Christos Spanos

Integrative vectors for regulated expression of SARS-CoV-2 proteins implicated in RNA metabolism.

Authors:

Stefan Bresson Nic Robertson Emanuela Sani Tomasz W Turowski Vadim Shchepachev Michaela Kompauerova Christos Spanos Aleksandra Helwak David Tollervey

Wellcome Open Res 2020 3;5:261. Epub 2020 Nov 3.

Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh, EH9 3BF, UK.

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November 2020

The Proteomic Landscape of Centromeric Chromatin Reveals an Essential Role for the Ctf19 Complex in Meiotic Kinetochore Assembly.

Authors:

Weronika E Borek Nadine Vincenten Eris Duro Vasso Makrantoni Christos Spanos Krishna K Sarangapani Flavia de Lima Alves David A Kelly Charles L Asbury Juri Rappsilber Adele L Marston

Curr Biol 2020 Oct 31. Epub 2020 Oct 31.

The Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK. Electronic address:

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October 2020

Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors.

Authors:

Stefan Bresson Vadim Shchepachev Christos Spanos Tomasz W Turowski Juri Rappsilber David Tollervey

Mol Cell 2020 11 13;80(3):470-484.e8. Epub 2020 Oct 13.

Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK. Electronic address:

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November 2020

The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment.

Authors:

Thibault Legal Daniel Hayward Agata Gluszek-Kustusz Elizabeth A Blackburn Christos Spanos Juri Rappsilber Ulrike Gruneberg Julie P I Welburn

J Cell Sci 2020 Aug 25;133(16). Epub 2020 Aug 25.

Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, Scotland, UK

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August 2020

The epigenetic regulator ICU11 as an accessory protein of Polycomb Repressive Complex 2.

Authors:

Rebecca H Bloomer Claire E Hutchison Isabel Bäurle James Walker Xiaofeng Fang Pumi Perera Christos N Velanis Serin Gümüs Christos Spanos Juri Rappsilber Xiaoqi Feng Justin Goodrich Caroline Dean

Proc Natl Acad Sci U S A 2020 07 29;117(28):16660-16666. Epub 2020 Jun 29.

Department of Cell and Developmental Biology, John Innes Centre, Colney Lane, NR47UH Norwich, United Kingdom;

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July 2020

Substrate specificity of the TRAMP nuclear surveillance complexes.

Authors:

Clémentine Delan-Forino Christos Spanos Juri Rappsilber David Tollervey

Nat Commun 2020 06 19;11(1):3122. Epub 2020 Jun 19.

Wellcome Center for Cell Biology, University of Edinburgh, Kings Buildings, Swann Building, Edinburgh, EH9 3BF, UK.

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June 2020

The domesticated transposase ALP2 mediates formation of a novel Polycomb protein complex by direct interaction with MSI1, a core subunit of Polycomb Repressive Complex 2 (PRC2).

PLoS Genet 2020 05 28;16(5):e1008681. Epub 2020 May 28.

Institute of Molecular Plant Science, School of Biological Sciences, University of Edinburgh, Daniel Rutherford Building, Max Born Crescent, Edinburgh, United Kingdom.

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May 2020

-Shaped Copolymer of Polyethylene and Poly(ethylene oxide) under Severe Confinement: Phase State and Dynamics.

Authors:

Mahdy M Elmahdy Dimitrios Gournis Athanasios Ladavos Christos Spanos George Floudas

Langmuir 2020 Apr 14;36(16):4261-4271. Epub 2020 Apr 14.

Department of Physics, University of Ioannina, 451 10 Ioannina, Greece.

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April 2020

Hap2-Ino80-facilitated transcription promotes de novo establishment of CENP-A chromatin.

Authors:

Puneet P Singh Manu Shukla Sharon A White Marcel Lafos Pin Tong Tatsiana Auchynnikava Christos Spanos Juri Rappsilber Alison L Pidoux Robin C Allshire

Genes Dev 2020 02 9;34(3-4):226-238. Epub 2020 Jan 9.

Wellcome Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, United Kingdom.

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February 2020

Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity.

