Dr. Chun Lai Too, PhD - Institute for Medical Reserach - Researcher

Dr. Chun Lai Too

PhD

Institute for Medical Reserach

Researcher

Kuala Lumpur | Malaysia

Main Specialties: Rheumatology

Additional Specialties: Genetic, Immunology and Rheumatology

Dr. Chun Lai Too, PhD - Institute for Medical Reserach - Researcher

Dr. Chun Lai Too

PhD

Introduction

Primary Affiliation: Institute for Medical Reserach - Kuala Lumpur , Malaysia

Specialties:

Additional Specialties:

Research Interests:

Publications

19Publications

388Reads

1Profile Views

120PubMed Central Citations

Incidental pharmacogenetics findings in an HLA-related research: Considerations for primary prevention.

Clin Exp Allergy 2019 Apr 22;49(4):537-540. Epub 2019 Feb 22.

Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia.

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http://dx.doi.org/10.1111/cea.13347DOI Listing
April 2019
12 Reads
4.769 Impact Factor

Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population.

Pharmacogenomics J 2017 03 1;17(2):170-173. Epub 2016 Mar 1.

Allergy and Immunology Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1038/tpj.2016.10DOI Listing
March 2017
26 Reads
6 Citations
4.230 Impact Factor

HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia.

Hum Immunol 2016 Oct 29;77(10):818-819. Epub 2016 Jun 29.

Allergy and Immunology Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia; Rheumatology Unit, Department of Medicine, CMM L8:O4, Karolinska University Hospital and Karolinska Institutet, 17176 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2016.06.022DOI Listing
October 2016
18 Reads
1 Citation
2.140 Impact Factor

Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case-control study.

Ann Rheum Dis 2016 06 17;75(6):997-1002. Epub 2015 Dec 17.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/annrheumdis-2015-208278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893106PMC
June 2016
45 Reads
7 Citations
10.380 Impact Factor

Recognizing rheumatoid arthritis: oncoprotein survivin opens new possibilities: a population-based case-control study.

Medicine (Baltimore) 2015 Jan;94(4):e468

From the Allergy and Immunology Research Center, Institute of Medical Research, Kuala Lumpur, Malaysia (TCL, SM, JSD); Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm (TCL); Department of Rheumatology and Inflammation Research, Institute of Medicine, the University of Gothenburg, Göteborg, Sweden (ME, MIB); Department of Medicine, Putrajaya Hospital, Putrajaya (HH); and Department of Medicine, Raja Perempuan Bainun Hospital, Ipoh, Perak, Malaysia (WS).

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http://dx.doi.org/10.1097/MD.0000000000000468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602940PMC
January 2015
26 Reads
8 Citations
5.723 Impact Factor

Increased IgG Rheumatoid Factor-Positivity in the Asian Rheumatoid Arthritis Patients Irrespective of Ethnicity

Open Journal of Rheumatology and Autoimmune Diseases, 2014, 4, 43-51

Open Journal of Rheumatology and Autoimmune Diseases

Aim of Work: Initial observations implied IgG rheumatoid factor (RF) to be common among Malaysian rheumatoid arthritis (RA) patients. We tested this hypothesis and used a multiethnic RA cohort (Malays, Chinese and Indians) to investigate whether the IgG RF predominance might be genetically or environmentally determined. Patients and Methods: 556 serum samples comprising 171 patients classified as RA according to the 1987 ACR criteria, 60 patients with other rheumatic diseases and 325 non-rheumatic controls were tested for IgG RF, IgM RF and anti-CCP by ELISA. The findings were then tested in a larger RA case-control cohort (n = 1844). Results: IgG RF predominated over IgM RF in all the investigated ethnic groups. The sensitivity, specificity, and diagnostic accuracy of IgG RF (55.6%, 91.2% and 80.2%, respectively) were superior compared to IgM RF, but comparable to anti-CCP. IgG RF was however, also increased in the Malaysian controls, but the IgG RF superiority over IgM RF was still apparent after cutoff adjustment according to the 1987 ACR criteria. Autoantibody levels did not differ between the three ethnic groups. The Receiver Operating Characteristics (ROC) curves showed larger areas under the curves for IgG RF (0.826) and for anti-CCP (0.867) than for IgM RF (0.737). Review of the literature showed consistently higher sensitivity for IgG RF in studies of Asian RA patients as compared to Caucasian and African-American studies. Conclusion: Increased frequency of IgG RF-positive in RA populations with different genetic background living in Malaysia argues for an environmental factor selectively amplifying the IgG RF response.

