Publications by authors named "Christopher J Morrow"

19Publications

Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.

Authors:
James S Scott Thomas A Moss Amber Balazs Bernard Barlaam Jason Breed Rodrigo J Carbajo Elisabetta Chiarparin Paul R J Davey Oona Delpuech Stephen Fawell David I Fisher Sladjana Gagrica Eric T Gangl Tyler Grebe Ryan D Greenwood Sudhir Hande Holia Hatoum-Mokdad Kara Herlihy Samantha Hughes Thomas A Hunt Hoan Huynh Sophie L M Janbon Tony Johnson Stefan Kavanagh Teresa Klinowska Mandy Lawson Andrew S Lister Stacey Marden Dermot F McGinnity Christopher J Morrow J Willem M Nissink Daniel H O'Donovan Bo Peng Radoslaw Polanski Darren S Stead Stephen Stokes Kumar Thakur Scott R Throner Michael J Tucker Jeffrey Varnes Haixia Wang David M Wilson Dedong Wu Ye Wu Bin Yang Wenzhan Yang

J Med Chem 2020 12 29;63(23):14530-14559. Epub 2020 Sep 29.

Advanced Drug Delivery, Pharmaceutical Sciences, R&D, Boston, Massachusetts, United States.

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December 2020

Isolation of Mycoplasma anserisalpingitidis from swan goose (Anser cygnoides) in China.

Authors:
Miklós Gyuranecz Alexa Mitter Áron B Kovács Dénes Grózner Zsuzsa Kreizinger Krisztina Bali Krisztián Bányai Christopher J Morrow

BMC Vet Res 2020 Jun 5;16(1):178. Epub 2020 Jun 5.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne, Victoria, 3010, Australia.

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June 2020

Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry.

Authors:
James S Scott Jason Breed Rodrigo J Carbajo Paul R Davey Ryan Greenwood Hoan K Huynh Teresa Klinowska Christopher J Morrow Thomas A Moss Radoslaw Polanski J Willem M Nissink Jeffrey Varnes Bin Yang

ACS Med Chem Lett 2019 Oct 23;10(10):1492-1497. Epub 2019 Sep 23.

Oncology R&D, AstraZeneca, R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.

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October 2019

Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists.

Authors:
James S Scott Andrew Bailey David Buttar Rodrigo J Carbajo Jon Curwen Paul R J Davey Robert D M Davies Sébastien L Degorce Craig Donald Eric Gangl Ryan Greenwood Sam D Groombridge Tony Johnson Scott Lamont Mandy Lawson Andrew Lister Christopher J Morrow Thomas A Moss Jennifer H Pink Radoslaw Polanski

J Med Chem 2019 02 30;62(3):1593-1608. Epub 2019 Jan 30.

Oncology IMED Biotech Unit , AstraZeneca, R&D Boston , 35 Gatehouse Drive , Waltham , Massachusetts 02451 , United States.

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February 2019

The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer.

Authors:
Alice Lallo Kristopher K Frese Christopher J Morrow Robert Sloane Sakshi Gulati Maximillian W Schenk Francesca Trapani Nicole Simms Melanie Galvin Stewart Brown Cassandra L Hodgkinson Lynsey Priest Adina Hughes Zhongwu Lai Elaine Cadogan Garima Khandelwal Kathryn L Simpson Crispin Miller Fiona Blackhall Mark J O'Connor Caroline Dive

Clin Cancer Res 2018 10 25;24(20):5153-5164. Epub 2018 Jun 25.

Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom.

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October 2018

Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer.

Authors:
Louise Carter Dominic G Rothwell Barbara Mesquita Christopher Smowton Hui Sun Leong Fabiola Fernandez-Gutierrez Yaoyong Li Deborah J Burt Jenny Antonello Christopher J Morrow Cassandra L Hodgkinson Karen Morris Lynsey Priest Mathew Carter Crispin Miller Andrew Hughes Fiona Blackhall Caroline Dive Ged Brady

Nat Med 2017 01 21;23(1):114-119. Epub 2016 Nov 21.

Clinical and Experimental Pharmacology Group, CRUK Manchester Institute, University of Manchester, Manchester, UK.

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January 2017

Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer.

Authors:
Nadine S Jahchan Jing Shan Lim Becky Bola Karen Morris Garrett Seitz Kim Q Tran Lei Xu Francesca Trapani Christopher J Morrow Sandra Cristea Garry L Coles Dian Yang Dedeepya Vaka Michael S Kareta Julie George Pawel K Mazur Thuyen Nguyen Wade C Anderson Scott J Dylla Fiona Blackhall Martin Peifer Caroline Dive Julien Sage

Cell Rep 2016 07 30;16(3):644-56. Epub 2016 Jun 30.

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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July 2016

Inhibition of PI3K/BMX Cell Survival Pathway Sensitizes to BH3 Mimetics in SCLC.

Authors:
Danielle S Potter Melanie Galvin Stewart Brown Alice Lallo Cassandra L Hodgkinson Fiona Blackhall Christopher J Morrow Caroline Dive

Mol Cancer Ther 2016 06 29;15(6):1248-60. Epub 2016 Mar 29.

Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom. CRUK Lung Cancer Centre of Excellence, Manchester, United Kingdom.

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June 2016

Somatically mutated ABL1 is an actionable and essential NSCLC survival gene.

Authors:
Ewelina Testoni Natalie L Stephenson Pedro Torres-Ayuso Anna A Marusiak Eleanor W Trotter Andrew Hudson Cassandra L Hodgkinson Christopher J Morrow Caroline Dive John Brognard

EMBO Mol Med 2016 Feb;8(2):105-16

Signalling Networks in Cancer Group, Cancer Research UK Manchester Institute The University of Manchester, Manchester, UK

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February 2016

Development of a circulating miRNA assay to monitor tumor burden: From mouse to man.

Authors:
Alastair Greystoke Mahmood Ayub Dominic G Rothwell Dan Morris Deborah Burt Cassandra L Hodgkinson Christopher J Morrow Nigel Smith Kyaw Aung Juan Valle Louise Carter Fiona Blackhall Caroline Dive Ged Brady

Mol Oncol 2016 Feb 28;10(2):282-91. Epub 2015 Oct 28.

Clinical & Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, UK. Electronic address:

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February 2016

Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer.

Authors:
Cassandra L Hodgkinson Christopher J Morrow Yaoyong Li Robert L Metcalf Dominic G Rothwell Francesca Trapani Radoslaw Polanski Deborah J Burt Kathryn L Simpson Karen Morris Stuart D Pepper Daisuke Nonaka Alastair Greystoke Paul Kelly Becky Bola Matthew G Krebs Jenny Antonello Mahmood Ayub Suzanne Faulkner Lynsey Priest Louise Carter Catriona Tate Crispin J Miller Fiona Blackhall Ged Brady Caroline Dive

Nat Med 2014 Aug 1;20(8):897-903. Epub 2014 Jun 1.

1] Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK. [2].

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August 2014

BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737.

Authors:
Danielle S Potter Paul Kelly Olive Denneny Veronique Juvin Len R Stephens Caroline Dive Christopher J Morrow

Neoplasia 2014 Feb;16(2):147-57

Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom. Electronic address:

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February 2014

Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.

Authors:
Radosław Polański Cassandra L Hodgkinson Alberto Fusi Daisuke Nonaka Lynsey Priest Paul Kelly Francesca Trapani Paul W Bishop Anne White Susan E Critchlow Paul D Smith Fiona Blackhall Caroline Dive Christopher J Morrow

Clin Cancer Res 2014 Feb 25;20(4):926-937. Epub 2013 Nov 25.

Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, UK.

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February 2014

[18F]-FLT positron emission tomography can be used to image the response of sensitive tumors to PI3-kinase inhibition with the novel agent GDC-0941.

Authors:
Christopher Cawthorne Natalie Burrows Roben G Gieling Christopher J Morrow Duncan Forster Jamil Gregory Marc Radigois Alison Smigova Muhammad Babur Kathryn Simpson Cassandra Hodgkinson Gavin Brown Adam McMahon Caroline Dive Duncan Hiscock Ian Wilson Kaye J Williams

Mol Cancer Ther 2013 May 20;12(5):819-28. Epub 2013 Feb 20.

Wolfson Molecular Imaging Centre, School of Cancer and Enabling Sciences, The University of Manchester, Manchester, United Kingdom.

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May 2013

Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1.

Authors:
Luke R E Harrison Dimitra Micha Martin Brandenburg Kathryn L Simpson Christopher J Morrow Olive Denneny Cassandra Hodgkinson Zaira Yunus Clare Dempsey Darren Roberts Fiona Blackhall Guy Makin Caroline Dive

J Clin Invest 2011 Mar;121(3):1075-87

Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom.

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March 2011

Src family kinase inhibitor Saracatinib (AZD0530) impairs oxaliplatin uptake in colorectal cancer cells and blocks organic cation transporters.

Authors:
Christopher J Morrow Mohammad Ghattas Christopher Smith Heinz Bönisch Richard A Bryce D Mark Hickinson Tim P Green Caroline Dive

Cancer Res 2010 Jul 15;70(14):5931-41. Epub 2010 Jun 15.

Paterson Institute for Cancer Research, University of Manchester, Manchester Cancer Research Centre and Manchester Academic Health Sciences Centre, Manchester, United Kingdom.

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July 2010

Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs.

Authors:
Cristina Martin-Fernandez Juliana Bales Cassandra Hodgkinson Arkadiusz Welman Melanie J Welham Caroline Dive Christopher J Morrow

Mol Cancer Res 2009 Jun 9;7(6):955-65. Epub 2009 Jun 9.

Paterson Institute for Cancer Research, University of Manchester, United Kingdom.

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June 2009

Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA.

Authors:
Christopher J Morrow Alexander Gray Caroline Dive

FEBS Lett 2005 Sep;579(23):5123-8

Cellular and Molecular Pharmacology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, United Kingdom.

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September 2005

Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.

Authors:
Christopher J Morrow Anthony Tighe Victoria L Johnson Maria I F Scott Claire Ditchfield Stephen S Taylor

J Cell Sci 2005 Aug 26;118(Pt 16):3639-52. Epub 2005 Jul 26.

Faculty of Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.

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August 2005