Publications by authors named "Christopher E Brightling"

100Publications

Volatile organic compounds in a headspace sampling system and asthmatics sputum samples.

J Breath Res 2020 Nov 23. Epub 2020 Nov 23.

University of Leicester College of Life Sciences, Leicester, Leicester, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

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http://dx.doi.org/10.1088/1752-7163/abcd2aDOI Listing
November 2020

Fibrocyte localisation to the ASM bundle in asthma: bidirectional effects on cell phenotype and behaviour.

Clin Transl Immunology 2020 13;9(11):e1205. Epub 2020 Nov 13.

Department of Respiratory Sciences Institute for Lung Health University of Leicester Leicester UK.

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http://dx.doi.org/10.1002/cti2.1205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662089PMC
November 2020

Bacteria and sputum inflammatory cell counts; a COPD cohort analysis.

Respir Res 2020 Nov 1;21(1):289. Epub 2020 Nov 1.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s12931-020-01552-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603729PMC
November 2020

A Refined View of Airway Microbiome in Chronic Obstructive Pulmonary Disease at Species and Strain-Levels.

Front Microbiol 2020 30;11:1758. Epub 2020 Jul 30.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

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http://dx.doi.org/10.3389/fmicb.2020.01758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406711PMC
July 2020

Pathophysiological regulation of lung function by the free fatty acid receptor FFA4.

Sci Transl Med 2020 Aug;12(557)

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1126/scitranslmed.aaw9009DOI Listing
August 2020

Proning reduces ventilation heterogeneity in patients with elevated BMI: implications for COVID-19 pneumonia management?

ERJ Open Res 2020 Apr 13;6(2). Epub 2020 Jul 13.

National Institute for Health Research (NIHR), Leicester Biomedical Research Centre (Respiratory theme) and College of Life Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1183/23120541.00292-2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357272PMC
April 2020

Detection of Cell-Dissociated Non-Typeable in the Airways of Patients with Chronic Obstructive Pulmonary Disease.

Int J Chron Obstruct Pulmon Dis 2020 12;15:1357-1365. Epub 2020 Jun 12.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.2147/COPD.S247130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297347PMC
June 2020

ST2 expression and release by the bronchial epithelium is downregulated in asthma.

Allergy 2020 Jun 9. Epub 2020 Jun 9.

Institute for Lung Health, Department of Respiratory Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/all.14436DOI Listing
June 2020

ARIA digital anamorphosis: Digital transformation of health and care in airway diseases from research to practice.

