Publications by authors named "Chufeng Liu"

14 Publications

  • Page 1 of 1

Profiles of inflammation factors and inflammatory pathways around the peri-miniscrew implant.

Histol Histopathol 2021 Apr 9:18336. Epub 2021 Apr 9.

Department of Orthodontics, Stomatological Hospital, Southern Medical University, Guangzhou, China.

Background: Peri-miniscrew implant is a temporary assistant armamentarium for the treatment of severe malocclusion and complex tooth movement, the inflammation around it is the main reason for the failure of orthodontic treatment due to the implant loosening and falling out. Inflammation around the peri-miniscrew implant is associated with the release of pro-inflammatory cytokines. These pro-inflammatory cytokines, in turn, recruit immune cells (such as macrophages, dendritic cells, T cells, and B cells), which can produce and release inflammatory biomarkers, regulate the interaction between immune cells, periodontal ligament cells, osteoblasts, and so on. However, there is currently no effective clinical treatment plan to prevent inflammation around implants.

Purpose: To investigate the potentially essential factors in the inflammatory response around the peri-miniscrew implant and explore the signaling pathways involved.

Methods: Here, we review the studies focused on inflammatory biomarkers (Interleukins, tumor necrosis factor-α (TNF-α), receptor activator of NF-κB ligand (RANKL), matrix metalloproteinases (MMPs), and cellular adhesion molecules (CAMs)) in peri-miniscrew implant crevicular fluid (PMICF), as well as inflammatory signaling pathways (Wnt5a, JNK, Erk1/2, NF-κBp65 and TAB/TAK) in periodontal cells from 1998 to 2020.

Results: A literature search revealed TLR-2, TLR-4, LOX-1, and BMPs are involved in regulating ILs (IL-1β, IL-6, IL-8, and IL-17), TNF-α, RANKL, MMP-2, MMP-9 expression via JNK, Erk1/2, Wnt5a, NF-κBp65, OPN, and TAB/TAK signaling pathways. Among them, IL-1β and IL-6 are the critical inflammation factors in the signaling pathways inducing the inflammatory reaction surrounding implants. Besides, CAM-1 was also regulated by MMP-9 and IL-17.

Conclusion: There are considerable potential factors involving regulating inflammatory biomarkers on downstream signaling pathways in peri-minisrew implant crevicular fluid.

Clinical Significance: This review provides the substantiation of these cell factors and signaling pathways around peri-miniscrew implants, proposes more practical clinical therapeutic ideas and schemes for improving the stability and clinical efficacy of peri-miniscrew implants.
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http://dx.doi.org/10.14670/HH-18-336DOI Listing
April 2021

Interleukin-20 differentially regulates bone mesenchymal stem cell activities in RANKL-induced osteoclastogenesis through the OPG/RANKL/RANK axis and the NF-κB, MAPK and AKT signalling pathways.

Scand J Immunol 2020 May 10;91(5):e12874. Epub 2020 Mar 10.

Department of Orthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, China.

The immune and skeletal systems share common mechanisms, and the crosstalk between the two has been termed osteoimmunology. Osteoimmunology mainly focuses on diseases between the immune and bone systems including bone loss diseases, and imbalances in osteoimmune regulation affect skeletal homeostasis between osteoclasts and osteoblasts. The immune mediator interleukin-20 (IL-20), a member of the IL-10 family, enhances inflammation, chemotaxis and angiogenesis in diseases related to bone loss. However, it is unclear how IL-20 regulates the balance between osteoclastogenesis and osteoblastogenesis; therefore, we explored the mechanisms by which IL-20 affects bone mesenchymal stem cells (BMSCs) in osteoclastogenesis in primary cells during differentiation, proliferation, apoptosis and signalling. We initially found that IL-20 differentially regulated preosteoclast proliferation and apoptosis; BMSC-conditioned medium (CM) significantly enhanced osteoclast formation and bone resorption, which was dose-dependently regulated by IL-20; IL-20 inhibited OPG expression and promoted M-CSF, RANKL and RANKL/OPG expression; and IL-20 differentially regulated the expression of osteoclast-specific gene and transcription factors through the OPG/RANKL/RANK axis and the NF-kB, MAPK and AKT pathways. Therefore, IL-20 differentially regulates BMSCs in osteoclastogenesis and exerts its function by activating the OPG/RANKL/RANK axis and the NF-κB, MAPK and AKT pathways, which make targeting IL-20 a promising direction for targeted regulation in diseases related to bone loss.
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http://dx.doi.org/10.1111/sji.12874DOI Listing
May 2020

