Christopher J Oldfield

Christopher J Oldfield

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Christopher J Oldfield

Publications by authors named "Christopher J Oldfield"

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Myokines as biomarkers of frailty and cardiovascular disease risk in females.

Exp Gerontol 2020 May 1;133:110859. Epub 2020 Feb 1.

Faculty of Kinesiology & Recreation Management, University of Manitoba, Winnipeg, Manitoba, Canada; Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2020.110859DOI Listing
May 2020

Mechanisms for the transition from physiological to pathological cardiac hypertrophy.

Can J Physiol Pharmacol 2020 Feb;98(2):74-84

Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB R2H 2A6, Canada.

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http://dx.doi.org/10.1139/cjpp-2019-0566DOI Listing
February 2020

Codon selection reduces GC content bias in nucleic acids encoding for intrinsically disordered proteins.

Cell Mol Life Sci 2020 Jan 7;77(1):149-160. Epub 2019 Jun 7.

Department of Computer Science, Virginia Commonwealth University, Richmond, VA, 23284, USA.

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http://dx.doi.org/10.1007/s00018-019-03166-6DOI Listing
January 2020

DISOselect: Disorder predictor selection at the protein level.

Protein Sci 2020 01 7;29(1):184-200. Epub 2019 Nov 7.

Department of Computer Science, Virginia Commonwealth University, Richmond, Virginia.

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http://dx.doi.org/10.1002/pro.3756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933862PMC
January 2020

Many-to-one binding by intrinsically disordered protein regions.

Pac Symp Biocomput 2020 ;25:159-170

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 410 W. 10th St, HS5000, Indianapolis, IN46202, USA,

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January 2020

Disordered Function Conjunction: On the in-silico function annotation of intrinsically disordered regions.

Pac Symp Biocomput 2020 ;25:171-182

Department of Computer Science, Virginia Commonwealth University, 401 West Main Street, Richmond, VA 23284, U.S.A.

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January 2020

Disordered RNA-Binding Region Prediction with DisoRDPbind.

Methods Mol Biol 2020 ;2106:225-239

Department of Computer Science, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.1007/978-1-0716-0231-7_14DOI Listing
January 2020

Prediction of Intrinsic Disorder with Quality Assessment Using QUARTER.

Methods Mol Biol 2020 ;2165:83-101

Department of Computer Science, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.1007/978-1-0716-0708-4_5DOI Listing
January 2020

Prehabilitation: The Right Medicine for Older Frail Adults Anticipating Transcatheter Aortic Valve Replacement, Coronary Artery Bypass Graft, and Other Cardiovascular Care.

Clin Geriatr Med 2019 11 3;35(4):571-585. Epub 2019 Jul 3.

Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, Manitoba, Canada; Institute of Cardiovascular Sciences, St. Boniface Hospital, Albrechtsen Research Centre, R4012-351 Tache Avenue, Winnipeg, Manitoba R2H 2A6, Canada; Department of Surgery, Section of Cardiac Surgery, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba R2H 2A6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cger.2019.07.006DOI Listing
November 2019

Accuracy of protein-level disorder predictions.

Brief Bioinform 2019 Oct 15. Epub 2019 Oct 15.

Department of Computer Science, Virginia Commonwealth University, USA.

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http://dx.doi.org/10.1093/bib/bbz100DOI Listing
October 2019

Intrinsically disordered domains: Sequence ➔ disorder ➔ function relationships.

Protein Sci 2019 09 9;28(9):1652-1663. Epub 2019 Aug 9.

Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1002/pro.3680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699093PMC
September 2019

Computational Prediction of Secondary and Supersecondary Structures from Protein Sequences.

Methods Mol Biol 2019 ;1958:73-100

Department of Computer Science, College of Engineering, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.1007/978-1-4939-9161-7_4DOI Listing
July 2019

Predicting Functions of Disordered Proteins with MoRFpred.