Authors:
Jean Bousquet Josep M Anto Claus Bachert Tari Haahtela Torsten Zuberbier Wienczyslawa Czarlewski Anna Bedbrook Sinthia Bosnic-Anticevich G Walter Canonica Victoria Cardona Elisio Costa Alvaro A Cruz Marina Erhola Wytske J Fokkens Joao A Fonseca Maddalena Illario Juan-Carlos Ivancevich Marek Jutel Ludger Klimek Piotr Kuna Violeta Kvedariene Ltt Le Désirée E Larenas-Linnemann Daniel Laune Olga M Lourenço Erik Melén Joaquim Mullol Marek Niedoszytko Mikaëla Odemyr Yoshitaka Okamoto Nikos G Papadopoulos Vincenzo Patella Oliver Pfaar Nhân Pham-Thi Christine Rolland Boleslaw Samolinski Aziz Sheikh Mikhail Sofiev Charlotte Suppli Ulrik Ana Todo-Bom Peter-Valentin Tomazic Sanna Toppila-Salmi Ioanna Tsiligianni Arunas Valiulis Erkka Valovirta Maria-Teresa Ventura Samantha Walker Sian Williams Arzu Yorgancioglu Ioana Agache Cezmi A Akdis Rute Almeida Ignacio J Ansotegui Isabella Annesi-Maesano Sylvie Arnavielhe Xavier Basagaña Eric D Bateman Annabelle Bédard Martin Bedolla-Barajas Sven Becker Kazi S Bennoor Samuel Benveniste Karl C Bergmann Michael Bewick Slawomir Bialek Nils E Billo Carsten Bindslev-Jensen Leif Bjermer Hubert Blain Matteo Bonini Philippe Bonniaud Isabelle Bosse Jacques Bouchard Louis-Philippe Boulet Rodolphe Bourret Koen Boussery Fluvio Braido Vitalis Briedis Andrew Briggs Christopher E Brightling Jan Brozek Guy Brusselle Luisa Brussino Roland Buhl Roland Buonaiuto Moises A Calderon Paulo Camargos Thierry Camuzat Luis Caraballo Ana-Maria Carriazo Warner Carr Christine Cartier Thomas Casale Lorenzo Cecchi Alfonso M Cepeda Sarabia Niels H Chavannes Ekaterine Chkhartishvili Derek K Chu Cemal Cingi Jaime Correia de Sousa David J Costa Anne-Lise Courbis Adnan Custovic Biljana Cvetkosvki Gennaro D'Amato Jane da Silva Carina Dantas Dejan Dokic Yves Dauvilliers Giulia De Feo Govert De Vries Philippe Devillier Stefania Di Capua Gerard Dray Ruta Dubakiene Stephen R Durham Marc Dykewicz Motohiro Ebisawa Mina Gaga Yehia El-Gamal Enrico Heffler Regina Emuzyte John Farrell Jean-Luc Fauquert Alessandro Fiocchi Antje Fink-Wagner Jean-François Fontaine José M Fuentes Perez Bilun Gemicioğlu Amiran Gamkrelidze Judith Garcia-Aymerich Philippe Gevaert René Maximiliano Gomez Sandra González Diaz Maia Gotua Nick A Guldemond Maria-Antonieta Guzmán Jawad Hajjam Yunuen R Huerta Villalobos Marc Humbert Guido Iaccarino Despo Ierodiakonou Tomohisa Iinuma Ewa Jassem Guy Joos Ki-Suck Jung Igor Kaidashev Omer Kalayci Przemyslaw Kardas Thomas Keil Musa Khaitov Nikolai Khaltaev Jorg Kleine-Tebbe Rostislav Kouznetsov Marek L Kowalski Vicky Kritikos Inger Kull Stefania La Grutta Lisa Leonardini Henrik Ljungberg Philip Lieberman Brian Lipworth Karin C Lodrup Carlsen Catarina Lopes-Pereira Claudia C Loureiro Renaud Louis Alpana Mair Bassam Mahboub Michaël Makris Joao Malva Patrick Manning Gailen D Marshall Mohamed R Masjedi Jorge F Maspero Pedro Carreiro-Martins Mika Makela Eve Mathieu-Dupas Marcus Maurer Esteban De Manuel Keenoy Elisabete Melo-Gomes Eli O Meltzer Enrica Menditto Jacques Mercier Yann Micheli Neven Miculinic Florin Mihaltan Branislava Milenkovic Dimitirios I Mitsias Giuliana Moda Maria-Dolores Mogica-Martinez Yousser Mohammad Steve Montefort Ricardo Monti Mario Morais-Almeida Ralph Mösges Lars Münter Antonella Muraro Ruth Murray Robert Naclerio Luigi Napoli Leyla Namazova-Baranova Hugo Neffen Kristoff Nekam Angelo Neou Björn Nordlund Ettore Novellino Dieudonné Nyembue Robyn O'Hehir Ken Ohta Kimi Okubo Gabrielle L Onorato Valentina Orlando Solange Ouedraogo Julia Palamarchuk Isabella Pali-Schöll Peter Panzner Hae-Sim Park Gianni Passalacqua Jean-Louis Pépin Ema Paulino Ruby Pawankar Jim Phillips Robert Picard Hilary Pinnock Davor Plavec Todor A Popov Fabienne Portejoie David Price Emmanuel P Prokopakis Fotis Psarros Benoit Pugin Francesca Puggioni Pablo Quinones-Delgado Filip Raciborski Rojin Rajabian-Söderlund Frederico S Regateiro Sietze Reitsma Daniela Rivero-Yeverino Graham Roberts Nicolas Roche Erendira Rodriguez-Zagal Christine Rolland Regina E Roller-Wirnsberger Nelson Rosario Antonino Romano Menachem Rottem Dermot Ryan Johanna Salimäki Mario M Sanchez-Borges Joaquin Sastre Glenis K Scadding Sophie Scheire Peter Schmid-Grendelmeier Holger J Schünemann Faradiba Sarquis Serpa Mohamed Shamji Juan-Carlos Sisul Mikhail Sofiev Dirceu Solé David Somekh Talant Sooronbaev Milan Sova François Spertini Otto Spranger Cristiana Stellato Rafael Stelmach Michel Thibaudon Teresa To Mondher Toumi Omar Usmani Antonio A Valero Rudolph Valenta Marylin Valentin-Rostan Marilyn Urrutia Pereira Rianne van der Kleij Michiel Van Eerd Olivier Vandenplas Tuula Vasankari Antonio Vaz Carneiro Giorgio Vezzani Frédéric Viart Giovanni Viegi Dana Wallace Martin Wagenmann De Yun Wang Susan Waserman Magnus Wickman Dennis M Williams Gary Wong Piotr Wroczynski Panayiotis K Yiallouros Osman M Yusuf Heather J Zar Stéphane Zeng Mario E Zernotti Luo Zhang Nan Shan Zhong Mihaela Zidarn

