Christopher J Bakkenist

Christopher J Bakkenist

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Christopher J Bakkenist

Publications by authors named "Christopher J Bakkenist"

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The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination.

Nucleic Acids Res 2019 Nov;47(19):10151-10165

Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1093/nar/gkz738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821187PMC
November 2019

WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells.

Proc Natl Acad Sci U S A 2019 Nov 11. Epub 2019 Nov 11.

Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15213.

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http://dx.doi.org/10.1073/pnas.1915108116DOI Listing
November 2019

Dormant origin signaling during unperturbed replication.

DNA Repair (Amst) 2019 Sep 8;81:102655. Epub 2019 Jul 8.

Department of Radiation Oncology, University of Pittsburgh School of Medicine, UPMC Hillman Cancer Center, Research Pavilion, Suite 2.6, 5117 Centre Avenue, Pittsburgh, PA 15213-1863, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15687864193020
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http://dx.doi.org/10.1016/j.dnarep.2019.102655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764875PMC
September 2019

Quantitative analysis of ATM phosphorylation in lymphocytes.

DNA Repair (Amst) 2019 Aug 4;80:1-7. Epub 2019 Jun 4.

Department of Medicine, University of Pittsburgh School of Medicine, 5117 Centre Avenue, Pittsburgh, PA, 15213-1863, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708498PMC
August 2019

ATR inhibition sensitizes HPV and HPV head and neck squamous cell carcinoma to cisplatin.

Oral Oncol 2019 Aug 6;95:35-42. Epub 2019 Jun 6.

Department of Otolaryngology, University of California, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2019.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827881PMC
August 2019

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication.

Proc Natl Acad Sci U S A 2019 Jul 17;116(27):13374-13383. Epub 2019 Jun 17.

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;

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http://dx.doi.org/10.1073/pnas.1903418116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613105PMC
July 2019

The neonatal Fc receptor is a pan-echovirus receptor.

Proc Natl Acad Sci U S A 2019 02 11;116(9):3758-3763. Epub 2019 Feb 11.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224;

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http://dx.doi.org/10.1073/pnas.1817341116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397586PMC
February 2019

Regulation of the initiation of DNA replication in human cells.

DNA Repair (Amst) 2018 12 12;72:99-106. Epub 2018 Sep 12.

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15687864183021
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http://dx.doi.org/10.1016/j.dnarep.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261693PMC
December 2018

ATM Is Required for the Repair of Oxaliplatin-Induced DNA Damage in Colorectal Cancer.

Clin Colorectal Cancer 2018 12 13;17(4):255-257. Epub 2018 Sep 13.

Department of Medicine, University of Pittsburgh School of Medicine, UPMC Hillman Cancer Center, Pittsburgh, PA.

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183043
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http://dx.doi.org/10.1016/j.clcc.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561466PMC
December 2018

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA.

Nat Commun 2018 12 17;9(1):5351. Epub 2018 Dec 17.

Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University, New York, NY, 10032-3802, USA.

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http://dx.doi.org/10.1038/s41467-018-07798-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297235PMC
December 2018

LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma.

J Pharm Biomed Anal 2017 Nov 31;146:244-250. Epub 2017 Aug 31.

Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2017.08.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632222PMC
November 2017

ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1.

Nat Commun 2017 11 9;8(1):1392. Epub 2017 Nov 9.

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Hillman Cancer Center, Research Pavilion, Suite 2.6, 5117 Centre Avenue, Pittsburgh, PA, 15213-1863, USA.

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http://dx.doi.org/10.1038/s41467-017-01401-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680267PMC
November 2017

LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma.

J Pharm Biomed Anal 2017 May 4;138:158-165. Epub 2017 Feb 4.

Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085173024
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http://dx.doi.org/10.1016/j.jpba.2017.01.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357441PMC
May 2017

RAD-ADAPT: Software for modelling clonogenic assay data in radiation biology.

DNA Repair (Amst) 2017 04 20;52:24-30. Epub 2017 Feb 20.

Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396547PMC
April 2017

ATM protein is deficient in over 40% of lung adenocarcinomas.

Oncotarget 2016 09;7(36):57714-57725

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.18632/oncotarget.9757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295384PMC
September 2016

ATM serine-1981 phosphorylation is a plausible biomarker.