Methods Mol Biol 2019 ;1851:337-352

Department of Computer Science, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.1007/978-1-4939-8736-8_19DOI Listing
May 2019

Quality assessment for the putative intrinsic disorder in proteins.

Bioinformatics 2019 05;35(10):1692-1700

Department of Computer Science, Virginia Commonwealth University, Richmond, VA, USA.

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https://academic.oup.com/bioinformatics/advance-article/doi/
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http://dx.doi.org/10.1093/bioinformatics/bty881DOI Listing
May 2019

Intrinsically Disordered Proteome of Human Membrane-Less Organelles.

Proteomics 2018 03 21;18(5-6):e1700193. Epub 2017 Dec 21.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1002/pmic.201700193DOI Listing
March 2018

Evidence for a Strong Correlation Between Transcription Factor Protein Disorder and Organismic Complexity.

Genome Biol Evol 2017 05;9(5):1248-1265

Department of Biochemistry and Molecular Biology, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN.

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http://dx.doi.org/10.1093/gbe/evx073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434936PMC
May 2017

Back to the Future: Nuclear Magnetic Resonance and Bioinformatics Studies on Intrinsically Disordered Proteins.

Adv Exp Med Biol 2015 ;870:1-34

Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, 46202, Indianapolis, IN, USA.

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http://link.springer.com/content/pdf/10.1007%2F978-3-319-201
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http://link.springer.com/10.1007/978-3-319-20164-1_1
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http://dx.doi.org/10.1007/978-3-319-20164-1_1DOI Listing
December 2015

Pliability of protein complexes and complexity of protein pliability.

FEBS Lett 2015 Sep 29;589(19 Pt A):2431-2. Epub 2015 Aug 29.

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University Schools of Medicine and Informatics, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1016/j.febslet.2015.08.035DOI Listing
September 2015

Erratum to: Improving protein order-disorder classification using charge-hydropathy plots.

BMC Bioinformatics 2015 Jul 31;16:241. Epub 2015 Jul 31.

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1186/s12859-015-0646-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520057PMC
July 2015

Intrinsically disordered proteins and intrinsically disordered protein regions.

Annu Rev Biochem 2014 5;83:553-84. Epub 2014 Mar 5.

Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana 46202; email: ,

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http://dx.doi.org/10.1146/annurev-biochem-072711-164947DOI Listing
January 2015

Intrinsically disordered proteins and multicellular organisms.

Semin Cell Dev Biol 2015 Jan 13;37:44-55. Epub 2014 Oct 13.

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University Schools of Medicine and Informatics, Indianapolis, IN 46202, United States. Electronic address:

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http://www.pnas.org/content/109/39/15781.full.pdf
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http://www.pnas.org/content/106/47/19819.full.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S108495211400292
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http://dx.doi.org/10.1016/j.semcdb.2014.09.025DOI Listing
January 2015

A creature with a hundred waggly tails: intrinsically disordered proteins in the ribosome.

Cell Mol Life Sci 2014 Apr 13;71(8):1477-504. Epub 2013 Aug 13.

Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, T6G 2V4, Canada.

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http://dx.doi.org/10.1007/s00018-013-1446-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079807PMC
April 2014

Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding.

Protein Sci 2013 Mar 27;22(3):258-73. Epub 2013 Jan 27.

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1002/pro.2207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595456PMC
March 2013

Utilization of protein intrinsic disorder knowledge in structural proteomics.

Biochim Biophys Acta 2013 Feb 8;1834(2):487-98. Epub 2012 Dec 8.

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1016/j.bbapap.2012.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951342PMC
February 2013

High-throughput characterization of intrinsic disorder in proteins from the Protein Structure Initiative.

J Struct Biol 2012 Oct 29;180(1):201-15. Epub 2012 May 29.

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1016/j.jsb.2012.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578346PMC
October 2012

Protein intrinsic disorder and induced pluripotent stem cells.

