Publications by authors named "Christopher McCurdy"

100Publications

Assessing the therapeutic potential and toxicity of in opioid use disorder.

Expert Opin Drug Metab Toxicol 2020 Nov 19. Epub 2020 Nov 19.

Department of Pharmaceutics, College of Pharmacy, University of Florida , Gainesville, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17425255.2021.1853706DOI Listing
November 2020

Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence.

Drug Alcohol Depend 2020 Nov 22;216:108310. Epub 2020 Sep 22.

Department of Medicinal Chemistry, University of Florida, Gainesville, FL, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2020.108310DOI Listing
November 2020

Bioanalytical method development and pharmacokinetics of MCI-92, a sigma-1 receptor ligand.

J Pharm Biomed Anal 2020 Nov 13;191:113610. Epub 2020 Sep 13.

Translational Drug Development Core, Clinical and Translational Science Institute, University of Florida, Gainesville, FL, USA; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2020.113610DOI Listing
November 2020

Adolescent nicotine and tobacco smoke exposure enhances nicotine self-administration in female rats.

Neuropharmacology 2020 10 20;176:108243. Epub 2020 Jul 20.

Department of Psychiatry, University of Florida, Gainesville, FL, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2020.108243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660018PMC
October 2020

Pharmacokinetics and Safety of Mitragynine in Beagle Dogs.

Planta Med 2020 Nov 21;86(17):1278-1285. Epub 2020 Jul 21.

Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1212-5475DOI Listing
November 2020

Kratom (Mitragyna speciosa): worldwide issues.

Curr Opin Psychiatry 2020 07;33(4):312-318

Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/YCO.0000000000000621DOI Listing
July 2020

Development of Cannabinoids in Flowers of Industrial Hemp ( L.): A Pilot Study.

J Agric Food Chem 2020 Jun 18;68(22):6058-6064. Epub 2020 May 18.

North Florida Research and Education Center, University of Florida, Quincy, Florida 32351, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jafc.0c01211DOI Listing
June 2020

Pharmacological characterization of mitragynine, the primary constituent in Kratom, as a potential medication for opioid use disorder.

J Pharmacol Toxicol Methods 2019 Sep - Oct;99:106595. Epub 2019 Oct 17.

University of Florida, Gainesville, FL, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vascn.2019.05.012DOI Listing
October 2019

Bioanalytical method development and validation of corynantheidine, a kratom alkaloid, using UPLC-MS/MS, and its application to preclinical pharmacokinetic studies.

J Pharm Biomed Anal 2020 Feb 5;180:113019. Epub 2019 Dec 5.

Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA; Translational Drug Development Core, Clinical and Translational Sciences Institute, University of Florida, Gainesville, FL, 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2019.113019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350276PMC
February 2020

Patterns and reasons for kratom (Mitragyna speciosa) use among current and former opioid poly-drug users.

J Ethnopharmacol 2020 Mar 7;249:112462. Epub 2019 Dec 7.

Centre for Drug Research, Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.112462DOI Listing
March 2020

Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Dec 12;1134-1135:121875. Epub 2019 Nov 12.

Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA; Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2019.121875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027589PMC
December 2019

Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids.

Toxicol Lett 2020 Feb 7;319:148-154. Epub 2019 Nov 7.

Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA; Translational Drug Development Core, Clinical and Translational Science Institute, University of Florida, Gainesville, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2019.11.005DOI Listing
February 2020

Benzimidazolone-based selective σ receptor ligands: Synthesis and pharmacological evaluation.

Eur J Med Chem 2019 Mar 9;165:250-257. Epub 2019 Jan 9.

Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA; Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369001PMC
March 2019

Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[]oxazol-2(3)-one (SN79) Derivatives.

J Pharmacol Exp Ther 2019 02 7;368(2):272-281. Epub 2018 Dec 7.

Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island (H.E.N., A.B.C., W.D.B.); Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (W.F.A., C.M., C.R.M.); and Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida (S.I., M.M., C.R.M.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.118.253484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346378PMC
February 2019

Comparative Pharmacokinetics of Mitragynine after Oral Administration of Mitragyna speciosa (Kratom) Leaf Extracts in Rats.

