Publications by authors named "Christopher Denton"

100Publications

Efficacy and safety of nintedanib in patients with systemic sclerosis-associated interstitial lung disease treated with mycophenolate: a subgroup analysis of the SENSCIS trial.

Lancet Respir Med 2021 01;9(1):96-106

National Heart and Lung Institute, Imperial College London, London, UK; National Institute for Health Research Clinical Research Facility, Royal Brompton Hospital, London, UK; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

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January 2021

Rituximab for the treatment of systemic sclerosis-interstitial lung disease.

Rheumatology (Oxford) 2020 Nov 27. Epub 2020 Nov 27.

Scleroderma Program, University of Michigan, Ann Arbor, MI, USA.

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November 2020

Kidney iron deposition by R2* is associated with haemolysis and urinary iron.

Br J Haematol 2020 Nov 20. Epub 2020 Nov 20.

Department of Pediatrics, Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.

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November 2020

STRATUS, a Phase II Study of Abituzumab in Patients with Systemic Sclerosis-associated Interstitial Lung Disease.

J Rheumatol 2020 Oct 1. Epub 2020 Oct 1.

From the University of Michigan, Ann Arbor, MI, USA; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Royal Brompton Hospital, London, UK; Scleroderma Research Consultants, LLC, Aiken, SC, USA; EMD Serono Inc., Billerica, MA, USA; University College London Medical School, Royal Free Hospital, London, UK. The STRATUS study was sponsored by Merck KGaA (for all study sites residing in countries outside of the USA) or EMD Serono Research and Development Institute, Inc., Billerica, MA, USA* (for study sites residing within the USA). Medical writing assistance was provided by Dan Booth (Bioscript Science, Macclesfield, UK) and funded by Merck KGaA. The STRATUS study was funded by Merck KGaA, Darmstadt, Germany and EMD Serono Research Institute Inc. (a business of Merck KGaA, Darmstadt, Germany). Merck KGaA authors were involved in the study design, collection, analysis and interpretation of the data, and in the writing of and decision to submit the manuscript. Address correspondence to Dr Dinesh Khanna, Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, Ann Arbor, MI 48109, USA. Email:

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October 2020

Comparison of non-invasive methodologies to assess mouth opening following lipotransfer techniques to reverse oral fibrosis.

Clin Exp Rheumatol 2020 May-Jun;38 Suppl 125(3):184. Epub 2020 Aug 27.

UCL Centre for Nanotechnology and Regenerative Medicine, Division of Surgery & Interventional Science, University College London; Department of Plastic Surgery, Royal Free London NHS Foundation Trust Hospital; and Charles Wolfson Centre for Plastic & Reconstructive Surgery, Royal Free London NHS Foundation Trust Hospital, London, UK.

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September 2020

Iloprost for COVID-19-related vasculopathy.

Lancet Rheumatol 2020 Oct 10;2(10):e582-e583. Epub 2020 Jul 10.

Centre for Rheumatology, Royal Free Hospital and University College Medical School, London NW3 2QG, UK.

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October 2020

High proton pump inhibitor exposure increases risk of calcinosis in systemic sclerosis.

Rheumatology (Oxford) 2020 Aug 23. Epub 2020 Aug 23.

Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Campus, London, UK.

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August 2020

News and failures from recent treatment trials in systemic sclerosis.

Eur J Rheumatol 2020 Oct 20;7(Suppl 3):S242-S248. Epub 2020 Jul 20.

Division of Medicine, Centre for Rheumatology, University College London, London, UK.

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October 2020

Cognitive dysfunction in autoimmune rheumatic diseases.

Arthritis Res Ther 2020 04 15;22(1):78. Epub 2020 Apr 15.

Division of Rheumatology, Faculty of Medicine, University of Debrecen, Nagyerdei str 98, Debrecen, 4032, Hungary.

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April 2020

Analysis of Anti-RNA Polymerase III Antibody-positive Systemic Sclerosis and Altered GPATCH2L and CTNND2 Expression in Scleroderma Renal Crisis.

J Rheumatol 2020 11 15;47(11):1668-1677. Epub 2020 Mar 15.

S.G. Guerra, PhD, H. Chinque, BSc, V. Acquaah, BSc, M. Ponticos, V.H. Ong, PhD, FRCP, K. Khan, BSc, S.I. Nihtyanova, MD, C. Fonseca, MD, C.P. Denton, PhD, FRCP, Professor of Experimental Rheumatology, UCL Centre for Rheumatology and Connective Tissue Diseases, London, UK;

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November 2020

Scleroderma mimics - Clinical features and management.

Best Pract Res Clin Rheumatol 2020 02 5;34(1):101489. Epub 2020 Mar 5.

