Christopher R Vakoc

Christopher R Vakoc

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Christopher R Vakoc

Christopher R Vakoc

Publications by authors named "Christopher R Vakoc"

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84Publications

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Disabling an oncogenic transcription factor by targeting of control kinases.

Oncotarget 2018 Aug 17;9(64):32276-32277. Epub 2018 Aug 17.

Molecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.18632/oncotarget.25971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122356PMC
August 2018

Enhancer dysfunction in leukemia.

Blood 2018 04 9;131(16):1795-1804. Epub 2018 Feb 9.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.

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http://dx.doi.org/10.1182/blood-2017-11-737379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909760PMC
April 2018

The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma.

Cancer Cell 2018 03 1;33(3):527-541.e8. Epub 2018 Mar 1.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881394PMC
March 2018

The Essential Transcriptional Function of BRD4 in Acute Myeloid Leukemia.

Cold Spring Harb Symp Quant Biol 2016 7;81:61-66. Epub 2017 Feb 7.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.

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http://dx.doi.org/10.1101/sqb.2016.81.031039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550326PMC
February 2018

Soils and Seeds That Initiate Pancreatic Cancer Metastasis.

Cancer Discov 2017 10;7(10):1067-1068

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0887DOI Listing
October 2017

Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis.

PLoS One 2017 23;12(2):e0172177. Epub 2017 Feb 23.

Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172177PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322889PMC
August 2017

Targeting Cancer Cells with BET Bromodomain Inhibitors.

Cold Spring Harb Perspect Med 2017 Jul 5;7(7). Epub 2017 Jul 5.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.

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http://dx.doi.org/10.1101/cshperspect.a026674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495050PMC
July 2017

Single-minded CRISPR screening.

Nat Biotechnol 2017 04;35(4):339-340

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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http://dx.doi.org/10.1038/nbt.3849DOI Listing
April 2017

Untangling the genetics from the epigenetics in pancreatic cancer metastasis.

Nat Genet 2017 Feb;49(3):323-324

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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http://dx.doi.org/10.1038/ng.3798DOI Listing
February 2017

Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.

Structure 2016 07 9;24(7):1201-8. Epub 2016 Jun 9.

Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://www.cell.com/structure/pdf/S0969-2126(16)30082-X.pdf
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http://dx.doi.org/10.1016/j.str.2016.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938737PMC
July 2016

Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H).

Cancer Cell 2016 07;30(1):9-10

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.06.018DOI Listing
July 2016

A Biomarker Harvest from One Thousand Cancer Cell Lines.

Cell 2016 Jul;166(3):536-537

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.07.010DOI Listing
July 2016

BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements.

Cell Rep 2016 Apr 7;15(3):519-530. Epub 2016 Apr 7.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838499PMC
April 2016

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.

Blood 2015 Nov 7;126(21):2392-403. Epub 2015 Oct 7.

Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia;

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http://dx.doi.org/10.1182/blood-2015-03-632984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653767PMC
November 2015

Targeting Transcription Factors in Cancer.

Trends Cancer 2015 Sep;1(1):53-65

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1016/j.trecan.2015.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669894PMC
September 2015

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains.

Nat Biotechnol 2015 Jun 11;33(6):661-7. Epub 2015 May 11.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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http://dx.doi.org/10.1038/nbt.3235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529991PMC
June 2015

BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia.

Mol Cell 2015 Jun 14;58(6):1028-39. Epub 2015 May 14.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475489PMC
June 2015

Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention.

Curr Opin Oncol 2015 Jan;27(1):57-63

aCold Spring Harbor Laboratory, Cold Spring Harbor, New York bMolecular and Cellular Biology Program, Stony Brook University, Stony Brook, New York, USA.

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http://dx.doi.org/10.1097/CCO.0000000000000151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355016PMC
January 2015

Brd4 is on the move during inflammation.

Trends Cell Biol 2014 Nov 3;24(11):615-6. Epub 2014 Oct 3.

Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2014.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252248PMC
November 2014

A rationale to target the SWI/SNF complex for cancer therapy.

Trends Genet 2014 Aug 3;30(8):356-63. Epub 2014 Jun 3.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2014.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112150PMC
August 2014

The mechanisms behind the therapeutic activity of BET bromodomain inhibition.

Mol Cell 2014 Jun;54(5):728-36

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236231PMC
June 2014

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.

Cancer Cell 2014 May 1;25(5):652-65. Epub 2014 May 1.

Cancer Biology and Genetics Program, Memorial-Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Memorial-Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206212PMC
May 2014

A new bump in the epigenetic landscape.

Mol Cell 2014 Mar;53(6):857-8

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058326PMC
March 2014

C/EBPα: critical at the origin of leukemic transformation.

J Exp Med 2014 Jan 6;211(1):1-4. Epub 2014 Jan 6.

the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.

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http://dx.doi.org/10.1084/jem.20132530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892974PMC
January 2014

Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia.

Proc Natl Acad Sci U S A 2013 Mar 14;110(10):3901-6. Epub 2013 Feb 14.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1073/pnas.1301045110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593849PMC
March 2013

WRAD: enabler of the SET1-family of H3K4 methyltransferases.

Brief Funct Genomics 2012 May 30;11(3):217-26. Epub 2012 May 30.

Department of Genetics, Dartmouth Medical School, USA.

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http://dx.doi.org/10.1093/bfgp/els017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388306PMC
May 2012

PAF is in the cabal of MLL1-interacting proteins that promote leukemia.

Cancer Cell 2010 Jun;17(6):531-2

Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.05.019DOI Listing
June 2010

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.

Mol Cell Biol 2008 Apr 19;28(8):2825-39. Epub 2008 Feb 19.

Division of Hematology, Abramson Research Center 315A, The Children's Hospital of Philadelphia, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.02076-07
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http://dx.doi.org/10.1128/MCB.02076-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293113PMC
April 2008

Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes.

Mol Cell Biol 2007 Dec 8;27(24):8466-79. Epub 2007 Oct 8.

Children's Hospital of Philadelphia, Division of Hematology, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1128/MCB.00993-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169421PMC
December 2007

Acetylation of GATA-1 is required for chromatin occupancy.

Blood 2006 Dec 3;108(12):3736-8. Epub 2006 Aug 3.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2006-07-032847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895476PMC
December 2006

Profile of histone lysine methylation across transcribed mammalian chromatin.

Mol Cell Biol 2006 Dec 9;26(24):9185-95. Epub 2006 Oct 9.

The Children's Hospital of Philadelphia, Division of Hematology, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1128/MCB.01529-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698537PMC
December 2006

In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation.

Biotechniques 2006 Dec;41(6):694, 696, 698

The Wistar Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.2144/000112297DOI Listing
December 2006

Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin.

Mol Cell 2005 Aug;19(3):381-91

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.06.011DOI Listing
August 2005

FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1.

EMBO J 2005 Jul 26;24(13):2367-78. Epub 2005 May 26.

Division of Hematology, Children's Hospital of Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1038/sj.emboj.7600703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1173144PMC
July 2005

Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.

Mol Cell 2005 Feb;17(3):453-62

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.molcel.2004.12.028DOI Listing
February 2005

Global regulation of erythroid gene expression by transcription factor GATA-1.

Blood 2004 Nov 5;104(10):3136-47. Epub 2004 Aug 5.

The Children's Hospital of Philadelphia, Division of Hematology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2004-04-1603DOI Listing
November 2004