Authors:

Alex A Makarov Juan Zou Douglas R Houston Christos Spanos Alexandra S Solovyova Cristina Cardenal-Peralta Juri Rappsilber Eric C Schirmer

Nat Commun 2019 07 11;10(1):3056. Epub 2019 Jul 11.

Wellcome Centre for Cell Biology, University of Edinburgh, Max Born Crescent, Edinburgh, EH9 3BF, UK.

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July 2019

Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation.

Authors:

Abdulrahim A Sajini Nila Roy Choudhury Rebecca E Wagner Susanne Bornelöv Tommaso Selmi Christos Spanos Sabine Dietmann Juri Rappsilber Gracjan Michlewski Michaela Frye

Nat Commun 2019 06 11;10(1):2550. Epub 2019 Jun 11.

Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.

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June 2019

The molecular basis of monopolin recruitment to the kinetochore.

Authors:

Rebecca Plowman Namit Singh Eelco C Tromer Angel Payan Eris Duro Christos Spanos Juri Rappsilber Berend Snel Geert J P L Kops Kevin D Corbett Adele L Marston

Chromosoma 2019 09 30;128(3):331-354. Epub 2019 Apr 30.

Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Max Born Crescent, Edinburgh, EH9 3BF, UK.

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September 2019

Reductional Meiosis I Chromosome Segregation Is Established by Coordination of Key Meiotic Kinases.

Authors:

Stefan Galander Rachael E Barton Weronika E Borek Christos Spanos David A Kelly Daniel Robertson Juri Rappsilber Adèle L Marston

Dev Cell 2019 05 25;49(4):526-541.e5. Epub 2019 Apr 25.

The Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK. Electronic address:

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May 2019

Defining the RNA interactome by total RNA-associated protein purification.

Authors:

Vadim Shchepachev Stefan Bresson Christos Spanos Elisabeth Petfalski Lutz Fischer Juri Rappsilber David Tollervey

Mol Syst Biol 2019 04 8;15(4):e8689. Epub 2019 Apr 8.

Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK

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April 2019

In vitro BioID: mapping the CENP-A microenvironment with high temporal and spatial resolution.

Authors:

Lucy Remnant Daniel G Booth Giulia Vargiu Christos Spanos Alastair R W Kerr William C Earnshaw

Mol Biol Cell 2019 05 20;30(11):1314-1325. Epub 2019 Mar 20.

Wellcome Trust Centre for Cell Biology, Institute of Cell Biology and.

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May 2019

Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Authors:

Ye Dee Tay Marcin Leda Christos Spanos Juri Rappsilber Andrew B Goryachev Kenneth E Sawin

Cell Rep 2019 02;26(6):1654-1667.e7

Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK. Electronic address:

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February 2019

Correction to: Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.

Proteome Sci 2018 25;16:13. Epub 2018 Jun 25.

1Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH UK.

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June 2018

Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore.

Authors:

Xun X Bao Christos Spanos Tomoko Kojidani Eric M Lynch Juri Rappsilber Yasushi Hiraoka Tokuko Haraguchi Kenneth E Sawin

Elife 2018 05 29;7. Epub 2018 May 29.

Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

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May 2018

Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.

Proteome Sci 2018 14;16. Epub 2018 Feb 14.

1Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH UK.

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February 2018

Genes Important for Meiosis Identified Through a Functional Genomics Screen.

Authors:

Julie Blyth Vasso Makrantoni Rachael E Barton Christos Spanos Juri Rappsilber Adele L Marston

Genetics 2018 02 19;208(2):589-603. Epub 2017 Dec 19.

Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, EH9 3BF, UK

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February 2018

Comprehensive identification of proteins binding to RNA G-quadruplex motifs in the 5' UTR of tumor-associated mRNAs.

Authors:

Tatsuo Serikawa Christos Spanos Annekathrin von Hacht Nediljko Budisa Juri Rappsilber Jens Kurreck

Biochimie 2018 Jan 10;144:169-184. Epub 2017 Nov 10.

Department of Applied Biochemistry, Institute of Biotechnology, TIB 4/3-2, Technische Universität Berlin, Gustav-Meyer-Allee 25, 13355, Berlin, Germany. Electronic address:

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January 2018