Christopher E Pearson

Christopher E Pearson

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Christopher E Pearson

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Molecular genetics of congenital myotonic dystrophy.

Neurobiol Dis 2019 Jul 19:104533. Epub 2019 Jul 19.

Program of Genetics & Genome Biology, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto M5G 0A4, Ontario, Canada; University of Toronto, Program of Molecular Genetics, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.104533DOI Listing
July 2019

Stress-induced acidification may contribute to formation of unusual structures in C9orf72-repeats.

Biochim Biophys Acta Gen Subj 2018 06 15;1862(6):1482-1491. Epub 2018 Mar 15.

Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2018.03.001DOI Listing
June 2018

Thermodynamic and spectroscopic investigations of TMPyP4 association with guanine- and cytosine-rich DNA and RNA repeats of C9orf72.

Biochem Biophys Res Commun 2018 Jan 20;495(4):2410-2417. Epub 2017 Dec 20.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, M5S 3M2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.12.108DOI Listing
January 2018

Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31.

Neuron 2017 Apr 23;94(1):108-124.e7. Epub 2017 Mar 23.

Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University (TMDU), Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8519, Japan; Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU), Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8519, Japan; Center for Personalized Medicine for Healthy Aging, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8519, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.02.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681996PMC
April 2017

Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks.

DNA Repair (Amst) 2016 06 16;42:107-18. Epub 2016 Apr 16.

Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1L7, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15687864153011
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http://dx.doi.org/10.1016/j.dnarep.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096786PMC
June 2016

An infant with MLH3 variants, FOXG1-duplication and multiple, benign cranial and spinal tumors: A clinical exome sequencing study.

Genes Chromosomes Cancer 2016 Feb 6;55(2):131-42. Epub 2015 Nov 6.

Pathology and Laboratory Medicine, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 90095.

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http://dx.doi.org/10.1002/gcc.22319DOI Listing
February 2016

Disease-associated repeat instability and mismatch repair.

DNA Repair (Amst) 2016 Feb 12;38:117-126. Epub 2015 Dec 12.

Genetics & Genome Biology, The Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, 686 Bay St., Toronto, Ontario M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Medical Sciences Bldg., 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.11.008DOI Listing
February 2016

Quadruplex formation by both G-rich and C-rich DNA strands of the C9orf72 (GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylation.

Nucleic Acids Res 2015 Nov 1;43(20):10055-64. Epub 2015 Oct 1.

Program of Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada Program of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A1, Canada

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http://dx.doi.org/10.1093/nar/gkv1008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787773PMC
November 2015

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Nat Genet 2015 Mar 2;47(3):257-62. Epub 2015 Feb 2.

1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [4] Department of Pediatrics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.3202DOI Listing
March 2015

Massive CAG repeat expansion and somatic instability in maternally transmitted infantile spinocerebellar ataxia type 7.

JAMA Neurol 2015 Feb;72(2):219-23

Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada5Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1001/jamaneurol.2014.1902DOI Listing
February 2015

Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability.

Nucleic Acids Res 2014 21;42(16):10473-87. Epub 2014 Aug 21.

Department of Genetics, The Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, 686 Bay Street, Toronto, Ontario M5G 0A4, Canada Program of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 0A4, Canada

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http://dx.doi.org/10.1093/nar/gku658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176329PMC
January 2015

Modifiers of (CAG)(n) instability in Machado-Joseph disease (MJD/SCA3) transmissions: an association study with DNA replication, repair and recombination genes.

Hum Genet 2014 Oct 16;133(10):1311-8. Epub 2014 Jul 16.

Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, 3801 rue University, Montreal, QC, H3A2B4, Canada,

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http://link.springer.com/10.1007/s00439-014-1467-8
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http://dx.doi.org/10.1007/s00439-014-1467-8DOI Listing
October 2014

Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locus in patient tissues.

PLoS Genet 2013 19;9(12):e1003866. Epub 2013 Dec 19.

Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada ; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1003866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868534PMC
August 2014

[Repeat-associated diseases, mutagenesis, pathogenesis, and therapeutic avenues].

Rinsho Shinkeigaku 2012 ;52(11):1023

Department of Genetics Hospital for Sick Children.