Allergy 2020 Jun 8. Epub 2020 Jun 8.

University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.

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http://dx.doi.org/10.1111/all.14422DOI Listing
June 2020

Managing Chronic Cough Due to Asthma and NAEB in Adults and Adolescents: CHEST Guideline and Expert Panel Report.

Chest 2020 Jul 20;158(1):68-96. Epub 2020 Jan 20.

Department of Respiratory Sciences, Institute for Lung Health, Glenfield Hospital, University of Leicester, Leicester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2019.12.021DOI Listing
July 2020

Clinical utility of fractional exhaled nitric oxide in severe asthma management.

Eur Respir J 2020 03 26;55(3). Epub 2020 Mar 26.

Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Dept of Respiratory Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1183/13993003.01633-2019DOI Listing
March 2020

The stability of blood Eosinophils in chronic obstructive pulmonary disease.

Respir Res 2020 Jan 10;21(1):15. Epub 2020 Jan 10.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s12931-020-1279-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954589PMC
January 2020

Asthma exacerbations during pregnancy: A need for precision medicine.

Respirology 2020 Jul 16;25(7):670-671. Epub 2019 Dec 16.

Institute for Lung Health, Department of Respiratory and Microbial Sciences, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/resp.13761DOI Listing
July 2020

Tensin1 expression and function in chronic obstructive pulmonary disease.

Sci Rep 2019 12 12;9(1):18942. Epub 2019 Dec 12.

Department of Respiratory Sciences, University of Leicester, UK, Institute of Lung Health and NIHR Leicester BRC-Respiratory, Leicester, UK.

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http://dx.doi.org/10.1038/s41598-019-55405-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908681PMC
December 2019

Fatty airways: a source of good and bad fats?

Eur Respir J 2019 12 12;54(6). Epub 2019 Dec 12.

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1183/13993003.02060-2019DOI Listing
December 2019

Comment on "Unraveling a Clinical Paradox: Why Does Bronchial Thermoplasty Work in Asthma?"

Am J Respir Cell Mol Biol 2019 11;61(5):660-661

University of LeicesterLeicester, United Kingdom.

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http://dx.doi.org/10.1165/rcmb.2019-0095LEDOI Listing
November 2019

Sputum microbiomic clustering in asthma and chronic obstructive pulmonary disease reveals a Haemophilus-predominant subgroup.

Allergy 2020 04 21;75(4):808-817. Epub 2019 Oct 21.

Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Department of Respiratory Sciences, College of Life Sciences, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UK.

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http://dx.doi.org/10.1111/all.14058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217013PMC
April 2020

The ERS fellowship portfolio: fostering excellence and diversity.

Eur Respir J 2019 09 5;54(3). Epub 2019 Sep 5.

Depts of Epidemiology and Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1183/13993003.01503-2019DOI Listing
September 2019

Neutrophil elastase as a biomarker for bacterial infection in COPD.

Respir Res 2019 Jul 30;20(1):170. Epub 2019 Jul 30.

Respiratory Medicine Unit, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Level 7, Oxford, OX3 7DU, UK.

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http://dx.doi.org/10.1186/s12931-019-1145-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668103PMC
July 2019

The impact of the prostaglandin D receptor 2 and its downstream effects on the pathophysiology of asthma.

Allergy 2020 04 20;75(4):761-768. Epub 2019 Aug 20.

Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.

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http://dx.doi.org/10.1111/all.14001DOI Listing
April 2020

Cough and Eosinophilia.

J Allergy Clin Immunol Pract 2019 Jul - Aug;7(6):1740-1747

Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Department of Respiratory Sciences, University of Leicester, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.04.048DOI Listing
September 2020

Sputum is reduced in COPD following treatment with benralizumab.

