Christopher P Austin

Christopher P Austin

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Christopher P Austin

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The NCATS Pharmaceutical Collection: a 10-year update.

Drug Discov Today 2019 Oct 1. Epub 2019 Oct 1.

Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.drudis.2019.09.019DOI Listing
October 2019

Deconstructing the Translational Tower of Babel.

Clin Transl Sci 2019 Mar 9;12(2):85. Epub 2018 Nov 9.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.

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http://doi.wiley.com/10.1111/cts.12595
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http://dx.doi.org/10.1111/cts.12595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440561PMC
March 2019

Recommendations toward a human pathway-based approach to disease research.

Drug Discov Today 2018 11 2;23(11):1824-1832. Epub 2018 Jun 2.

Humane Society International, The Humane Society of the United States, 700 Professional Drive, Gaithersburg, MD 20879, USA.

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http://dx.doi.org/10.1016/j.drudis.2018.05.038DOI Listing
November 2018

Genome editing to 're-write' wrongs.

Nat Rev Drug Discov 2018 10 22;17(10):689-690. Epub 2018 Jun 22.

National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/nrd.2018.91DOI Listing
October 2018

Translating translation.

Nat Rev Drug Discov 2018 07 20;17(7):455-456. Epub 2018 Apr 20.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/nrd.2018.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023744PMC
July 2018

A Global Approach to Rare Diseases Research and Orphan Products Development: The International Rare Diseases Research Consortium (IRDiRC).

Adv Exp Med Biol 2017 ;1031:349-369

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, 20892-1851, USA.

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http://dx.doi.org/10.1007/978-3-319-67144-4_20DOI Listing
June 2018

Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development.

Clin Transl Sci 2018 03 22;11(2):166-174. Epub 2017 Dec 22.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/cts.12531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866991PMC
March 2018

A dynamic map for learning, communicating, navigating and improving therapeutic development.

Nat Rev Drug Discov 2018 02 22;17(2):150. Epub 2017 Dec 22.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20817, USA.

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http://dx.doi.org/10.1038/nrd.2017.217DOI Listing
February 2018

Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles.

Sci Rep 2018 02 28;8(1):3783. Epub 2018 Feb 28.

Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, 20850, USA.

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http://dx.doi.org/10.1038/s41598-018-22046-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830476PMC
February 2018

Progress in Rare Diseases Research 2010-2016: An IRDiRC Perspective.

Clin Transl Sci 2018 01 23;11(1):11-20. Epub 2017 Oct 23.

National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/cts.12501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759730PMC
January 2018

Voluntary Site Accreditation - Improving the Execution of Multicenter Clinical Trials.

N Engl J Med 2017 Oct;377(15):1414-1415

From Dell Medical School, University of Texas, Austin (S.C.J.); Pfizer, New York (F.L.-H.); and the National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD (C.P.A.).

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http://dx.doi.org/10.1056/NEJMp1709203DOI Listing
October 2017

Medical research: Next decade's goals for rare diseases.

Nature 2017 08;548(7666):158

Office of Population Health Genomics, Government of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1038/548158cDOI Listing
August 2017

'IRDiRC Recognized Resources': a new mechanism to support scientists to conduct efficient, high-quality research for rare diseases.

Eur J Hum Genet 2017 02 26;25(2):162-165. Epub 2016 Oct 26.

Department of Genetics, Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1038/ejhg.2016.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255942PMC
February 2017

Fostering collaborative research for rare genetic disease: the example of niemann-pick type C disease.

Orphanet J Rare Dis 2016 12 1;11(1):161. Epub 2016 Dec 1.

Diabetic Cardiovascular Disease Center, Washington University School of Medicine, Box 8086, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1186/s13023-016-0540-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131440PMC
December 2016

The NIH-Industry New Therapeutic Uses Pilot Program: Demonstrating the Power of Crowdsourcing.

Assay Drug Dev Technol 2015 Jul-Aug;13(6):297-8

National Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland.

