Christopher E Brightling

Christopher E Brightling

UNVERIFIED PROFILE

Are you Christopher E Brightling?   Register this Author

Register author
Christopher E Brightling

Christopher E Brightling

Publications by authors named "Christopher E Brightling"

Are you Christopher E Brightling?   Register this Author

100Publications

2876Reads

30Profile Views

Comment on "Unraveling a Clinical Paradox: Why Does Bronchial Thermoplasty Work in Asthma?"

Am J Respir Cell Mol Biol 2019 Nov;61(5):660-661

University of LeicesterLeicester, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2019-0095LEDOI Listing
November 2019

Benralizumab for the Prevention of COPD Exacerbations.

N Engl J Med 2019 09 20;381(11):1023-1034. Epub 2019 May 20.

From the Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia (G.J.C.); Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston (B.R.C.); the Institute for Lung Health, Leicester National Institute for Health Research Biomedical Research Centre, Department of Respiratory Sciences, University of Leicester, Leicester (C.E.B.), the University of Manchester, Manchester University NHS Hospital Trust, Manchester (D.S.), and the Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford (M.B.) - all in the United Kingdom; Respiratory Institute, Hospital Clinic, University of Barcelona, Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red (CIBER) Enfermedades Respiratorias, Barcelona (A.A.); the Department of Medical Sciences, University of Ferrara, Ferrara, Italy (A.P.); the Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada (D.D.S.); the Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, German Center for Lung Research (DZL), Marburg, Germany (C.F.V.); University of Pittsburgh School of Medicine, Pittsburgh (F.C.S.); the Department of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen (V.B.); Kishiwada City Hospital, Osaka, Japan (M.K.); the Departamento de Investigación en Tabaquismo y EPOC, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, Mexico City (A.R.-V.); the Division of Respiratory and Chest Medicine, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan (Y.-F.W.); the Department of Respiratory Medicine and Allergology, Skane University Hospital, Lund University, Lund, Sweden (L.B.); and AstraZeneca, Gaithersburg, MD (V.H.S., M.J., S.O., N.M., P.N., M.G., U.J.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1905248DOI Listing
September 2019

The ERS fellowship portfolio: fostering excellence and diversity.

Eur Respir J 2019 Sep 5;54(3). Epub 2019 Sep 5.

Depts of Epidemiology and Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01503-2019DOI Listing
September 2019

Sputum microbiomic clustering in asthma and COPD reveals a Haemophilus-predominant subgroup.

Allergy 2019 Sep 25. Epub 2019 Sep 25.

Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Department of Respiratory Sciences, College of Life Sciences, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.14058DOI Listing
September 2019

The impact of the prostaglandin D receptor 2 and its downstream effects on the pathophysiology of asthma.

Allergy 2019 Jul 29. Epub 2019 Jul 29.

Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.14001DOI Listing
July 2019

Neutrophil elastase as a biomarker for bacterial infection in COPD.

Respir Res 2019 Jul 30;20(1):170. Epub 2019 Jul 30.

Respiratory Medicine Unit, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Level 7, Oxford, OX3 7DU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12931-019-1145-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668103PMC
July 2019

Sputum is reduced in COPD following treatment with benralizumab.

Int J Chron Obstruct Pulmon Dis 2019 5;14:1177-1185. Epub 2019 Jun 5.

Department of Respiratory Sciences, Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/COPD.S198302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559763PMC
June 2019

Sputum strains exhibit diversity within and between COPD subjects.

Int J Chron Obstruct Pulmon Dis 2018;13:3663-3667. Epub 2018 Nov 8.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK,

View Article

Download full-text PDF

Source
https://www.dovepress.com/sputum-moraxella-catarrhalis-strai
Publisher Site
http://dx.doi.org/10.2147/COPD.S180961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231509PMC
April 2019

Reply.

J Allergy Clin Immunol 2019 Mar 11;143(3):1265-1266. Epub 2019 Jan 11.