Int J Chron Obstruct Pulmon Dis 2019 5;14:1177-1185. Epub 2019 Jun 5.

Department of Respiratory Sciences, Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.2147/COPD.S198302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559763PMC
January 2020

Benralizumab for the Prevention of COPD Exacerbations.

N Engl J Med 2019 09 20;381(11):1023-1034. Epub 2019 May 20.

From the Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia (G.J.C.); Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston (B.R.C.); the Institute for Lung Health, Leicester National Institute for Health Research Biomedical Research Centre, Department of Respiratory Sciences, University of Leicester, Leicester (C.E.B.), the University of Manchester, Manchester University NHS Hospital Trust, Manchester (D.S.), and the Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford (M.B.) - all in the United Kingdom; Respiratory Institute, Hospital Clinic, University of Barcelona, Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red (CIBER) Enfermedades Respiratorias, Barcelona (A.A.); the Department of Medical Sciences, University of Ferrara, Ferrara, Italy (A.P.); the Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada (D.D.S.); the Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, German Center for Lung Research (DZL), Marburg, Germany (C.F.V.); University of Pittsburgh School of Medicine, Pittsburgh (F.C.S.); the Department of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen (V.B.); Kishiwada City Hospital, Osaka, Japan (M.K.); the Departamento de Investigación en Tabaquismo y EPOC, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, Mexico City (A.R.-V.); the Division of Respiratory and Chest Medicine, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan (Y.-F.W.); the Department of Respiratory Medicine and Allergology, Skane University Hospital, Lund University, Lund, Sweden (L.B.); and AstraZeneca, Gaithersburg, MD (V.H.S., M.J., S.O., N.M., P.N., M.G., U.J.M.).

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http://dx.doi.org/10.1056/NEJMoa1905248DOI Listing
September 2019

T2 Biologics for Chronic Obstructive Pulmonary Disease.

J Allergy Clin Immunol Pract 2019 May - Jun;7(5):1405-1416

Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Department of Infection, Immunity & Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.01.036DOI Listing
August 2020

Comparison of CT ventilation imaging and hyperpolarised gas MRI: effects of breathing manoeuvre.

Phys Med Biol 2019 03 7;64(5):055013. Epub 2019 Mar 7.

POLARIS, Academic Radiology, University of Sheffield, Sheffield, United Kingdom. Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom. Author to whom any correspondence should be addressed.

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http://dx.doi.org/10.1088/1361-6560/ab0145DOI Listing
March 2019

Reply.

J Allergy Clin Immunol 2019 03 11;143(3):1265-1266. Epub 2019 Jan 11.

Division of Respiratory Medicine, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183173
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http://dx.doi.org/10.1016/j.jaci.2018.11.026DOI Listing
March 2019

Sputum strains exhibit diversity within and between COPD subjects.

Int J Chron Obstruct Pulmon Dis 2018;13:3663-3667. Epub 2018 Nov 8.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK,

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https://www.dovepress.com/sputum-moraxella-catarrhalis-strai
Publisher Site
http://dx.doi.org/10.2147/COPD.S180961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231509PMC
April 2019

Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles.

J Allergy Clin Immunol 2018 06 28;141(6):2027-2036.e12. Epub 2018 Apr 28.

Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Department of Infection, Immunity & Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986707PMC
June 2018

Biologic Drugs: A New Target Therapy in COPD?

COPD 2018 04 23;15(2):99-107. Epub 2018 Apr 23.

a NIHR Leicester Biomedical Research Centre, Institute for Lung Health, Department of Infection, Immunity & Inflammation , University of Leicester , Leicester , United Kingdom.

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http://dx.doi.org/10.1080/15412555.2018.1437897DOI Listing
April 2018

Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis.

J Allergy Clin Immunol 2018 11 14;142(5):1457-1468. Epub 2018 Mar 14.

