Christopher S Chen

Christopher S Chen

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Christopher S Chen

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Mechanical regulation of glycolysis via cytoskeleton architecture.

Nature 2020 02 12;578(7796):621-626. Epub 2020 Feb 12.

Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1038/s41586-020-1998-1DOI Listing
February 2020

From Simple to Architecturally Complex Hydrogel Scaffolds for Cell and Tissue Engineering Applications: Opportunities Presented by Two-Photon Polymerization.

Adv Healthc Mater 2020 Jan 20;9(1):e1901217. Epub 2019 Nov 20.

Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1002/adhm.201901217DOI Listing
January 2020

Sarco/endoplasmic reticulum Ca-ATPase is a more effective calcium remover than sodium-calcium exchanger in human embryonic stem cell-derived cardiomyocytes.

Am J Physiol Heart Circ Physiol 2019 11 26;317(5):H1105-H1115. Epub 2019 Jul 26.

Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1152/ajpheart.00540.2018DOI Listing
November 2019

Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A.

Cell Stem Cell 2019 Aug;25(2):273-289.e5

Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785828PMC
August 2019

A Bile Duct-on-a-Chip With Organ-Level Functions.

Hepatology 2019 Aug 29. Epub 2019 Aug 29.

Division of Gastroenterology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30918
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http://dx.doi.org/10.1002/hep.30918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048662PMC
August 2019

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling.

Sci Adv 2019 08 28;5(8):eaav6789. Epub 2019 Aug 28.

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/sciadv.aav6789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713506PMC
August 2019

Osteochondral Allograft Transplantation Surgery for Osteochondral Lesions of the Talus in Athletes.

J Foot Ankle Surg 2019 Jul 20;58(4):623-627. Epub 2019 Apr 20.

Associate Professor of Surgery, Department of Orthopaedic Surgery, Tripler Army Medical Center, Honolulu, HI. Electronic address:

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http://dx.doi.org/10.1053/j.jfas.2018.11.020DOI Listing
July 2019

Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting.

Mol Biol Cell 2019 07 18;30(16):1974-1984. Epub 2019 Jul 18.

Biological Design Center, Department of Biomedical Engineering, Boston University, Boston, MA 02215.

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http://dx.doi.org/10.1091/mbc.E19-02-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727772PMC
July 2019

Microfabricated blood vessels for modeling the vascular transport barrier.

Nat Protoc 2019 05 5;14(5):1425-1454. Epub 2019 Apr 5.

The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.

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http://www.nature.com/articles/s41596-019-0144-8
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http://dx.doi.org/10.1038/s41596-019-0144-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046311PMC
May 2019

SarcTrack.

Circ Res 2019 04;124(8):1172-1183

From the Department of Genetics (C.N.T., A.S., A.C.G., M.N., J.A.L.W., R.A., M.S., J.R., O.P., J.G.S., C.E.S.), Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485312PMC
April 2019

Studies of 3D directed cell migration enabled by direct laser writing of curved wave topography.

Biofabrication 2019 02 25;11(2):021001. Epub 2019 Feb 25.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States of America.

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http://dx.doi.org/10.1088/1758-5090/ab047fDOI Listing
February 2019

Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration.

APL Bioeng 2018 Dec 26;2(4):046107. Epub 2018 Dec 26.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1063/1.5052239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481732PMC
December 2018

Motile Dendritic Cells Sense and Respond to Substrate Geometry.

Ann Biomed Eng 2018 Sep 22;46(9):1348-1361. Epub 2018 May 22.

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.

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http://link.springer.com/10.1007/s10439-018-2041-7
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http://dx.doi.org/10.1007/s10439-018-2041-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095716PMC
September 2018

Fabrication and Mechanical Properties Measurements of 3D Microtissues for the Study of Cell-Matrix Interactions.

Methods Mol Biol 2018 ;1722:303-328

Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/978-1-4939-7553-2_18DOI Listing
August 2018

Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis.

Development 2018 04 30;145(9). Epub 2018 Apr 30.

Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA

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http://dx.doi.org/10.1242/dev.162123DOI Listing
April 2018

Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise.

Cell Stem Cell 2018 03;22(3):340-354

Biological Design Center, Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849079PMC
March 2018

Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.