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http://dx.doi.org/10.1089/adt.2015.29006.cmcdrrrDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533092PMC
May 2016

Putting translational science on to a global stage.

Nat Rev Drug Discov 2016 04;15(4):217-8

EATRIS ERIC, European Infrastructure for Translational Medicine, Amsterdam 1081 HZ, Netherlands.

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http://dx.doi.org/10.1038/nrd.2016.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378162PMC
April 2016

Gene Therapy: The View from NCATS.

Hum Gene Ther 2016 Jan;27(1):7-13

3 Office of the Director, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health , Bethesda, Maryland.

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http://dx.doi.org/10.1089/hum.2016.29018.pjbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743673PMC
January 2016

Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.

Nat Commun 2016 Jan 26;7:10425. Epub 2016 Jan 26.

Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA.

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http://dx.doi.org/10.1038/ncomms10425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777217PMC
January 2016

Genome-wide Analysis of Host-Plasmodium yoelii Interactions Reveals Regulators of the Type I Interferon Response.

Cell Rep 2015 Jul 16;12(4):661-72. Epub 2015 Jul 16.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8132, USA; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, PRC. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520759PMC
July 2015

A high throughput screening assay system for the identification of small molecule inhibitors of gsp.

PLoS One 2014 25;9(3):e90766. Epub 2014 Mar 25.

Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090766PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965391PMC
January 2015

Identification of small molecule modulators of gene transcription with anticancer activity.

ACS Chem Biol 2014 Nov 16;9(11):2603-11. Epub 2014 Sep 16.

Hamon Center for Therapeutic Oncology Research and ∥Department of Pharmacology, University of Texas Southwestern Medical Center , Dallas, Texas 75390, United States.

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http://dx.doi.org/10.1021/cb500532xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245161PMC
November 2014

Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay.

Mol Endocrinol 2014 Jul 21;28(7):1194-206. Epub 2014 May 21.

Steroid Hormones Section (J.A.B., E.J.D., M.P., S.S.S.), Laboratory of Endocrinology and Receptor Biology, and Laboratory of Biological Modeling (C.C.C.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; and National Center for Advancing Translational Sciences (K.R.B., M.S., Z.L., D.S.A., C.P.A.), National Institutes of Health, Rockville, Maryland 20892.

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http://dx.doi.org/10.1210/me.2014-1069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075162PMC
July 2014

Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs.

PLoS One 2013 20;8(9):e75252. Epub 2013 Sep 20.

National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075252PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779154PMC
May 2014

Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia.

Cancer Res 2014 May 5;74(9):2520-32. Epub 2014 Mar 5.

Authors' Affiliations: Houston Methodist Research Institute; The University of Texas M.D. Anderson Cancer Center, Houston, Texas; Hematology Branch, National Heart Lung and Blood Institute (NHLBI); National Center for Advancing Translational Sciences, NIH, Bethesda, Maryland; The University of Kansas Medical Center; Institute for Advancing Medical Innovation, Kansas University, Kansas City, Kansas; Division of Hematology, Department of Internal Medicine, The Comprehensive Cancer Center at the Ohio State University, Columbus, Ohio; and Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172421PMC
May 2014

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.

Proc Natl Acad Sci U S A 2014 Feb 27;111(6):2349-54. Epub 2014 Jan 27.

Division of Preclinical Innovation, National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, Metabolism Branch, Center for Cancer Research, and Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1311846111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926026PMC
February 2014

Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format.

J Biomol Screen 2014 Jan 3;19(1):66-76. Epub 2013 Sep 3.

1National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://journals.sagepub.com/doi/10.1177/1087057113502851
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http://dx.doi.org/10.1177/1087057113502851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550094PMC
January 2014

Innovation in therapeutics development at the NCATS.

Neuropsychopharmacology 2014 Jan;39(1):230-2

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/npp.2013.247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857672PMC
January 2014

Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor.

J Med Chem 2013 Nov 11;56(22):9045-56. Epub 2013 Nov 11.