Department of Infection Immunity and Inflammation, Institute for Lung Health, University of Leicester, Glenfield Hospital, Leicester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2017.12.982DOI Listing
November 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Authors:
Florence Demenais Patricia Margaritte-Jeannin Kathleen C Barnes William O C Cookson Janine Altmüller Wei Ang R Graham Barr Terri H Beaty Allan B Becker John Beilby Hans Bisgaard Unnur Steina Bjornsdottir Eugene Bleecker Klaus Bønnelykke Dorret I Boomsma Emmanuelle Bouzigon Christopher E Brightling Myriam Brossard Guy G Brusselle Esteban Burchard Kristin M Burkart Andrew Bush Moira Chan-Yeung Kian Fan Chung Alexessander Couto Alves John A Curtin Adnan Custovic Denise Daley Johan C de Jongste Blanca E Del-Rio-Navarro Kathleen M Donohue Liesbeth Duijts Celeste Eng Johan G Eriksson Martin Farrall Yuliya Fedorova Bjarke Feenstra Manuel A Ferreira Maxim B Freidin Zofia Gajdos Jim Gauderman Ulrike Gehring Frank Geller Jon Genuneit Sina A Gharib Frank Gilliland Raquel Granell Penelope E Graves Daniel F Gudbjartsson Tari Haahtela Susan R Heckbert Dick Heederik Joachim Heinrich Markku Heliövaara John Henderson Blanca E Himes Hiroshi Hirose Joel N Hirschhorn Albert Hofman Patrick Holt Jouke Hottenga Thomas J Hudson Jennie Hui Medea Imboden Vladimir Ivanov Vincent W V Jaddoe Alan James Christer Janson Marjo-Riitta Jarvelin Deborah Jarvis Graham Jones Ingileif Jonsdottir Pekka Jousilahti Michael Kabesch Mika Kähönen David B Kantor Alexandra S Karunas Elza Khusnutdinova Gerard H Koppelman Anita L Kozyrskyj Eskil Kreiner Michiaki Kubo Rajesh Kumar Ashish Kumar Mikko Kuokkanen Lies Lahousse Tarja Laitinen Catherine Laprise Mark Lathrop Susanne Lau Young-Ae Lee Terho Lehtimäki Sébastien Letort Albert M Levin Guo Li Liming Liang Laura R Loehr Stephanie J London Daan W Loth Ani Manichaikul Ingo Marenholz Fernando J Martinez Melanie C Matheson Rasika A Mathias Kenji Matsumoto Hamdi Mbarek Wendy L McArdle Mads Melbye Erik Melén Deborah Meyers Sven Michel Hamida Mohamdi Arthur W Musk Rachel A Myers Maartje A E Nieuwenhuis Emiko Noguchi George T O'Connor Ludmila M Ogorodova Cameron D Palmer Aarno Palotie Julie E Park Craig E Pennell Göran Pershagen Alexey Polonikov Dirkje S Postma Nicole Probst-Hensch Valery P Puzyrev Benjamin A Raby Olli T Raitakari Adaikalavan Ramasamy Stephen S Rich Colin F Robertson Isabelle Romieu Muhammad T Salam Veikko Salomaa Vivi Schlünssen Robert Scott Polina A Selivanova Torben Sigsgaard Angela Simpson Valérie Siroux Lewis J Smith Maria Solodilova Marie Standl Kari Stefansson David P Strachan Bruno H Stricker Atsushi Takahashi Philip J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Carla M T Tiesler Dara G Torgerson Tatsuhiko Tsunoda André G Uitterlinden Ralf J P van der Valk Amaury Vaysse Sailaja Vedantam Andrea von Berg Erika von Mutius Judith M Vonk Johannes Waage Nick J Wareham Scott T Weiss Wendy B White Magnus Wickman Elisabeth Widén Gonneke Willemsen L Keoki Williams Inge M Wouters James J Yang Jing Hua Zhao Miriam F Moffatt Carole Ober Dan L Nicolae

Nat Genet 2018 01 22;50(1):42-53. Epub 2017 Dec 22.

Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

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http://www.nature.com/articles/s41588-017-0014-7
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http://dx.doi.org/10.1038/s41588-017-0014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974PMC
January 2018

Human group 2 innate lymphoid cells do not express the IL-5 receptor.

J Allergy Clin Immunol 2017 11 10;140(5):1430-1433.e4. Epub 2017 May 10.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicestershire, United Kingdom; MRC &Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2017.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667579PMC
November 2017

Blood and sputum eosinophils in COPD; relationship with bacterial load.

Respir Res 2017 05 8;18(1):88. Epub 2017 May 8.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, Manchester, M23 9QZ, UK.

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http://dx.doi.org/10.1186/s12931-017-0570-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422866PMC
May 2017

Regional Ventilation Changes in the Lung: Treatment Response Mapping by Using Hyperpolarized Gas MR Imaging as a Quantitative Biomarker.

