Publications by authors named "Christopher J Ott"

35Publications

Circles with a Point: New Insights into Oncogenic Extrachromosomal DNA.

Cancer Cell 2020 02;37(2):145-146

Massachusetts General Hospital Center for Cancer Research, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.01.008DOI Listing
February 2020

Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.

Cell Stem Cell 2019 11 5;25(5):682-696.e8. Epub 2019 Sep 5.

Human Oncology and Pathogenesis Program and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193033
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http://dx.doi.org/10.1016/j.stem.2019.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842438PMC
November 2019

Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma.

Cell Rep 2018 12;25(13):3693-3705.e6

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; VA Boston Healthcare System, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407615PMC
December 2018

Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia.

Cancer Cell 2018 12 29;34(6):982-995.e7. Epub 2018 Nov 29.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA; Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183048
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http://dx.doi.org/10.1016/j.ccell.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298230PMC
December 2018

Opportunities for targeting gene regulatory factors in B-cell acute lymphoblastic leukemia.

Int J Hematol Oncol 2017 Nov 20;6(3):57-59. Epub 2017 Nov 20.

Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

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https://www.futuremedicine.com/doi/10.2217/ijh-2017-0018
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http://dx.doi.org/10.2217/ijh-2017-0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171982PMC
November 2017

HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL.

Cancer Cell 2017 07;32(1):1-3

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.06.008DOI Listing
July 2017

A chemical probe toolbox for dissecting the cancer epigenome.

Nat Rev Cancer 2017 02;17(3):160-183

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nrc.2016.148DOI Listing
February 2017

Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET.

ChemMedChem 2016 Dec 15;11(23):2575-2581. Epub 2016 Nov 15.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1002/cmdc.201600502DOI Listing
December 2016

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis.

J Exp Med 2015 Oct 5;212(11):1819-32. Epub 2015 Oct 5.

Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Department of Pathology, Molecular Cytology Core Facility, and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065 Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Department of Pathology, Molecular Cytology Core Facility, and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065 Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Department of Pathology, Molecular Cytology Core Facility, and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065

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http://dx.doi.org/10.1084/jem.20151317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612085PMC
October 2015

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

Nat Genet 2014 Apr 2;46(4):364-70. Epub 2014 Mar 2.

1] Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [3] Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [4] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.

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http://www.nature.com/articles/ng.2913
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http://dx.doi.org/10.1038/ng.2913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086945PMC
April 2014

Nucleosome mapping across the CFTR locus identifies novel regulatory factors.

Nucleic Acids Res 2013 Mar 15;41(5):2857-68. Epub 2013 Jan 15.

Human Molecular Genetics Program, Children's Memorial Research Center, Department of Pediatrics, Northwestern University Feinberg School of Medicine Chicago, IL 60614, USA.

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http://dx.doi.org/10.1093/nar/gks1462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597660PMC
March 2013

Nucleosome occupancy reveals regulatory elements of the CFTR promoter.

Nucleic Acids Res 2012 Jan 24;40(2):625-37. Epub 2011 Sep 24.

Human Molecular Genetics Program, Children's Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA.

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http://dx.doi.org/10.1093/nar/gkr754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258145PMC
January 2012

Molecular mechanisms controlling CFTR gene expression in the airway.

J Cell Mol Med 2012 Jun;16(6):1321-30

Human Molecular Genetic Program, Children's Memorial Research Center, Chicago, IL 60614, USA.

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http://dx.doi.org/10.1111/j.1582-4934.2011.01439.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289769PMC
June 2012

Genomic approaches to studying CFTR transcriptional regulation.

Methods Mol Biol 2011 ;741:193-209

Human Molecular Genetics Program, Children's Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1007/978-1-61779-117-8_13DOI Listing
September 2011

Genomic approaches for the discovery of CFTR regulatory elements.

Transcription 2011 Jan-Feb;2(1):23-7

Human Molecular Genetics Program, Children's Memorial Research Center, Chicago, IL, USA.

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http://dx.doi.org/10.4161/trns.2.1.13693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023643PMC
June 2012

Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus.

Proc Natl Acad Sci U S A 2009 Nov 6;106(47):19934-9. Epub 2009 Nov 6.

Human Molecular Genetics Program, Children's Memorial Research Center, Northwestern University Feinberg School of Medicine, 2300 Children's Plaza #211, Chicago, IL 60614, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0900946106
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http://dx.doi.org/10.1073/pnas.0900946106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785270PMC
November 2009

Interaction of intestinal and pancreatic transcription factors in the regulation of CFTR gene expression.

Biochim Biophys Acta 2009 Nov-Dec;1789(11-12):709-18. Epub 2009 Sep 24.

Paediatric Molecular Genetics, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/j.bbagrm.2009.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783911PMC
March 2010

Novel regulatory mechanisms for the CFTR gene.

Biochem Soc Trans 2009 Aug;37(Pt 4):843-8

Human Molecular Genetics Program, Children's Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA.

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http://dx.doi.org/10.1042/BST0370843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794656PMC
August 2009

A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter.

J Cell Mol Med 2009 Apr;13(4):680-92

Children's Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822875PMC
http://dx.doi.org/10.1111/j.1582-4934.2008.00621.xDOI Listing
April 2009

An insulator element 3' to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells.

Nucleic Acids Res 2009 Mar 7;37(4):1086-94. Epub 2009 Jan 7.

Human Molecular Genetics Program, Children's Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA.

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http://dx.doi.org/10.1093/nar/gkn1056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651798PMC
March 2009

Mouse model for acute bacterial prostatitis in genetically distinct inbred strains.

Urology 2005 Oct;66(4):883-7

Division of Urology, Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1016/j.urology.2005.04.013DOI Listing
October 2005

Inheritance of susceptibility to induced Escherichia coli bladder and kidney infections in female C3H/HeJ mice.

J Infect Dis 2003 Feb 24;187(3):418-23. Epub 2003 Jan 24.

Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1086/367963DOI Listing
February 2003