Cell Cycle 2015 ;14(20):3207-8

c Department of Medicine ; University of Pittsburgh School of Medicine, Hillman Cancer Center ; Pittsburgh , PA USA.

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http://dx.doi.org/10.1080/15384101.2015.1084205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825586PMC
August 2016

Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.

DNA Repair (Amst) 2016 07 7;43:9-17. Epub 2016 May 7.

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Hillman Cancer Center, Research Pavilion, Suite 2.6, 5117 Centre Avenue, Pittsburgh, PA 15213-1863, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Hillman Cancer Center, Research Pavilion, Suite 2.6, 5117 Centre Avenue, Pittsburgh, PA 15213-1863, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2016.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917431PMC
July 2016

Chromatin perturbations during the DNA damage response in higher eukaryotes.

DNA Repair (Amst) 2015 Dec 9;36:8-12. Epub 2015 Sep 9.

Executive Director, Duke Cancer Institute, William W. Shingleton Professor of Pharmacology and Cancer Biology, Duke University School of Medicine, 422 Seeley Mudd Building, Box 3917, Durham, NC 27 710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727245PMC
December 2015

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma.

BMC Cancer 2015 Oct 5;15:649. Epub 2015 Oct 5.

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1186/s12885-015-1649-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595318PMC
October 2015

Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells.

Gynecol Oncol 2015 Mar 2;136(3):554-61. Epub 2015 Jan 2.

Women's Health Integrated Research Center at Inova Health System, Department of Defense Gynecologic Cancer Center of Excellence, Annandale, VA 22003, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2014.12.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382918PMC
March 2015

Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase.

J Immunol 2014 Jun 5;192(12):5933-42. Epub 2014 May 5.

Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213;

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http://dx.doi.org/10.4049/jimmunol.1303470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078001PMC
June 2014

ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.

Nucleic Acids Res 2013 Dec 14;41(22):10334-44. Epub 2013 Sep 14.

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Department of Cell Biology and Physiology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA and Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1093/nar/gkt833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905881PMC
December 2013

Stoichiometry of ubiquitin-binding proteins directs DSB repair.

Cell Cycle 2013 Dec 28;12(24):3716-7. Epub 2013 Oct 28.

Department of Pathology; University of North Carolina Chapel Hill; Chapel Hill, NC USA.

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http://dx.doi.org/10.4161/cc.26963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905061PMC
December 2013

Erratum: Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation: erratum.

Biomed Opt Express 2013 14;4(11):2491. Epub 2013 Oct 14.

Biomedical and Optical Imaging Laboratory (BOIL), Departments of Medicine and Bioengineering, University of Pittsburgh, Pittsburgh PA 15213, USA.

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https://www.osapublishing.org/boe/abstract.cfm?uri=boe-4-11-
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http://dx.doi.org/10.1364/BOE.4.002491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829542PMC
October 2013

Brd4 shields chromatin from ATM kinase signaling storms.

Sci Signal 2013 Sep 17;6(293):pe30. Epub 2013 Sep 17.

1UPMC Medical Education Transitional Year Residency Program, University of Pittsburgh School of Medicine, Hillman Cancer Center, Research Pavilion, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1126/scisignal.2004622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936316PMC
September 2013

Radiation therapy induces the DNA damage response in peripheral blood.

Oncotarget 2013 Aug;4(8):1143-8

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787146PMC
http://dx.doi.org/10.18632/oncotarget.1084DOI Listing
August 2013

Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation.

Biomed Opt Express 2013 04 22;4(4):596-613. Epub 2013 Mar 22.

Biomedical and Optical Imaging Laboratory (BOIL), Departments of Medicine and Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1364/BOE.4.000596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617721PMC
April 2013

Homologous chromosomes move and rapidly initiate contact at the sites of double-strand breaks in genes in G₀-phase human cells.

Cell Cycle 2013 Feb 31;12(4):547-52. Epub 2013 Jan 31.

Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.4161/cc.23754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594255PMC
February 2013

Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress.

J Cell Sci 2012 Dec 26;125(Pt 23):5745-57. Epub 2012 Sep 26.

Department of Pharmacology and Chemical Biology, Hillman Cancer Center Pittsburgh, PA 15213 USA.

