Christopher Goldring

Christopher Goldring

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Christopher Goldring

Christopher Goldring

Publications by authors named "Christopher Goldring"

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63Publications

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Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development.

J Appl Toxicol 2018 Jun 11. Epub 2018 Jun 11.

Tissue Engineering and Regenerative Medicine, Northwick Park Institute for Medical Research (NPIMR), Harrow, London, HA1 3UJ, UK.

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June 2018

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.

Oncotarget 2018 Jun 5;9(43):27104-27116. Epub 2018 Jun 5.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

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June 2018

Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins.

Toxicol In Vitro 2018 Feb 15;46:29-38. Epub 2017 Sep 15.

CN Bio Innovations Limited, BioPark, Broadwater Road, Welwyn Garden City AL7 3AX, UK. Electronic address:

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February 2018

MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury.

Expert Rev Mol Diagn 2018 01 15;18(1):47-54. Epub 2017 Dec 15.

a MRC Centre for Drug Safety Science , University of Liverpool , Liverpool , UK.

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January 2018

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity.

Sci Rep 2017 Nov 22;7(1):16084. Epub 2017 Nov 22.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK.

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November 2017

Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo.

Toxicol Appl Pharmacol 2017 10 26;332:64-74. Epub 2017 Jul 26.

Department of Molecular & Clinical Pharmacology, MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. Electronic address:

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October 2017

A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat.

Biomarkers 2017 Jul 15;22(5):461-469. Epub 2016 Dec 15.

g Department of Physiology and Pharmacology, Science for Life Laboratory , Karolinska Institutet , Stockholm , Sweden.

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July 2017

Circulating levels of miR-122 increase post-mortem, particularly following lethal dosing with pentobarbital sodium: implications for pre-clinical liver injury studies.

Toxicol Res (Camb) 2017 Jul 11;6(4):406-411. Epub 2017 Apr 11.

MRC Centre for Drug Safety Science , Department of Molecular and Clinical Pharmacology , Institute of Translational Medicine , University of Liverpool , UK . Email: ; Email: ; Tel: +44 (0)151 795 5460 ; Tel: +44 (0)151 795 0149.

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July 2017

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells.

Toxicol Sci 2017 07;158(1):76-89

Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool L69 3GE, UK.

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July 2017

Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats.

Toxicol Lett 2016 Sep 27;258:207-215. Epub 2016 Jun 27.

Translational Safety, Drug Safety & Metabolism, AstraZeneca, Cambridge Science Park, Cambridge, UK. Electronic address:

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September 2016

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites.

J Med Chem 2016 Mar 8;59(6):2396-409. Epub 2016 Mar 8.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , L69 3GE Liverpool, U.K.

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March 2016

Understanding the pathophysiological regulatory role of microRNAs in acute liver failure.

Hepatology 2015 Apr 9;61(4):1439-40. Epub 2015 Mar 9.

MRC Center for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

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April 2015

The role of ERK5 in endothelial cell function.

Biochem Soc Trans 2014 Dec;42(6):1584-9

*MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, U.K.

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December 2014

Chemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoids.

Toxicol Sci 2014 Aug 5;140(2):462-9. Epub 2014 May 5.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, UK.

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August 2014

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.

J Proteomics 2014 Aug 21;108:171-87. Epub 2014 May 21.

MRC Centre for Drug Safety Science, School of Biomedical Sciences, University of Liverpool, Sherrington Buildings, Liverpool, Merseyside L69 3GE, United Kingdom. Electronic address:

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August 2014

Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis.

Br J Clin Pharmacol 2014 May;77(5):904-5

National Poisons Information Service Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK; University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Edinburgh, UK.

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May 2014

Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers.

Toxicology 2013 Dec 3;314(2-3):262-6. Epub 2013 Jul 3.

Department of Clinical and Molecular Pharmacology, Institute of Translational Medicine, University of Liverpool, UK; Veterinary Pathology, School of Veterinary Science, University of Liverpool, UK; MRC Centre for Drug Safety Science, University of Liverpool, UK. Electronic address:

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December 2013

Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling.

J Biol Chem 2013 Aug 17;288(31):22281-8. Epub 2013 Jun 17.

Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, Sherrington Buildings, Ashton Street, University of Liverpool, Liverpool L69 3GE, United Kingdom.

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August 2013

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation.

Biochem Pharmacol 2013 Mar 5;85(6):705-17. Epub 2012 Dec 5.

MRC Centre for Drug Safety Science, Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, L69 3GE, UK.

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March 2013

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.

Pharmacol Rep 2012 ;64(3):680-97

Department of Pharmacology, University of Liverpool, Sherrington Buildings, Liverpool, Merseyside, L69 3GE, United Kingdom.

