Publications by authors named "Christos Tsagkaris"

84 Publications

The fractal viewpoint of tumors and nanoparticles.

Curr Med Chem 2022 Aug 1. Epub 2022 Aug 1.

Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.

Even though the promising therapies against cancer are rapidly improved, the oncology patients population has seen exponential growth, placing cancer in 5th place among the ten deadliest diseases. Efficient drug delivery systems must overcome multiple barriers and maximize drug delivery to the target tumors, limiting the side effects simultaneously. Since the first observation of the quantum tunneling phenomenon, many multidisciplinary studies have offered quantum-inspired solutions to optimized tumor mapping and efficient nanodrug design. The property of a wave function to propagate through a potential barrier offer the capability of obtaining 3D surface profiles using imaging of individual atoms on the surface of a material. The application of quantum tunneling on a scanning tunneling microscope offers an exact surface roughness mapping of tumors and pharmaceutical particles. Critical elements to cancer nanotherapeutics apply the fractal theory and calculate the fractal dimension for efficient tumor surface imaging at the atomic level. This review study presents the latest biological approaches to cancer management based on fractal geometry.
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http://dx.doi.org/10.2174/0929867329666220801152347DOI Listing
August 2022

Polypharmacy and major adverse events in atrial fibrillation.

J Cardiovasc Pharmacol 2022 Jul 29. Epub 2022 Jul 29.

First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, St. Kiriakidi 1, 54636, Thessaloniki, Greece.

Abstract: Patients with atrial fibrillation (AF) often receive multiple medications daily. The purpose of this study was to examine the prognostic implications of polypharmacy in patients with AF. This is a retrospective post-hoc analysis of 1,113 AF patients, enrolled in a randomized trial during an acute hospitalization (MISOAC-AF, NCT02941978). The presence of polypharmacy (use of >4 drugs daily) was assessed at hospital discharge. Regression analyses were performed to identify clinical predictors of polypharmacy and compare the outcomes of patients with or without confirmed polypharmacy. The coprimary outcomes were all cause- and cardiovascular (CV)-mortality. Among patients with polypharmacy, the difference in the risk of mortality was also assessed per each added drug as a numeric variable. Polypharmacy was found in 36.9% of participants. Dyslipidemia, coronary artery disease, lower left ventricular ejection fraction and higher glomerular filtration rates were independent predictors of polypharmacy. Polypharmacy was an independent predictor for all-cause death [adjusted hazard ratio (aHR): 1.29, 95% confidence interval (CI): 1.01 to 1.64] and CV death (aHR: 1.39, 95% CI: 1.05 to 1.84). Among patients with polypharmacy, each additional concomitant medication was independently associated with a 4% increased risk of all-cause mortality (aHR=1.04, 95% CI: 1.00 to 1.08) and a 5% increased risk of CV mortality (aHR=1.05, 95% CI: 1.00 to 1.10). Polypharmacy was common among patients with AF hospitalized in a tertiary hospital and was incrementally associated with higher rates of mortality.
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http://dx.doi.org/10.1097/FJC.0000000000001339DOI Listing
July 2022

Periscyphismus and Section of the Temporal Vessels: Two Byzantine Surgical Remedies for Headache Relief.

Surg Innov 2022 Jun 4:15533506221106256. Epub 2022 Jun 4.

Department of History of Medicine, 69156University of Ioannina, Ioannina, Greece.

Headache is a prevalent clinical symptom and condition, whose management has been challenging from the antiquity to the 21st century. Physicians in the Greek, Roman and Byzantine antiquity employed surgical techniques to treat headache in patients presenting with persistent symptoms that were not alleviated with conservative means. A survey in the medical literature of the period reveals that two surgical procedures, periscyphismus and section of the temporal vessels, were developed for this purpose. The present study describes the techniques presented in the sources of the period and elaborates on their evolution and influence across different historical periods and contexts.
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http://dx.doi.org/10.1177/15533506221106256DOI Listing
June 2022

The association between the risk of breast cancer and Epigallocatechin-3-Gallate intake: A literature review of a potential chemopreventive agent.

Curr Med Chem 2022 Jul 26. Epub 2022 Jul 26.