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http://dx.doi.org/10.5692/clinicalneurol.52.1023DOI Listing
April 2014

TMPyP4 porphyrin distorts RNA G-quadruplex structures of the disease-associated r(GGGGCC)n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins.

J Biol Chem 2014 Feb 26;289(8):4653-9. Epub 2013 Dec 26.

From the Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2.

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http://dx.doi.org/10.1074/jbc.C113.502336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931028PMC
February 2014

RAN translation: fragile X in the running.

Neuron 2013 May;78(3):405-8

Program of Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.neuron.2013.04.034DOI Listing
May 2013

The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures.

J Biol Chem 2013 Apr 19;288(14):9860-6. Epub 2013 Feb 19.

Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1074/jbc.C113.452532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617286PMC
April 2013

Illuminating CNS and cognitive issues in myotonic dystrophy: Workshop report.

Neuromuscul Disord 2013 Apr 1;23(4):370-4. Epub 2013 Mar 1.

Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.nmd.2013.01.003DOI Listing
April 2013

Diced triplets expose neurons to RISC.

PLoS Genet 2012 23;8(2):e1002545. Epub 2012 Feb 23.

Division of Neurobiology, Laboratory of Genetic Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285583PMC
February 2013

Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues.

DNA Repair (Amst) 2013 Jan 24;12(1):46-52. Epub 2012 Nov 24.

Genetics and Genome Biology, The Hospital for Sick Children, TMDT Building 101 College St., 15th Floor, Room 15-312 East Tower, Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.dnarep.2012.10.006DOI Listing
January 2013

Human mismatch repair protein hMutLα is required to repair short slipped-DNAs of trinucleotide repeats.

J Biol Chem 2012 Dec 18;287(50):41844-50. Epub 2012 Oct 18.

Department of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.420398
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http://dx.doi.org/10.1074/jbc.M112.420398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516732PMC
December 2012

Co-opting endogenous microRNAs for therapy.

Nat Med 2012 Jul 6;18(7):1011-2. Epub 2012 Jul 6.

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http://dx.doi.org/10.1038/nm.2864DOI Listing
July 2012

The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeats.

Biochemistry 2012 May 23;51(18):3919-32. Epub 2012 Apr 23.

Department of Neurogenetics and Translational Medicine, Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR 7104-CNRS/INSERM/UdS, Illkirch, France.

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http://dx.doi.org/10.1021/bi300410dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357312PMC
May 2012

Replacement of the myotonic dystrophy type 1 CTG repeat with 'non-CTG repeat' insertions in specific tissues.

J Med Genet 2011 Jul 27;48(7):438-43. Epub 2011 May 27.

Genetics and Genome Biology, The Hospital for Sick Children, TMDT Building 101 College Street, 15th Floor, Rm 15-312 East Tower, Toronto, ON M5G 1L7, Canada.

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http://dx.doi.org/10.1136/jmg.2010.085944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379714PMC
July 2011

Maternal germline-specific effect of DNA ligase I on CTG/CAG instability.

Hum Mol Genet 2011 Jun 5;20(11):2131-43. Epub 2011 Mar 5.

Program of Genetics and Genome Biology, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/hmg/ddr099DOI Listing
June 2011

Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats.

Nucleic Acids Res 2011 Mar 4;39(5):1749-62. Epub 2010 Nov 4.

Program of Genetics & Genome Biology, The Hospital for Sick Children, 101 College Street, East Tower, 15-312 TMDT, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1093/nar/gkq935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061079PMC
March 2011

Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities!

PLoS Genet 2011 Mar 10;7(3):e1002018. Epub 2011 Mar 10.

Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1002018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053344PMC
March 2011

Bidirectional transcription stimulates expansion and contraction of expanded (CTG)*(CAG) repeats.

Hum Mol Genet 2011 Feb 18;20(3):580-8. Epub 2010 Nov 18.

Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1093/hmg/ddq501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016912PMC
February 2011

Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissues.

Hum Mol Genet 2011 Jan 1;20(1):1-15. Epub 2010 Nov 1.

Genetics and Genome Biology, Department of Pediatrics, The Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/hmg/ddq427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000673PMC
January 2011

FSHD: a repeat contraction disease finally ready to expand (our understanding of its pathogenesis).

