Publications by authors named "Christopher Goldring"

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NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis.
Sci Rep 2018 Apr 4;8(1):5629. Epub 2018 Apr 4.
Department of Pharmaceutical Sciences, Division of Molecular and Systems Toxicology, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland.

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity.
Sci Rep 2017 Nov 22;7(1):16084. Epub 2017 Nov 22.
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK.

A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat.
Biomarkers 2017 Jul 15;22(5):461-469. Epub 2016 Dec 15.
g Department of Physiology and Pharmacology, Science for Life Laboratory , Karolinska Institutet , Stockholm , Sweden.

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells.
Toxicol Sci 2017 Jul;158(1):76-89
Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool L69 3GE, UK.


Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats.
Toxicol Lett 2016 Sep 27;258:207-215. Epub 2016 Jun 27.
Translational Safety, Drug Safety & Metabolism, AstraZeneca, Cambridge Science Park, Cambridge, UK. Electronic address:

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites.
J Med Chem 2016 Mar 8;59(6):2396-409. Epub 2016 Mar 8.
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , L69 3GE Liverpool, U.K.






Chemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoids.
Toxicol Sci 2014 Aug 5;140(2):462-9. Epub 2014 May 5.
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, UK.

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.
J Proteomics 2014 Aug 21;108:171-87. Epub 2014 May 21.
MRC Centre for Drug Safety Science, School of Biomedical Sciences, University of Liverpool, Sherrington Buildings, Liverpool, Merseyside L69 3GE, United Kingdom. Electronic address:


Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers.
Toxicology 2013 Dec 3;314(2-3):262-6. Epub 2013 Jul 3.
Department of Clinical and Molecular Pharmacology, Institute of Translational Medicine, University of Liverpool, UK; Veterinary Pathology, School of Veterinary Science, University of Liverpool, UK; MRC Centre for Drug Safety Science, University of Liverpool, UK. Electronic address:



Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling.
J Biol Chem 2013 Aug 17;288(31):22281-8. Epub 2013 Jun 17.
Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, Sherrington Buildings, Ashton Street, University of Liverpool, Liverpool L69 3GE, United Kingdom.

Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.
J Biol Chem 2012 Mar 6;287(13):10556-64. Epub 2012 Feb 6.
Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.


Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.
J Proteome Res 2010 May;9(5):2658-68
MRC Centre for Drug Safety Science, Department of Pharmacology & Therapeutics, Sherrington Building, Ashton Street, The University of Liverpool, Liverpool L69 3GE, United Kingdom.

Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway.
J Biol Chem 2010 May 8;285(22):16782-8. Epub 2010 Apr 8.
Medical Research Council Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, the University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.

Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells.
Am J Physiol Endocrinol Metab 2009 Feb 16;296(2):E367-77. Epub 2008 Dec 16.
Depts. of Nephrology and Hypertension and Clinical Research, Freiburgstrasse 15, Univ. Hospital, Berne, CH-3010 Berne, Switzerland.





Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo.
Toxicol Appl Pharmacol 2017 10 26;332:64-74. Epub 2017 Jul 26.
Department of Molecular & Clinical Pharmacology, MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. Electronic address:


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