West China School of Nursing / Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

According to the latest epidemiological data, breast cancer has recently been acknowledged as the most frequently diagnosed malignancy. To date, a body of evidence has established the involvement of multiple - and frequently interrelated - genetic and environmental factors in the pathogenesis of the disease. Emerging research on cancer prevention has highlighted the deterrence potential of interventions targeting environmental risk factors, particularly diet. In this aspect, the current review reveals the latest scientific results regarding epigallocatechin-3-gallate (EGCG) - a catechin most commonly found in green tea, as a potential chemopreventive dietary agent against breast cancer. In vitro studies on EGCG have demonstrated its effect on cell cycle progression and its potential to suppress several intracellular signaling pathways involved in breast cancer pathogenesis. In addition, EGCG possesses specific apoptosis-inducing characteristics that seem to enhance its role as a regulator of cell survival. Preclinical data seem to support the use of EGCG as an effective adjunct to EGFR-targeting treatments. The authors' appraisal of the literature suggests that although preclinical evidence has documented the anticarcinogenic features of EGCG, limited large-scale epidemiological studies are investigating the consumption of EGCG - containing nutrients in the prevention and management of breast cancer risk. This literature review aims to serve as a liaison between preclinical and epidemiological research, surveying the existing evidence and unraveling relevant knowledge gaps.
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http://dx.doi.org/10.2174/0929867329666220726153412DOI Listing
July 2022

Resistance to TKIs in EGFR-Mutated Non-Small Cell Lung Cancer: From Mechanisms to New Therapeutic Strategies.

Cancers (Basel) 2022 Jul 8;14(14). Epub 2022 Jul 8.

Clinical Trials Unit, Fourth Department of Medical Oncology, Henry Dunant Hospital Center, 11526 Athens, Greece.

Resistance to tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) in advanced mutant Non-Small Cell Lung Cancer (NSCLC) constitutes a therapeutic challenge. This review intends to summarize the existing knowledge about the mechanisms of resistance to TKIs in the context of EGFR mutant NSCLC and discuss its clinical and therapeutic implications. EGFR-dependent and independent molecular pathways have the potential to overcome or circumvent the activity of EGFR-targeted agents including the third-generation TKI, osimertinib, negatively impacting clinical outcomes. CNS metastases occur frequently in patients on EGFR-TKIs, due to the inability of first and second-generation agents to overcome both the BBB and the acquired resistance of cancer cells in the CNS. Newer-generation TKIs, TKIs targeting EGFR-independent resistance mechanisms, bispecific antibodies and antibody-drug conjugates or combinations of TKIs with other TKIs or chemotherapy, immunotherapy and Anti-Vascular Endothelial Growth Factors (anti-VEGFs) are currently in use or under investigation in EGFR mutant NSCLC. Liquid biopsies detecting mutant cell-free DNA (cfDNA) provide a window of opportunity to attack mutant clones before they become clinically apparent. Overall, EGFR TKIs-resistant NSCLC constitutes a multifaceted therapeutic challenge. Mapping its underlying mutational landscape, accelerating the detection of resistance mechanisms and diversifying treatment strategies are essential for the management of the disease.
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http://dx.doi.org/10.3390/cancers14143337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320011PMC
July 2022

Polycystic Ovary Syndrome Triggers Atrial Conduction Disorders: A Systematic Review and Meta-Analysis.

Eur J Investig Health Psychol Educ 2022 Jul 13;12(7):802-813. Epub 2022 Jul 13.

Family Planning Unit, Third Department of Obstetrics and Gynaecology, Attiko Hospital, National and Kapodistrian University of Athens, 15772 Athens, Greece.