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January 2013

ERK5: structure, regulation and function.

Cell Signal 2012 Nov 16;24(11):2187-96. Epub 2012 Jul 16.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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November 2012

Oct-1 cooperates with the TATA binding initiation complex to control rapid transcription of human iNOS.

Cell Mol Life Sci 2012 Aug 19;69(15):2609-19. Epub 2012 Feb 19.

EPHE Laboratory, Faculty of Medicine, University of Bourgogne, Dijon, France.

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August 2012

Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.

J Biol Chem 2012 Mar 6;287(13):10556-64. Epub 2012 Feb 6.

Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.

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March 2012

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.

J Cell Sci 2011 Jun 24;124(Pt 12):1992-2000. Epub 2011 May 24.

Centre for Regenerative Medicine and Department of Pharmacy and Pharmacology, University of Bath, Bath BA27AY, UK.

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June 2011

Tetracycline-inducible protein expression in pancreatic cancer cells: effects of CapG overexpression.

World J Gastroenterol 2011 Apr;17(15):1947-60

Liverpool CR-UK Centre, Department of Molecular and Therapeutic Cancer Medicine, University of Liverpool, Liverpool, L69 3GA, UK.

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April 2011

Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB.

Biochem Pharmacol 2010 Aug 21;80(3):410-21. Epub 2010 Apr 21.

MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, Merseyside, L69 3GE, UK.

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August 2010

Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.

J Proteome Res 2010 May;9(5):2658-68

MRC Centre for Drug Safety Science, Department of Pharmacology & Therapeutics, Sherrington Building, Ashton Street, The University of Liverpool, Liverpool L69 3GE, United Kingdom.

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May 2010

Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway.

J Biol Chem 2010 May 8;285(22):16782-8. Epub 2010 Apr 8.

Medical Research Council Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, the University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.

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May 2010

The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.

Handb Exp Pharmacol 2010 (196):233-66

MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, The University of Liverpool, Sherrington Building, Ashton Street, Liverpool, Merseyside L69 3GE, UK.

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March 2010

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1.

Toxicol Appl Pharmacol 2009 Jul 7;238(2):120-32. Epub 2009 May 7.

MRC Centre for Drug Safety Science, The University of Liverpool, Department of Pharmacology and Therapeutics, Ashton Street, Liverpool, L69 3GE, UK.

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July 2009

Extract of Ginkgo biloba induces glutathione-S-transferase subunit-P1 in vitro.

Phytomedicine 2009 May 7;16(5):451-5. Epub 2009 Jan 7.

Department of Pharmacology, Wannan Medical College, Wuhu, Anhui, PR China.

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May 2009

Comparison of the antioxidant activity amongst Gingko biloba extract and its main components.

Zhong Yao Cai 2009 May;32(5):736-40

Institute of Pharmacy and Therapeutics,Wannan Medical College, Wuhu 241001, China.

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May 2009

Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells.

Am J Physiol Endocrinol Metab 2009 Feb 16;296(2):E367-77. Epub 2008 Dec 16.

Depts. of Nephrology and Hypertension and Clinical Research, Freiburgstrasse 15, Univ. Hospital, Berne, CH-3010 Berne, Switzerland.

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February 2009

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.

Hepatology 2008 Oct;48(4):1292-301

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, The University of Liverpool, Liverpool, UK.

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October 2008

The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.

Toxicology 2008 Apr 12;246(1):24-33. Epub 2007 Nov 12.

The Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, Merseyside L69 3GE, UK.

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April 2008

Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC).

Phytother Res 2008 Mar;22(3):367-71

Institute of Clinical Pharmacology, Anhui Medical University, Hefei, Anhui, P. R. China.

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March 2008

Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway.

Life Sci 2007 Apr 27;80(17):1586-91. Epub 2007 Jan 27.

Institute of Clinical Pharmacology, Key Laboratory of Anti-inflammatory and Immunopharmacology in Anhui, Anhui Medical University, Meishan Road 81, Hefei Anhui 230032, PR China.

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April 2007

Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.

J Biol Chem 2003 Jun 19;278(25):22243-9. Epub 2003 Mar 19.

Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, United Kingdom.

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June 2003

In vivo footprinting of the human 11beta-hydroxysteroid dehydrogenase type 2 promoter: evidence for cell-specific regulation by Sp1 and Sp3.

J Biol Chem 2002 Apr 15;277(17):14647-56. Epub 2002 Feb 15.

Division of Nephrology and Hypertension, Department of Internal Medicine, University Hospital of Berne, CH-3010 Berne, Switzerland.

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April 2002