Christopher J Schofield

Christopher J Schofield

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Christopher J Schofield

Publications by authors named "Christopher J Schofield"

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Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.

Sci Rep 2020 May 26;10(1):8650. Epub 2020 May 26.

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, OX1 3TA, Oxford, United Kingdom.

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http://dx.doi.org/10.1038/s41598-020-65123-9DOI Listing
May 2020

Structures of Penicillin-Binding Protein 3 in Complex with Five -Lactam Antibiotics Reveal Mechanism of Inactivation.

Mol Pharmacol 2020 04 21;97(4):287-294. Epub 2020 Feb 21.

Key Laboratory of Biomarker Based Rapid-detection Technology for Food Safety of Henan Province, Xuchang University, Xuchang, Henan, China (Z.L., A.Z.); College of Life Sciences (Z.L., H.W., W.Z. and Z.R.) and College of Pharmacy (X.L., C.Y.), Nankai University, Tianjin, China; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia (L.G.); School of Life Sciences, Tianjin University, Tianjin, China (H.Y.); University of Oxford, Chemistry Research Laboratory, Oxford, United Kingdom (C.J.S.); National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China (Z.R.); and Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China (Z.R.)

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http://dx.doi.org/10.1124/mol.119.118042DOI Listing
April 2020

Author Correction: Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.

Sci Rep 2020 Apr 8;10(1):6041. Epub 2020 Apr 8.

Institute for Science and Technology in Medicine, School of Pharmacy, Keele University, Newcastle under Lyme, Staffordshire, ST5 5BG, United Kingdom.

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http://dx.doi.org/10.1038/s41598-020-63108-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142094PMC
April 2020

Synthesis of Novel Pyridine-Carboxylates as Small-Molecule Inhibitors of Human Aspartate/Asparagine-β-Hydroxylase.

ChemMedChem 2020 Apr 24. Epub 2020 Apr 24.

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/cmdc.202000147DOI Listing
April 2020

A Fluorescence-Based Assay for Screening β-Lactams Targeting the Mycobacterium tuberculosis Transpeptidase Ldt.

Chembiochem 2020 Feb 8;21(3):368-372. Epub 2019 Nov 8.

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/cbic.201900379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028133PMC
February 2020

MeLAD: an integrated resource for metalloenzyme-ligand associations.

Bioinformatics 2020 Feb;36(3):904-909

Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China.

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https://academic.oup.com/bioinformatics/advance-article/doi/
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http://dx.doi.org/10.1093/bioinformatics/btz648DOI Listing
February 2020

HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity.

FASEB J 2020 Feb 19;34(2):2344-2358. Epub 2019 Dec 19.

Institute of Physiology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1096/fj.201902240RDOI Listing
February 2020

Mechanism of Molecular Oxygen Diffusion in a Hypoxia-Sensing Prolyl Hydroxylase Using Multiscale Simulation.

J Am Chem Soc 2020 Feb 23;142(5):2253-2263. Epub 2020 Jan 23.

Chemistry Research Laboratory, Mansfield Road , University of Oxford , Oxford OX1 3TA , United Kingdom.

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http://dx.doi.org/10.1021/jacs.9b09236DOI Listing
February 2020

Kinetic parameters of human aspartate/asparagine-β-hydroxylase suggest that it has a possible function in oxygen sensing.

J Biol Chem 2020 Feb 26. Epub 2020 Feb 26.

Chemistry Research Laboratory, Oxford University, United Kingdom.

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http://dx.doi.org/10.1074/jbc.RA119.012202DOI Listing
February 2020

Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles.

Bioorg Chem 2020 Jan 28;94:103386. Epub 2019 Oct 28.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.103386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958525PMC
January 2020

Broad Spectrum β-Lactamase Inhibition by a Thioether Substituted Bicyclic Boronate.

ACS Infect Dis 2020 Jan 6. Epub 2020 Jan 6.

The Chemistry Research Laboratory, The Department of Chemistry , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.9b00330DOI Listing
January 2020

Quantitative MS-Based Proteomics: Comparing the MCF-7 Cellular Response to Hypoxia and a 2-Oxoglutarate Analogue.

Chembiochem 2020 Jan 10. Epub 2020 Jan 10.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/cbic.201900719DOI Listing
January 2020

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.

Sci Rep 2020 Jan 31;10(1):1597. Epub 2020 Jan 31.

Institute for Science and Technology in Medicine, School of Pharmacy, Keele University, Newcastle under Lyme, Staffordshire, ST5 5BG, United Kingdom.

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http://dx.doi.org/10.1038/s41598-020-58482-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994562PMC
January 2020

F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode.

Chem Commun (Camb) 2019 Dec;55(98):14717-14720

The Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/c9cc06466dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927413PMC
December 2019

Formaldehyde quantification using ampicillin is not selective.

Sci Rep 2019 12 4;9(1):18289. Epub 2019 Dec 4.

Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1038/s41598-019-54610-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892939PMC
December 2019

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam.

Antimicrob Agents Chemother 2019 10 23;63(10). Epub 2019 Sep 23.

