Publications by authors named "Christopher L Morton"

82Publications

In-bag enzymatic splenic digestion: a novel alternative to manual morcellation?

J Surg Res 2017 10 21;218:209-216. Epub 2017 Jun 21.

Division of Pediatric Surgery, Baptist Children's Hospital, Memphis, Tennessee. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00224804173031
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http://dx.doi.org/10.1016/j.jss.2017.05.060DOI Listing
October 2017

Distribution of AAV8 particles in cell lysates and culture media changes with time and is dependent on the recombinant vector.

Mol Ther Methods Clin Dev 2016 30;3:16015. Epub 2016 Mar 30.

Department of Therapeutics Production & Quality, St. Jude Children's Research Hospital , Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/mtm.2016.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813606PMC
April 2016

Regulated lysosomal exocytosis mediates cancer progression.

Sci Adv 2015 Dec 18;1(11):e1500603. Epub 2015 Dec 18.

Department of Genetics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1126/sciadv.1500603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730843PMC
December 2015

The role of histone demethylase KDM4B in Myc signaling in neuroblastoma.

J Natl Cancer Inst 2015 Jun 29;107(6):djv080. Epub 2015 Apr 29.

Department of Surgery (JY, AMA, DH, PHC, CLM, AMD) and Department of Bioinformatics (CQ), St. Jude Children's Research Hospital, Memphis, TN; Yale Cardiovascular Research Center, Yale School of Medicine, New Haven, CT (YW); Department of Oncology, University College London Cancer Institute, London, UK (ACN); Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX (JMS); Division of Biomedical Research, Foundation of Research and Technology-Hellas, Institute of Molecular Biology and Biotechnology, Ioannina, Greece (TF); Laboratory of Biological Chemistry, Medical School, University of Ioannina, Ioannina, Greece (TF); Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands (JK, RV); Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan (HO); Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK (ALH).

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http://dx.doi.org/10.1093/jnci/djv080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555638PMC
June 2015

Inhibition of type I interferon-mediated antiviral action in human glioma cells by the IKK inhibitors BMS-345541 and TPCA-1.

J Interferon Cytokine Res 2012 Aug 17;32(8):368-77. Epub 2012 Apr 17.

Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.1089/jir.2012.0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422054PMC
August 2012

Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the pediatric preclinical testing program.

Pediatr Blood Cancer 2012 May 31;58(5):729-35. Epub 2011 May 31.

A.I. duPont Hospital for Children, Nemours Center for Childhood Cancer Research, Wilmington, Delaware 19803, USA.

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http://dx.doi.org/10.1002/pbc.23157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166415PMC
May 2012

National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.

Pediatr Blood Cancer 2011 Feb 4;56(2):239-49. Epub 2010 Oct 4.

Cancer Center, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA.

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http://dx.doi.org/10.1002/pbc.22801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005554PMC
February 2011

Initial testing of aplidin by the pediatric pre-clinical testing program.

Pediatr Blood Cancer 2009 Sep;53(3):509-12

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1002/pbc.21976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777698PMC
September 2009

Initial testing of VNP40101M (Cloretazine) by the pediatric preclinical testing program.

Pediatr Blood Cancer 2008 Sep;51(3):439-41

Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1002/pbc.21620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836208PMC
September 2008

Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program.

Pediatr Blood Cancer 2008 Jul;51(1):42-8

Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/pbc.21535DOI Listing
July 2008

Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program.

Pediatr Blood Cancer 2008 Jun;50(6):1181-9

Children's Cancer Institute Australia for Medical Research, Randwick, NSW, Australia.

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http://dx.doi.org/10.1002/pbc.21433DOI Listing
June 2008

Preclinical chemotherapeutic tumor models of common childhood cancers: solid tumors, acute lymphoblastic leukemia, and disseminated neuroblastoma.

Curr Protoc Pharmacol 2007 Dec;Chapter 14:Unit14.8

St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1002/0471141755.ph1408s39DOI Listing
December 2007

Initial testing of cisplatin by the pediatric preclinical testing program.

Pediatr Blood Cancer 2008 May;50(5):992-1000

Children's Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia.

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http://doi.wiley.com/10.1002/pbc.21263
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http://dx.doi.org/10.1002/pbc.21263DOI Listing
May 2008

Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program.

Pediatr Blood Cancer 2008 Mar;50(3):581-7

Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/pbc.21232DOI Listing
March 2008

Establishment of human tumor xenografts in immunodeficient mice.

Nat Protoc 2007 ;2(2):247-50

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://www.nature.com/articles/nprot.2007.25
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http://dx.doi.org/10.1038/nprot.2007.25DOI Listing
June 2007

Evaluation of ABT-751 against childhood cancer models in vivo.

Invest New Drugs 2007 Aug 24;25(4):285-95. Epub 2007 Mar 24.

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 North Lauderdale St, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1007/s10637-007-9042-yDOI Listing
August 2007

SK-NEP-1 and Rh1 are Ewing family tumor lines.

Pediatr Blood Cancer 2008 Mar;50(3):703-6

Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/pbc.21099DOI Listing
March 2008

Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1.

J Mol Biol 2006 Oct 15;363(1):201-14. Epub 2006 Aug 15.

Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762004PMC
October 2006

Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.

Chem Biol Interact 2005 Dec 28;157-158:247-52. Epub 2005 Oct 28.

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.cbi.2005.10.033DOI Listing
December 2005

Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.

J Biol Chem 2005 Sep 11;280(36):31924-35. Epub 2005 Jul 11.

Department of Chemistry, Western Illinois University, Macomb 61455, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M507057200
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http://dx.doi.org/10.1074/jbc.M507057200DOI Listing
September 2005

Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice.

Cancer Chemother Pharmacol 2005 Dec 26;56(6):629-36. Epub 2005 May 26.

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1007/s00280-005-1027-yDOI Listing
December 2005

Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.

Mol Cancer Ther 2004 Aug;3(8):903-9

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 3810, USA.

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August 2004

Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model.

Biochemistry 2004 Feb;43(7):1874-82

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/bi035586rDOI Listing
February 2004

Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies.

Mol Cancer Ther 2003 Nov;2(11):1171-81

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38015, USA.

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November 2003

Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance.

Mol Pharmacol 2003 Aug;64(2):279-88

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1124/mol.64.2.279DOI Listing
August 2003

Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism.

Bioorg Med Chem 2003 Jul;11(15):3237-44

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1016/s0968-0896(03)00302-xDOI Listing
July 2003

Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.

Chem Biol 2003 Apr;10(4):341-9

Department of Chemistry, School of Dentistry, University of North Carolina, Chapel Hill, 27599, USA.

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http://dx.doi.org/10.1016/s1074-5521(03)00071-1DOI Listing
April 2003

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme.

Nat Struct Biol 2003 May;10(5):349-56

Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/nsb919DOI Listing
May 2003

p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11).

J Pharmacol Exp Ther 2003 Feb;304(2):699-705

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105,USA.

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http://dx.doi.org/10.1124/jpet.102.044149DOI Listing
February 2003

Structural insights into CPT-11 activation by mammalian carboxylesterases.

Nat Struct Biol 2002 May;9(5):337-42

Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/nsb790DOI Listing
May 2002