Root resorption in orthodontic treatment with clear aligners: A systematic review and meta-analysis.

Orthod Craniofac Res 2019 Nov 29;22(4):259-269. Epub 2019 Aug 29.

Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong, China.

The aim of this study was to investigate the external root resorption in participants receiving clear aligners and compare it with those treated with fixed appliances. Systematic review with meta-analysis. Electronic and manual search were performed, and specific inclusion and exclusion criteria were used. Data extraction and analysis were conducted by two investigators independently. The original outcome underwent statistical pooling by Review Manager 5. The quality of studies was assessed by ROBINS-I tool. A total of 11 studies were included for qualitative analysis (six in moderate risk of bias while another five in serious risk of bias), and three of them were statistically pooled in meta-analysis. The external root resorption in treatment with clear aligners was significantly lower than that with fixed appliances (SMD = -0.65, 95% CI [-0.74, -0.55], P < .01). Subgroup analysis on each quadrant of incisors was consistent with the former result. Current evidences suggest that clear aligners might not avoid root resorption, but the incidence and severity of resorption could both be lower compared with results reported by treatment with fixed appliances.
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http://dx.doi.org/10.1111/ocr.12337DOI Listing
November 2019

Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cells.

Sci Rep 2017 09 22;7(1):12168. Epub 2017 Sep 22.

Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

Increased availability of homeostatic cytokines is considered a major mechanism by which lymphodepletion enhances the efficacy of adoptive T cell therapy (ACT). IL-7 is one such cytokine capable of augmenting the function of tumor-reactive CD8+ T cells. However, whether host-derived IL-7 plays a role in driving the proper function of CD4+ T cells in an ACT setting remains unclear. Here we report that lymphodepleting chemotherapy by cyclophosphamide (CTX) does not lead to increased availability of the endogenous IL-7 in mice. Despite of a paucity of IL-7 in the immune milieu, CTX preconditioning allowed adoptively transferred naïve tumor-specific CD4+ T cells to undergo effector differentiation and regain IL-7Rα expression, giving rise to IL-7-responsive polyfunctional CD4+ effector cells. Correspondingly, supplementation of exogenous recombinant IL-7 markedly amplified and sustained polyfunctional CD4+ effector cells, resulting in improved therapeutic outcome in a mouse lymphoma model. We further demonstrated that the immune-enhancing effects of IL-7 were also applicable to donor CD4+ T cells pre-activated under Th1 polarizing condition. These findings suggest caution in relying on the endogenous IL-7 to enhance donor T cell expansion and persistence after lymphodepleting chemotherapy, and highlight the usefulness of recombinant IL-7 as an adjuvant for adoptive immunotherapy.
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http://dx.doi.org/10.1038/s41598-017-12488-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610351PMC
September 2017

The effect of mucin, fibrinogen and IgG on the corrosion behaviour of Ni-Ti alloy and stainless steel.

Biometals 2017 06 25;30(3):367-377. Epub 2017 Mar 25.

The Stomatological Hospital of Southern Medical University, Guangdong Provincial Stomatological Hospital, No. 366 South of Jiangnan Road, Guangzhou, 510280, People's Republic of China.