Polycystic ovary syndrome (PCOS) is closely related to various adverse cardiovascular manifestations and increased cardiovascular risk. However, atrial fibrillation (AF) development and atrial conduction abnormalities have not been thoroughly studied in patients with PCOS. This meta-analysis (CRD42021261375) was conducted in accordance with the PRISMA guidelines. Our aim was to investigate associations between PCOS and disorders in atrial conduction parameters linked with an increased risk for AF occurrence. Five cohort studies with aggregate data on 406 adult women (229 with PCOS and 177 age-matched without PCOS) were included in this analysis. Our results showed a significantly increased mean difference in P-wave maximum duration (+7.63 ± 7.07 msec; < 0.01) and P-wave dispersion (+11.42 ± 5.22 msec; = 0.03) of patients with PCOS compared to healthy women. The mean difference in P-wave minimum duration (-2.22 ± 2.68 msec; = 0.11) did not reach the statistical threshold between the compared groups. Echocardiographic measurements of atrial electromechanical delay (AED) also indicated a statistically significant mean difference in favour of the PCOS group in all assessed parameters, except for atrial electromechanical coupling (PA) in the tricuspid annulus. Particularly, PCOS was associated with increased lateral PA, septal PA, inter- and intra-AED durations (mean difference: +17.31 ± 9.02 msec; < 0.01, +11.63 ± 7.42 msec; < 0.01, +15.31 ± 9.18 msec; < 0.01, +9.31 ± 6.85 msec; < 0.01, respectively). PCOS is strongly associated with alterations in several electrocardiographic and echocardiographic parameters indicating abnormal atrial conduction. Therefore, PCOS could be considered as a causal or triggering factor of AF. Larger studies are needed to confirm these results and investigate direct associations between PCOS and AF.
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http://dx.doi.org/10.3390/ejihpe12070059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323031PMC
July 2022

Elective surgery and postoperative shower: mind the gap and push the limits.

Ann Palliat Med 2022 Jul 15. Epub 2022 Jul 15.

Department of Surgery II, University Hospital Witten-Herdecke, University of Witten-Herdecke, Wuppertal, Germany.

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http://dx.doi.org/10.21037/apm-22-784DOI Listing
July 2022

Promoting Research, Awareness, and Discussion on AI in Medicine Using #MedTwitterAI: A Longitudinal Twitter Hashtag Analysis.

Front Public Health 2022 1;10:856571. Epub 2022 Jul 1.

Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical University of Vienna, Vienna, Austria.

Background: Artificial intelligence (AI) has the potential to reshape medical practice and the delivery of healthcare. Online discussions surrounding AI's utility in these domains are increasingly emerging, likely due to considerable interest from healthcare practitioners, medical technology developers, and other relevant stakeholders. However, many practitioners and medical students report limited understanding and familiarity with AI.

Objective: To promote research, events, and resources at the intersection of AI and medicine for the online medical community, we created a Twitter-based campaign using the hashtag #MedTwitterAI.

Methods: In the present study, we analyze the use of #MedTwitterAI by tracking tweets containing this hashtag posted from 26th March, 2019 to 26th March, 2021, using the Symplur Signals hashtag analytics tool. The full text of all #MedTwitterAI tweets was also extracted and subjected to a natural language processing analysis.

Results: Over this time period, we identified 7,441 tweets containing #MedTwitterAI, posted by 1,519 unique Twitter users which generated 59,455,569 impressions. The most common identifiable locations for users including this hashtag in tweets were the United States (378/1,519), the United Kingdom (80/1,519), Canada (65/1,519), India (46/1,519), Spain (29/1,519), France (24/1,519), Italy (16/1,519), Australia (16/1,519), Germany (16/1,519), and Brazil (15/1,519). Tweets were frequently enhanced with links (80.2%), mentions of other accounts (93.9%), and photos (56.6%). The five most abundant single words were AI (artificial intelligence), patients, medicine, data, and learning. Sentiment analysis revealed an overall majority of positive single word sentiments (e.g., intelligence, improve) with 230 positive and 172 negative sentiments with a total of 658 and 342 mentions of all positive and negative sentiments, respectively. Most frequently mentioned negative sentiments were cancer, risk, and bias. Most common bigrams identified by Markov chain depiction were related to analytical methods (e.g., label-free detection) and medical conditions/biological processes (e.g., rare circulating tumor cells).

Conclusion: These results demonstrate the generated considerable interest of using #MedTwitterAI for promoting relevant content and engaging a broad and geographically diverse audience. The use of hashtags in Twitter-based campaigns can be an effective tool to raise awareness of interdisciplinary fields and enable knowledge-sharing on a global scale.
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http://dx.doi.org/10.3389/fpubh.2022.856571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283788PMC
July 2022

Natural products derived from medicinal plants and microbes might act as a game-changer in breast cancer: a comprehensive review of preclinical and clinical studies.