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http://dx.doi.org/10.1242/jcs.109769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074216PMC
December 2012

Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes.

J Proteome Res 2012 Oct 18;11(10):4983-91. Epub 2012 Sep 18.

Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.

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http://dx.doi.org/10.1021/pr3005524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495236PMC
October 2012

Homologous chromosomes make contact at the sites of double-strand breaks in genes in somatic G0/G1-phase human cells.

Proc Natl Acad Sci U S A 2012 Jun 29;109(24):9454-9. Epub 2012 May 29.

Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1073/pnas.1205759109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386068PMC
June 2012

ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.

J Biol Chem 2012 Apr 23;287(15):12445-54. Epub 2012 Feb 23.

Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-1863, USA.

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http://dx.doi.org/10.1074/jbc.M112.352310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320994PMC
April 2012

The ATM kinase signaling induced by the low-energy β-particles emitted by (33)P is essential for the suppression of chromosome aberrations and is greater than that induced by the energetic β-particles emitted by (32)P.

Mutat Res 2011 Mar 16;708(1-2):28-36. Epub 2011 Feb 16.

Department of Radiation Oncology, University of Pittsburgh Medical School, Hillman Cancer Center, Research Pavilion, Suite 2.6, 5117 Centre Avenue, Pittsburgh, PA 15213-1863, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2011.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182116PMC
March 2011

Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors.

Cell Cycle 2010 Oct 27;9(20):4052-7. Epub 2010 Oct 27.

Medical Scientist Training Program, Molecular Pharmacology Graduate Program, University of Pittsburgh School of Medicine, Hillman Cancer Center, Research Pavilion, Pittsburgh, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230471PMC
http://dx.doi.org/10.4161/cc.9.20.13471DOI Listing
October 2010

HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically.

J Biol Chem 2010 Jun 26;285(24):18139-43. Epub 2010 Apr 26.

Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1074/jbc.C110.131599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881737PMC
June 2010

Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

Sci Signal 2010 Jun 1;3(124):ra44. Epub 2010 Jun 1.

Department of Radiation Oncology, University of Pittsburgh Medical School, Hillman Cancer Center, Research Pavilion, Suite 2.6, Pittsburgh, PA 15213-1863, USA.

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http://dx.doi.org/10.1126/scisignal.2000758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261617PMC
June 2010

Sumoylation of eIF4E activates mRNA translation.

EMBO Rep 2010 Apr 12;11(4):299-304. Epub 2010 Mar 12.

Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, 5117 Centre Avenue, Suite 2.42D, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1038/embor.2010.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854592PMC
April 2010

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.

Cell Cycle 2008 May 18;7(9):1277-84. Epub 2008 Mar 18.

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.4161/cc.7.9.5961DOI Listing
May 2008

ATM activation in normal human tissues and testicular cancer.

Cell Cycle 2005 Jun 13;4(6):838-45. Epub 2005 Jun 13.

Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark.

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http://dx.doi.org/10.4161/cc.4.6.1742DOI Listing
June 2005

Initiating cellular stress responses.

Cell 2004 Jul;118(1):9-17

Department of Hematology-Oncology, St. Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.cell.2004.06.023DOI Listing
July 2004

Phosphatases join kinases in DNA-damage response pathways.

Trends Cell Biol 2004 Jul;14(7):339-41

Department of Hematology and Oncology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096289240400133
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http://dx.doi.org/10.1016/j.tcb.2004.05.001DOI Listing
July 2004

Disappearance of the telomere dysfunction-induced stress response in fully senescent cells.

Cancer Res 2004 Jun;64(11):3748-52

Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0453DOI Listing
June 2004

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.

Genes Dev 2004 Jun 2;18(12):1423-38. Epub 2004 Jun 2.

Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38018, USA.

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http://dx.doi.org/10.1101/gad.1200304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC423193PMC
June 2004

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation.

Oncogene 2004 Apr;23(17):3122-7

Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, Copenhagen DK-2100 Denmark.

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http://dx.doi.org/10.1038/sj.onc.1207447DOI Listing
April 2004

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.

Nature 2003 Jan;421(6922):499-506

Department of Hematology-Oncology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/nature01368DOI Listing
January 2003