Division of Respiratory Medicine, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749183173
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2018.11.026DOI Listing
March 2019

Comparison of CT ventilation imaging and hyperpolarised gas MRI: effects of breathing manoeuvre.

Phys Med Biol 2019 03 7;64(5):055013. Epub 2019 Mar 7.

POLARIS, Academic Radiology, University of Sheffield, Sheffield, United Kingdom. Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom. Author to whom any correspondence should be addressed.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6560/ab0145DOI Listing
March 2019

Cough and Eosinophilia.

J Allergy Clin Immunol Pract 2019 Jul - Aug;7(6):1740-1747

Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Department of Respiratory Sciences, University of Leicester, Leicester, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2019.04.048DOI Listing
March 2019

Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis.

J Allergy Clin Immunol 2018 11 14;142(5):1457-1468. Epub 2018 Mar 14.

Department of Infection Immunity and Inflammation, Institute for Lung Health, University of Leicester, Glenfield Hospital, Leicester, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2017.12.982DOI Listing
November 2018

T2 Biologics for Chronic Obstructive Pulmonary Disease.

J Allergy Clin Immunol Pract 2019 May - Jun;7(5):1405-1416

Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Department of Infection, Immunity & Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2019.01.036DOI Listing
October 2018

Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles.

J Allergy Clin Immunol 2018 06 28;141(6):2027-2036.e12. Epub 2018 Apr 28.

Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Department of Infection, Immunity & Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2018.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986707PMC
June 2018

Biologic Drugs: A New Target Therapy in COPD?

COPD 2018 04 23;15(2):99-107. Epub 2018 Apr 23.

a NIHR Leicester Biomedical Research Centre, Institute for Lung Health, Department of Infection, Immunity & Inflammation , University of Leicester , Leicester , United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15412555.2018.1437897DOI Listing
April 2018

Investigating the role of pentraxin 3 as a biomarker for bacterial infection in subjects with COPD.

Int J Chron Obstruct Pulmon Dis 2017 18;12:1199-1205. Epub 2017 Apr 18.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/COPD.S123528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402921PMC
March 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Authors:
Florence Demenais Patricia Margaritte-Jeannin Kathleen C Barnes William O C Cookson Janine Altmüller Wei Ang R Graham Barr Terri H Beaty Allan B Becker John Beilby Hans Bisgaard Unnur Steina Bjornsdottir Eugene Bleecker Klaus Bønnelykke Dorret I Boomsma Emmanuelle Bouzigon Christopher E Brightling Myriam Brossard Guy G Brusselle Esteban Burchard Kristin M Burkart Andrew Bush Moira Chan-Yeung Kian Fan Chung Alexessander Couto Alves John A Curtin Adnan Custovic Denise Daley Johan C de Jongste Blanca E Del-Rio-Navarro Kathleen M Donohue Liesbeth Duijts Celeste Eng Johan G Eriksson Martin Farrall Yuliya Fedorova Bjarke Feenstra Manuel A Ferreira Maxim B Freidin Zofia Gajdos Jim Gauderman Ulrike Gehring Frank Geller Jon Genuneit Sina A Gharib Frank Gilliland Raquel Granell Penelope E Graves Daniel F Gudbjartsson Tari Haahtela Susan R Heckbert Dick Heederik Joachim Heinrich Markku Heliövaara John Henderson Blanca E Himes Hiroshi Hirose Joel N Hirschhorn Albert Hofman Patrick Holt Jouke Hottenga Thomas J Hudson Jennie Hui Medea Imboden Vladimir Ivanov Vincent W V Jaddoe Alan James Christer Janson Marjo-Riitta Jarvelin Deborah Jarvis Graham Jones Ingileif Jonsdottir Pekka Jousilahti Michael Kabesch Mika Kähönen David B Kantor Alexandra S Karunas Elza Khusnutdinova Gerard H Koppelman Anita L Kozyrskyj Eskil Kreiner Michiaki Kubo Rajesh Kumar Ashish Kumar Mikko Kuokkanen Lies Lahousse Tarja Laitinen Catherine Laprise Mark Lathrop Susanne Lau Young-Ae Lee Terho Lehtimäki Sébastien Letort Albert M Levin Guo Li Liming Liang Laura R Loehr Stephanie J London Daan W Loth Ani Manichaikul Ingo Marenholz Fernando J Martinez Melanie C Matheson Rasika A Mathias Kenji Matsumoto Hamdi Mbarek Wendy L McArdle Mads Melbye Erik Melén Deborah Meyers Sven Michel Hamida Mohamdi Arthur W Musk Rachel A Myers Maartje A E Nieuwenhuis Emiko Noguchi George T O'Connor Ludmila M Ogorodova Cameron D Palmer Aarno Palotie Julie E Park Craig E Pennell Göran Pershagen Alexey Polonikov Dirkje S Postma Nicole Probst-Hensch Valery P Puzyrev Benjamin A Raby Olli T Raitakari Adaikalavan Ramasamy Stephen S Rich Colin F Robertson Isabelle Romieu Muhammad T Salam Veikko Salomaa Vivi Schlünssen Robert Scott Polina A Selivanova Torben Sigsgaard Angela Simpson Valérie Siroux Lewis J Smith Maria Solodilova Marie Standl Kari Stefansson David P Strachan Bruno H Stricker Atsushi Takahashi Philip J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Carla M T Tiesler Dara G Torgerson Tatsuhiko Tsunoda André G Uitterlinden Ralf J P van der Valk Amaury Vaysse Sailaja Vedantam Andrea von Berg Erika von Mutius Judith M Vonk Johannes Waage Nick J Wareham Scott T Weiss Wendy B White Magnus Wickman Elisabeth Widén Gonneke Willemsen L Keoki Williams Inge M Wouters James J Yang Jing Hua Zhao Miriam F Moffatt Carole Ober Dan L Nicolae

