Christopher S Francklyn

Christopher S Francklyn

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Christopher S Francklyn

Christopher S Francklyn

Publications by authors named "Christopher S Francklyn"

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33Publications

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Immunity-Guided Identification of Threonyl-tRNA Synthetase as the Molecular Target of Obafluorin, a β-Lactone Antibiotic.

ACS Chem Biol 2019 12 14;14(12):2663-2671. Epub 2019 Nov 14.

Department of Molecular Microbiology , John Innes Centre , Norwich Research Park , Norwich NR4 7UH , U.K.

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http://dx.doi.org/10.1021/acschembio.9b00590DOI Listing
December 2019

Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics.

J Biol Chem 2019 04 22;294(14):5365-5385. Epub 2019 Jan 22.

From the Department of Biochemistry, College of Medicine, University of Vermont, Burlington, Vermont 05405.

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http://dx.doi.org/10.1074/jbc.REV118.002956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462538PMC
April 2019

A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases.

PLoS One 2017 21;12(9):e0185317. Epub 2017 Sep 21.

Department of Biology, University of Vermont, Burlington, VT, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185317PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608375PMC
October 2017

The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity.

Biochemistry 2017 07 7;56(28):3619-3631. Epub 2017 Jul 7.

Department of Biochemistry, University of Vermont , Burlington, Vermont 05405, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00114DOI Listing
July 2017

Characterization of aminoacyl-tRNA synthetase stability and substrate interaction by differential scanning fluorimetry.

Methods 2017 01 26;113:64-71. Epub 2016 Oct 26.

Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2016.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493479PMC
January 2017

Aminoacyl-Transfer RNA Synthetases: Connecting Nutrient Status to Angiogenesis Through the Unfolded Protein Response.

Arterioscler Thromb Vasc Biol 2016 Apr;36(4):582-3

From the Departments of Pharmacology (K.M.L.) and Biochemistry (C.S.F.), University of Vermont, College of Medicine, Burlington.

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http://dx.doi.org/10.1161/ATVBAHA.116.307193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807867PMC
April 2016

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.

Nat Commun 2015 Mar 31;6:6402. Epub 2015 Mar 31.

Department of Cancer Biology, Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, Florida 33458, USA.

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http://dx.doi.org/10.1038/ncomms7402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389257PMC
March 2015

Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo.

Proc Natl Acad Sci U S A 2014 Dec 8;111(51):E5508-17. Epub 2014 Dec 8.

Institute for Research in Biomedicine, 08028 Barcelona, Catalonia, Spain; Catalan Institution for Research and Advanced Studies, 08010 Barcelona, Catalonia, Spain

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http://dx.doi.org/10.1073/pnas.1405994111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280603PMC
December 2014

Regulation of angiogenesis by aminoacyl-tRNA synthetases.

Int J Mol Sci 2014 Dec 19;15(12):23725-48. Epub 2014 Dec 19.

Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.3390/ijms151223725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284789PMC
December 2014

Transfer RNA and human disease.

Front Genet 2014 3;5:158. Epub 2014 Jun 3.

Department of Biochemistry, College of Medicine, University of Vermont Burlington, VT, USA.

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http://dx.doi.org/10.3389/fgene.2014.00158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042891PMC
June 2014

Standardizing analysis of circulating microRNA: clinical and biological relevance.

J Cell Biochem 2014 May;115(5):805-11

Vermont Cancer Center for Basic and Translational Research, University of Vermont College of Medicine, Burlington, Vermont, 05405; Department of Biochemistry, University of Vermont College of Medicine, Burlington, Vermont, 05405.

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http://dx.doi.org/10.1002/jcb.24745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992702PMC
May 2014

Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis.

Sci Rep 2013 ;3:1317

Department of Pharmacology, University of Vermont, College of Medicine, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1038/srep01317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578223PMC
August 2013

The α-amino group of the threonine substrate as the general base during tRNA aminoacylation: a new version of substrate-assisted catalysis predicted by hybrid DFT.

J Phys Chem A 2011 Nov 26;115(45):13050-60. Epub 2011 Sep 26.

Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada.

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http://dx.doi.org/10.1021/jp205037aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773706PMC
November 2011

Substrate specificity and catalysis by the editing active site of Alanyl-tRNA synthetase from Escherichia coli.

Biochemistry 2011 Mar 31;50(9):1474-82. Epub 2011 Jan 31.

Department of Biochemistry, College of Medicine, Health Sciences Complex, 89 Beaumont Avenue, University of Vermont, Burlington, Vermont 05405, United States.

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http://dx.doi.org/10.1021/bi1013535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069921PMC
March 2011

Fidelity escape by the unnatural amino acid β-hydroxynorvaline: an efficient substrate for Escherichia coli threonyl-tRNA synthetase with toxic effects on growth.

Biochemistry 2011 Feb 24;50(6):1101-9. Epub 2011 Jan 24.