PLoS Genet 2010 Oct 28;6(10):e1001180. Epub 2010 Oct 28.

Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1001180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965764PMC
October 2010

Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus.

Nat Struct Mol Biol 2010 Sep 15;17(9):1079-87. Epub 2010 Aug 15.

Program of Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nsmb.1876DOI Listing
September 2010

Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.

Proc Natl Acad Sci U S A 2010 Jul 22;107(28):12593-8. Epub 2010 Jun 22.

Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada M5G 1L7.

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http://www.pnas.org/lookup/doi/10.1073/pnas.0909087107
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http://dx.doi.org/10.1073/pnas.0909087107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906547PMC
July 2010

Repeat instability as the basis for human diseases and as a potential target for therapy.

Nat Rev Mol Cell Biol 2010 Mar;11(3):165-70

Program of Genetics & Genome Biology, The Hospital for Sick Children, 101 College Avenue, East Tower 15-312, TMDT Toronto, Ontario, Canada, M5G 1L7.

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http://www.nature.com/articles/nrm2854
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http://dx.doi.org/10.1038/nrm2854DOI Listing
March 2010

CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair.

J Biol Chem 2009 Sep 22;284(39):26631-45. Epub 2009 Jul 22.

Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1074/jbc.M109.034405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785351PMC
September 2009

MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.

PLoS Genet 2009 May 15;5(5):e1000482. Epub 2009 May 15.

INSERM, U781, Université Paris Descartes, Hôpital Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.1371/journal.pgen.1000482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674216PMC
May 2009

The ATTCT repeats of spinocerebellar ataxia type 10 display strong nucleosome assembly which is enhanced by repeat interruptions.

Gene 2009 Apr 25;434(1-2):29-34. Epub 2008 Dec 25.

Program of Genetics and Genome Biology, the Hospital for Sick Children, Toronto, ON, Canada M5G 1X8.

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http://dx.doi.org/10.1016/j.gene.2008.12.011DOI Listing
April 2009

Mutagenic roles of DNA "repair" proteins in antibody diversity and disease-associated trinucleotide repeat instability.

DNA Repair (Amst) 2008 Jul 16;7(7):1135-54. Epub 2008 May 16.

Program of Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1L7.

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http://dx.doi.org/10.1016/j.dnarep.2008.03.014DOI Listing
July 2008

Deletion hotspot in the argininosuccinate lyase gene: association with topoisomerase II and DNA polymerase alpha sites.

Hum Mutat 2006 Nov;27(11):1065-71

Program in Genetics and Genomic Biology, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/humu.20352DOI Listing
November 2006

Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10: repeat purity as a disease modifier?

Am J Hum Genet 2006 Jan 15;78(1):125-9. Epub 2005 Nov 15.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1086/498654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1380209PMC
January 2006

Repeat instability: mechanisms of dynamic mutations.

Nat Rev Genet 2005 Oct;6(10):729-42

Program of Genetics and Genomic Biology, The Hospital for Sick Children, 15-312, TMDT, 101 College Street, East Tower, Toronto, Ontario M5G 1L7, Canada.

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http://www.nature.com/doifinder/10.1038/nrg1689
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http://dx.doi.org/10.1038/nrg1689DOI Listing
October 2005

Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair.

Nat Struct Mol Biol 2005 Aug 17;12(8):654-62. Epub 2005 Jul 17.

Program of Genetics & Genomic Biology, The Hospital for Sick Children, 555 University Avenue, Elm Wing 11-135, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1038/nsmb959DOI Listing
August 2005

Replication fork dynamics and dynamic mutations: the fork-shift model of repeat instability.

Trends Genet 2005 May;21(5):272-80

Department of Molecular and Medical Genetics, University of Toronto, The Hospital for Sick Children, Ontario, Canada M5G 1X8.

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http://linkinghub.elsevier.com/retrieve/pii/S016895250500084
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http://dx.doi.org/10.1016/j.tig.2005.03.008DOI Listing
May 2005

Effect of CAT or AGG interruptions and CpG methylation on nucleosome assembly upon trinucleotide repeats on spinocerebellar ataxia, type 1 and fragile X syndrome.