School of Cellular and Molecular Medicine, Biomedical Sciences Building, University of Bristol, Bristol, United Kingdom

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http://dx.doi.org/10.1128/AAC.00564-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761529PMC
October 2019

Expansion of base excision repair compensates for a lack of DNA repair by oxidative dealkylation in budding yeast.

J Biol Chem 2019 09 18;294(37):13629-13637. Epub 2019 Jul 18.

Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600

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http://dx.doi.org/10.1074/jbc.RA119.009813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746446PMC
September 2019

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.

J Med Chem 2019 09 16;62(18):8544-8556. Epub 2019 Sep 16.

Chemistry Research Laboratory, Department of Chemistry , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767355PMC
September 2019

Profiling interactions of vaborbactam with metallo-β-lactamases.

Bioorg Med Chem Lett 2019 08 17;29(15):1981-1984. Epub 2019 May 17.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X193032
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http://dx.doi.org/10.1016/j.bmcl.2019.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593178PMC
August 2019

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.

J Biol Chem 2019 07 30;294(30):11637-11652. Epub 2019 May 30.

Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom

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http://dx.doi.org/10.1074/jbc.RA119.008693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663879PMC
July 2019

Inhibition of a viral prolyl hydroxylase.

Bioorg Med Chem 2019 06 23;27(12):2405-2412. Epub 2019 Jan 23.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.01.018DOI Listing
June 2019

Will morphing boron-based inhibitors beat the β-lactamases?

Curr Opin Chem Biol 2019 06 18;50:101-110. Epub 2019 Apr 18.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13675931193003
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http://dx.doi.org/10.1016/j.cbpa.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591701PMC
June 2019

Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases.

Commun Chem 2019 May 24;2. Epub 2019 Jan 24.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1038/s42004-018-0106-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542682PMC
May 2019

Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates.

Biochim Biophys Acta Gen Subj 2019 04 7;1863(4):742-748. Epub 2019 Feb 7.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2019.02.004DOI Listing
April 2019

Conformational Dynamics Underlies Different Functions of Human KDM7 Histone Demethylases.

Chemistry 2019 Apr 26;25(21):5422-5426. Epub 2019 Mar 26.

Department of Chemistry, Michigan Technological University, Houghton, Michigan, 49931, USA.

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http://doi.wiley.com/10.1002/chem.201900492
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http://dx.doi.org/10.1002/chem.201900492DOI Listing
April 2019

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors.

Medchemcomm 2019 Apr 1;10(4):500-504. Epub 2019 Mar 1.

Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford , OX1 3TA , UK . Email:

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http://dx.doi.org/10.1039/c8md00548fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482412PMC
April 2019

Rapid Identification of Novel Psychoactive and Other Controlled Substances Using Low-Field H NMR Spectroscopy.

ACS Omega 2019 Apr 19;4(4):7103-7112. Epub 2019 Apr 19.

School of Science and the Environment, Division of Chemistry and Environmental Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester M1 5GD, U.K.

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http://dx.doi.org/10.1021/acsomega.9b00302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547625PMC
April 2019

Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library.

J Med Chem 2019 03 6;62(6):2928-2937. Epub 2019 Mar 6.

Division of Structural Biology , University of Oxford , The Henry Wellcome Building for Genomic Medicine , Headington, Oxford OX3 7BN , U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441942PMC
March 2019

A Fluorescent Benzo[g]isoquinoline-Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging.

ChemMedChem 2019 01 21;14(1):94-99. Epub 2018 Dec 21.

Department of Chemistry and Pharmacy, Inorganic and Organometallic Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Egerlandstraße 1, 91058, Erlangen, Germany.

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http://dx.doi.org/10.1002/cmdc.201800483DOI Listing
January 2019

New developments for prevention of type 1 diabetes: a paradigm shift?

Br J Hosp Med (Lond) 2019 Jan;80(1):4-5

Professor of Molecular and Cellular Diabetes, Department of Cellular Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY.

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http://www.magonlinelibrary.com/doi/10.12968/hmed.2019.80.1.
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http://dx.doi.org/10.12968/hmed.2019.80.1.4DOI Listing
January 2019

Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis.

Chem Rec 2018 Dec 27;18(12):1760-1781. Epub 2018 Aug 27.

Department of Chemistry, University of Oxford Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1002/tcr.201800056DOI Listing
December 2018

Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain.

Chembiochem 2018 11 26;19(21):2262-2267. Epub 2018 Sep 26.

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/cbic.201800246DOI Listing
November 2018

Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively.

J Cell Sci 2018 11 19;131(22). Epub 2018 Nov 19.

Ludwig Institute for Cancer Research Ltd., Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom

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http://dx.doi.org/10.1242/jcs.219782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250434PMC
November 2018

Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1-Dichloromethylinden-1-ol Analogues.

ChemMedChem 2018 09 21;13(18):1949-1956. Epub 2018 Aug 21.

Departamento de Química Orgánica, Facultade de Química, CINBIO and IBIV, Universidade de Vigo, Campus As Lagoas-Marcosende, 36310, Vigo, Spain.