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December 2014
2 Reads

Silica exposure is associated with an increased risk of developing ACPA-positive rheumatoid arthritis in an Asian population: evidence from the Malaysian MyEIRA case-control study.

Mod Rheumatol 2013 Apr 25. Epub 2013 Apr 25.

Institute of Environmental Medicine, Karolinska Institutet, Nobel väg 13, Box 210, 17177, Stockholm, Sweden,

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http://dx.doi.org/10.1007/s10165-013-0890-3DOI Listing
April 2013
13 Reads
2.210 Impact Factor

Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population.

Int J Dermatol 2011 Feb;50(2):221-4

Department of Dermatology, Kuala Lumpur Hospital Allergy and Immunology Research Center, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1111/j.1365-4632.2010.04745.xDOI Listing
February 2011
35 Reads
30 Citations
1.230 Impact Factor

HLA polymorphism in three indigenous populations of Sabah and Sarawak.

Tissue Antigens 2010 Feb;75(2):166-9

Allergy and Immunology Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1111/j.1399-0039.2009.01410.xDOI Listing
February 2010
5 Reads
1 Citation
2.140 Impact Factor

HLA-A, -B and -DR allele and haplotype frequencies in Malays.

Asian Pac J Allergy Immunol 2007 Mar;25(1):47-51

Allergy and Immunology Research Centre, Institute for Medical Research, 50588 Kuala Lumpur, Malaysia.

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March 2007
4 Citations
1.255 Impact Factor

Barrett's oesophagus and HLA-B*0702/HLA-B*0706.

Aliment Pharmacol Ther 2006 May;23(9):1375-6

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http://dx.doi.org/10.1111/j.1365-2036.2006.02902.xDOI Listing
May 2006
9 Reads
5.730 Impact Factor

Human leucocyte antigen determinants of susceptibility to Barrett's oesophagus in Asians--a preliminary study.

Aliment Pharmacol Ther 2005 Jun;21(11):1377-83

Division of Gastroenterology, Department of Medicine, Royal Perak College of Medicine, Ipoh, Malaysia.

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http://dx.doi.org/10.1111/j.1365-2036.2005.02496.xDOI Listing
June 2005
1 Read
5 Citations
5.730 Impact Factor

HLA-B27 polymorphism in the Malays.

Tissue Antigens 2003 Oct;62(4):330-2

Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.

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October 2003
4 Reads
4 Citations
2.140 Impact Factor

Top co-authors

Shahnaz Murad
Shahnaz Murad

Institute for Medical Research

11
Lars Alfredsson
Lars Alfredsson

Institute of Environmental Medicine

7
Lars Klareskog
Lars Klareskog

Karolinska Institutet

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Leonid Padyukov
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Karolinska Institutet

6
Nor Asiah Muhamad
Nor Asiah Muhamad

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Abqariyah Yahya
Abqariyah Yahya

Institute of Environmental Medicine

4
Camilla Bengtsson
Camilla Bengtsson

Karolinska Institutet

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Jasbir Singh Dhaliwal
Jasbir Singh Dhaliwal

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4
Amal Nasir Mustafa
Amal Nasir Mustafa

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3
Nor Aini Abdullah
Nor Aini Abdullah

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3