Planta Med 2019 Mar 16;85(4):340-346. Epub 2018 Nov 16.

Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0770-3683DOI Listing
March 2019

The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360.

AAPS PharmSciTech 2018 Nov 3;19(8):3325-3327. Epub 2018 Nov 3.

, 3601 Sweeten Creek Road, Chapel Hill, NC, 27514, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12249-018-1200-3DOI Listing
November 2018

Structure-Based Identification of Potent Natural Product Chemotypes as Cannabinoid Receptor 1 Inverse Agonists.

Molecules 2018 Oct 13;23(10). Epub 2018 Oct 13.

Department of BioMolecular Sciences, Division of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, MS 38677, USA.

View Article

Download full-text PDF

Source
http://www.mdpi.com/1420-3049/23/10/2630
Publisher Site
http://dx.doi.org/10.3390/molecules23102630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222380PMC
October 2018

Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.

Addict Biol 2019 09 27;24(5):874-885. Epub 2018 Jun 27.

Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/adb.12639
Publisher Site
http://dx.doi.org/10.1111/adb.12639DOI Listing
September 2019

Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel.

Oncotarget 2017 Aug 26;8(35):59345-59358. Epub 2017 Jul 26.

McPherson Eye Research Institute, University of Wisconsin, Madison, WI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.19581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601737PMC
August 2017

Radiosynthesis and First-In-Human PET/MRI Evaluation with Clinical-Grade [F]FTC-146.

Mol Imaging Biol 2017 Oct;19(5):779-786

Molecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, 1201 Welch Road, PS049, Stanford, CA, 94305-5484, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11307-017-1064-z
Publisher Site
http://dx.doi.org/10.1007/s11307-017-1064-zDOI Listing
October 2017

A Role for Sigma Receptors in Stimulant Self-Administration and Addiction.

Handb Exp Pharmacol 2017 ;244:177-218

Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, Oxford, MS, 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/164_2016_94DOI Listing
April 2018

Quantification of highly selective sigma-1 receptor antagonist CM304 using liquid chromatography tandem mass spectrometry and its application to a pre-clinical pharmacokinetic study.

Drug Test Anal 2017 Aug 11;9(8):1236-1242. Epub 2017 Apr 11.

Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dta.2156DOI Listing
August 2017

Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine.

J Med Toxicol 2016 12 17;12(4):341-349. Epub 2016 Oct 17.

Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA, 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13181-016-0588-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135684PMC
December 2016

Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists.

J Pharmacol Exp Ther 2016 07 21;358(1):109-24. Epub 2016 Apr 21.

Psychobiology Section, Intramural Research Program, National Institutes of Health National Institute on Drug Abuse, Baltimore, Maryland (J.L.K., T.H., T.A.K.); Drug Design and Synthesis Section, Intramural Research Program, National Institutes of Health National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Baltimore, Maryland (K.C.R.); and Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (C.M., S.N., A.H.A., C.R.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.116.232728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931880PMC
July 2016

The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes.

EBioMedicine 2015 Nov 19;2(11):1806-13. Epub 2015 Oct 19.

Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2015.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740303PMC
November 2015

Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma.

J Pharmacol Exp Ther 2016 Feb 16;356(2):232-43. Epub 2015 Nov 16.

Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island (H.N., W.D.B.); and Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (C.M., C.R.M.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.115.228387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746495PMC
February 2016

In vitro opioid receptor affinity and in vivo behavioral studies of Nelumbo nucifera flower.

J Ethnopharmacol 2015 Nov 7;174:57-65. Epub 2015 Aug 7.

National Center for Natural Products Research, School of Pharmacy, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2015.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636954PMC
November 2015

Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity.

J Pharmacol Exp Ther 2015 Aug 1;354(2):203-12. Epub 2015 Jun 1.

Department of Molecular Pharmacology, Physiology & Biotechnology, Brown University, Providence, Rhode Island (H.N., A.C., W.D.B.); and Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (C.M., C.R.M.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.115.224105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518069PMC
August 2015

Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents.