Mol Biosyst 2012 Jan 14;8(1):134-50. Epub 2011 Jul 14.

Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, Florida 33612, USA.

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http://dx.doi.org/10.1039/c1mb05163fDOI Listing
January 2012

Viral disorder or disordered viruses: do viral proteins possess unique features?

Protein Pept Lett 2010 Aug;17(8):932-51

Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.2174/092986610791498984DOI Listing
August 2010

Archaic chaos: intrinsically disordered proteins in Archaea.

BMC Syst Biol 2010 May 28;4 Suppl 1:S1. Epub 2010 May 28.

Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1186/1752-0509-4-S1-S1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880407PMC
May 2010

Unfoldomics of human genetic diseases: illustrative examples of ordered and intrinsically disordered members of the human diseasome.

Protein Pept Lett 2009 ;16(12):1533-47

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 410 W. 10th Street, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.2174/092986609789839377DOI Listing
February 2010

Protein disorder in the human diseasome: unfoldomics of human genetic diseases.

BMC Genomics 2009 Jul 7;10 Suppl 1:S12. Epub 2009 Jul 7.

Center for Information Science and Technology, Temple University, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1186/1471-2164-10-S1-S12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709255PMC
July 2009

Unfoldomics of human diseases: linking protein intrinsic disorder with diseases.

BMC Genomics 2009 Jul 7;10 Suppl 1:S7. Epub 2009 Jul 7.

Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1186/1471-2164-10-S1-S7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709268PMC
July 2009

CDF it all: consensus prediction of intrinsically disordered proteins based on various cumulative distribution functions.

FEBS Lett 2009 May 5;583(9):1469-74. Epub 2009 Apr 5.

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 410 W. 10th Street, HS 5009, Indianapolis, IN 46202, USA.

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http://doi.wiley.com/10.1016/j.febslet.2009.03.070
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http://dx.doi.org/10.1016/j.febslet.2009.03.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683465PMC
May 2009

Close encounters of the third kind: disordered domains and the interactions of proteins.

Bioessays 2009 Mar;31(3):328-35

Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary.

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http://dx.doi.org/10.1002/bies.200800151DOI Listing
March 2009

Do viral proteins possess unique biophysical features?

Trends Biochem Sci 2009 Feb 4;34(2):53-9. Epub 2008 Dec 4.

Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1016/j.tibs.2008.10.009DOI Listing
February 2009

Malleable machines in transcription regulation: the mediator complex.

PLoS Comput Biol 2008 Dec 19;4(12):e1000243. Epub 2008 Dec 19.

Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary.

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http://dx.doi.org/10.1371/journal.pcbi.1000243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588115PMC
December 2008

The unfoldomics decade: an update on intrinsically disordered proteins.

BMC Genomics 2008 Sep 16;9 Suppl 2:S1. Epub 2008 Sep 16.

Center for Computational Biology and Bioinformatics, Indiana University Schools of Medicine and Informatics, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1186/1471-2164-9-S2-S1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2559873PMC
September 2008

Intrinsically disordered proteins in human diseases: introducing the D2 concept.

Annu Rev Biophys 2008 ;37:215-46

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1146/annurev.biophys.37.032807.125924DOI Listing
August 2008

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners.

BMC Genomics 2008 ;9 Suppl 1:S1

Center for Computational Biology and Bioinformatics, Indiana University Schools of Medicine and Informatics, 410 W, 10th Street, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1186/1471-2164-9-S1-S1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386051PMC
June 2008

Mining alpha-helix-forming molecular recognition features with cross species sequence alignments.

Biochemistry 2007 Nov 1;46(47):13468-77. Epub 2007 Nov 1.

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1021/bi7012273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570644PMC
November 2007

Characterization of molecular recognition features, MoRFs, and their binding partners.

J Proteome Res 2007 Jun 9;6(6):2351-66. Epub 2007 May 9.

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1021/pr0701411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570643PMC
June 2007

Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions.