Nat Genet 2018 01 22;50(1):42-53. Epub 2017 Dec 22.

Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41588-017-0014-7
Publisher Site
http://dx.doi.org/10.1038/s41588-017-0014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974PMC
January 2018

Human group 2 innate lymphoid cells do not express the IL-5 receptor.

J Allergy Clin Immunol 2017 11 10;140(5):1430-1433.e4. Epub 2017 May 10.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicestershire, United Kingdom; MRC &Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2017.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667579PMC
November 2017

Regional Ventilation Changes in the Lung: Treatment Response Mapping by Using Hyperpolarized Gas MR Imaging as a Quantitative Biomarker.

Radiology 2017 09 4;284(3):854-861. Epub 2017 May 4.

From the Unit of Academic Radiology, Department of Infection, Immunity and Cardiovascular Disease, C Floor, Royal Hallamshire Hospital, University of Sheffield, Glossop Rd, Sheffield S10 2JF, England (F.C.H., H.M., G.J.C., J.P., J.M.W.); Novartis, Basel, Switzerland (R.K.); Department of Respiratory Medicine, Glenfield Hospital, Leicester, England (S.S., C.E.B.); Insigneo Institute of In-Silico Medicine, University of Sheffield, Sheffield, England (J.M.W.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1148/radiol.2017160532DOI Listing
September 2017

HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4.

J Allergy Clin Immunol 2017 08 1;140(2):584-587.e8. Epub 2017 Mar 1.

Institute for Lung Health, Department of Infection, Immunity & Inflammation, Glenfield Hospital, University of Leicester, Leicester, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2016.11.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540224PMC
August 2017

Emerging Therapies in Severe Eosinophilic Asthma.

Arch Bronconeumol 2017 05 6;53(5):233-234. Epub 2017 Mar 6.

Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity & Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arbres.2017.01.012DOI Listing
May 2017

Blood and sputum eosinophils in COPD; relationship with bacterial load.