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http://dx.doi.org/10.1002/cmdc.201800377DOI Listing
September 2018

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis.

Nat Prod Rep 2018 08;35(8):735-756

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/c8np00002fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097109PMC
August 2018

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases.

Bioorg Med Chem 2018 07 19;26(11):2984-2991. Epub 2018 Mar 19.

Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom; Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380468PMC
July 2018

Antibiotics as food for bacteria.

Nat Microbiol 2018 07;3(7):752-753

Chemistry Research Laboratory, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41564-018-0181-zDOI Listing
July 2018

Symmetry breaking by enzyme-catalyzed epoxide hydrolysis.

IUCrJ 2018 Jul 18;5(Pt 4):373-374. Epub 2018 May 18.

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1107/S2052252518007005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038963PMC
July 2018

Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models.

Mar Drugs 2018 Jul 19;16(7). Epub 2018 Jul 19.

Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/md16070241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071056PMC
July 2018

2-Oxoglutarate-Dependent Oxygenases.

Annu Rev Biochem 2018 06 1;87:585-620. Epub 2018 Mar 1.

The Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-biochem-061516-044724DOI Listing
June 2018

Inhibitors of both the -methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases.

Philos Trans R Soc Lond B Biol Sci 2018 06;373(1748)

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK

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http://dx.doi.org/10.1098/rstb.2017.0071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915715PMC
June 2018

Lysine-241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4-Catalysed Histone Demethylation.

Chembiochem 2018 05 6;19(9):917-921. Epub 2018 Apr 6.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/cbic.201800002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969224PMC
May 2018

YcfD is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase.

Extremophiles 2018 May 9;22(3):553-562. Epub 2018 Mar 9.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1007/s00792-018-1016-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862935PMC
May 2018

Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis.

Chemistry 2018 Apr 17;24(22):5734-5737. Epub 2018 Jan 17.

Department of Chemistry, University of Waterloo, 200 University Ave. W., Waterloo, Ontario, N2L 3G1, Canada.

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http://dx.doi.org/10.1002/chem.201705886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947706PMC
April 2018

Publisher Correction: JMJD5 is a human arginyl C-3 hydroxylase.

Nat Commun 2018 04 23;9(1):1675. Epub 2018 Apr 23.

The Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1038/s41467-018-04196-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913133PMC
April 2018

A comparison of 2-hydroxyglutarate detection at 3 and 7 T with long-TE semi-LASER.

NMR Biomed 2018 03 5;31(3). Epub 2018 Jan 5.

FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1002/nbm.3886DOI Listing
March 2018

JMJD5 is a human arginyl C-3 hydroxylase.

Nat Commun 2018 03 21;9(1):1180. Epub 2018 Mar 21.

The Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1038/s41467-018-03410-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862942PMC
March 2018

In Vitro Enzyme Assays for JmjC-Domain-Containing Lysine Histone Demethylases (JmjC-KDMs).

Curr Protoc Pharmacol 2018 03;80(1):3.15.1-3.15.12

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/cpph.34DOI Listing
March 2018

Deciphering Functions of Intracellular Formaldehyde: Linking Cancer and Aldehyde Metabolism.

Biochemistry 2018 02 25;57(6):904-906. Epub 2018 Jan 25.

Department of Chemistry, University of Oxford , Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1021/acs.biochem.7b01304DOI Listing
February 2018

Direct sulfonylation of anilines mediated by visible light.

Chem Sci 2018 Jan 16;9(3):629-633. Epub 2017 Nov 16.

Department of Chemistry , University of Oxford , Chemical Research Laboratory , Mansfield Road , Oxford , OX1 3TA , UK . Email: ; Email: ; Email: ; Email: ; Email:

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http://dx.doi.org/10.1039/c7sc03891gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868301PMC
January 2018

New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis.

Antimicrob Agents Chemother 2017 12 22;61(12). Epub 2017 Nov 22.

Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom

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http://dx.doi.org/10.1128/AAC.01224-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700305PMC
December 2017

Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1.

Cell Chem Biol 2017 Nov 28;24(11):1377-1387.e3. Epub 2017 Sep 28.

Section of Virology, Department of Medicine, Imperial College, London W2 1PG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696563PMC
November 2017

Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses and .

Wellcome Open Res 2017 26;2:104. Epub 2017 Oct 26.

MRC/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK.

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http://dx.doi.org/10.12688/wellcomeopenres.12871.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701443PMC
October 2017

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.

J Mol Biol 2017 09 18;429(19):2895-2906. Epub 2017 Aug 18.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636616PMC
September 2017

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.

J Cell Biol 2017 04 28;216(4):999-1013. Epub 2017 Feb 28.

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU Scotland, UK

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http://dx.doi.org/10.1083/jcb.201607032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379941PMC
April 2017

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors.

Chem Sci 2017 Feb 14;8(2):928-937. Epub 2016 Dec 14.

Department of Chemistry , University of Oxford , 12 Mansfield Road , Oxford , OX1 3TA , UK . Email: ; Email:

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http://dx.doi.org/10.1039/c6sc04524cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369532PMC
February 2017