Technical Advisor (Policy, Access and Introduction)
Nairobi | Kenya
Main Specialties: Epidemiology, Infectious Disease, Public Health
Additional Specialties: Epidemiology, Public/ Community Health, Health Impact
I have over 10 years’ research experience, having worked with the KEMRICDC Research and Public Health Collaboration in Western Kenya and contributing to the conceptualization, implementation and evaluation of numerous malaria research projects and interventions. I have led a number of malaria prevention studies ranging from community prevalence studies, drug efficacy studies and clinical trials on malaria vaccines.
I’m currently a Technical Advisor at PATH’s Center for Vaccine Innovation and Access (CVIA). I support Ministries of Health (MoH) through the Malaria (National Malaria Control Program - NMCP) and Immunization (Expanded Program on Immunization - EPI) programs on planning for introduction, implementation and evaluation of vaccines and malaria interventions. These range from support for writing vaccine introduction plans, EPI program reviews, joint planning processes, cMYP reviews, cold chain capacity assessments among others for the EPI programs and Global Fund Country applications, NMCP program assessment and reviews, planning, conducting, analysis and presentation of Malaria Indicator Surveys amongst others for NMCP.
My experience covers multi-disciplinary and multi-cultural teams and I possess strong interpersonal skills. My main aspiration is to continue to contribute to the body of knowledge while advancing knowledge on public health interventions particularly on disadvantaged communities. I aspire to contribute to the efforts aimed at making available efficacious and cost effective interventions to people who need them most and ensuring their most optimal use and application.
Primary Affiliation: PATH - Nairobi , Kenya
898PubMed Central Citations
Nat Commun 2018 04 11;9(1):1381. Epub 2018 Apr 11.
Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Lancet Infect Dis 2016 Oct 7;16(10):1134-1144. Epub 2016 Jul 7.
Division of Parasitic Diseases and Malaria, Centers for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Malar J 2016 08 19;15(1):421. Epub 2016 Aug 19.
Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Background Although malaria control intervention has greatly decreased malaria morbidity and mortality in many African countries, further decline in parasite prevalence has stagnated in western Kenya. In order to assess if malaria transmission reservoir is associated with this stagnation, submicroscopic infection and gametocyte carriage was estimated. Risk factors and associations between malaria control interventions and gametocyte carriage were further investigated in this study. Methods A total of 996 dried blood spot samples were used from two strata, all smear-positives (516 samples) and randomly selected smear-negatives (480 samples), from a community cross-sectional survey conducted at peak transmission season in 2012 in Siaya County, western Kenya. Plasmodium falciparum parasite presence and density were determined by stained blood smear and by 18S mRNA transcripts using nucleic acid sequence-based amplification assay (NASBA), gametocyte presence and density were determined by blood smear and by Pfs25 mRNA-NASBA, and gametocyte diversity by Pfg377 mRNA RT-PCR and RT-qPCR. Results Of the randomly selected smear-negative samples, 69.6 % (334/480) were positive by 18S-NASBA while 18S-NASBA detected 99.6 % (514/516) smear positive samples. Overall, 80.2 % of the weighted population was parasite positive by 18S-NASBA vs 30.6 % by smear diagnosis and 44.0 % of the weighted population was gametocyte positive by Pfs25-NASBA vs 2.6 % by smear diagnosis. Children 5–15 years old were more likely to be parasitaemic and gametocytaemic by NASBA than individuals >15 years old or children <5 years old while gametocyte density decreased with age. Anaemia and self-reported fever within the past 24 h were associated with increased odds of gametocytaemia. Fever was also positively associated with parasite density, but not with gametocyte density. Anti-malarial use within the past 2 weeks decreased the odds of gametocytaemia, but not the odds of parasitaemia. In contrast, recent anti-malarial use was associated with lowered parasite density, but not the gametocyte density. Use of ITNs was associated with lower odds for parasitaemia in part of the study area with a longer history of ITN interventions. In the same part of study area, the odds of having multiple gametocyte alleles were also lower in individuals using ITNs than in those not using ITNs and parasite density was positively associated with gametocyte diversity. Conclusion A large proportion of submicroscopic parasites and gametocytes in western Kenya might contribute to the stagnation in malaria prevalence, suggesting that additional interventions targeting the infectious reservoir are needed. As school aged children and persons with anaemia and fever were major sources for gametocyte reservoir, these groups should be targeted for intervention and prevention to reduce malaria transmission. Anti-malarial use was associated with lower parasite density and odds of gametocytaemia, but not the gametocyte density, indicating a limitation of anti-malarial impact on the transmission reservoir. ITN use had a protective role against parasitaemia and gametocyte diversity in western Kenya.
Malar J 2015 Dec 9;13 Suppl 1:495. Epub 2015 Dec 9.
Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Lancet 2015 Jul 23;386(9988):31-45. Epub 2015 Apr 23.
Malar J 2015 Feb 14;14:75. Epub 2015 Feb 14.
Malaria Branch and Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Malar J 2014 Nov 22;13:451. Epub 2014 Nov 22.
Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA.
PLoS Med 2014 Jul 29;11(7):e1001685. Epub 2014 Jul 29.
Malar J 2013 Jul 19;12:254. Epub 2013 Jul 19.
Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA.
N Engl J Med 2012 Dec 9;367(24):2284-95. Epub 2012 Nov 9.
Albert Schweitzer Hospital, Lambaréné, Gabon.
N Engl J Med 2011 11 18;365(20):1863-75. Epub 2011 Oct 18.
Albert Schweitzer Hospital, Lambarene, Gabon.
Trop Med Int Health 2009 Mar 28;14(3):294-300. Epub 2009 Jan 28.
Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.