased risk of B-cell non-Hodgkin's lymphoma and multiple myeloma.

Aliment Pharmacol Ther 2019 03 25;49(5):589-598. Epub 2019 Jan 25.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/apt.15132DOI Listing
March 2019

Profile and value of FIB-4 in patients with dual chronic hepatitis C and B.

J Gastroenterol Hepatol 2019 Feb 20;34(2):410-417. Epub 2018 Sep 20.

Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jgh.14455DOI Listing
February 2019

Early antiviral therapy reduces the risk of lymphoma in patients with chronic hepatitis C infection.

Aliment Pharmacol Ther 2019 02 27;49(3):331-339. Epub 2018 Dec 27.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/apt.15101DOI Listing
February 2019

Taiwan consensus statement on the management of chronic hepatitis B.

J Formos Med Assoc 2019 Jan 6;118(1 Pt 1):7-38. Epub 2018 Dec 6.

Liver Research Unit, Linkou Chang Gung Memorial Hospital and University College of Medicine, Taoyuan, Taiwan.

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http://dx.doi.org/10.1016/j.jfma.2018.11.008DOI Listing
January 2019

Real-world effectiveness of direct-acting antiviral agents for chronic hepatitis C in Taiwan: Real-world data.

J Microbiol Immunol Infect 2018 Sep 26. Epub 2018 Sep 26.

Department of Internal Medicine and Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S16841182183040
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http://dx.doi.org/10.1016/j.jmii.2018.09.005DOI Listing
September 2018

Significance of definitions of relapse after discontinuation of oral antivirals in HBeAg-negative chronic hepatitis B.

Hepatology 2018 08 10;68(2):415-424. Epub 2018 May 10.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1002/hep.29497DOI Listing
August 2018

Acoustic Radiation Force Impulse US Imaging: Liver Stiffness in Patients with Chronic Hepatitis B with and without Antiviral Therapy.

Radiology 2018 07 27;288(1):293-299. Epub 2018 Mar 27.

From the Division of Gastroenterology and Hepatology, Department of Internal Medicine (T.H.S., Chen-Hua Liu, T.C.T., H.C.Y., C.J.L., P.J.C., D.S.C., J.H.K.), Hepatitis Research Center (T.H.S., Chen-Hua Liu, K.W.H., T.C.T., C.J.L., P.J.C., D.S.C., J.H.K.), Department of Surgery (K.W.H.), and Department of Medical Research (P.J.C., J.H.K.), National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Jin-shan Branch, New Taipei City, Taiwan (T.C.T.); School of Medicine, National Taiwan University, Taipei, Taiwan (Chun-Hsun Liao); and Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, 1 Chang-Te Street, Taipei 10048, Taiwan (C.J.L., P.J.C., D.S.C., J.H.K.).

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http://dx.doi.org/10.1148/radiol.2018171116DOI Listing
July 2018

Boceprevir-based triple therapy to rescue HCV genotype 1/HBV dually infected patients refractory to peginterferon plus ribavirin combination therapy in Taiwan.

J Formos Med Assoc 2018 Jun 8;117(6):497-504. Epub 2017 Jul 8.

School of Medicine, Graduate Institute of Clinical Medicine, College of Medicine, Lipid Science and Aging Research Center, Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan; Hepatitis Center and Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan; Liver Center, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2017.06.007DOI Listing
June 2018

Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma.

Helicobacter 2018 Apr 26;23(2):e12473. Epub 2018 Feb 26.

Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/hel.12473DOI Listing
April 2018

Efficacy of Ledipasvir and Sofosbuvir Treatment of HCV Infection in Patients Coinfected With HBV.

Gastroenterology 2018 03 22;154(4):989-997. Epub 2017 Nov 22.

Graduate Institute of Clinical Medicine, Hepatitis Research Center and Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085173636
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http://dx.doi.org/10.1053/j.gastro.2017.11.011DOI Listing
March 2018

Distinct Relapse Rates and Risk Predictors After Discontinuing Tenofovir and Entecavir Therapy.

J Infect Dis 2018 03;217(8):1193-1201

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1093/infdis/jix690DOI Listing
March 2018

A noninvasive diagnosis of hepatic fibrosis by BioFibroScore® in chronic hepatitis C patients.

J Gastroenterol Hepatol 2018 Jan;33(1):291-297

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jgh.13834DOI Listing
January 2018

Mother-to-infant transmission of hepatitis B virus: challenges and perspectives.

Hepatol Int 2017 Nov 24;11(6):481-484. Epub 2017 Oct 24.