Respir Res 2017 05 8;18(1):88. Epub 2017 May 8.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, Manchester, M23 9QZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12931-017-0570-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422866PMC
May 2017

Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma.

J Allergy Clin Immunol 2017 Apr 7;139(4):1167-1175.e2. Epub 2016 Oct 7.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2016.08.008DOI Listing
April 2017

Clinical trial research in focus: do trials prepare us to deliver precision medicine in those with severe asthma?

Lancet Respir Med 2017 02;5(2):92-95

Institute for Lung Health, NIHR BRU Respiratory Medicine, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, LE3 9QP, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(17)30011-5DOI Listing
February 2017

Chronic obstructive pulmonary disease phenotypes, biomarkers, and prognostic indicators.

Allergy Asthma Proc 2016 Nov;37(6):432-438

Institute for Lung Health, National Institute for Health Research Respiratory Biomedical Research Unit, Department of Infection, Immunity and Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2500/aap.2016.37.3996DOI Listing
November 2016

Anti-IL-5 for Severe Asthma: Aiming High to Achieve Success.

Chest 2016 10;150(4):766-768

Department of Infection, Immunity and Inflammation, Institute for Lung Health, Glenfield Hospital, University of Leicester, Leicester, England. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2016.06.013DOI Listing
October 2016

Blood Eosinophils and Outcomes in Severe Hospitalized Exacerbations of COPD.

Chest 2016 08 3;150(2):320-8. Epub 2016 Feb 3.

Centre for Exercise and Rehabilitation Science, University of Leicester NHS Hospitals Trust, Glenfield Hospital, Leicester, UK; NIHR Respiratory Biomedical Research Unit, University of Leicester, Leicester, UK; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2016.01.026DOI Listing
August 2016

Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies.

Lancet Respir Med 2016 07 10;4(7):549-556. Epub 2016 May 10.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(16)30031-5DOI Listing
July 2016

Circulating fibrocytes: Will the real fibrocyte please stand up?

J Allergy Clin Immunol 2016 05 22;137(5):1625-6. Epub 2016 Mar 22.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicestershire, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2016.01.023DOI Listing
May 2016

Lung microbiome dynamics in COPD exacerbations.

Eur Respir J 2016 Apr 25;47(4):1082-92. Epub 2016 Feb 25.

Computational Biology, Target Sciences, GSK R&D, Collegeville, PA, USA Both authors contributed equally.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.01406-2015DOI Listing
April 2016

Airway bacteria measured by quantitative polymerase chain reaction and culture in patients with stable COPD: relationship with neutrophilic airway inflammation, exacerbation frequency, and lung function.

Int J Chron Obstruct Pulmon Dis 2015 9;10:1075-83. Epub 2015 Jun 9.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK ; Institute for Lung Health, National Institute for Health Research Respiratory Biomedical Research Unit, Glenfield Hospital, University of Leicester, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/COPD.S80091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468933PMC
March 2016

Characterization of acinar airspace involvement in asthmatic patients by using inert gas washout and hyperpolarized (3)helium magnetic resonance.

J Allergy Clin Immunol 2016 Feb 1;137(2):417-25. Epub 2015 Aug 1.

Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749150088
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2015.06.027DOI Listing
February 2016

Severe asthma: novel advances in the pathogenesis and therapy.

Pol Arch Med Wewn 2014 29;124(5):247-54. Epub 2014 Apr 29.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20452/pamw.2253DOI Listing
January 2016

Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease.

Ther Adv Chronic Dis 2016 Jan;7(1):34-51

Institute for Lung Health, Clinical Science Wing, University Hospital of Leicester, Leicester LE3 9QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2040622315609251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707428PMC
January 2016

Is the eosinophil a leading villain in lung function decline?

Chest 2015 Oct;148(4):844-846

Institute for Lung Health, National Institute of Health Research Respiratory Biomedical Research Unit, Department of Infection, Immunity, and Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, England.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1378/chest.15-0915DOI Listing
October 2015

Cigarette Smoke and the Induction of Urokinase Plasminogen Activator Receptor In Vivo: Selective Contribution of Isoforms to Bronchial Epithelial Phenotype.

