Christopher G Hughes

Christopher G Hughes

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Christopher G Hughes

Christopher G Hughes

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Association of neuronal repair biomarkers with delirium among survivors of critical illness.

J Crit Care 2020 Apr 16;56:94-99. Epub 2019 Dec 16.

Department of Anesthesiology, Division of Anesthesiology Critical Care Medicine, Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, United States.

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http://dx.doi.org/10.1016/j.jcrc.2019.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080575PMC
April 2020

Intraoperative Oxidative Damage and Delirium after Cardiac Surgery.

Anesthesiology 2020 03;132(3):551-561

From the Divisions of Anesthesiology Critical Care Medicine (M.G.L., C.G.H., F.T.B.) Cardiothoracic Anesthesiology (J.B.O., F.T.B.), Department of Anesthesiology Department of Biostatistics (M.S.S., J.M.) Department of Cardiac Surgery (M.R.P., A.S.S.) Divisions of Allergy, Pulmonary, and Critical Care Medicine (J.B.M.) Clinical Pharmacology (A.D., N.J.B., F.T.B.), Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1097/ALN.0000000000003016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015795PMC
March 2020

Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients.

PLoS One 2019 19;14(12):e0226412. Epub 2019 Dec 19.

The Critical Illness, Brain Dysfunction and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226412PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922408PMC
March 2020

Statistical analysis plan for the Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients with Acute Respiratory Failure trial.

Crit Care Resusc 2020 Mar;22(1):63-71

Critical Illness, Brain Dysfunction, and Survivorship Center, Vanderbilt University Medical Center, Nashville, TN, USA.

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March 2020

Special Considerations for the Aging Brain and Perioperative Neurocognitive Dysfunction.

Anesthesiol Clin 2019 Sep 17;37(3):521-536. Epub 2019 Jun 17.

Department of Anesthesiology, Division of Anesthesiology Critical Care Medicine, Vanderbilt University School of Medicine, 1211 21st Avenue South, 422 MAB, Nashville, TN 37212, USA.

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http://dx.doi.org/10.1016/j.anclin.2019.04.010DOI Listing
September 2019

Delirium's Arousal Subtypes and Their Relationship with 6-Month Functional Status and Cognition.

Psychosomatics 2019 Jan - Feb;60(1):27-36. Epub 2018 May 17.

Center for Quality Aging, Vanderbilt University Medical Center, Nashville, TN; Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN; Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Medical Center, Tennessee Valley Health Care Center, Nashville, TN.

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http://dx.doi.org/10.1016/j.psym.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296894PMC
August 2019

In the ICU - delirium post cardiac arrest.

Curr Opin Crit Care 2019 06;25(3):218-225

Division of Critical Care Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1097/MCC.0000000000000615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902119PMC
June 2019

Delirium after Cardiac Surgery and Cognitive Change: Comment.

Anesthesiology 2019 05;130(5):857-859

Vanderbilt University Medical Center, Nashville, Tennessee (C.B.).

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http://dx.doi.org/10.1097/ALN.0000000000002698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720126PMC
May 2019

Long-term Cognitive and Functional Impairments After Critical Illness.

Anesth Analg 2019 04;128(4):772-780

From the Department of Anesthesiology, Division of Anesthesiology Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1213/ANE.0000000000004066DOI Listing
April 2019

Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness.

N Engl J Med 2018 12 22;379(26):2506-2516. Epub 2018 Oct 22.