Department of Internal Medicine and Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, 1 Chang-Te St, Taipei, 100, Taiwan.

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http://dx.doi.org/10.1007/s12072-017-9831-0DOI Listing
November 2017

NOhep: Toward Global Control of Hepatitis B Virus Infection-An Introduction.

J Infect Dis 2017 11;216(suppl_8):S749

Department of Internal Medicine.

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http://dx.doi.org/10.1093/infdis/jix313DOI Listing
November 2017

Viral Factors Affecting the Clinical Outcomes of Chronic Hepatitis B.

J Infect Dis 2017 11;216(suppl_8):S757-S764

Graduate Institute of Clinical Medicine.

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http://dx.doi.org/10.1093/infdis/jix461DOI Listing
November 2017

Influence of Metabolic Risk Factors on Risk of Hepatocellular Carcinoma and Liver-Related Death in Men With Chronic Hepatitis B: A Large Cohort Study.

Gastroenterology 2017 10 12;153(4):1006-1017.e5. Epub 2017 Jul 12.

Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1053/j.gastro.2017.07.001DOI Listing
October 2017

Fibrosis-4 Index Helps Identify HBV Carriers With the Lowest Risk of Hepatocellular Carcinoma.

Am J Gastroenterol 2017 Oct 29;112(10):1564-1574. Epub 2017 Aug 29.

Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1038/ajg.2017.254DOI Listing
October 2017

Impact of occult hepatitis B on the clinical outcomes of patients with chronic hepatitis C virus infection: A 10-year follow-up.

J Formos Med Assoc 2017 Sep 21;116(9):697-704. Epub 2016 Dec 21.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2016.11.002DOI Listing
September 2017

Combination Therapy for Chronic Hepatitis B: Current Updates and Perspectives.

Gut Liver 2017 Sep;11(5):590-603

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.5009/gnl16215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593320PMC
September 2017

Synergistic Effect of Hyperglycemia and Helicobacterpylori Infection Status on Colorectal Adenoma Risk.

J Clin Endocrinol Metab 2017 08;102(8):2744-2750

Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei 10449, Taiwan.

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http://dx.doi.org/10.1210/jc.2017-00257DOI Listing
August 2017

Addition of ribavirin to daclatasvir plus asunaprevir for chronic hepatitis C 1b patients with baseline NS5A resistance-associated variants improved response.

J Formos Med Assoc 2017 Apr 26;116(4):295-299. Epub 2016 Dec 26.

Department of Traumatology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2016.11.014DOI Listing
April 2017

Genome-wide identification of blood DNA methylation patterns associated with early-onset hepatocellular carcinoma development in hepatitis B carriers.

Mol Carcinog 2017 02 10;56(2):425-435. Epub 2016 Jun 10.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1002/mc.22505DOI Listing
February 2017

Hepatitis B Virus Reactivation in Patients Receiving Interferon-Free Direct-Acting Antiviral Agents for Chronic Hepatitis C Virus Infection.

Open Forum Infect Dis 2017 11;4(1):ofx028. Epub 2017 Feb 11.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei.

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http://dx.doi.org/10.1093/ofid/ofx028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414056PMC
February 2017

Associated factors and clinical implications of serum aminotransferase elevation in scrub typhus.

J Microbiol Immunol Infect 2016 Dec 11;49(6):941-946. Epub 2014 Nov 11.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2014.10.005DOI Listing
December 2016

How Does Aging Affect Presentation and Management of Biliary Stones?

J Am Geriatr Soc 2016 11 27;64(11):2330-2335. Epub 2016 Sep 27.

Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jgs.14481DOI Listing
November 2016

Prevalence and clinical implications of IL28B genotypes in Taiwanese patients with chronic hepatitis C.

J Formos Med Assoc 2016 Nov 15;115(11):953-960. Epub 2016 Oct 15.

Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Department of Medical Research, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2016.07.013DOI Listing
November 2016

Progressive accumulation of mutations in the hepatitis B virus genome and its impact on time to diagnosis of hepatocellular carcinoma.

Hepatology 2016 09 7;64(3):720-31. Epub 2016 Jul 7.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1002/hep.28654DOI Listing
September 2016

Long-term Effects of Hepatitis B Immunization of Infants in Preventing Liver Cancer.

Gastroenterology 2016 09 4;151(3):472-480.e1. Epub 2016 Jun 4.

Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Academia Sinica, Taipei, Taiwan.