Am J Respir Cell Mol Biol 2015 Aug;53(2):174-83

1 Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2014-0296OCDOI Listing
August 2015

CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET.

Am J Physiol Lung Cell Mol Physiol 2015 May 20;308(9):L962-72. Epub 2015 Feb 20.

Department of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00021.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421784PMC
May 2015

Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease.

Int J Chron Obstruct Pulmon Dis 2014 15;9:975-81. Epub 2014 Sep 15.

Respiratory Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/COPD.S63568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168852PMC
February 2015

D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells.

J Allergy Clin Immunol 2015 Feb 11;135(2):395-406. Epub 2014 Oct 11.

Institute of Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2014.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314591PMC
February 2015

Association between pathogens detected using quantitative polymerase chain reaction with airway inflammation in COPD at stable state and exacerbations.

Chest 2015 Jan;147(1):46-55

Respiratory Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Oxford, England. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1378/chest.14-0764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285081PMC
January 2015

Inhaled glucocorticoids and COPD exacerbations.

N Engl J Med 2015 01;372(1):93

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1413308DOI Listing
January 2015

A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid hyperpolarized gas/1H MRI.

Phys Med Biol 2014 Dec 10;59(23):7267-77. Epub 2014 Nov 10.

Academic Unit of Clinical Oncology, University of Sheffield, UK. Academic Unit of Academic Radiology, University of Sheffield, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/0031-9155/59/23/7267DOI Listing
December 2014

Destination Airway: Tracking Granulocytes in Asthma.

EBioMedicine 2014 Dec 7;1(2-3):105-6. Epub 2014 Nov 7.

Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester LE3 9QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2014.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457434PMC
December 2014

Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis.

Eur Respir J 2014 Sep 12;44(3):789-91. Epub 2014 Jun 12.

Dept of Respiratory Medicine, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/09031936.00062614DOI Listing
September 2014

Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial.

Int J Chron Obstruct Pulmon Dis 2014 7;9:179-86. Epub 2014 Feb 7.

Department of Respiratory Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/COPD.S55419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923615PMC
August 2014

Asthma therapy and its effect on airway remodelling.

Drugs 2014 Aug;74(12):1345-69

Department of Infection, Immunity and Inflammation, Institute for Lung Health, Glenfield Hospital, University of Leicester, Leicester, LE3 9QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40265-014-0250-4DOI Listing
August 2014

Effectiveness of voriconazole in the treatment of Aspergillus fumigatus-associated asthma (EVITA3 study).

J Allergy Clin Immunol 2014 Jul 28;134(1):33-9. Epub 2013 Nov 28.

Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, and the Department of Respiratory Medicine, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2013.09.050DOI Listing
July 2014

Between-visit variability of small airway obstruction markers in patients with asthma.

Eur Respir J 2014 Jul 6;44(1):242-4. Epub 2014 Mar 6.

Institute for Lung Health, Dept of Infection, Immunity and Inflammation, University of Leicester, Leicester.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/09031936.00001814DOI Listing
July 2014

[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma.

Respirology 2014 Jul 22;19(5):763-6. Epub 2014 May 22.

Institute for Lung Health, Department of Infection, Immunity and Inflammation, NIHR Biomedical Unit, Glenfield Hospital, University of Leicester, Leicester, UK; Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/resp.12318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190647PMC
July 2014

Reply: To PMID 24238646.

J Allergy Clin Immunol 2014 Jun 1;133(6):1777-8. Epub 2014 May 1.

Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Glenfield Hospital, Leicester, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2014.01.043DOI Listing
June 2014

Quantitative computed tomography-derived clusters: redefining airway remodeling in asthmatic patients.

J Allergy Clin Immunol 2014 Mar 12;133(3):729-38.e18. Epub 2013 Nov 12.

Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2013.09.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969578PMC
March 2014

Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: a 12-month follow-up analysis.

J Allergy Clin Immunol 2014 Mar 10;133(3):921-3. Epub 2014 Jan 10.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Headington, Oxford, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2013.11.026DOI Listing
March 2014

Cough in asthma is due to eosinophilic airway inflammation: a pro/con debate.

Lung 2014 Feb 14;192(1):33-8. Epub 2013 Dec 14.

Division of Respiratory Medicine, Department of Medical Oncology and Immunology, University Graduate School of Medical Sciences, Nagoya City University Hospital, Nagoya, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00408-013-9543-8DOI Listing
February 2014

Origins of increased airway smooth muscle mass in asthma.

BMC Med 2013 Jun 6;11:145. Epub 2013 Jun 6.

Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1186%2F1741-7015-11-
Web Search
http://www.biomedcentral.com/1741-7015/11/145
Publisher Site
http://dx.doi.org/10.1186/1741-7015-11-145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688527PMC
June 2013

Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma.

J Allergy Clin Immunol 2013 Apr 16;131(4):1008-16. Epub 2013 Feb 16.

Respiratory Medicine, Institute of Infection, Immunity & Inflammation, University of Glasgow and Respiratory Medicine, Gartnavel General Hospital, Glasgow, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2012.12.1574DOI Listing
April 2013

Phenotyping the heterogeneity of chronic obstructive pulmonary disease.

Clin Sci (Lond) 2013 Mar;124(6):371-87

Institute for Lung Health, Department of Infection, Immunity & Inflammation, University of Leicester, Leicester LE3 9QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/CS20120340DOI Listing
March 2013

Eosinophils as diagnostic tools in chronic lung disease.

Expert Rev Respir Med 2013 Feb;7(1):33-42

Department of Infection, Inflammation and Immunity, Institute of Lung Health, University of Leicester, Leicester, LE3 9QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/ers.12.81DOI Listing
February 2013

Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma.

Respir Res 2013 Feb 11;14:17. Epub 2013 Feb 11.

Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity & Inflammation, University of Leicester, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1465-9921-14-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577477PMC
February 2013

Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation.

PLoS One 2012 27;7(8):e43545. Epub 2012 Aug 27.

Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043545PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428358PMC
January 2013

The effects of nociceptin peptide (N/OFQ)-receptor (NOP) system activation in the airways.

Peptides 2013 Jan 1;39:36-46. Epub 2012 Nov 1.

Department of Cardiovascular Sciences (Pharmacology and Therapeutics Group), Division of Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester Royal Infirmary, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.peptides.2012.10.008DOI Listing
January 2013

Airway impedance entropy and exacerbations in severe asthma.

Eur Respir J 2012 Nov 9;40(5):1156-63. Epub 2012 Mar 9.

Dept of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/09031936.00228611DOI Listing
November 2012

How to diagnose and phenotype asthma.

Clin Chest Med 2012 Sep 7;33(3):445-57. Epub 2012 Jul 7.

Department of Medicine, St Joseph's Healthcare, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario L8N4A6, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccm.2012.05.003DOI Listing
September 2012

The relationship between clinical outcomes and medication adherence in difficult-to-control asthma.

Thorax 2012 Aug 21;67(8):751-3. Epub 2012 Mar 21.

Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2011-201096DOI Listing
August 2012

Regulator of G-protein signaling-5 inhibits bronchial smooth muscle contraction in severe asthma.

Am J Respir Cell Mol Biol 2012 Jun 26;46(6):823-32. Epub 2012 Jan 26.

Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Insitute of Allergy and Infectious Diseases/NIH, 10 Center Drive, Bethesda, MD 20982, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2011-0110OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380291PMC
June 2012

Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement.

Am J Physiol Lung Cell Mol Physiol 2012 May 2;302(10):L1118-27. Epub 2012 Mar 2.

Respiratory Research Group, Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00232.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362261PMC
May 2012