National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States .

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http://pubs.acs.org/doi/10.1021/jm400904m
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http://dx.doi.org/10.1021/jm400904mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877059PMC
November 2013

Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening.

Chem Res Toxicol 2013 Sep 15;26(9):1323-32. Epub 2013 Aug 15.

National Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/tx4001754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154066PMC
September 2013

A high-throughput screening assay for determining cellular levels of total tau protein.

Curr Alzheimer Res 2013 Sep;10(7):679-87

National Center for Advancing Translational Sciences, NIH, 9800 Medical Center Drive, MSC: 3370, Bethesda, MD 20892-3370, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010324PMC
September 2013

The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality.

Drug Discov Today 2013 Aug 31;18(15-16):716-23. Epub 2013 May 31.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.drudis.2013.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771082PMC
August 2013

Are hERG channel blockers also phospholipidosis inducers?

Bioorg Med Chem Lett 2013 Aug 20;23(16):4587-90. Epub 2013 Jun 20.

National Center for Advancing Translational Sciences, National Institutes of Health (NIH), 9800 Medical Center Drive, Bethesda, Rockville, MD 20892, USA.

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http://dx.doi.org/10.1016/j.bmcl.2013.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736554PMC
August 2013

Improving the human hazard characterization of chemicals: a Tox21 update.

Environ Health Perspect 2013 Jul 19;121(7):756-65. Epub 2013 Apr 19.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/ehp.1205784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701992PMC
July 2013

Identification of repurposed small molecule drugs for chordoma therapy.

Cancer Biol Ther 2013 Jul 10;14(7):638-47. Epub 2013 May 10.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.4161/cbt.24596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742493PMC
July 2013

Bisphenol A affects androgen receptor function via multiple mechanisms.

Chem Biol Interact 2013 May 4;203(3):556-64. Epub 2013 Apr 4.

DNTP Biomolecular Screening Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Research Triangle Park, NC, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00092797130007
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http://dx.doi.org/10.1016/j.cbi.2013.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722857PMC
May 2013

A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.

Antimicrob Agents Chemother 2013 Jan 5;57(1):425-35. Epub 2012 Nov 5.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.00920-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535893PMC
January 2013

High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model.

Curr Chem Genomics 2012 28;6:79-86. Epub 2012 Dec 28.

National Center for Advancing Translational Sciences, National Institutes of Health. 9800 Medical Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.2174/1875397301206010079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551243PMC
January 2013

Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors.

ACS Med Chem Lett 2013 Jan;4(1):79-84

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1021/ml300286hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770298PMC
January 2013

Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules.

Mol Inform 2012 Nov 11;31(11-12):783-792. Epub 2012 Oct 11.

National Center for Advancing Translational Sciences, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/minf.201200065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583379PMC
November 2012

Evaluation of cholesterol reduction activity of methyl-β-cyclodextrin using differentiated human neurons and astrocytes.

J Biomol Screen 2012 Oct 24;17(9):1243-51. Epub 2012 Aug 24.

Therapeutics of Rare and Neglected Disease, National Center for Advancing Translational Sciences, Bethesda, Maryland, NIH, Bethesda, MD 20892-3370, USA.

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http://dx.doi.org/10.1177/1087057112456877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530257PMC
October 2012

Paradigm shift in toxicity testing and modeling.

AAPS J 2012 Sep 20;14(3):473-80. Epub 2012 Apr 20.

Department of Health and Human Services, NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892-3370, USA.

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http://dx.doi.org/10.1208/s12248-012-9358-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385826PMC
September 2012

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.

Proc Natl Acad Sci U S A 2012 Sep 21;109(36):14592-7. Epub 2012 Aug 21.

Oncogenesis and Development Section, National Institute of Allergy and Infectious Diseases, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1200037109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437880PMC
September 2012

Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening.

J Transl Med 2012 Sep 21;10:198. Epub 2012 Sep 21.