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http://dx.doi.org/10.1053/j.gastro.2016.05.048DOI Listing
September 2016

Rapid Prediction of Treatment Futility of Boceprevir with Peginterferon-Ribavirin for Taiwanese Treatment Experienced Hepatitis C Virus Genotype 1-Infected Patients.

PLoS One 2015 14;10(9):e0137852. Epub 2015 Sep 14.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137852PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569190PMC
June 2016

Perspectives on dual hepatitis B and C infection in Taiwan.

J Formos Med Assoc 2016 May 15;115(5):298-305. Epub 2015 Jul 15.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.jfma.2015.06.005DOI Listing
May 2016

Incorporating Serum Level of Hepatitis B Surface Antigen or Omitting Level of Hepatitis B Virus DNA Does not Affect Calculation of Risk for Hepatocellular Carcinoma in Patients Without Cirrhosis.

Clin Gastroenterol Hepatol 2016 Mar 18;14(3):461-468.e2. Epub 2015 Nov 18.

Genomics Research Center, Academia Sinica, Taipei, Taiwan; Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2015.10.033DOI Listing
March 2016

Hepatitis C viral infection increases the risk of lymphoid-neoplasms: A population-based cohort study.

Hepatology 2016 Mar 14;63(3):721-30. Epub 2016 Jan 14.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1002/hep.28387DOI Listing
March 2016

Hepatitis B Surface Antigen Loss and Hepatocellular Carcinoma Development in Patients With Dual Hepatitis B and C Infection.

Medicine (Baltimore) 2016 Mar;95(10):e2995

From the Division of Gastroenterology (T-CT, C-CW), Department of Internal Medicine, Taipei Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation; Division of Gastroenterology (H-CY, T-HS, C-HL, P-JC, C-JL, J-HK), Department of Internal Medicine; Graduate Institute of Clinical Medicine (C-LC, T-HS, C-HL, C-JL, J-HK); Hepatitis Research Center (W-TY, C-HL, J-HK); Department of Medical Research (J-HK); Department of Microbiology (H-CY), National Taiwan University College of Medicine and National Taiwan University Hospital; Master of Public Health Degree Program (W-TY), National Taiwan University, Taipei; Division of Gastroenterology (L-WW), Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei; School of Medicine (T-CT, C-CW), Tzu Chi University, Hualien; Genomics Research Center Academia Sinica (D-SC), Taipei, Taiwan; St Vincent's Hospital (SF-TK), Melbourne VIC, Australia; and Taiwan Liver Disease Consortium (TLC) (C-JL), Taipei, Taiwan.

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http://dx.doi.org/10.1097/MD.0000000000002995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998890PMC
March 2016

Serum Biomarkers Predictive of Significant Fibrosis and Cirrhosis in Chronic Hepatitis B.

J Clin Gastroenterol 2015 Sep;49(8):705-13

*Department of Gastroenterology, Taipei City Hospital, Ren-Ai branch †Department of Psychology, National Chengchi University ‡Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine §Department of Internal Medicine, Division of Gastroenterology and Hepatology ∥Hepatitis Research Center **Department of Medical Research, National Taiwan University Hospital #Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei ¶Department of Hepatology, Buddhist Tzu Chi General Hospital, Taipei Branch and School of Medicine, Tzu Chi University, Hualien, Taiwan.

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http://dx.doi.org/10.1097/MCG.0000000000000250DOI Listing
September 2015

Peginterferon plus weight-based ribavirin for treatment-naïve hepatitis C virus genotype 2 patients not achieving rapid virologic response: a randomized trial.

Sci Rep 2015 Jul 1;5:11710. Epub 2015 Jul 1.

1] Institute of Clinical Medicine and Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan [2] Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan [3] Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486927PMC
July 2015

Development of risk scoring system for stratifying population for hepatocellular carcinoma screening.

Hepatology 2015 Jun 13;61(6):1934-44. Epub 2015 Apr 13.

1nstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1002/hep.27610DOI Listing
June 2015

Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition.

Proc Natl Acad Sci U S A 2015 Jun 26;112(23):7243-8. Epub 2015 May 26.

Graduate Institute of Clinical Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hepatitis Research Center, Genomics Research Center, Academia Sinica, Nankang, Taipei 11529, Taiwan

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http://www.pnas.org/lookup/doi/10.1073/pnas.1507499112
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http://dx.doi.org/10.1073/pnas.1507499112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466718PMC
June 2015

Advanced hepatic fibrosis and steatosis are associated with persistent alanine aminotransferase elevation in chronic hepatitis C patients negative for hepatitis C virus RNA during pegylated interferon plus ribavirin therapy.