From the Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh (T.D.G.); the Pulmonary, Critical Care, and Sleep Medicine Division, Department of Medicine, Ohio State University Wexner Medical Center, Columbus (M.C.E.), and the Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic Foundation, Cleveland (R.D.H.) - both in Ohio; the Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill (S.S.C.), the Section on Critical Care, Department of Anesthesiology, Wake Forest Baptist Health, Winston-Salem (D.L.B.), and Cone Health System, Greensboro (D.J.F.) - all in North Carolina; the Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle (C.L.H.); the Department of Anesthesiology, University of Maryland School of Medicine, Baltimore (P.R.); the Division of Critical Care Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, New York (M.N.G.); the Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, Denver Health Medical Center, Denver (I.S.D.); the Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California at San Diego, San Diego (A.M., R.L.O.); the Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis (B.K.); the Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT (M.A.P.); the Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor (R.C.H.); the Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Medicine, University of Iowa Hospitals and Clinics, Iowa City (G.A.S.); , and the Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia (W.D.S.); the Center for Clinical Effectiveness, Baylor Scott and White Health, Dallas (A.L.M.); and the Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center (J.L.T., R.C., B.T.P., C.S., L.M.B., J.C.J., P.P.P., N.E.B., C.G.H., M.B.P., J.L.S., G.R.B., R.S.D., E.W.E.), the Center for Health Services Research (R.C., J.C.J., C.S., N.E.B., R.S.D., E.W.E.), the Center for Quality Aging (N.E.B., E.W.E.), the Division of Allergy, Pulmonary, and Critical Care Medicine (J.C.J., C.S., N.E.B., G.R.B., E.W.E.), the Division of General Internal Medicine and Public Health (R.S.D.), Department of Medicine, the Department of Biostatistics (J.L.T., R.C.), the Department of Psychiatry (J.C.J.), the Division of Anesthesiology Critical Care Medicine, Department of Anesthesiology (P.P.P., C.G.H.), the Division of Trauma and Surgical Critical Care, Department of Surgery (M.B.P.), and the Department of Pharmaceutical Services (J.L.S.), Vanderbilt University School of Medicine, Vanderbilt University School of Nursing (L.M.B.), and the Anesthesia Service (P.P.P., C.G.H.), Research Service (J.C.J.), Surgical Service (M.B.P.), and Geriatric Research, Education, and Clinical Center Service (R.S.D., E.W.E.), Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - all in Nashville.

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http://dx.doi.org/10.1056/NEJMoa1808217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364999PMC
December 2018

The effect of ketamine on delirium and opioid-induced hyperalgesia in the Intensive Care Unit.

Anaesth Crit Care Pain Med 2018 12;37(6):525-527

Department of Anesthesiology, Division of Anesthesiology Critical Care Medicine, Vanderbilt University Medical Center, 1211 Medical Center Dr, 37232 Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.accpm.2018.11.001DOI Listing
December 2018

Targeting light versus deep sedation for patients receiving mechanical ventilation.

J Emerg Crit Care Med 2018 Oct 19;2. Epub 2018 Oct 19.

Department of Anesthesiology, Division of Anesthesiology Critical Care Medicine, Vanderbilt University Medical Center, Nashville, USA.

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http://jeccm.amegroups.com/article/view/4672/5217
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http://dx.doi.org/10.21037/jeccm.2018.10.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233900PMC
October 2018

Pain and Its Long-term Interference of Daily Life After Critical Illness.

Anesth Analg 2018 09;127(3):690-697

Division of Anesthesiology Critical Care Medicine and Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1213/ANE.0000000000003358DOI Listing
September 2018

Co-Occurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness.

Crit Care Med 2018 09;46(9):1393-1401

Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1097/CCM.0000000000003218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095801PMC
September 2018

Postoperative delirium.

Presse Med 2018 Apr 19;47(4 Pt 2):e53-e64. Epub 2018 Apr 19.

Vanderbilt University Medical Center, department of anesthesiology, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.lpm.2018.03.012DOI Listing
April 2018

Balanced Crystalloids versus Saline in Critically Ill Adults.

N Engl J Med 2018 03 27;378(9):829-839. Epub 2018 Feb 27.

From the Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine (M.W.S., J.D.C., G.R.B., T.W.R.), the Departments of Emergency Medicine (W.H.S.), Anesthesiology (J.P.W., J.M.E., A.B.K., C.G.H., A.H., L. Weavind, A.D.S.), Biomedical Informatics (J.P.W., J.M.E.), Surgery (J.M.E., O.D.G., A.K.M.), Health Policy (J.M.E.), Biostatistics (L. Wang, D.W.B.), and Pharmaceutical Services (J.L.S.), and the Division of Nephrology and Hypertension, Vanderbilt Center for Kidney Disease and Integrated Program for Acute Kidney Disease (E.D.S.) - all at Vanderbilt University Medical Center, Nashville.