Radiology 2017 09 4;284(3):854-861. Epub 2017 May 4.

From the Unit of Academic Radiology, Department of Infection, Immunity and Cardiovascular Disease, C Floor, Royal Hallamshire Hospital, University of Sheffield, Glossop Rd, Sheffield S10 2JF, England (F.C.H., H.M., G.J.C., J.P., J.M.W.); Novartis, Basel, Switzerland (R.K.); Department of Respiratory Medicine, Glenfield Hospital, Leicester, England (S.S., C.E.B.); Insigneo Institute of In-Silico Medicine, University of Sheffield, Sheffield, England (J.M.W.).

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http://dx.doi.org/10.1148/radiol.2017160532DOI Listing
September 2017

Investigating the role of pentraxin 3 as a biomarker for bacterial infection in subjects with COPD.

Int J Chron Obstruct Pulmon Dis 2017 18;12:1199-1205. Epub 2017 Apr 18.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford.

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http://dx.doi.org/10.2147/COPD.S123528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402921PMC
March 2018

Emerging Therapies in Severe Eosinophilic Asthma.

Arch Bronconeumol 2017 05 6;53(5):233-234. Epub 2017 Mar 6.

Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity & Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.arbres.2017.01.012DOI Listing
May 2017

HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4.

J Allergy Clin Immunol 2017 08 1;140(2):584-587.e8. Epub 2017 Mar 1.

Institute for Lung Health, Department of Infection, Immunity & Inflammation, Glenfield Hospital, University of Leicester, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.11.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540224PMC
August 2017

Clinical trial research in focus: do trials prepare us to deliver precision medicine in those with severe asthma?

Lancet Respir Med 2017 02;5(2):92-95

Institute for Lung Health, NIHR BRU Respiratory Medicine, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, LE3 9QP, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(17)30011-5DOI Listing
February 2017

Chronic obstructive pulmonary disease phenotypes, biomarkers, and prognostic indicators.

Allergy Asthma Proc 2016 Nov;37(6):432-438

Institute for Lung Health, National Institute for Health Research Respiratory Biomedical Research Unit, Department of Infection, Immunity and Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UK.

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http://dx.doi.org/10.2500/aap.2016.37.3996DOI Listing
November 2016

Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma.

J Allergy Clin Immunol 2017 Apr 7;139(4):1167-1175.e2. Epub 2016 Oct 7.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.08.008DOI Listing
April 2017

Anti-IL-5 for Severe Asthma: Aiming High to Achieve Success.

Chest 2016 10;150(4):766-768

Department of Infection, Immunity and Inflammation, Institute for Lung Health, Glenfield Hospital, University of Leicester, Leicester, England. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2016.06.013DOI Listing
October 2016

Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies.

Lancet Respir Med 2016 07 10;4(7):549-556. Epub 2016 May 10.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S2213-2600(16)30031-5DOI Listing
July 2016

Circulating fibrocytes: Will the real fibrocyte please stand up?

J Allergy Clin Immunol 2016 05 22;137(5):1625-6. Epub 2016 Mar 22.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicestershire, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.01.023DOI Listing
May 2016

Lung microbiome dynamics in COPD exacerbations.

Eur Respir J 2016 Apr 25;47(4):1082-92. Epub 2016 Feb 25.

Computational Biology, Target Sciences, GSK R&D, Collegeville, PA, USA Both authors contributed equally.

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http://dx.doi.org/10.1183/13993003.01406-2015DOI Listing
April 2016

Blood Eosinophils and Outcomes in Severe Hospitalized Exacerbations of COPD.

Chest 2016 08 3;150(2):320-8. Epub 2016 Feb 3.

Centre for Exercise and Rehabilitation Science, University of Leicester NHS Hospitals Trust, Glenfield Hospital, Leicester, UK; NIHR Respiratory Biomedical Research Unit, University of Leicester, Leicester, UK; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.

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http://dx.doi.org/10.1016/j.chest.2016.01.026DOI Listing
August 2016

Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease.

Ther Adv Chronic Dis 2016 Jan;7(1):34-51

Institute for Lung Health, Clinical Science Wing, University Hospital of Leicester, Leicester LE3 9QP, UK.

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http://dx.doi.org/10.1177/2040622315609251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707428PMC
January 2016

Is the eosinophil a leading villain in lung function decline?