Dev Cell 2018 01 8;44(1):87-96.e5. Epub 2018 Jan 8.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421364PMC
January 2018

Forces as regulators of cell adhesions.

Nat Rev Mol Cell Biol 2017 12 2;18(12):715. Epub 2017 Nov 2.

The Biological Design Center, Boston University, Massachusetts, MA 02215, USA; and Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, MA 02138, USA.

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http://dx.doi.org/10.1038/nrm.2017.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001849PMC
December 2017

A non-canonical Notch complex regulates adherens junctions and vascular barrier function.

Nature 2017 12 13;552(7684):258-262. Epub 2017 Nov 13.

The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nature24998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730479PMC
December 2017

Designer biomaterials for mechanobiology.

Nat Mater 2017 11;16(12):1164-1168

Biological Design Center and in the Department of Biomedical Engineering, Boston University, Boston, Massachusetts, 02215, USA, and at the Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, 02115, USA.

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http://dx.doi.org/10.1038/nmat5049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001850PMC
November 2017

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro.

Cell Rep 2017 Oct;21(2):508-516

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02139, USA; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173133
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http://dx.doi.org/10.1016/j.celrep.2017.09.043DOI Listing
October 2017

Making bone via nanoscale kicks.

Nat Biomed Eng 2017 Sep;1(9):689-690

Biological Design Center, Department of Biomedical Engineering, Boston University, 610 Commonwealth Avenue, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41551-017-0133-6DOI Listing
September 2017

Full-Length Fibronectin Drives Fibroblast Accumulation at the Surface of Collagen Microtissues during Cell-Induced Tissue Morphogenesis.

PLoS One 2016 26;11(8):e0160369. Epub 2016 Aug 26.

Laboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zurich, Vladimir-Prelog-Weg 4, Zurich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160369PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001707PMC
August 2017

The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation.

Integr Biol (Camb) 2017 08;9(8):695-708

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1039/c7ib00070gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830129PMC
August 2017

Matrix degradability controls multicellularity of 3D cell migration.

Nat Commun 2017 08 29;8(1):371. Epub 2017 Aug 29.

The Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41467-017-00418-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575316PMC
August 2017

Cdc42 regulates branching in angiogenic sprouting in vitro.

Microcirculation 2017 07;24(5)

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/micc.12372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505782PMC
July 2017

Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices.

Proc Natl Acad Sci U S A 2017 06 3;114(23):E4549-E4555. Epub 2017 May 3.

Department of Materials Science and Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1620486114
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http://dx.doi.org/10.1073/pnas.1620486114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468675PMC
June 2017

Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning.

Dev Cell 2017 03;40(5):505-511.e6

Department of Biochemistry and Molecular Biology, Wise Faculty of Life Science, Tel Aviv University, Tel Aviv, 69978, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435110PMC
March 2017

3D culture models of tissues under tension.

J Cell Sci 2017 01 1;130(1):63-70. Epub 2016 Dec 1.

Department of Biomedical Engineering and the Biological Design Center, Boston University, Boston, MA 02215, USA

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http://dx.doi.org/10.1242/jcs.198630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394782PMC
January 2017

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.

Cell Rep 2016 12;17(12):3292-3304

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193246PMC
December 2016

3D Biomimetic Cultures: The Next Platform for Cell Biology.

Trends Cell Biol 2016 11 13;26(11):798-800. Epub 2016 Sep 13.

Biomedical Engineering and The Biological Design Center, Boston University, Boston, MA, USA; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2016.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184827PMC
November 2016

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity.

Elife 2016 11 30;5. Epub 2016 Nov 30.

McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

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http://dx.doi.org/10.7554/eLife.18207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148611PMC
November 2016

Forces and mechanotransduction in 3D vascular biology.

Curr Opin Cell Biol 2016 10 19;42:73-79. Epub 2016 May 19.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064809PMC
http://dx.doi.org/10.1016/j.ceb.2016.04.011DOI Listing
October 2016

Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy.

Oncotarget 2016 10;7(40):65429-65440

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.18632/oncotarget.11748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323166PMC
October 2016

Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling.

Sci Rep 2016 Sep 27;6:33919. Epub 2016 Sep 27.