Crit Rev Food Sci Nutr 2022 Jul 15:1-45. Epub 2022 Jul 15.

Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Breast cancer (BC) is the most prevalent neoplasm among women. Genetic and environmental factors lead to BC development and on this basis, several preventive - screening and therapeutic interventions have been developed. Hormones, both in the form of endogenous hormonal signaling or hormonal contraceptives, play an important role in BC pathogenesis and progression. On top of these, breast microbiota includes both species with an immunomodulatory activity enhancing the host's response against cancer cells and species producing proinflammatory cytokines associated with BC development. Identification of novel multitargeted therapeutic agents with poly-pharmacological potential is a dire need to combat advanced and metastatic BC. A growing body of research has emphasized the potential of natural compounds derived from medicinal plants and microbial species as complementary BC treatment regimens, including dietary supplements and probiotics. In particular, extracts from plants such as Delile Post Poir. ex Savigny (Dombey) Burdet & B.B. Simpson and metabolites extracted from microbes such as and strains as well as probiotics like and MK05 have exhibited antitumor effects in the form of antiproliferative and cytotoxic activity, increase in tumors' chemosensitivity, antioxidant activity and modulation of BC - associated molecular pathways. Further, bioactive compounds like 3,3'-diindolylmethane, epigallocatechin gallate, genistein, rutin, resveratrol, lycopene, sulforaphane, silibinin, rosmarinic acid, and shikonin are of special interest for the researchers and clinicians because these natural agents have multimodal action and act via multiple ways in managing the BC and most of these agents are regularly available in our food and fruit diets. Evidence from clinical trials suggests that such products had major potential in enhancing the effectiveness of conventional antitumor agents and decreasing their side effects. We here provide a comprehensive review of the therapeutic effects and mechanistic underpinnings of medicinal plants and microbial metabolites in BC management. The future perspectives on the translation of these findings to the personalized treatment of BC are provided and discussed.
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http://dx.doi.org/10.1080/10408398.2022.2097196DOI Listing
July 2022

[Burnout and dependence among medical personnel timeless and during the COVID-19 pandemic, using surgery and anesthesia as examples].

Chirurgie (Heidelb) 2022 Jun 23. Epub 2022 Jun 23.

Klinik für Chirurgie II, Universität Witten-Herdecke, Heusnerstr. 40, 442283, Wuppertal, Deutschland.

Background: The COVID-19 pandemic affects the mental health and professional behavior of surgeons and anesthesiologists and seems to have an impact on substance dependence.

Question: What are the reasons for the occurrence of substance dependence and burnout in surgeons and anesthesiologists timelessly and during the COVID-19 pandemic and what improvement measures could help in the clinical practice?

Material And Methods: A literature search was conducted in the form of a systematic review of studies and review articles relevant to the topic.

Results: Over the years it has been shown that surgeons and anesthesiologists are prone to drug dependence due to their direct access to medications in the clinical field and work-related stress. In particular, surgeons and anesthesiologists appeared to have an increased propensity for addictive diseases and an increased risk of burnout in the pandemic.

Conclusion: Preventive measures in favor of better working conditions in surgery and anesthesia and better drug control (not only for dispensing but also for correct drug testing), as well as more treatment and reintegration programs under psychiatric supervision and in collaboration with a multidisciplinary team are meaningful.
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http://dx.doi.org/10.1007/s00104-022-01675-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219363PMC
June 2022

Migration and newborn screening: time to build on the European Asylum, Integration and Migration Fund?

Eur J Contracept Reprod Health Care 2022 Jun 21:1-5. Epub 2022 Jun 21.

3rd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.

Purpose: The authors discuss the need for newborn screening in the context of the migration policy of the European Union, and particularly, the European Asylum, Migration and Integration Fund.

Methods: The authors searched scholarly databases (Pubmed, Scopus, Google scholar) and grey literature (LexEuropa, Policy reports) to identify original peer-reviewed research examining the migration to the European Union and the provision of healthcare to infants born to refugees and immigrant mothers. Resources in language different from English, French, German and Greek were not taken into consideration.