In this study, Ni-Ti alloy and stainless steal were exposed to artificial saliva containing fibrinogen, IgG or mucin, and the resultant corrosion behavior was studied. The purpose was to determine the mechanisms by which different types of protein contribute to corrosion. The effect of different proteins on the electrochemical resistance of Ni-Ti and SS was tested by potentiodynamic polarization, and the repair capacity of passivation film was tested by cyclic polarization measurements. The dissolved corrosion products were determined by ICP-OES, and the surface was analyzed by SEM and AFM. The results showed fibrinogen, IgG or mucin could have different influences on the susceptibility to corrosion of the same alloy. Adding protein lead to the decrease of corrosion resistance of SS, whereas protein could slow down the corrosion process of Ni-Ti. For Ni-Ti, adding mucin could enhance the corrosion stability and repair capacity of passivation film. The susceptibility to pitting corrosion of Ni-Ti and stainless steal in fibrinogen AS is not as high as mucin and IgG AS. There are different patterns of deposition formation on the metal surface by different types of protein, which is associated with their effects on the corrosion process of the alloys.
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http://dx.doi.org/10.1007/s10534-017-0012-3DOI Listing
June 2017

High sensitivity of gold nanoparticles co-doped with GdO mesoporous silica nanocomposite to nasopharyngeal carcinoma cells.

Sci Rep 2016 10 3;6:34367. Epub 2016 Oct 3.

State Key Laboratory of Oncology in South China, Sun Yat-sen University CancerCentre, Guangzhou 510060, China.

Nanoprobes for combined optical and magnetic resonance imaging have tremendous potential in early cancer diagnosis. Gold nanoparticles (AuNPs) co-doped with GdO mesoporous silica nanocomposite (Au/[email protected]) can produce pronounced contrast enhancement for T1 weighted image in magnetic resonance imaging (MRI). Here, we show the remarkably high sensitivity of Au/[email protected] to the human poorly differentiated nasopharyngeal carcinoma (NPC) cell line (CNE-2) using fluorescence lifetime imaging (FLIM). The upconversion luminescences from CNE-2 and the normal nasopharyngeal (NP) cells (NP69) after uptake of Au/[email protected] show the characteristic of two-photon-induced-radiative recombination of the AuNPs. The presence of the Gd ion induces a much shorter luminescence lifetime in CNE-2 cells. The interaction between AuNPs and Gd ion clearly enhances the optical sensitivity of Au/[email protected] to CNE-2. Furthermore, the difference in the autofluorescence between CNE-2 and NP69 cells can be efficiently demonstrated by the emission lifetimes of Au/[email protected] through the Forster energy transfers from the endogenous fluorophores to AuNPs. The results suggest that Au/[email protected] may impart high optical resolution for the FLIM imaging that differentiates normal and high-grade precancers.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046069PMC
http://dx.doi.org/10.1038/srep34367DOI Listing
October 2016

IL-7 signaling imparts polyfunctionality and stemness potential to CD4(+) T cells.

Oncoimmunology 2016 Jun 25;5(6):e1171445. Epub 2016 Apr 25.

Cancer Immunology, Inflammation and Tolerance Program, Georgia Cancer Center, Augusta University , Augusta, GA, USA.

The functional status of CD4(+) T cells is a critical determinant of antitumor immunity. Polyfunctional CD4(+) T cells possess the ability to concomitantly produce multiple Th1-type cytokines, exhibiting a functional attribute desirable for cancer immunotherapy. However, the mechanisms by which these cells are induced are neither defined nor it is clear if these cells can be used therapeutically to treat cancer. Here, we report that CD4(+) T cells exposed to exogenous IL-7 during antigenic stimulation can acquire a polyfunctional phenotype, characterized by their ability to simultaneously express IFNγ, IL-2, TNFα and granzyme B. This IL-7-driven polyfunctional phenotype was associated with increased histone acetylation in the promoters of the effector genes, indicative of increased chromatin accessibility. Moreover, forced expression of a constitutively active (CA) form of STAT5 recapitulated IL-7 in inducing CD4(+) T-cell polyfunctionality. Conversely, the expression of a dominant negative (DN) form of STAT5 abolished the ability of IL-7 to induce polyfunctional CD4(+) T cells. These in-vitro-generated polyfunctional CD4(+) T cells can traffic to tumor and expand intratumorally in response to immunization. Importantly, adoptive transfer of polyfunctional CD4(+) T cells following lymphodepletive chemotherapy was able to eradicate large established tumors. This beneficial outcome was associated with the occurrence of antigen epitope spreading, activation of the endogenous CD8(+) T cells and persistence of donor CD4(+) T cells exhibiting memory stem cell attributes. These findings indicate that IL-7 signaling can impart polyfunctionality and stemness potential to CD4(+) T cells, revealing a previously unknown property of IL-7 that can be exploited in adoptive T-cell immunotherapy.
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http://dx.doi.org/10.1080/2162402X.2016.1171445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938319PMC
June 2016