Department of Physics and Astronomy, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://www.nature.com/articles/srep33919
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037370PMC
http://dx.doi.org/10.1038/srep33919DOI Listing
September 2016

Measuring cell-generated forces: a guide to the available tools.

Nat Methods 2016 04;13(5):415-23

Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.3834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474291PMC
April 2016

The mechanical regulation of integrin-cadherin crosstalk organizes cells, signaling and forces.

J Cell Sci 2016 Mar 26;129(6):1093-100. Epub 2016 Feb 26.

Department of Systems Pharmacology and Translational Therapeutics, Program in Translational Biomechanics, Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://jcs.biologists.org/lookup/doi/10.1242/jcs.183699
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http://dx.doi.org/10.1242/jcs.183699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813297PMC
March 2016

Cellular forces and matrix assembly coordinate fibrous tissue repair.

Nat Commun 2016 Mar 16;7:11036. Epub 2016 Mar 16.

Department of Biomedical Engineering, Boston University, 36 Cummington Mall, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncomms11036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799373PMC
March 2016

Biomimetic on-a-chip platforms for studying cancer metastasis.

Curr Opin Chem Eng 2016 Feb 18;11:20-27. Epub 2015 Dec 18.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, United States.

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http://dx.doi.org/10.1016/j.coche.2015.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999336PMC
February 2016

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments.

Nat Mater 2015 Dec 12;14(12):1262-8. Epub 2015 Oct 12.

Tissue Microfabrication Lab, Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nmat4444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654682PMC
December 2015

Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering.

J Biomed Mater Res A 2015 Oct 30;103(10):3331-8. Epub 2015 Apr 30.

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139.

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https://pdfs.semanticscholar.org/2c2c/b058b2f48cefcaca3d1bfa
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https://lmrt.mit.edu/sites/default/files/Stevens_JBMR-A_2015
Web Search
http://doi.wiley.com/10.1002/jbm.a.35478
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http://dx.doi.org/10.1002/jbm.a.35478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890565PMC
October 2015

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors.

Cancer Res 2015 Aug 29;75(16):3255-67. Epub 2015 Jun 29.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. Howard Hughes Medical Institute, Cambridge, Massachusetts. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts. Broad Institute, Cambridge, Massachusetts. Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833008PMC
August 2015

Protrusive and Contractile Forces of Spreading Human Neutrophils.

Biophys J 2015 Aug;109(4):699-709

Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania; Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.05.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547143PMC
August 2015

HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.

Science 2015 Aug;349(6251):982-6

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.1126/science.aaa5458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618316PMC
August 2015

ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis.

Elife 2015 Jun 25;4:e06821. Epub 2015 Jun 25.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

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http://dx.doi.org/10.7554/eLife.06821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501333PMC
June 2015

Patterning vascular networks in vivo for tissue engineering applications.

Tissue Eng Part C Methods 2015 May 18;21(5):509-17. Epub 2015 Feb 18.

1 Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/ten.TEC.2014.0258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410304PMC
May 2015

Hypoxia increases the abundance but not the assembly of extracellular fibronectin during epithelial cell transdifferentiation.

J Cell Sci 2015 Mar 22;128(6):1083-9. Epub 2015 Jan 22.

Department of Cell and Tissue Biology, University of California, San Francisco, CA 94143, USA

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.155036
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http://dx.doi.org/10.1242/jcs.155036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359919PMC
March 2015

N-Cadherin Induction by ECM Stiffness and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells.

Cell Rep 2015 Mar 5;10(9):1477-1486. Epub 2015 Mar 5.

Program in Translational Biomechanics, Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560684PMC
March 2015

Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs.

Circ Arrhythm Electrophysiol 2015 Feb 10;8(1):193-202. Epub 2014 Dec 10.

From the Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, Manhattan, NY (G.C., I.K., K.D.C., R.J.H., R.A.L.); Department of Physiology (G.C., S.L., L.R., M.Z.-Y.C., W.K., C.-W.K., R.A.L.), Stem Cell and Regenerative Medicine Consortium (G.C., S.L., L.R., M.Z.-Y.C., W.K., B.Y., C.W.Y.C., C.-W.K., R.A.L.), Department of Anatomy (C.W.Y.C.), LKS Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong; Department of Bioengineering, Boston University, MA (A.C., C.S.C.); Harvard Wyss Institute for Biologically Inspired Engineering, Boston, MA (A.C., C.S.C.); and Department of Biology, Hong Kong Baptist University, Hong Kong (B.Y.).

