Christopher W J Smith

Christopher W J Smith

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Christopher W J Smith

Christopher W J Smith

Publications by authors named "Christopher W J Smith"

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Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing.

Cell 2018 08 2;174(5):1067-1081.e17. Epub 2018 Aug 2.

The Francis Crick Institute, Midland Road 1, Kings Cross, London NW1 1AT, UK; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108849PMC
August 2018

Intron retention as a component of regulated gene expression programs.

Hum Genet 2017 09 8;136(9):1043-1057. Epub 2017 Apr 8.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK.

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http://dx.doi.org/10.1007/s00439-017-1791-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602073PMC
September 2017

Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins.

Biochem Soc Trans 2016 08;44(4):1058-65

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, U.K.

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http://dx.doi.org/10.1042/BST20160080DOI Listing
August 2016

Matrin3: connecting gene expression with the nuclear matrix.

Wiley Interdiscip Rev RNA 2016 05 26;7(3):303-15. Epub 2016 Jan 26.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/wrna.1336DOI Listing
May 2016

Regulation of alternative pre-mRNA splicing.

Methods Mol Biol 2014 ;1126:55-82

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-62703-980-2_5DOI Listing
October 2014

The organization of RNA contacts by PTB for regulation of FAS splicing.

Nucleic Acids Res 2014 Jul 23;42(13):8605-20. Epub 2014 Jun 23.

Department of Biochemistry, University of Cambridge, Downing Site, Tennis Court Road, Cambridge, CB2 1QW, UK

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http://dx.doi.org/10.1093/nar/gku519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117754PMC
July 2014

Dissecting domains necessary for activation and repression of splicing by Muscleblind-like protein 1.

BMC Mol Biol 2013 Dec 27;14:29. Epub 2013 Dec 27.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1186/1471-2199-14-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880588PMC
December 2013

MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3.

Nucleic Acids Res 2013 May 19;41(9):4765-82. Epub 2013 Mar 19.

Department of Biochemistry, University of Cambridge, CB2 1QW, UK.

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http://dx.doi.org/10.1093/nar/gkt168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643581PMC
May 2013

Defining the roles and interactions of PTB.

Biochem Soc Trans 2012 Aug;40(4):815-20

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1042/BST20120044DOI Listing
August 2012

Decoding muscle alternative splicing.

Curr Opin Genet Dev 2011 Aug 21;21(4):380-7. Epub 2011 Apr 21.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1016/j.gde.2011.03.006DOI Listing
August 2011

Genome-wide association between branch point properties and alternative splicing.

PLoS Comput Biol 2010 Nov 24;6(11):e1001016. Epub 2010 Nov 24.

Computational Genomics, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1371/journal.pcbi.1001016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991248PMC
November 2010

Four exons of the serotonin receptor 4 gene are associated with multiple distant branch points.

RNA 2010 Apr 2;16(4):839-51. Epub 2010 Mar 2.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.

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http://dx.doi.org/10.1261/rna.2013110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844630PMC
April 2010

Alternative splicing: global insights.

FEBS J 2010 Feb 15;277(4):856-66. Epub 2010 Jan 15.

Department of Biochemistry, University of Cambridge, UK.

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http://dx.doi.org/10.1111/j.1742-4658.2009.07521.xDOI Listing
February 2010

Tropomyosin exons as models for alternative splicing.

Adv Exp Med Biol 2008 ;644:27-42

Department of Biochemistry, University of Cambridge, CB2 1GA, UK.

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http://dx.doi.org/10.1007/978-0-387-85766-4_3DOI Listing
February 2009

A nonsense exon in the Tpm1 gene is silenced by hnRNP H and F.

RNA 2009 Jan 26;15(1):33-43. Epub 2008 Nov 26.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.

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http://dx.doi.org/10.1261/rna.1225209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612778PMC
January 2009

Polypyrimidine tract binding protein regulates alternative splicing of an aberrant pseudoexon in NF1.

FEBS J 2008 Dec 1;275(24):6101-8. Epub 2008 Nov 1.

Human Genetics Division, University of Southampton, UK.

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http://dx.doi.org/10.1111/j.1742-4658.2008.06734.xDOI Listing
December 2008

Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?

Trends Biochem Sci 2008 Aug 11;33(8):385-93. Epub 2008 Jul 11.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK.

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http://dx.doi.org/10.1016/j.tibs.2008.06.001DOI Listing
August 2008

Expression of human nPTB is limited by extreme suboptimal codon content.

PLoS One 2008 Mar 12;3(3):e1801. Epub 2008 Mar 12.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001801PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258417PMC
March 2008

Repression of alpha-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract.