Results: Every year, a large number of refugees and immigrants from sub-Saharan Africa and Middle East countries travel to and enter in Europe. It has been estimated that two thirds of those seeking asylum are women and children. Many of these children have been born on the way to Europe or in migrant camps. Essential newborns' health screening is not accessible in most cases. Congenital conditions such as hypothyroidism and phenylketonuria may remain untreated, and once these infants are diagnosed, the organic damage could be irreversible. Prolonged necessary hospitalisation might be out of consideration at a time when clinics and hospitals are overstrained with COVID-19 patients.

Conclusions: It is essential to ensure that newborn screening will be performed in a timely and evidence-based manner as well as that the information will be communicated between hospitals and within countries' health networks. In order to achieve these goals interdisciplinary and international technical and logistical collaboration are required.
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http://dx.doi.org/10.1080/13625187.2022.2088729DOI Listing
June 2022

A potential rise of breast cancer risk in the UAE post-COVID-19 lockdown: A call for action.

Ann Med Surg (Lond) 2022 Jul 8;79:103976. Epub 2022 Jun 8.

Department of Oncology, Burjeel Cancer Institute, Burjeel Medical City, Abu Dhabi, United Arab Emirates.

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http://dx.doi.org/10.1016/j.amsu.2022.103976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176180PMC
July 2022

Infectious diseases amidst a humanitarian crisis in Ukraine: A rising concern.

Ann Med Surg (Lond) 2022 Jun 3;78:103950. Epub 2022 Jun 3.

Clinical Informatics Research Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

As of the 24th of February 2022, the war in Ukraine has increased the risk for infectious diseases outbreaks in the country and beyond. The disruption of healthcare services, the destruction of critical infrastructure, the displacement of millions of civilians and the crowded living conditions in bunkers pose a formiddable threat to public health. Infections are emphasized due to the low rates of vaccination against COVID-19 and the high prevalence of chronic infections such as Tuberculosis and HIV/AIDS in Ukraine compared to the WHO Europe region. Collaboration between authorities and humanitatian organizations is necessary, in order to strengthen epidemiological surveillance and deploy vital resources that are required for the prevention and the management of infections.
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http://dx.doi.org/10.1016/j.amsu.2022.103950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172576PMC
June 2022

Viruses monkeying around with surgical safety: Monkeypox preparedness in surgical settings.

J Med Virol 2022 Jun 3. Epub 2022 Jun 3.

Department of Surgery II, University of Witten-Herdecke, Wuppertal, Germany.

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http://dx.doi.org/10.1002/jmv.27915DOI Listing
June 2022

To pollute or not to pollute? Decreasing the ecological footprint of pediatrics in the COVID-19 era.

J Clim Chang Health 2022 May 18:100141. Epub 2022 May 18.

Unit of Developmental and Behavioral Pediatrics, First Department of Pediatrics, School of Medicine, NKUA, "Aghia Sophia" Children's Hospital, Athens, Greece.

The climate crisis impacts child health increasing the burden of pediatric healthcare. During the COVID-19 pandemic, the ecological footprint of pediatric healthcare has significantly increased due to the use of personal protective equipment and the provision of large-scale testing and vaccination against COVID-19. The situation calls for coordinated action to make pediatric healthcare more resource-efficient. To achieve this goal, pediatricians should work together with children and parents in order to rationalize the use of electricity, water, paper and plastic and promote environmental sustainability in healthcare and beyond. The present article discusses the main sources of environmental pollution in pediatric healthcare and proposes evidence-based solutions.
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http://dx.doi.org/10.1016/j.joclim.2022.100141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113769PMC
May 2022

Making obstetrics more environmentally sustainable during and beyond the COVID-19 pandemic.

Int J Health Plann Manage 2022 May 7. Epub 2022 May 7.

Third Department of Obstetrics and Gynecology, 'Attikon' University Hospital, National and Kapodistrian University of Athens, Faculty of Medicine, Athens, Greece.