Endocrine Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 10 Center Drive, MSC 1201, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1479-5876-10-198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493320PMC
September 2012

Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach.

Environ Health Perspect 2012 Aug 2;120(8):1150-6. Epub 2012 May 2.

NIH Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA.

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http://dx.doi.org/10.1289/ehp.1104709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440086PMC
August 2012

Structure based model for the prediction of phospholipidosis induction potential of small molecules.

J Chem Inf Model 2012 Jul 5;52(7):1798-805. Epub 2012 Jul 5.

National Institutes of Health (NIH) Chemical Genomics Center, NIH, Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/ci3001875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484221PMC
July 2012

High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase.

PLoS One 2012 17;7(1):e29861. Epub 2012 Jan 17.

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029861PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260169PMC
June 2012

Application of a homogenous membrane potential assay to assess mitochondrial function.

Physiol Genomics 2012 May 20;44(9):495-503. Epub 2012 Mar 20.

NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892-3370, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00161.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426425PMC
May 2012

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.

Proc Natl Acad Sci U S A 2012 Apr 19;109(14):5423-8. Epub 2012 Mar 19.

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1114278109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325711PMC
April 2012

Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership.

Cancer Res 2012 Mar 13;72(5):1055-8. Epub 2012 Jan 13.

Institute for Advancing Medical Innovation, University of Kansas Cancer Center, Kansas City, Kansas, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-11-3439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341848PMC
March 2012

Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.

Anal Bioanal Chem 2012 Feb 5;402(5):1889-98. Epub 2012 Jan 5.

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00216-011-5604-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280409PMC
February 2012

Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data.

J Chem Inf Model 2011 Oct 26;51(10):2474-81. Epub 2011 Sep 26.

National Institutes of Health, Chemical Genomics Center, NIH, Bethesda, Maryland 20892, United States.

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http://pubs.acs.org/doi/abs/10.1021/ci200311w
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http://dx.doi.org/10.1021/ci200311wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200453PMC
October 2011

Discovery, synthesis, and biological evaluation of novel SMN protein modulators.

J Med Chem 2011 Sep 19;54(18):6215-33. Epub 2011 Aug 19.

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Rockville, Maryland 20850, USA.

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http://dx.doi.org/10.1021/jm200497tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174349PMC
September 2011

Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors.

Bioorg Med Chem Lett 2011 Sep 21;21(18):5239-43. Epub 2011 Jul 21.

NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Dr., Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.07.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681418PMC
September 2011

Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

Environ Health Perspect 2011 Aug 4;119(8):1142-8. Epub 2011 May 4.

National Institutes of Health Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-3370, USA.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.1002952
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http://dx.doi.org/10.1289/ehp.1002952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237348PMC
August 2011

Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format.

Cell Mol Neurobiol 2011 Aug 20;31(6):901-7. Epub 2011 May 20.

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://link.springer.com/10.1007/s10571-011-9689-y
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http://dx.doi.org/10.1007/s10571-011-9689-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146558PMC
August 2011

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.

Science 2011 Aug;333(6043):724-9

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/science.1205216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396183PMC
August 2011

Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells.

Curr Chem Genomics 2011 10;5:21-9. Epub 2011 May 10.

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.2174/1875397301105010021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106354PMC
July 2011

Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents.

Pharmacol Biochem Behav 2011 May 4;98(3):349-55. Epub 2011 Feb 4.

Biomarker Laboratory, National Institute of Mental Health, Mood and Anxiety Disorders Program, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.pbb.2011.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065502PMC
May 2011

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.

Toxicol Appl Pharmacol 2011 May 26;252(3):250-8. Epub 2011 Feb 26.

NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892-3370, USA.

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http://dx.doi.org/10.1016/j.taap.2011.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079779PMC
May 2011

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.

J Med Chem 2011 Feb 20;54(4):1033-58. Epub 2011 Jan 20.

NIH Chemical Genomic Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland, United States.

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http://dx.doi.org/10.1021/jm1008902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103057PMC
February 2011