[Changes of protein kinases Mζ expression in the anterior cingulate cortex after applying three different magnitude of orthodontic force].

Zhonghua Kou Qiang Yi Xue Za Zhi 2014 Dec;49(12):748-52

Email:

Objective: To investigate the regulatory effect of central synaptic plasticity on pain induced by experimental tooth movement and to analyzethe expression of protein kinases Mζ (PKMζ) in the anterior cingulate cortex (ACC) after applying different magnitude of orthodontic force.

Methods: One hundred and thirty-six male Sprague-Dawley (SD) rats (200-250 g) were used in this study. Orthodontic tooth movement devices were placed on the teeth in the experimental group, and different orthodontic forces (0.39, 0.78, 1.17 N) were applied to move the maxillary first molars, respectively. The same mechanical devices were placed on the teeth in sham-treated group and no orthodontic force was applied. No orthodontic procedure was applied in blank control group. The average time spent on mouth- wiping behavior in each group was recorded after experimental tooth movement. Brain tissue of the anterior cingulate cortex was isolated on day 3 after experiment, and the expression level of PKMζ was analyzed with the method of immunohistochemistry and enzyme-linked immune sorbent assay. ζ-pseudosubstrate inhibitory peptide (ZIP), a selective inhibitor for PKMζ, was injected into ACC on day 3 after experimental tooth movement, and the effects of ZIP on mouth-wiping behavior were evaluated.

Results: No statistical difference was found between the blank control group and the sham- treated group in the average time spent on mouth-wiping, value of A and expression level of PKMζ (P > 0.05). Compared with the sham-treated group and blank control group, the average time of mouth-wiping behavior [(58.6±6.9), (66.3±7.8), (78.9±8.7) s], value of A (4 569±454, 6 850±365, 8 294±558) and expression level of PKMζ [(0.32±0.02), (0.34±0.02), (0.36±0.02) mg/L] in 0.39, 0.78, 1.17 N force group were found to be up-regulated with the increase of orthodontic force (P < 0.05). LSD test in three experimental sub-group showed statistical difference (P < 0.05). After microinjection of ZIP, the average time spent on mouth-wiping behavior significantly decreased (P < 0.01), while microinjecting saline did not change rats' mouth-wiping behavior (P > 0.05).

Conclusions: More pain caused by increased orthodontic force maybe due to the up-regulation of PKMζ in the anterior cingulate cortex.
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December 2014

Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells.

J Immunol 2015 Feb 5;194(4):2011-21. Epub 2015 Jan 5.

Cancer Center, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912; Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912; and

In recent years, the immune-potentiating effects of some widely used chemotherapeutic agents have been increasingly appreciated. This provides a rationale for combining conventional chemotherapy with immunotherapy strategies to achieve durable therapeutic benefits. Previous studies have implicated the immunomodulatory effects of melphalan, an alkylating agent commonly used to treat multiple myeloma, but the underlying mechanisms remain obscure. In the present study, we investigated the impact of melphalan on endogenous immune cells as well as adoptively transferred tumor-specific CD4(+) T cells in tumor-bearing mice. We showed that melphalan treatment resulted in a rapid burst of inflammatory cytokines and chemokines during the cellular recovery phase after melphalan-induced myelodepletion and leukodepletion. After melphalan treatment, tumor cells exhibited characteristics of immunogenic cell death, including membrane translocation of the endoplasmic reticulum-resident calreticulin and extracellular release of high-mobility group box 1. Additionally, there was enhanced tumor Ag uptake by dendritic cells in the tumor-draining lymph node. Consistent with these immunomodulatory effects, melphalan treatment of tumor-bearing mice led to the activation of the endogenous CD8(+) T cells and, more importantly, effectively drove the clonal expansion and effector differentiation of adoptively transferred tumor-specific CD4(+) T cells. Notably, the combination of melphalan and CD4(+) T cell adoptive cell therapy was more efficacious than either treatment alone in prolonging the survival of mice with advanced B cell lymphomas or colorectal tumors. These findings provide mechanistic insights into melphalan's immunostimulatory effects and demonstrate the therapeutic potential of combining melphalan with adoptive cell therapy utilizing antitumor CD4(+) T cells.
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http://dx.doi.org/10.4049/jimmunol.1401894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324150PMC
February 2015