The climate crisis has increased the burden of obstetrical care due to the negative impact of environmental disruption on the health of pregnant women, new mothers, foetuses and neonates. During the COVID-19 pandemic, the ecological footprint of obstetrical care has significantly increased due to the use of personal protective equipment and the provision of large-scale testing and vaccination of pregnant women and healthcare personnel against COVID-19. The situation calls for coordinated action to make obstetrics more resource efficient. To achieve this goal, obstetricians need to rationalise the use of electricity, water, paper and plastic, adopt green surgical practices and integrate environmental sustainability in their working culture and personal life at large. The present article discusses the main sources of environmental pollution in obstetrical care and proposes evidence-based solutions.
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http://dx.doi.org/10.1002/hpm.3493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347924PMC
May 2022

Delmicron and Flurona: Bracing for Surgical Impact.

Disaster Med Public Health Prep 2022 May 4:1-2. Epub 2022 May 4.

Faculty of Medicine, University of Crete, Heraklion, Greece.

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http://dx.doi.org/10.1017/dmp.2022.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151634PMC
May 2022

Medical supplies for musculoskeletal infections are needed in Kharkiv and throughout Ukraine.

BMJ 2022 05 3;377:o1072. Epub 2022 May 3.

L T Malaya Therapy National Institute, National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine.

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http://dx.doi.org/10.1136/bmj.o1072DOI Listing
May 2022

Immunization in state of siege: the importance of thermostable vaccines for Ukraine and other war-torn countries and territories.

Expert Rev Vaccines 2022 Jul 18;21(7):1007-1008. Epub 2022 Apr 18.

Department of Chronic Diseases Risk Prevention, National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine.

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http://dx.doi.org/10.1080/14760584.2022.2067146DOI Listing
July 2022

Novel approaches for the application of Herbs for Skin Care.

Curr Pharm Biotechnol 2022 Apr 11. Epub 2022 Apr 11.

Institutes of Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, China.

Skin is the largest non - parenchymal organ of the human body. It constitutes a natural barrier against pathogens and harmful environmental exposures and contributes to the human body's homeostasis. Conditions affecting the skin range from infections and injury to autoimmune diseases and cancer. Herbs have been used in the treatment of dermatological conditions for a long time. Traditional approaches to delivering herbs to the skin include ointments, gels, creams, and lotions. However, poor lipophilicity or hydrophilicity in most herbal preparations results in limited bioavailability and poor penetration, restricting their effectiveness. Nanotechnology-based approaches have a major potential to this end, showing promising results in enhancing transdermal penetration compared to traditional approaches. This review article summarizes such advances and sheds light on future directions on the use of nanotechnology-based strategies.
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http://dx.doi.org/10.2174/1389201023666220411110358DOI Listing
April 2022

Children growing up in conflict zones in Ukraine and beyond need urgent mental health support.

Lancet 2022 04 6;399(10336):1689-1690. Epub 2022 Apr 6.

LT Malaya Therapy National Institute, National Academy of Medical Sciences of Ukraine, Kharkiv 61039, Ukraine.

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http://dx.doi.org/10.1016/S0140-6736(22)00579-7DOI Listing
April 2022

Vaccine wastage as collateral damage in Ukrainian conflict.

BMJ 2022 04 8;377:o911. Epub 2022 Apr 8.

Bogomolets National Medical University, Kyiv, Ukraine.

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http://dx.doi.org/10.1136/bmj.o911DOI Listing
April 2022

Education level predicts mortality and morbidity in hospitalised patients with atrial fibrillation.

Hellenic J Cardiol 2022 May-Jun;65:19-24. Epub 2022 Apr 1.

First Department of Cardiology, AHEPA University Hospital, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece. Electronic address:

Aim: Education level has been long considered a life-quality modifier, but little is known about its relation to life expectancy in patients with cardiovascular disease. This study aims to assess possible correlations between education level and survival in patients with atrial fibrillation (AF).

Methods: This retrospective cohort study used data from a randomised trial of 1082 hospitalised patients with AF (mean age of 75 ± 11 years) who were followed up after discharge. Patients were divided into three groups based on their education level: i) none or primary (NPEL), ii) secondary (SEL), and iii) tertiary education level (TEL). Kaplan-Meier curves and multivariable-adjusted hazard ratios (aHRs) were used to compare survival rates between groups. The primary outcome was all-cause mortality. The composite secondary outcome was cardiovascular mortality or any hospitalisation.