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http://dx.doi.org/10.1056/NEJMoa1711584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846085PMC
March 2018

Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study.

Lancet Respir Med 2018 03;6(3):213-222

ICU Delirium and Cognitive Impairment Study Group at the Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Quality Aging, Vanderbilt University School of Medicine, Nashville, TN, USA; Geriatric Research, Education and Clinical Center (GRECC) Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN, USA.

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http://dx.doi.org/10.1016/S2213-2600(18)30062-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709878PMC
March 2018

Relationships between markers of neurologic and endothelial injury during critical illness and long-term cognitive impairment and disability.

Intensive Care Med 2018 03 9;44(3):345-355. Epub 2018 Mar 9.

Department of Critical Care Medicine and Clinical Research, Investigation and Systems Modeling of Acute Illnesses Center, University of Pittsburgh, Pittsburgh, USA.

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http://dx.doi.org/10.1007/s00134-018-5120-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870884PMC
March 2018

Creation and Execution of a Novel Anesthesia Perioperative Care Service at a Veterans Affairs Hospital.

Anesth Analg 2017 11;125(5):1526-1531

From the *Department of Anesthesiology, Pain Management & Perioperative Medicine, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee; †Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee; ‡Department of Anesthesiology, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee; §Department of Orthopaedic Surgery, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee; ‖Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee; ¶Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee; #Department of Urology, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee; and **Department of Surgery, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee.

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http://dx.doi.org/10.1213/ANE.0000000000001930DOI Listing
November 2017

Subsyndromal Delirium and Institutionalization Among Patients With Critical Illness.

Am J Crit Care 2017 Nov;26(6):447-455

Nathan E. Brummel is an assistant professor and E. Wesley Ely is a professor, Department of Medicine, Center for Quality Aging and the Center for Health Services Research, Vanderbilt University Medical Center, Nashville, Tennessee. Dr Ely is also the associate director for research for the Geriatric Research, Education, and Clinical Center Service (GRECC), Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee. Leanne M. Boehm is a postdoctoral fellow, Vanderbilt University School of Nursing, a quality scholar, GRECC, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, and a research nurse, Department of Medicine, Center for Health Services Research, Vanderbilt University Medical Center. Timothy D. Girard is an associate professor, Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Pratik P. Pandharipande is a professor and Christopher G. Hughes is an associate professor, Department of Anesthesiology, Vanderbilt University Medical Center. James C. Jackson is a research associate professor, Department of Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, and Mayur B. Patel is an assistant professor, Department of Surgery, Vanderbilt University Medical Center. Jin H. Han is an associate professor, Department of Emergency Medicine and Center for Quality Aging, Vanderbilt University Medical Center. Eduard E. Vasilevskis is a staff physician, GRECC, Department of Veterans Affairs Medical Center, VA Tennessee Valley Healthcare System, and an assistant professor, Department of Medicine and Center for Health Services Research, Vanderbilt University Medical Center. Jennifer L. Thompson is a biostatistician and Rameela Chandrasekhar is an assistant professor, Department of Biostatistics, Vanderbilt University School of Medicine. Gordon R. Bernard is associate vice-chancellor for research and a professor, Department of Medicine, Vanderbilt University Medical Center. Robert S. Dittus is director, GRECC, Department of Veterans Affairs Medical Center, VA Tennessee Valley Healthcare System, and a professor, Department of Medicine, Vanderbilt University Medical Center.

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http://dx.doi.org/10.4037/ajcc2017263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831547PMC
November 2017

Surgery and Anesthesia Exposure Is Not a Risk Factor for Cognitive Impairment After Major Noncardiac Surgery and Critical Illness.