Up-regulation of PKMζ expression in the anterior cingulate cortex following experimental tooth movement in rats.

Arch Oral Biol 2014 Jul 18;59(7):749-55. Epub 2014 Apr 18.

Department of Orthodontics, Guangdong Provincial Stomatological Hospital, Affiliated Stomatological Hospital of Southern Medical University, Guangzhou, China.

Objective: To explore the involvement of synaptic plasticity in pain induced by experimental tooth movement, we evaluated the expression of protein kinase M zeta (PKMζ), an enzyme necessary for maintaining long-term potentiation (LTP) in the anterior cingulate cortex (ACC).

Methods: Male Sprague-Dawley rats weighing 250-300g were used. The change of the expression of PKMζ in the ACC was measured by western blot, and the mRNA of PKMζ was detected by quantitative real-time PCR 1, 3, 7 days after experimental tooth movement. The average time spent on mouth-wiping behaviour of rats involved in pain perception was detected. After that a selective PKMζ inhibitor, called myristoylated ζ-pseudosubstrate inhibitory peptide (ZIP) was injected into ACC, and the effects of ZIP were evaluated.

Results: The mouth-wiping behaviour of rats was significantly increased 1, 3, and 7 days after experimental tooth movement. Changes in PKMζ levels were not detected on day 1 but were found to be increased 3 days following the tooth movement, and then declined to the baseline 7 days after tooth movement in the ACC. PKMζ mRNA levels were not significantly different between the experimental and sham-treated groups at the three time points. Time spent on mouth-wiping behaviour was reduced after ZIP was injected into ACC 3 days after tooth movement, and the analgesic effect last for at least 24h.

Conclusion: PKMζ in the ACC acts to maintain the pain induced by experimental tooth movement. Increased expression of PKMζ protein is attributed to persistent translation of PKMζ mRNA. Synaptic plasticity may be involved in the development of tooth movement pain.
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http://dx.doi.org/10.1016/j.archoralbio.2014.04.002DOI Listing
July 2014

A simple way to intrude overerupted upper second molars with miniscrews.

J Prosthodont 2013 Dec 31;22(8):597-602. Epub 2013 May 31.

Associate Professor, Department of Orthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.

Various methods of using skeletal anchorage for the intrusion of overerupted maxillary molars have been reported; however, it is difficult to intrude the overerupted upper second molars because of the low bone density in the region of the tuberosity. This article illustrates a new treatment method using partial fixed edgewise appliances and miniscrews to intrude the overerupted upper second molars. The miniscrews were applied to reinforce the anchorage of the upper first molar. The intrusive force was generated by the Ni-Ti wire. The clinical results showed a significant intrusion effect without root resorption or periodontal problems. This report demonstrates that the combination of partial conventional fixed appliances with miniscrews is a simple and effective treatment option to intrude overerupted upper second molars, especially in situations where miniscrews cannot be inserted directly next to the second molar.
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http://dx.doi.org/10.1111/jopr.12057DOI Listing
December 2013

Rapid maxillary anterior teeth retraction en masse by bone compression: a canine model.

PLoS One 2011 19;6(10):e26398. Epub 2011 Oct 19.

Department of Orthodontics, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, China.