Results: After a median 31-month follow-up period, 289 (41.9%) patients died in the NPEL group, 75 (31.1%) in the SEL group, and 29 (19.1%) in the TEL group. The aHRs for all-cause mortality were 0.42 (95% CI, 0.27 to 0.66; p < 0.001) for the TEL group compared with the NPEL group, 0.55 (95% CI, 0.33 to 0.93; p = 0.02) for the TEL group compared with the SEL group, and 0.68 (95% CI, 0.50 to 0.93; p = 0.01) for the SEL group compared with the NPEL group. The corresponding aHRs for the composite secondary outcome were 0.36 (95% CI, 0.23 to 0.52; p < 0.001), 0.49 (95% CI, 0.29 to 0.80; p < 0.001), and 0.67 (95% CI, 0.50 to 9.91; p = 0.01).

Conclusion: Higher education levels were independently associated with fewer fatal and non-fatal outcomes in recently hospitalised patients with AF.
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http://dx.doi.org/10.1016/j.hjc.2022.03.005DOI Listing
June 2022

Infrared Radiation in the Management of Musculoskeletal Conditions and Chronic Pain: A Systematic Review.

Eur J Investig Health Psychol Educ 2022 Mar 14;12(3):334-343. Epub 2022 Mar 14.

Faculty of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Infrared radiation (IR) is a promising complementary treatment for musculoskeletal conditions and chronic pain. By means of a systematic review, we evaluated the contribution of IR to the management of these ailments. PubMed-MEDLINE, Scopus, and Cochrane Library-Cochrane Central Register of Controlled Trials were systematically searched until 20 December 2021. The literature search yielded 233 relevant records. Following the screening of titles and abstracts, 42 full-texts were evaluated. As per inclusion/exclusion criteria, 13 publications were entered into the qualitative assessment. These studies described the effects of IR in humans: three studies focused on osteoarthritis, four studies on fibromyalgia, and six encompassed a wider range of diseases (ankylosing spondylitis, recovery from sports injuries, myofascial pain syndrome). Based on the findings of our systematic review, we noted a decrease in pain levels, as evaluated by the visual analog scale (VAS), in patients suffering from musculoskeletal disorders treated with IR. In addition, IR use led to a decrease in Fibromyalgia Impact Questionnaire (FiQ) scores in subjects diagnosed with fibromyalgia. Nevertheless, IR has failed to facilitate muscle recovery following athletic injuries.
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http://dx.doi.org/10.3390/ejihpe12030024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946909PMC
March 2022

Anorexia and bulimia in late antiquity and early Byzantine period in the eastern Mediterranean region.

Int J Eat Disord 2022 05 22;55(5):637-641. Epub 2022 Mar 22.

Department of History of Medicine, University of Ioannina, Ioannina, Greece.

Objective: The purpose of this study is to identify clinical manifestations of eating disorders in the Eastern Mediterranean region from the first century AD until the seventh century AD and evaluate relevant awareness among the physicians of the era.

Method: The authors searched original medical texts written in Greek by physicians practicing in the Eastern Mediterranean region from the first century AD to the seventh century AD. The search focused on passages that include possible references to clinical entities analogous to anorexia nervosa (AN) and bulimia nervosa (BN) as described in the DSM-5 and the contemporary literature.

Results: Descriptions of conditions that resemble AN or BN can be found in the work of Galen, Oribasius, Aetius of Amida, Leon Philoumenos, Alexander Trallian, and Paul of Egina. Successive physicians confirmed the observations of their predecessors and add to the description of the clinical presentations and their etiology.

Discussion: This research provides evidence of awareness of presentations resembling currently defined eating disorders in the Eastern Mediterranean region during a period with different norms and values. Observations from the period can serve as a point for reflection about the characteristics and etiology of AN and BN in the 21st century.
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http://dx.doi.org/10.1002/eat.23703DOI Listing
May 2022

Letter to the Editor: Radiographic Severity May Not be Associated With Pain and Function in Glenohumeral Arthritis.

Clin Orthop Relat Res 2022 05 22;480(5):1022-1023. Epub 2022 Mar 22.

European Student Think Tank, Public Health and Policy Working Group, Amsterdam, Netherlands.

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Source
http://dx.doi.org/10.1097/CORR.0000000000002179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007192PMC
May 2022
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