J Biol Chem 2005 Feb 1;280(6):4498-503. Epub 2004 Dec 1.

Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA.

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http://www.cepearsonlab.com/pdf/p7_Mulvhill%20et%20al%20JBC%
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http://www.jbc.org/lookup/doi/10.1074/jbc.M413239200
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http://dx.doi.org/10.1074/jbc.M413239200DOI Listing
February 2005

Role of replication and CpG methylation in fragile X syndrome CGG deletions in primate cells.

Am J Hum Genet 2005 Feb 29;76(2):302-11. Epub 2004 Dec 29.

Program of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1086/427928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1196375PMC
February 2005

Replication inhibitors modulate instability of an expanded trinucleotide repeat at the myotonic dystrophy type 1 disease locus in human cells.

Am J Hum Genet 2003 Nov 21;73(5):1092-105. Epub 2003 Oct 21.

Program of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180489PMC
http://dx.doi.org/10.1086/379523DOI Listing
November 2003

Slipping while sleeping? Trinucleotide repeat expansions in germ cells.

Trends Mol Med 2003 Nov;9(11):490-5

Program of Genetics and Genomic Biology, The Hospital for Sick Children, 555 University Avenue, Elm Wing 11-135, Toronto, Ontario, Canada M5G 1X8.

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November 2003

Fidelity of primate cell repair of a double-strand break within a (CTG).(CAG) tract. Effect of slipped DNA structures.

J Biol Chem 2003 Sep 14;278(36):33848-56. Epub 2003 Jun 14.

Department of Molecular & Medical Genetics, University of Toronto, Ontario M5A 1X8, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M304284200
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http://dx.doi.org/10.1074/jbc.M304284200DOI Listing
September 2003

Slipped (CTG).(CAG) repeats of the myotonic dystrophy locus: surface probing with anti-DNA antibodies.

J Mol Biol 2003 Sep;332(3):585-600

Program of Genetics and Genomic Biology, The Hospital for Sick Children, Room 11-135, 555 University Avenue, Elm Wing, M5G 1X8, Toronto, Ont., Canada

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http://dx.doi.org/10.1016/s0022-2836(03)00880-5DOI Listing
September 2003

RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila.

Neuron 2003 Aug;39(5):739-47

Department of Human Genetics, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/s0896-6273(03)00533-6DOI Listing
August 2003

Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctions.

Nucleic Acids Res 2002 Oct;30(20):4534-47

Program of Genetics and Genomic Biology, The Hospital for Sick Children, 555 University Avenue, Elm Wing 11-135, Toronto, Ontario M5G 1X8, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137136PMC
http://dx.doi.org/10.1093/nar/gkf572DOI Listing
October 2002

CpG methylation modifies the genetic stability of cloned repeat sequences.

Genome Res 2002 Aug;12(8):1246-56

Program of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1101/gr.74502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC186631PMC
August 2002

Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells.

Nat Genet 2002 May 22;31(1):37-46. Epub 2002 Apr 22.

Program of Genetics & Genomic Biology, The Hospital for Sick Children, 555 University Avenue, Elm Wing 11-135, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1038/ng870DOI Listing
May 2002

In vitro (CTG)*(CAG) expansions and deletions by human cell extracts.

J Biol Chem 2002 Apr 6;277(16):13926-34. Epub 2002 Feb 6.

Program of Genetics and Genomic Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5A 1X8, Canada.

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http://dx.doi.org/10.1074/jbc.M109761200DOI Listing
April 2002

The human cruciform-binding protein, CBP, is involved in DNA replication and associates in vivo with mammalian replication origins.

J Biol Chem 2002 Mar 22;277(13):11174-83. Epub 2002 Jan 22.

McGill Cancer Center and Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1074/jbc.M107902200DOI Listing
March 2002

Triplet repeat DNA structures and human genetic disease: dynamic mutations from dynamic DNA.

J Biosci 2002 Feb;27(1 Suppl 1):53-65

Laboratory of DNA Structure and Mutagenesis, Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University System Health Sciences Center, 2121 West Holcombe Blvd., Houston, TX 77030-3303, USA.

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http://dx.doi.org/10.1007/bf02703683DOI Listing
February 2002