Publications

CircNet: a database of circular RNAs derived from transcriptome sequencing data.
Nucleic Acids Res 2016 Jan 7;44(D1):D209-15. Epub 2015 Oct 7.
Institute of Bioinformatics and Systems Biology, National Chiao Tung University, HsinChu, Taiwan Department of Biological Science and Technology, National Chiao Tung University, HsinChu, Taiwan Center for Bioinformatics Research, National Chiao Tung University, Hsinchu 300, Taiwan Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database.
Nucleic Acids Res 2016 Jan 20;44(D1):D239-47. Epub 2015 Nov 20.
Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan Center for Bioinformatics Research, National Chiao Tung University, Hsinchu, 300, Taiwan Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan

Molecular recognition of CYP26A1 binding pockets and structure-activity relationship studies for design of potent and selective retinoic acid metabolism blocking agents.
J Mol Graph Model 2015 Mar 8;56:10-9. Epub 2014 Dec 8.
Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China. Electronic address:

DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.
Nucleic Acids Res 2015 Jan 7;43(2):1268-82. Epub 2015 Jan 7.
Laboratory of Structural Biology, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital & State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410008, China Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA

DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections.
Nucleic Acids Res 2014 Jul 3;42(Web Server issue):W137-46. Epub 2014 Jun 3.
Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA

High-resolution functional annotation of human transcriptome: predicting isoform functions by a novel multiple instance-based label propagation method.
Nucleic Acids Res 2014 Apr 25;42(6):e39. Epub 2013 Dec 25.
Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA, Institute of Genomics and Bioinformatics, National Chung Hsing University, Taiwan 40227, Republic of China, National Center for Mathematics and Interdisciplinary Sciences, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China and Department of Computer Science, University of Southern California, Los Angeles, CA 90089, USA.

DPRP: a database of phenotype-specific regulatory programs derived from transcription factor binding data.
Nucleic Acids Res 2014 Jan 2;42(Database issue):D178-83. Epub 2013 Dec 2.
Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan, Department of Computer Science and Engineering, National Chung Hsing University, Taichung 402, Taiwan, Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA, Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan, Institute for Quantitative Biomedical Sciences, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.

miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions.
Nucleic Acids Res 2014 Jan 4;42(Database issue):D78-85. Epub 2013 Dec 4.
Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan, Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan, Department of Computer Science and Engineering, National Chung Hsing University, Taichung 402, Taiwan, Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan, Molecular Bioinformatics Center, National Chiao Tung University, Hsinchu 300, Taiwan, Graduate Department of Clinical Pharmacy, Taipei Medical University, Taipei 110, Taiwan, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu 300, Taiwan, Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 110, Taiwan, Department of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsinchu 300, Taiwan, Mackay Medicine, Nursing and Management College, Taipei 112, Taiwan, Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan, and Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.
Cancer Res 2009 Mar 3;69(6):2623-9. Epub 2009 Mar 3.
Department of Urology, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

MicroRNA signature predicts survival and relapse in lung cancer.
Cancer Cell 2008 Jan;13(1):48-57
Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan 100, Republic of China.

A five-gene signature and clinical outcome in non-small-cell lung cancer.
N Engl J Med 2007 Jan;356(1):11-20
National Taiwan University College of Public Health, National Taiwan University College of Medicine, Taipei, Taiwan.


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