RNA 2007 Aug 25;13(8):1214-23. Epub 2007 Jun 25.

Department of Biochemistry, University of Cambridge, UK.

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http://dx.doi.org/10.1261/rna.219607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924891PMC
August 2007

Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1.

Mol Cell 2007 Aug;27(3):420-34

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK.

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http://dx.doi.org/10.1016/j.molcel.2007.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940037PMC
August 2007

A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain.

Nat Struct Mol Biol 2006 Sep 27;13(9):839-48. Epub 2006 Aug 27.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA, UK.

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http://dx.doi.org/10.1038/nsmb1137DOI Listing
September 2006

A class of human exons with predicted distant branch points revealed by analysis of AG dinucleotide exclusion zones.

Genome Biol 2006 13;7(1):R1. Epub 2006 Jan 13.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

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http://dx.doi.org/10.1186/gb-2006-7-1-r1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1431707PMC
August 2006

An apparent pseudo-exon acts both as an alternative exon that leads to nonsense-mediated decay and as a zero-length exon.

Mol Cell Biol 2006 Mar;26(6):2237-46

Department of Biochemistry, University of Cambridge, 80 Tennis Court Rd., Cambridge CB2 1GA, United Kingdom.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.26.6.2237-2246.2006
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http://dx.doi.org/10.1128/MCB.26.6.2237-2246.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1430291PMC
March 2006

Novel modes of splicing repression by PTB.

Trends Biochem Sci 2006 Feb 5;31(2):73-6. Epub 2006 Jan 5.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

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http://dx.doi.org/10.1016/j.tibs.2005.12.003DOI Listing
February 2006

A splicing repressor domain in polypyrimidine tract-binding protein.

J Biol Chem 2006 Jan 9;281(2):800-6. Epub 2005 Nov 9.

Department of Biochemistry, University of Cambridge, UK.

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http://dx.doi.org/10.1074/jbc.M510578200DOI Listing
January 2006

Visualization of alternative splicing in vivo.

Methods 2005 Dec;37(4):360-7

Department of Biochemistry, University of Cambridge, 80, Tennis Court Road, Cambridge, CB2 1GA, UK.

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http://dx.doi.org/10.1016/j.ymeth.2005.07.017DOI Listing
December 2005

Alternative splicing--when two's a crowd.

Cell 2005 Oct;123(1):1-3

Department of Biochemistry, Cambridge, UK.

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http://dx.doi.org/10.1016/j.cell.2005.09.010DOI Listing
October 2005

Understanding alternative splicing: towards a cellular code.

Nat Rev Mol Cell Biol 2005 May;6(5):386-98

Department of Biochemistry, 80 Tennis Court Road, University of Cambridge, CB2 1GA, UK.

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http://dx.doi.org/10.1038/nrm1645DOI Listing
May 2005

Regulated tissue-specific alternative splicing of enhanced green fluorescent protein transgenes conferred by alpha-tropomyosin regulatory elements in transgenic mice.

J Biol Chem 2004 Aug 11;279(35):36660-9. Epub 2004 Jun 11.

Department of Biochemistry, Tennis Court Road, University of Cambridge, Cambridge CB2 1QW, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M405380200DOI Listing
August 2004

Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay.

Mol Cell 2004 Jan;13(1):91-100

Department of Biochemistry, 80 Tennis Court Road, University of Cambridge, Cambridge CB2 1GA, United Kingdom.

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http://dx.doi.org/10.1016/s1097-2765(03)00502-1DOI Listing
January 2004

The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing.

EMBO J 2003 Dec;22(23):6356-64

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

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http://dx.doi.org/10.1093/emboj/cdg609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC291850PMC
December 2003

A novel polypyrimidine tract-binding protein paralog expressed in smooth muscle cells.

J Biol Chem 2003 Apr 10;278(17):15201-7. Epub 2003 Feb 10.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M210131200DOI Listing
April 2003

A splicing silencer that regulates smooth muscle specific alternative splicing is active in multiple cell types.

Nucleic Acids Res 2002 Aug;30(16):3548-57

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134246PMC
http://dx.doi.org/10.1093/nar/gkf480DOI Listing
August 2002

Alternative splicing: combinatorial output from the genome.

Curr Opin Chem Biol 2002 Jun;6(3):375-83

Cambridge Consultants Limited, Science Park, Milton Road, Cambridge, CB4 0DW, Cambridge, UK.

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http://dx.doi.org/10.1016/s1367-5931(02)00320-4DOI Listing
June 2002