Bioorg Med Chem 2015 Jul 25;23(13):3248-59. Epub 2015 Apr 25.

National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, MS 38677, USA; Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, MS 38677, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2015.04.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467529PMC
July 2015

Evaluation of Phytocannabinoids from High Potency using Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2.

Med Chem Res 2014 Sep;23(9):4295-4300

Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, MS 38677, USA ; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University Mississippi 38677, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s00044-014-0972
Web Search
http://link.springer.com/10.1007/s00044-014-0972-6
Publisher Site
http://dx.doi.org/10.1007/s00044-014-0972-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235762PMC
September 2014

Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors.

J Med Chem 2014 Nov 21;57(21):8903-27. Epub 2014 Oct 21.

Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi , University, Mississippi 38677, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm500989nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234442PMC
November 2014

Flavanones from

Phytochem Lett 2014 Feb;7:130-132

Department of Medicinal Chemistry, The University of Mississippi, University, MS 38677, USA ; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phytol.2013.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070512PMC
February 2014

Novel pyrazolopyrimidine derivatives targeting COXs and iNOS enzymes; design, synthesis and biological evaluation as potential anti-inflammatory agents.

Eur J Pharm Sci 2014 Oct 4;62:197-211. Epub 2014 Jun 4.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejps.2014.05.025DOI Listing
October 2014

SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation.

Exp Neurol 2014 Apr 6;254:180-9. Epub 2014 Feb 6.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, 1 Medical Center Dr., West Virginia University Health Sciences Center, Morgantown, WV 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, 1 Medical Center Dr., West Virginia University Health Sciences Center, Morgantown, WV 26506, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2014.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241368PMC
April 2014

Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro.

Eur J Pharmacol 2014 Feb 28;724:193-203. Epub 2013 Dec 28.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2013.12.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993961PMC
February 2014

Development and validation of a UPLC-MS/MS method for the determination of 7-hydroxymitragynine, a μ-opioid agonist, in rat plasma and its application to a pharmacokinetic study.

Biomed Chromatogr 2013 Dec 25;27(12):1726-32. Epub 2013 Jul 25.

Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bmc.2986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029328PMC
December 2013

Mephedrone (4-methylmethcathinone), a principal constituent of psychoactive bath salts, produces behavioral sensitization in rats.

Drug Alcohol Depend 2013 Dec 23;133(2):746-50. Epub 2013 Jul 23.

Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA; Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2013.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989200PMC
December 2013

Structure activity relationship study of benzo[d]thiazol-2(3H)one based σ receptor ligands.

Bioorg Med Chem Lett 2013 Sep 29;23(17):5011-3. Epub 2013 Jun 29.

Department of Medicinal Chemistry, University of Mississippi, University, MS 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2013.06.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762478PMC
September 2013

σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation.

Pharmacol Rep 2013 ;65(2):343-9

Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, 1 Medical Center Drive, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1734-1140(13)71009-0DOI Listing
February 2014

SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation.

Exp Neurol 2013 Sep 28;247:134-42. Epub 2013 Apr 28.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, 1 Medical Center Dr., West Virginia University Health Sciences Center, Morgantown, WV 26506, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2013.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742718PMC
September 2013

Heteroatom analogues of hydrocodone: synthesis and biological activity.

J Org Chem 2013 Apr 6;78(7):2914-25. Epub 2013 Mar 6.

Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo3026753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618612PMC
April 2013

The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice.

Int J Neuropsychopharmacol 2013 Jun 29;16(5):1033-44. Epub 2012 Aug 29.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1461145712000831DOI Listing
June 2013

Antidepressive effects of the κ-opioid receptor agonist salvinorin A in a rat model of anhedonia.

Behav Pharmacol 2012 Oct;23(7):710-5

Department of Behavioral Neuroscience, University of Missouri, St Louis, Missouri 63121, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FBP.0b013e3283586189DOI Listing
October 2012

Pharmacological evaluation of SN79, a sigma (σ) receptor ligand, against methamphetamine-induced neurotoxicity in vivo.