Chest 2015 Oct;148(4):844-846

Institute for Lung Health, National Institute of Health Research Respiratory Biomedical Research Unit, Department of Infection, Immunity, and Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, England.

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http://dx.doi.org/10.1378/chest.15-0915DOI Listing
October 2015

Characterization of acinar airspace involvement in asthmatic patients by using inert gas washout and hyperpolarized (3)helium magnetic resonance.

J Allergy Clin Immunol 2016 Feb 1;137(2):417-25. Epub 2015 Aug 1.

Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749150088
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http://dx.doi.org/10.1016/j.jaci.2015.06.027DOI Listing
February 2016

Destination Airway: Tracking Granulocytes in Asthma.

EBioMedicine 2014 Dec 7;1(2-3):105-6. Epub 2014 Nov 7.

Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester LE3 9QP, UK.

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http://dx.doi.org/10.1016/j.ebiom.2014.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457434PMC
December 2014

Airway bacteria measured by quantitative polymerase chain reaction and culture in patients with stable COPD: relationship with neutrophilic airway inflammation, exacerbation frequency, and lung function.

Int J Chron Obstruct Pulmon Dis 2015 9;10:1075-83. Epub 2015 Jun 9.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK ; Institute for Lung Health, National Institute for Health Research Respiratory Biomedical Research Unit, Glenfield Hospital, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.2147/COPD.S80091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468933PMC
March 2016

CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET.

Am J Physiol Lung Cell Mol Physiol 2015 May 20;308(9):L962-72. Epub 2015 Feb 20.

Department of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom; and

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http://dx.doi.org/10.1152/ajplung.00021.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421784PMC
May 2015

Inhaled glucocorticoids and COPD exacerbations.

N Engl J Med 2015 01;372(1):93

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http://dx.doi.org/10.1056/NEJMc1413308DOI Listing
January 2015

Cigarette Smoke and the Induction of Urokinase Plasminogen Activator Receptor In Vivo: Selective Contribution of Isoforms to Bronchial Epithelial Phenotype.

Am J Respir Cell Mol Biol 2015 Aug;53(2):174-83

1 Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom; and.

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http://dx.doi.org/10.1165/rcmb.2014-0296OCDOI Listing
August 2015

A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid hyperpolarized gas/1H MRI.

Phys Med Biol 2014 Dec 10;59(23):7267-77. Epub 2014 Nov 10.

Academic Unit of Clinical Oncology, University of Sheffield, UK. Academic Unit of Academic Radiology, University of Sheffield, UK.

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http://dx.doi.org/10.1088/0031-9155/59/23/7267DOI Listing
December 2014

D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells.

J Allergy Clin Immunol 2015 Feb 11;135(2):395-406. Epub 2014 Oct 11.

Institute of Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314591PMC
February 2015

Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease.

Int J Chron Obstruct Pulmon Dis 2014 15;9:975-81. Epub 2014 Sep 15.

Respiratory Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom.

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http://dx.doi.org/10.2147/COPD.S63568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168852PMC
February 2015

Association between pathogens detected using quantitative polymerase chain reaction with airway inflammation in COPD at stable state and exacerbations.

Chest 2015 Jan;147(1):46-55

Respiratory Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Oxford, England. Electronic address:

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http://dx.doi.org/10.1378/chest.14-0764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285081PMC
January 2015

Asthma therapy and its effect on airway remodelling.

Drugs 2014 Aug;74(12):1345-69

Department of Infection, Immunity and Inflammation, Institute for Lung Health, Glenfield Hospital, University of Leicester, Leicester, LE3 9QP, UK.

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http://dx.doi.org/10.1007/s40265-014-0250-4DOI Listing
August 2014

Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis.

Eur Respir J 2014 Sep 12;44(3):789-91. Epub 2014 Jun 12.

Dept of Respiratory Medicine, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1183/09031936.00062614DOI Listing
September 2014

[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma.

Respirology 2014 Jul 22;19(5):763-6. Epub 2014 May 22.

Institute for Lung Health, Department of Infection, Immunity and Inflammation, NIHR Biomedical Unit, Glenfield Hospital, University of Leicester, Leicester, UK; Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1111/resp.12318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190647PMC
July 2014

Reply: To PMID 24238646.

J Allergy Clin Immunol 2014 Jun 1;133(6):1777-8. Epub 2014 May 1.

Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Glenfield Hospital, Leicester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2014.01.043DOI Listing
June 2014