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http://dx.doi.org/10.1161/CIRCEP.114.002049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884688PMC
February 2015

Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions.

J Biomech 2015 Feb 28;48(3):520-8. Epub 2014 Nov 28.

Department of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, UK.

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http://dx.doi.org/10.1016/j.jbiomech.2014.11.025DOI Listing
February 2015

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting.

Nat Commun 2015 Jan 22;6:6135. Epub 2015 Jan 22.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1038/ncomms7135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317495PMC
January 2015

Forms, forces, and stem cell fate.

Curr Opin Cell Biol 2014 Dec 29;31:92-7. Epub 2014 Sep 29.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States; The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2014.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252586PMC
December 2014

A DNA-based molecular probe for optically reporting cellular traction forces.

Nat Methods 2014 Dec 12;11(12):1229-32. Epub 2014 Oct 12.

1] Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA. [2] Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA. [3] The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.3145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247985PMC
December 2014

Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibers.

Biophys J 2014 Dec 2;107(11):2592-603. Epub 2014 Dec 2.

Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.09.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255175PMC
December 2014

Microfabrication of a platform to measure and manipulate the mechanics of engineered microtissues.

Methods Cell Biol 2014 ;121:191-211

Laboratory of Materials and Physical Engineering, CNRS UMR5628, and Grenoble Institute of Technology, Grenoble, France.

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http://dx.doi.org/10.1016/B978-0-12-800281-0.00013-0DOI Listing
November 2014

Computational and experimental investigation of local stress fiber orientation in uniaxially and biaxially constrained microtissues.

Biomech Model Mechanobiol 2014 Oct 24;13(5):1053-63. Epub 2014 Jan 24.

Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB , Eindhoven, The Netherlands,

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http://dx.doi.org/10.1007/s10237-014-0554-zDOI Listing
October 2014

Remodeling of fibrous extracellular matrices by contractile cells: predictions from discrete fiber network simulations.

Biophys J 2014 Oct;107(8):1829-1840

Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213674PMC
October 2014

"Stamp-off" to micropattern sparse, multicomponent features.

Methods Cell Biol 2014 ;119:3-16

Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania USA; Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/B978-0-12-416742-1.00001-9DOI Listing
September 2014

Force-driven evolution of mesoscale structure in engineered 3D microtissues and the modulation of tissue stiffening.

Biomaterials 2014 Jun 12;35(19):5056-64. Epub 2014 Mar 12.

Department of Physics and Astronomy, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2014.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046864PMC
June 2014

Force measurement tools to explore cadherin mechanotransduction.

Cell Commun Adhes 2014 Jun 23;21(3):193-205. Epub 2014 Apr 23.

Department of Chemical and Biomolecular Engineering, University of Pennsylvania , Philadelphia, PA , USA.

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http://dx.doi.org/10.3109/15419061.2014.905929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079283PMC
June 2014

Fluid shear stress threshold regulates angiogenic sprouting.

Proc Natl Acad Sci U S A 2014 Jun 19;111(22):7968-73. Epub 2014 May 19.

Departments of Bioengineering,Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104;Department of Biomedical Engineering, Boston University, Boston, MA 02215; andThe Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115

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http://www.pnas.org/cgi/doi/10.1073/pnas.1310842111
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http://dx.doi.org/10.1073/pnas.1310842111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050561PMC
June 2014

Stem cell differentiation: sticky mechanical memory.

Nat Mater 2014 Jun;13(6):542-3

Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02115, USA, and the Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nmat3989DOI Listing
June 2014

Jostling for position in angiogenic sprouts: continuous rearrangement of cells explained by differential adhesion dynamics.

EMBO J 2014 May 7;33(10):1089-90. Epub 2014 Apr 7.

Wyss Institute for Biologically Inspired Engineering Harvard University, Boston, MA, USA Department of Biomedical Engineering, Boston University, Boston, MA, USA.

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http://dx.doi.org/10.1002/embj.201488452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193916PMC
May 2014

Measuring cell-cell tugging forces using bowtie-patterned mPADs (microarray post detectors).