Eur Neuropsychopharmacol 2013 Aug 24;23(8):960-71. Epub 2012 Aug 24.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, PO Box 9500, Morgantown, WV 26506, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euroneuro.2012.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748261PMC
August 2013

A 96-well filtration method for radioligand binding analysis of σ receptor ligands.

J Pharm Biomed Anal 2012 Dec 9;71:157-61. Epub 2012 Aug 9.

Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2012.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726061PMC
December 2012

Sigma receptor antagonists attenuate acute methamphetamine-induced hyperthermia by a mechanism independent of IL-1β mRNA expression in the hypothalamus.

Eur J Pharmacol 2012 Sep 20;691(1-3):103-9. Epub 2012 Jul 20.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2012.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726051PMC
September 2012

Nonpeptide ligands of neuropeptide FF: current status and structural insights.

Future Med Chem 2012 Jun;4(9):1085-92

Department of Medicinal Chemistry, 419 Faser Hall, The University of Mississippi, MS 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/fmc.12.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606921PMC
June 2012

SAR analysis of new dual targeting fluoroquinolones. Implications of the benzenesulfonyl group.

Med Chem 2012 May;8(3):349-60

Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville, Edwardsville, IL 62026, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/157340612800786633DOI Listing
May 2012

Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its application to a pharmacokinetic study.

J Chromatogr B Analyt Technol Biomed Life Sci 2012 Apr 20;891-892:1-6. Epub 2011 Dec 20.

Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2011.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992999PMC
April 2012

CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain.

Pharmacol Biochem Behav 2012 Mar 30;101(1):174-80. Epub 2011 Dec 30.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pbb.2011.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726055PMC
March 2012

Herbal medicines for the management of opioid addiction: safe and effective alternatives to conventional pharmacotherapy?

CNS Drugs 2011 Dec;25(12):999-1007

Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.2165/11596830-000000000-00000
Publisher Site
http://dx.doi.org/10.2165/11596830-000000000-00000DOI Listing
December 2011

Synthesis and pharmacological evaluation of indole-based sigma receptor ligands.

Eur J Med Chem 2011 Oct 29;46(10):5154-61. Epub 2011 Aug 29.

Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2011.08.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272488PMC
October 2011

CM156, a high affinity sigma ligand, attenuates the stimulant and neurotoxic effects of methamphetamine in mice.

Neuropharmacology 2011 Oct-Nov;61(5-6):992-1000. Epub 2011 Jul 7.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2011.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615888PMC
February 2012

Strategies to treat substance abuse and addiction.

Curr Top Med Chem 2011 ;11(9):1102

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/156802611795371297DOI Listing
August 2011

Early development of sigma-receptor ligands.

Future Med Chem 2011 Jan;3(1):79-94

Departments of Medicinal Chemsitry, School of Pharmacy, The University of Mississippi, MS 38655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/fmc.10.279DOI Listing
January 2011

N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers.

Proc Natl Acad Sci U S A 2011 Mar 8;108(12):5098-103. Epub 2011 Mar 8.

Department of Medicinal Chemistry, College of Pharmacy, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1016277108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064379PMC
March 2011

Computational Study on the Conformations of Mitragynine and Mitragynaline.

Theochem 2010 Apr;945(1-3):57-63

Department of Medicinal Chemistry, University of Mississippi, MS, 38677-1848, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.theochem.2010.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031075PMC
April 2010

Synthesis and characterization of [³H]-SN56, a novel radioligand for the σ₁ receptor.

Eur J Pharmacol 2011 Feb 2;653(1-3):1-7. Epub 2010 Dec 2.

Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2010.10.099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726058PMC
February 2011

Sigma receptors and cocaine abuse.

Curr Top Med Chem 2011 ;11(9):1128-50

Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/156802611795371323DOI Listing
August 2011

Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity.

Curr Top Med Chem 2011 ;11(9):1165-75

Department of Medicinal Chemistry, Laboratory for Applied Drug Design and Synthesis, School of Pharmacy, The University of Mississippi, University, 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/156802611795371305DOI Listing
August 2011

Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis.