J Infect Dis 2015 May 11;211(9):1429-36. Epub 2014 Nov 11.

Department of Internal Medicine Hepatitis Research Center, National Taiwan University Hospital Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine.

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http://dx.doi.org/10.1093/infdis/jiu630DOI Listing
May 2015

Comparison of Abbott RealTime HCV Genotype II with Versant line probe assay 2.0 for hepatitis C virus genotyping.

J Clin Microbiol 2015 May 4;53(5):1754-7. Epub 2015 Mar 4.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

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http://dx.doi.org/10.1128/JCM.03548-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400777PMC
May 2015

Association of adjuvant antiviral therapy with risk of cancer progression and deaths in patients with hepatitis-B-virus-related hepatocellular carcinoma following curative treatment: a nationwide cohort study.

PLoS One 2014 15;9(7):e102051. Epub 2014 Jul 15.

Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Center for Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098996PMC
March 2015

Peginterferon alfa-2a with or without low-dose ribavirin for treatment-naive patients with hepatitis C virus genotype 2 receiving haemodialysis: a randomised trial.

Gut 2015 Feb 19;64(2):303-11. Epub 2014 Apr 19.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1136/gutjnl-2014-307080DOI Listing
February 2015

Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers.

Gut 2015 Feb 24;64(2):292-302. Epub 2014 Apr 24.

Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1136/gutjnl-2014-306977DOI Listing
February 2015

Micro-evolution of the hepatitis B virus genome in hepatitis B e-antigen-positive carriers: comparison of genotypes B and C at various immune stages.

J Gastroenterol Hepatol 2015 Jan;30(1):172-7

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jgh.12654DOI Listing
January 2015

Clinical significance of circulating miR-122 in patients with dual chronic hepatitis B and C virus infection.

Hepatol Int 2015 Jan 18;9(1):35-42. Epub 2014 Nov 18.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, 1 Chang-Te Street, Taipei, 10002, Taiwan.

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http://dx.doi.org/10.1007/s12072-014-9591-zDOI Listing
January 2015

Serum cytokine/chemokine profiles in acute exacerbation of chronic hepatitis B: clinical and mechanistic implications.

J Gastroenterol Hepatol 2014 Aug;29(8):1629-36

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jgh.12606DOI Listing
August 2014

Plasma adipokines and risk of hepatocellular carcinoma in chronic hepatitis B virus-infected carriers: a prospective study in taiwan.

Cancer Epidemiol Biomarkers Prev 2014 Aug 3;23(8):1659-71. Epub 2014 Jun 3.

Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University; Genomics Research Center, Academia Sinica, Taipei;

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0161DOI Listing
August 2014

The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo.

Mol Ther Nucleic Acids 2014 Aug 19;3:e186. Epub 2014 Aug 19.

1] Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan [2] Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan [3] Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan [4] Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1038/mtna.2014.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221598PMC
August 2014

Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence.

World J Gastroenterol 2014 Aug;20(32):11384-93

Chun-Jen Liu, Juliana Chang, Po-Huang Lee, Ming-Chih Ho, Rey-Heng Hu, Pei-Jer Chen, Graduate Institute of Clinical Medicine, Hepatitis Research Center and Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei 10002, Taiwan.

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http://dx.doi.org/10.3748/wjg.v20.i32.11384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145780PMC
August 2014

Molecular mechanism and treatment of viral hepatitis-related liver fibrosis.

Int J Mol Sci 2014 Jun 12;15(6):10578-604. Epub 2014 Jun 12.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, 1 Chang-Te Street, Taipei 10002, Taiwan.

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http://dx.doi.org/10.3390/ijms150610578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100170PMC
June 2014

Nonalcoholic fatty liver disease: updates in noninvasive diagnosis and correlation with cardiovascular disease.

World J Gastroenterol 2014 Jun;20(24):7718-29

Kuang-Chun Hu, Horng-Yuan Wang, Chuan-Chuan Liu, Shou-Chuan Shih, Mackay Medical College, New Taipei City 25245, Taiwan.

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http://dx.doi.org/10.3748/wjg.v20.i24.7718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069300PMC
June 2014

Updates on the treatment and outcomes of dual chronic hepatitis C and B virus infection.

World J Gastroenterol 2014 Mar;20(11):2955-61

Chun-Jen Liu, Pei-Jer Chen, Graduate Institute of Clinical Medicine, Department of Internal Medicine, and Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei 10002, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961993PMC
March 2014