Methods Mol Biol 2013 ;1066:157-68

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-1-62703-604-7_14DOI Listing
March 2014

Acute slowing of cardiac conduction in response to myofibroblast coupling to cardiomyocytes through N-cadherin.

J Mol Cell Cardiol 2014 Mar 9;68:29-37. Epub 2014 Jan 9.

Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2013.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993970PMC
March 2014

Substrates with engineered step changes in rigidity induce traction force polarity and durotaxis.

Cell Mol Bioeng 2014 Mar 9;7(1):26-34. Epub 2013 Oct 9.

Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055071PMC
http://dx.doi.org/10.1007/s12195-013-0307-6DOI Listing
March 2014

Micropatterned multicolor dynamically adhesive substrates to control cell adhesion and multicellular organization.

Langmuir 2014 Feb 30;30(5):1327-35. Epub 2014 Jan 30.

Department of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania, United States.

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http://dx.doi.org/10.1021/la404037sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983373PMC
February 2014

Label-free evaluation of angiogenic sprouting in microengineered devices using ultrahigh-resolution optical coherence microscopy.

J Biomed Opt 2014 Jan;19(1):16006

Lehigh University, Department of Electrical and Computer Engineering, Bethlehem, Pennsylvania 18015bLehigh University, Center for Photonics and Nanoelectronics, Bethlehem, Pennsylvania 18015hLehigh University, Bioengineering Program, Bethlehem, Pennsylvan.

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http://dx.doi.org/10.1117/1.JBO.19.1.016006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881608PMC
January 2014

Necking and failure of constrained 3D microtissues induced by cellular tension.

Proc Natl Acad Sci U S A 2013 Dec 9;110(52):20923-8. Epub 2013 Dec 9.

Department of Materials Science and Engineering and Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1313662110
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876233PMC
December 2013

Contact inhibition of locomotion probabilities drive solitary versus collective cell migration.

J R Soc Interface 2013 Nov 18;10(88):20130717. Epub 2013 Sep 18.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1098/rsif.2013.0717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785843PMC
November 2013

Endothelial cell sensing of flow direction.

Arterioscler Thromb Vasc Biol 2013 Sep 27;33(9):2130-6. Epub 2013 Jun 27.

Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.

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http://atvb.ahajournals.org/cgi/doi/10.1161/ATVBAHA.113.3018
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http://dx.doi.org/10.1161/ATVBAHA.113.301826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812824PMC
September 2013

Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway.

J Cell Sci 2013 Sep 10;126(Pt 18):4121-35. Epub 2013 Jul 10.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1242/jcs.121988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772387PMC
September 2013

The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions.

PeerJ 2013 20;1:e134. Epub 2013 Aug 20.

Department of Cell Biology, Johns Hopkins University School of Medicine , Baltimore, MD , USA ; Department of Bioengineering, University of Pennsylvania , Philadelphia, PA , USA.

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http://dx.doi.org/10.7717/peerj.134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757464PMC
September 2013

Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients.

Lab Chip 2013 Aug 20;13(16):3246-52. Epub 2013 Jun 20.

Tissue Microfabrication Lab, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1039/c3lc50493jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082768PMC
August 2013

Fibrous hyaluronic acid hydrogels that direct MSC chondrogenesis through mechanical and adhesive cues.

Biomaterials 2013 Jul 24;34(22):5571-80. Epub 2013 Apr 24.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2013.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652578PMC
July 2013

Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation.

J Cell Mol Med 2013 Jul 15;17(7):823-32. Epub 2013 May 15.

Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jcmm.12061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741348PMC
July 2013

Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1.

Curr Biol 2013 Jun 16;23(11):1024-30. Epub 2013 May 16.

Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1016/j.cub.2013.04.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676707PMC
June 2013

How vinculin regulates force transmission.

Proc Natl Acad Sci U S A 2013 Jun 28;110(24):9788-93. Epub 2013 May 28.

Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1216209110
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http://dx.doi.org/10.1073/pnas.1216209110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683711PMC
June 2013

Manipulation of 3D Cluster Size and Geometry by Release from 2D Micropatterns.

Cell Mol Bioeng 2012 Sep;5(3):299-306

Department of Bioengineering, University of Pennsylvania, 510 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s12195-012-0236-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665517PMC
September 2012