Ann Surg 2017 06;265(6):1126-1133

*Department of Anesthesiology, Division of Anesthesiology Critical Care Medicine and Center for Health Services Research, Vanderbilt University Medical Center, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee †Section of Surgical Sciences, Departments of Surgery, Neurosurgery and Hearing and Speech Sciences, Division of Trauma and, Surgical Critical Care, and Emergency General Surgery, Vanderbilt Brain Institute, Center for Health Services Research, Vanderbilt University Medical Center, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee ‡Department of Medicine, Division of Pulmonary and Critical Care Medicine and Center for Health Services Research, Vanderbilt University Medical Center, Research Service, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee §Department of Medicine, Division of Pulmonary and Critical Care Medicine and Center for Health Services Research, Vanderbilt University Medical Center, Geriatric Research, Education and Clinical Center Service, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee ¶Department of Surgery, Radiology, and Radiological Sciences, Vanderbilt University Medical Center, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee ||Department of Medicine, Division of Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee **Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee ††Department of Medicine, Division of Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee ‡‡Section of Surgical Sciences, Department of Surgery, Division of Trauma and Surgical Critical Care, and Emergency General Surgery, Vanderbilt University Medical Center, Nashville, Tennessee §§Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Utah School of Medicine, George E. Wahlen Department of Veterans Affairs Medical Center, Veterans Administration Salt Lake City Health Care System, Salt Lake City, Utah ¶¶George E. Wahlen Department of Veterans Affairs Medical Center, Veterans Administration Salt Lake City Health Care System, Salt Lake City, Utah ||||Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle Division, Veterans Affairs Puget Sound Health Care System, Seattle, Washington ***Clinical Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands †††Departments of Anesthesiology and Surgery, Division of Anesthesiology Critical Care Medicine, Vanderbilt University Medical Center, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee.

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http://dx.doi.org/10.1097/SLA.0000000000001885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856253PMC
June 2017

Intensive Care Unit Delirium: A Review of Diagnosis, Prevention, and Treatment.

Anesthesiology 2016 12;125(6):1229-1241

From the Division of Anesthesiology Critical Care Medicine, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1097/ALN.0000000000001378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119532PMC
December 2016

Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery.

J Thorac Dis 2016 Dec;8(12):E1759-E1762

Department of Anesthesiology, Division of Anesthesiology Critical Care Medicine and Center for Health Services Research, Vanderbilt University Medical Center, Nashville, USA.

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http://dx.doi.org/10.21037/jtd.2016.12.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227247PMC
December 2016

Endothelial Activation and Blood-Brain Barrier Injury as Risk Factors for Delirium in Critically Ill Patients.

Crit Care Med 2016 09;44(9):e809-17

1Division of Anesthesiology Critical Care Medicine, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN.2Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.3Anesthesia Service, Department of Veterans Affairs Medical Center, Tennessee Valley Health Care System, Nashville, TN.4Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN.5Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.6Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN.7Geriatric Research, Education and Clinical Center (GRECC) Service, Department of Veterans Affairs Medical Center, Tennessee Valley Health Care System, Nashville, TN.

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http://dx.doi.org/10.1097/CCM.0000000000001739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987204PMC
September 2016

Dexmedetomidine for the treatment of hyperactive delirium refractory to haloperidol in non-intubated patients.

J Thorac Dis 2016 Jul;8(7):E596-8

Divsion of Anesthesiology Critical Care Medicine, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.21037/jtd.2016.05.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958851PMC
July 2016

The role of anesthesia in the prevention of postoperative delirium: a systematic review.

Minerva Anestesiol 2016 Jun 28;82(6):669-83. Epub 2016 Jan 28.

Neuroanesthesia and Intensive Care Unit, Carlo Besta Neurological Institute, Milan, Italy -

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June 2016

Physiology Considerations in Geriatric Patients.

Anesthesiol Clin 2015 Sep 3;33(3):447-56. Epub 2015 Jul 3.

Division of Critical Care Medicine, Department of Anesthesiology, Vanderbilt University School of Medicine, 1211 21st Avenue South, 526 MAB, Nashville, TN 37212, USA. Electronic address:

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http://dx.doi.org/10.1016/j.anclin.2015.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556136PMC
September 2015

Statins and delirium during critical illness: a multicenter, prospective cohort study.