Objective: The present study sought to establish an animal model to study the feasibility and safety of rapid retraction of maxillary anterior teeth en masse aided by alveolar surgery in order to reduce orthodontic treatment time.

Method: Extraction of the maxillary canine and alveolar surgery were performed on twelve adult beagle dogs. After that, the custom-made tooth-borne distraction devices were placed on beagles' teeth. Nine of the dogs were applied compression at 0.5 mm/d for 12 days continuously. The other three received no force as the control group. The animals were killed in 1, 14, and 28 days after the end of the application of compression.

Results: The tissue responses were assessed by craniometric measurement as well as histological examination. Gross alterations were evident in the experimental group, characterized by anterior teeth crossbite. The average total movements of incisors within 12 days were 4.63±0.10 mm and the average anchorage losses were 1.25±0.12 mm. Considerable root resorption extending into the dentine could be observed 1 and 14 days after the compression. But after consolidation of 28 days, there were regenerated cementum on the dentine. There was no apparent change in the control group. No obvious tooth loosening, gingival necrosis, pulp degeneration, or other adverse complications appeared in any of the dogs.

Conclusions: This is the first experimental study for testing the technique of rapid anterior teeth retraction en masse aided by modified alveolar surgery. Despite a preliminary animal model study, the current findings pave the way for the potential clinical application that can accelerate orthodontic tooth movement without many adverse complications.

Clinical Relevance: It may become a novel method to shorten the clinical orthodontic treatment time in the future.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026398PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198430PMC
February 2012

[Establishment of normal value of posterior arch length of adolescence in Chengdu].

Hua Xi Kou Qiang Yi Xue Za Zhi 2003 Jun;21(3):208-10

Department of Orthodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, China.

Objective: To investigate the development of third molar embryo and establish the normal value of posterior arch length of adolescence in Chengdu.

Methods: The samples consisted of 40 males and 41 females with Class 1 dentitions, normal second molar occlusion, no history of orthodontic treatment, and good facial balance. Cephalometry and statistic analysis were conducted for all the subject.

Results: The normal value of posterior arch length of maxilla in male was(16.52 +/- 2.35) mm and in female was(16.42 +/- 2.55) mm. The normal length of mandible was(13.00 +/- 2.44) mm in male and(12.43 +/- 2.18) mm in female. But statistic analysis showed no gender difference. Most of the third molar embryo had been formed and their tooth crowns had been calcified, the occurrence ratio was 84.0% in maxilla and 85.2% in mandible. Most of them located in the middle and inclined mesially.

Conclusion: The data obtained in this study will be valuable for our clinical practice and be helpful for the study concerning dento-facial growth and development.
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June 2003

[A pilot study on changes of posterior available spaces in mandible dentitions for adolescents between the ages of 11 and 20 years in Chengdu area].

Hua Xi Kou Qiang Yi Xue Za Zhi 2003 Feb;21(1):67-9

Department of Orthodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, China.

Objective: The purpose of this study was to study the changes of available spaces of posterior arch segments in mandible dentitions (ASPAS) from ages of 11 to 20 years, which would provide information on normal growth and development of the dental arches in teenagers in Chengdu area.

Methods: The data were derived from systematically collected preorthodontic lateral cephalograms of 526 patients, including 232 males and 294 females from the Orthodontic Department of West China College of Stomatology, Sichuan University during the period of 1999-2000 (aged 11-20 years). The values of ANB angle, FH-MP, ASPAS were obtained using the cephalometric analysis. Afterwards, the growth changes of ASPAS from the subjects and their correlations with age, gender, angle malocclusion types and vertical skeletal patterns were analyzed.

Results: ASPAS was related to age and class II angle malocclusion. Though gender was not associated with ASPAS, significant differences in curves of ASPAS were found between males and females. The growth changes of ASPAS in the patients with skeletal Class III malocclusion were more obvious than in patients with Class I and II malocclusion.

Conclusion: Our results reveal that significant differences were demonstrated in growth change values in posterior available spaces of patients with different races and angle malocclusion types.
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February 2003