Cell and Molecular Biology Program, College of Medicine, Health Sciences Complex, University of Vermont, Burlington, Vermont 05405-0068, United States.

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http://dx.doi.org/10.1021/bi101360aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063515PMC
February 2011

Aminoacyl transfer rate dictates choice of editing pathway in threonyl-tRNA synthetase.

J Biol Chem 2010 Jul 26;285(31):23810-7. Epub 2010 May 26.

Cell and Molecular Biology Program, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1074/jbc.M110.105320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911285PMC
July 2010

tRNA as an active chemical scaffold for diverse chemical transformations.

FEBS Lett 2010 Jan;584(2):366-75

Cell and Molecular Biology Program, University of Vermont, Burlington, VT 05405, United States.

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http://dx.doi.org/10.1016/j.febslet.2009.11.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241936PMC
January 2010

Asymmetric amino acid activation by class II histidyl-tRNA synthetase from Escherichia coli.

J Biol Chem 2009 Jul 1;284(31):20753-62. Epub 2009 Jun 1.

Department of Biochemistry, College of Medicine, Health Sciences Complex, University of Vermont, Burlington, Vermont 05405, USA.

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http://dx.doi.org/10.1074/jbc.M109.021311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743188PMC
July 2009

DNA polymerases and aminoacyl-tRNA synthetases: shared mechanisms for ensuring the fidelity of gene expression.

Biochemistry 2008 Nov 14;47(45):11695-703. Epub 2008 Oct 14.

Department of Biochemistry, Department of Microbiology, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA.

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http://dx.doi.org/10.1021/bi801500zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638074PMC
November 2008

RNA-assisted catalysis in a protein enzyme: The 2'-hydroxyl of tRNA(Thr) A76 promotes aminoacylation by threonyl-tRNA synthetase.

Proc Natl Acad Sci U S A 2008 Nov 7;105(46):17748-53. Epub 2008 Nov 7.

Cell and Molecular Biology Program, College of Medicine, Health Sciences Complex, 89 Beaumont Avenue, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1073/pnas.0804247105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584683PMC
November 2008

Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases.

Methods 2008 Feb;44(2):100-18

Department of Biochemistry, University of Vermont, Health Sciences Complex, 89 Beaumont Avenue, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1016/j.ymeth.2007.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288706PMC
February 2008

Kinetic discrimination of tRNA identity by the conserved motif 2 loop of a class II aminoacyl-tRNA synthetase.

Mol Cell 2007 Feb;25(4):531-42

Department of Biochemistry, University of Vermont, Health Sciences Complex, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1016/j.molcel.2007.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2020812PMC
February 2007

Substrate recognition by the hetero-octameric ATP phosphoribosyltransferase from Lactococcus lactis.

Biochemistry 2006 Dec;45(50):14933-43

Department of Microbiology and Molecular Genetics, University of Vermont, B403 Given Building, 89 Beaumont Avenue, Burlington, Vermont 05405, USA.

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http://dx.doi.org/10.1021/bi061802vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567060PMC
December 2006

Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog.

J Biol Chem 2005 Oct 28;280(40):34096-104. Epub 2005 Jul 28.

Department of Microbiology and Molecular Genetics and Biochemistry, University of Vermont, Burlington, Vermont 05405, USA.

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http://dx.doi.org/10.1074/jbc.M505041200DOI Listing
October 2005

A substrate-assisted concerted mechanism for aminoacylation by a class II aminoacyl-tRNA synthetase.

Biochemistry 2005 Mar;44(10):3785-94

Department of Biochemistry, University of Vermont, Health Sciences Complex, Burlington, Vermont 05405, USA.

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http://dx.doi.org/10.1021/bi047923hDOI Listing
March 2005

G-1:C73 recognition by an arginine cluster in the active site of Escherichia coli histidyl-tRNA synthetase.

Biochemistry 2004 Feb;43(4):962-9

Department of Biochemistry, University of Vermont, Health Sciences Complex, Burlington 05405, USA.

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http://dx.doi.org/10.1021/bi035708fDOI Listing
February 2004

Induced fit and kinetic mechanism of adenylation catalyzed by Escherichia coli threonyl-tRNA synthetase.

Biochemistry 2003 Dec;42(51):15102-13

Department of Biochemistry, The University of Vermont Health Sciences Complex, Burlington, Vermont 05405-0068, USA.

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https://pubs.acs.org/doi/10.1021/bi0355701
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http://dx.doi.org/10.1021/bi0355701DOI Listing
December 2003

The quaternary structure of the HisZ-HisG N-1-(5'-phosphoribosyl)-ATP transferase from Lactococcus lactis.

Biochemistry 2002 Oct;41(39):11838-46

Department of Biochemistry, The University of Vermont Health Sciences Complex, Burlington, Vermont, 05405-0068, USA.

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http://dx.doi.org/10.1021/bi020243zDOI Listing
October 2002