Crit Care Med 2014 Aug;42(8):1899-909

1Rehabilitation and Aged Care Unit, Hospital Ancelle, Cremona, Italy. 2Geriatric Research Group, Brescia, Italy. 3Center for Quality Aging, Vanderbilt University School of Medicine, Nashville, TN. 4Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN. 5Anesthesia Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN. 6Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN. 7Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN. 8Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN. 9Geriatric Research, Education and Clinical Center Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN. 10Department of Emergency Medicine, Vanderbilt University School of Medicine, Nashville, TN. 11Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN. 12Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN. 13Research Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN. 14Division of Neurology, Department of Medicine, Department of Anesthesiology, and Department of Neurobiology, Duke University Medical Center, Durham, NC.

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http://dx.doi.org/10.1097/CCM.0000000000000398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103957PMC
August 2014

Only a small subset of sedation-related delirium is innocuous: we cannot let our guard down.

Am J Respir Crit Care Med 2014 Jun;189(11):1443-4

1 Vanderbilt University School of Medicine Nashville, Tennessee and.

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http://dx.doi.org/10.1164/rccm.201403-0506LEDOI Listing
June 2014

Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study.

Lancet Respir Med 2014 May 7;2(5):369-79. Epub 2014 Apr 7.

Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA; Geriatric Research, Education and Clinical Center (GRECC) Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN, USA.

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http://dx.doi.org/10.1016/S2213-2600(14)70051-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107313PMC
May 2014

Daily sedation interruption versus targeted light sedation strategies in ICU patients.

Crit Care Med 2013 Sep;41(9 Suppl 1):S39-45

Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1097/CCM.0b013e3182a168c5DOI Listing
September 2013

Association between endothelial dysfunction and acute brain dysfunction during critical illness.

Anesthesiology 2013 Mar;118(3):631-9

Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, 1211 21st Ave. South, 526 MAB, Nashville, Tennessee 37212, USA.

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http://dx.doi.org/10.1097/ALN.0b013e31827bd193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580006PMC
March 2013

Sedation in the intensive care setting.

Clin Pharmacol 2012 25;4:53-63. Epub 2012 Oct 25.

Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.2147/CPAA.S26582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508653PMC
December 2012

Pathophysiology of acute brain dysfunction: what's the cause of all this confusion?

Curr Opin Crit Care 2012 Oct;18(5):518-26

Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA.

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http://dx.doi.org/10.1097/MCC.0b013e328357effaDOI Listing
October 2012

Epidemiology and risk factors for delirium across hospital settings.

Best Pract Res Clin Anaesthesiol 2012 Sep;26(3):277-87

Geriatric Research, Education and Clinical Center, Tennessee Valley Healthcare System, Nashville, USA.

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http://dx.doi.org/10.1016/j.bpa.2012.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580997PMC
September 2012

Future directions of delirium research and management.

Best Pract Res Clin Anaesthesiol 2012 Sep;26(3):395-405

Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1016/j.bpa.2012.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638881PMC
September 2012

Statins and brain dysfunction: a hypothesis to reduce the burden of cognitive impairment in patients who are critically ill.

Chest 2011 Sep;140(3):580-585

Department of Anesthesiology, Division of Critical Care Medicine, Vanderbilt University School of Medicine; Anesthesia Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN.

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http://dx.doi.org/10.1378/chest.10-3065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168859PMC
September 2011

Review articles: the effects of perioperative and intensive care unit sedation on brain organ dysfunction.

Anesth Analg 2011 May 7;112(5):1212-7. Epub 2011 Apr 7.

Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA.

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http://dx.doi.org/10.1213/ANE.0b013e318215366dDOI Listing
May 2011

Intraoperative risk factors for acute respiratory distress syndrome in critically ill patients.

Anesth Analg 2010 Aug 24;111(2):464-7. Epub 2010 Apr 24.

Department of Anesthesiology, Division of Critical Care, Vanderbilt University Medical Center, 526 MAB, 1211 21st Ave. South, Nashville, TN 37212, USA.

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http://dx.doi.org/10.1213/ANE.0b013e3181d8a16aDOI Listing
August 2010