J Proteome Res 2007 May 29;6(5):1882-98. Epub 2007 Mar 29.

Center for Information Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA.

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http://dx.doi.org/10.1021/pr060392uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2543138PMC
May 2007

Intrinsic disorder and functional proteomics.

Biophys J 2007 Mar 8;92(5):1439-56. Epub 2006 Dec 8.

School of Informatics, Indiana University, Bloomington, Indiana, USA.

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http://dx.doi.org/10.1529/biophysj.106.094045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796814PMC
March 2007

Rational drug design via intrinsically disordered protein.

Trends Biotechnol 2006 Oct 28;24(10):435-42. Epub 2006 Jul 28.

Molecular Kinetics Inc., 6201 La Pas Trail, Suite 160, Indianapolis, IN 46268, USA.

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http://dx.doi.org/10.1016/j.tibtech.2006.07.005DOI Listing
October 2006

Abundance of intrinsic disorder in protein associated with cardiovascular disease.

Biochemistry 2006 Sep;45(35):10448-60

Molecular Kinetics, Inc., Indianapolis, Indiana 46268, USA.

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http://dx.doi.org/10.1021/bi060981dDOI Listing
September 2006

Protein intrinsic disorder and human papillomaviruses: increased amount of disorder in E6 and E7 oncoproteins from high risk HPVs.

J Proteome Res 2006 Aug;5(8):1829-42

Department of Biochemistry and Molecular Biology, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, 46202, USA.

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http://dx.doi.org/10.1021/pr0602388DOI Listing
August 2006

Intrinsic disorder in transcription factors.

Biochemistry 2006 Jun;45(22):6873-88

School of Informatics, Indiana University-Purdue University Indianapolis, 535 West Michigan Street, Indianapolis, Indiana 46202, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi0602718
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http://dx.doi.org/10.1021/bi0602718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538555PMC
June 2006

Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling.

J Mol Recognit 2005 Sep-Oct;18(5):343-84

Molecular Kinetics, 6201 La Pas Trail, Suite 160, Indianapolis, IN 46268, USA.

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http://dx.doi.org/10.1002/jmr.747DOI Listing
October 2005

Coupled folding and binding with alpha-helix-forming molecular recognition elements.

Biochemistry 2005 Sep;44(37):12454-70

Molecular Kinetics Inc., 6201 La Pas Trail, Suite 160, Indianapolis, Indiana 46268, USA.

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http://dx.doi.org/10.1021/bi050736eDOI Listing
September 2005

Addressing the intrinsic disorder bottleneck in structural proteomics.

Proteins 2005 May;59(3):444-53

Center for Eukaryotic Structural Genomics, Biochemistry Department, University of Wisconsin, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1002/prot.20446DOI Listing
May 2005

Comparing and combining predictors of mostly disordered proteins.

Biochemistry 2005 Feb;44(6):1989-2000

Molecular Kinetics, Inc., 6201 La Pas Trail, Suite 160, Indianapolis, Indiana 46268, USA.

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https://pubs.acs.org/doi/10.1021/bi047993o
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http://dx.doi.org/10.1021/bi047993oDOI Listing
February 2005

The C-terminal domain of measles virus nucleoprotein belongs to the class of intrinsically disordered proteins that fold upon binding to their physiological partner.

Virus Res 2004 Feb;99(2):157-67

Architecture et Fonction des Macromolécules Biologiques, UMR 6098 CNRS et Université Aix-Marseille I et II, ESIL, Campus de Luminy, Cedex 09 13288, Marseille, France.

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http://dx.doi.org/10.1016/j.virusres.2003.11.007DOI Listing
February 2004

Evolutionary rate heterogeneity in proteins with long disordered regions.

J Mol Evol 2002 Jul;55(1):104-10

School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA.

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http://dx.doi.org/10.1007/s00239-001-2309-6DOI Listing
July 2002