Biol Psychiatry 2011 Feb 15;69(3):208-17. Epub 2010 Oct 15.

Psychobiology Section, Medication Discovery Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopsych.2010.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015019PMC
February 2011

A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice.

J Pharmacol Exp Ther 2010 May 25;333(2):491-500. Epub 2010 Jan 25.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.109.161398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872963PMC
May 2010

Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A.

Nat Prod Commun 2009 Jul;4(7):907-10

Department of Medicinal Chemistry & National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.

View Article

Download full-text PDF

Source
July 2009

Determination of mitragynine in rat plasma by LC-MS/MS: application to pharmacokinetics.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Aug 21;877(24):2593-7. Epub 2009 Jun 21.

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP 14040-903, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2009.06.023DOI Listing
August 2009

Beta-triketone inhibitors of plant p-hydroxyphenylpyruvate dioxygenase: modeling and comparative molecular field analysis of their interactions.

J Agric Food Chem 2009 Jun;57(12):5194-200

US Department of Agriculture, Natural Products Utilization Research Unit, Agricultural Research Service, University, Mississippi 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jf9005593DOI Listing
June 2009

Ligand macromolecule interactions: theoretical principles of molecular recognition.

Methods Mol Biol 2009 ;572:13-29

Department of Medicinal Chemistry, University of Mississippi, Jackson, MS, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-60761-244-5_2DOI Listing
December 2010

Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth).

Addiction 2008 Jun;103(6):1048-50

Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1360-0443.2008.02209.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670991PMC
June 2008

Chemical function-based pharmacophore development for novel, selective kappa opioid receptor agonists.

J Mol Graph Model 2008 Sep 28;27(2):131-9. Epub 2008 Mar 28.

Department of Medicinal Chemistry, Laboratory for Applied Drug Design and Synthesis, The University of Mississippi, Mississippi 38677, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S109332630800045
Publisher Site
http://dx.doi.org/10.1016/j.jmgm.2008.03.007DOI Listing
September 2008

Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor.

J Med Chem 2008 Mar 23;51(6):1824-30. Epub 2008 Feb 23.

Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/jm701040v
Publisher Site
http://dx.doi.org/10.1021/jm701040vDOI Listing
March 2008

Opioid receptors and legal highs: Salvia divinorum and Kratom.

Clin Toxicol (Phila) 2008 Feb;46(2):146-52

Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650701241795DOI Listing
February 2008

Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations.

J Comput Aided Mol Des 2007 Sep 14;21(9):511-22. Epub 2007 Sep 14.

Department of Medicinal Chemistry, Laboratory for Applied Drug Design and Synthesis, University of Mississippi, University, MS, 38677-1848, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10822-007-9132-0
Publisher Site
http://dx.doi.org/10.1007/s10822-007-9132-0DOI Listing
September 2007

The hallucinogen derived from Salvia divinorum, salvinorin A, has kappa-opioid agonist discriminative stimulus effects in rats.

Neuropharmacology 2007 Sep 27;53(4):481-6. Epub 2007 Jun 27.

Ohio Northern University, Department of Pharmaceutical and Biomedical Sciences, Raabe College of Pharmacy, 525 S. Main Street, Ada, OH 45810, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2007.06.008DOI Listing
September 2007

o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label.

J Med Chem 2007 Jul 8;50(14):3392-6. Epub 2007 Jun 8.

Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm061194hDOI Listing
July 2007

Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme.

Curr Pharm Des 2007 ;13(11):1161-77

Department of Medicinal Chemistry and Laboratory for Applied Drug Design and Synthesis, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/138161207780618939DOI Listing
May 2007

p-Hydroxyphenylpyruvate dioxygenase is a herbicidal target site for beta-triketones from Leptospermum scoparium.

Phytochemistry 2007 Jul 26;68(14):2004-14. Epub 2007 Mar 26.

United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, P.O. Box 8048, University, MS 38677, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S003194220700064
Publisher Site
http://dx.doi.org/10.1016/j.phytochem.2007.01.026DOI Listing
July 2007