Publications by authors named "Christopher J Penkett"

32Publications

The Polygenic and Monogenic Basis of Blood Traits and Diseases.

Authors:
Dragana Vuckovic Erik L Bao Parsa Akbari Caleb A Lareau Abdou Mousas Tao Jiang Ming-Huei Chen Laura M Raffield Manuel Tardaguila Jennifer E Huffman Scott C Ritchie Karyn Megy Hannes Ponstingl Christopher J Penkett Patrick K Albers Emilie M Wigdor Saori Sakaue Arden Moscati Regina Manansala Ken Sin Lo Huijun Qian Masato Akiyama Traci M Bartz Yoav Ben-Shlomo Andrew Beswick Jette Bork-Jensen Erwin P Bottinger Jennifer A Brody Frank J A van Rooij Kumaraswamy N Chitrala Peter W F Wilson Hélène Choquet John Danesh Emanuele Di Angelantonio Niki Dimou Jingzhong Ding Paul Elliott Tõnu Esko Michele K Evans Stephan B Felix James S Floyd Linda Broer Niels Grarup Michael H Guo Qi Guo Andreas Greinacher Jeff Haessler Torben Hansen Joanna M M Howson Wei Huang Eric Jorgenson Tim Kacprowski Mika Kähönen Yoichiro Kamatani Masahiro Kanai Savita Karthikeyan Fotios Koskeridis Leslie A Lange Terho Lehtimäki Allan Linneberg Yongmei Liu Leo-Pekka Lyytikäinen Ani Manichaikul Koichi Matsuda Karen L Mohlke Nina Mononen Yoshinori Murakami Girish N Nadkarni Kjell Nikus Nathan Pankratz Oluf Pedersen Michael Preuss Bruce M Psaty Olli T Raitakari Stephen S Rich Benjamin A T Rodriguez Jonathan D Rosen Jerome I Rotter Petra Schubert Cassandra N Spracklen Praveen Surendran Hua Tang Jean-Claude Tardif Mohsen Ghanbari Uwe Völker Henry Völzke Nicholas A Watkins Stefan Weiss Na Cai Kousik Kundu Stephen B Watt Klaudia Walter Alan B Zonderman Kelly Cho Yun Li Ruth J F Loos Julian C Knight Michel Georges Oliver Stegle Evangelos Evangelou Yukinori Okada David J Roberts Michael Inouye Andrew D Johnson Paul L Auer William J Astle Alexander P Reiner Adam S Butterworth Willem H Ouwehand Guillaume Lettre Vijay G Sankaran Nicole Soranzo

Cell 2020 Sep;182(5):1214-1231.e11

Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK; National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2020.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482360PMC
September 2020

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Blood 2016 06 15;127(23):2791-803. Epub 2016 Apr 15.

Department of Haematology, University of Cambridge, National Institute for Health Research BioResource-Rare Diseases, Cambridge University Hospitals, and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2015-12-688267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016734PMC
June 2016

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.

Sci Transl Med 2016 Mar 2;8(328):328ra30. Epub 2016 Mar 2.

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. National Institute for Health Research (NIHR) BioResource-Rare Diseases, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aad7666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903547PMC
March 2016

Mutations in CACNA2D4 Cause Distinctive Retinal Dysfunction in Humans.

Ophthalmology 2016 Mar 7;123(3):668-71.e2. Epub 2015 Nov 7.

UCL Institute of Ophthalmology, University College London, London, UK; Moorfields Eye Hospital, London, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2015.09.045DOI Listing
March 2016

Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing.

Eur J Immunol 2015 Nov 1;45(11):3200-3. Epub 2015 Oct 1.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Research Campus, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201545646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832369PMC
November 2015

Straightforward and complete deposition of NMR data to the PDBe.

J Biomol NMR 2010 Oct 3;48(2):85-92. Epub 2010 Aug 3.

Protein Data Bank in Europe, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10858-010-9439-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950272PMC
October 2010

The NMR restraints grid at BMRB for 5,266 protein and nucleic acid PDB entries.

J Biomol NMR 2009 Dec 7;45(4):389-96. Epub 2009 Oct 7.

Radboud University Medical Centre Nijmegen, Geert Grooteplein 26-28, HB, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10858-009-9378-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777234PMC
December 2009

Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2.

Nat Struct Mol Biol 2009 Apr 8;16(4):449-51. Epub 2009 Mar 8.

Gurdon Institute and Department of Pathology, Cambridge CB2 1QN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.1569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350867PMC
April 2009

Navigating public microarray databases.

Comp Funct Genomics 2004 ;5(6-7):471-9

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cfg.427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447434PMC
June 2010

Rapidly regulated genes are intron poor.

Trends Genet 2008 Aug 27;24(8):375-8. Epub 2008 Jun 27.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tig.2008.05.006DOI Listing
August 2008

Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.

Nature 2008 Jun 18;453(7199):1239-43. Epub 2008 May 18.

Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature07002DOI Listing
June 2008

Multiple pathways differentially regulate global oxidative stress responses in fission yeast.

Mol Biol Cell 2008 Jan 14;19(1):308-17. Epub 2007 Nov 14.

Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.e07-08-0735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174203PMC
January 2008

Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation.

Nature 2007 Oct 26;449(7164):928-32. Epub 2007 Sep 26.

Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature06160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350864PMC
October 2007

Simplified primer design for PCR-based gene targeting and microarray primer database: two web tools for fission yeast.

Yeast 2006 Oct;23(13):921-8

Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Cambridge CB10 1HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/yea.1422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964512PMC
October 2006

Genome-wide characterization of fission yeast DNA replication origins.

EMBO J 2006 Nov 19;25(21):5171-9. Epub 2006 Oct 19.

Laboratory of Yeast Genetics and Cell Biology, The Rockefeller University, New York, NY 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.emboj.7601390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1630417PMC
November 2006

YOGY: a web-based, integrated database to retrieve protein orthologs and associated Gene Ontology terms.

Nucleic Acids Res 2006 Jul;34(Web Server issue):W330-4

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkl311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538793PMC
July 2006

Periodic gene expression program of the fission yeast cell cycle.

Nat Genet 2004 Aug 13;36(8):809-17. Epub 2004 Jun 13.

The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng1377DOI Listing
August 2004