Centre for Rheumatology, Royal Free Campus, University College London, Rowland Hill Street, London NW3 2PF, UK. Electronic address:

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February 2020

Autonomically-mediated decrease in microvascular blood flow due to mental stress and pain in sickle cell disease: A target for neuromodulatory interventions.

Complement Ther Med 2020 Mar 15;49:102334. Epub 2020 Feb 15.

Division of Hematology, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, Mailstop #64, Los Angeles, CA, 90027, USA. Electronic address:

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March 2020

Challenges in evidence-based therapy for systemic sclerosis associated interstitial lung disease.

Lancet Respir Med 2020 03 27;8(3):226-227. Epub 2020 Feb 27.

Division of Medicine, Royal Free Campus, University College London, London NW3 2PF, UK.

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March 2020

Developing a quantitative tool to evaluate dermal fibrosis in systemic sclerosis patients: a case-control study.

Clin Exp Rheumatol 2020 May-Jun;38 Suppl 125(3):172-173. Epub 2020 Feb 18.

Charles Wolfson Centre for Reconstructive Surgery, Royal Free Hospital, London; UCL Centre for Nanotechnology and Regenerative Medicine, Division of Surgery & Interventional Science, University College London; Centre for Rheumatology, Royal Free Hospital, London; and Plastic & Reconstructive Surgery, Royal Free Hospital, London, UK.

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September 2020

Raynaud phenomenon and digital ulcers in systemic sclerosis.

Nat Rev Rheumatol 2020 04 25;16(4):208-221. Epub 2020 Feb 25.

Division of Rheumatology, University of Florence, Florence, Italy.

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April 2020

Gender-related differences in systemic sclerosis.

Autoimmun Rev 2020 Apr 13;19(4):102494. Epub 2020 Feb 13.

Department of Health and Social Sciences, University of the West of England, Bristol, UK.

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April 2020

Improving access to digital ulcer care through nurse-led clinic: a service evaluation.

Musculoskeletal Care 2020 03 21;18(1):92-97. Epub 2020 Jan 21.

Rheumatology Department, Royal Free NHS Foundation Trust, Pond Street, London, NW3 2QG, UK.

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March 2020

Etiology, Risk Factors, and Biomarkers in Systemic Sclerosis with Interstitial Lung Disease.

Am J Respir Crit Care Med 2020 03;201(6):650-660

Northwestern Scleroderma Program, Feinberg School of Medicine, Chicago, Illinois.

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March 2020

Challenges in systemic sclerosis trial design.

Semin Arthritis Rheum 2019 12;49(3S):S3-S7

Centre for Rheumatology, Royal Free Hospital and University College London, Pond Street, Hampstead, London NW3 2QG, UK. Electronic address:

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December 2019

Vaso-Occlusion in Sickle Cell Disease: Is Autonomic Dysregulation of the Microvasculature the Trigger?

J Clin Med 2019 Oct 15;8(10). Epub 2019 Oct 15.

Hematology Section, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, 4650 Sunset boulevard, Los Angeles, CA 90027, USA.

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October 2019

Fast track algorithm: How to differentiate a "scleroderma pattern" from a "non-scleroderma pattern".

Autoimmun Rev 2019 Nov 11;18(11):102394. Epub 2019 Sep 11.

Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS San Martino Polyclinic Hospital, Genoa, Italy. Electronic address:

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November 2019

Progressive fibrosing interstitial lung diseases: current practice in diagnosis and management.

Curr Med Res Opin 2019 11 2;35(11):2015-2024. Epub 2019 Aug 2.

Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Claude Bernard University Lyon 1 , Lyon , France.

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November 2019

Stem cell enriched lipotransfer reverses the effects of fibrosis in systemic sclerosis.

PLoS One 2019 17;14(7):e0218068. Epub 2019 Jul 17.

UCL Division of Surgery & Interventional Science, University College London, London, United Kingdom.

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February 2020

Multidisciplinary Evaluation in Patients with Lung Disease Associated with Connective Tissue Disease.

Semin Respir Crit Care Med 2019 04 28;40(2):184-193. Epub 2019 May 28.

Department of Rheumatology, Royal Free Hospital, London, United Kingdom.

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April 2019

Pulmonary Complications of Connective Tissue Disease.

Semin Respir Crit Care Med 2019 04 28;40(2):145-146. Epub 2019 May 28.

Centre for Rheumatology and Connective Tissue Disease, UCL Division of Medicine, Royal Free London NHS Foundation Trust, London, United Kingdom.

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April 2019

Cause or effect? Interpreting emerging evidence for dysbiosis in systemic sclerosis.

Arthritis Res Ther 2019 03 27;21(1):81. Epub 2019 Mar 27.

Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG, UK.

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March 2019

Elevated kynurenine levels in diffuse cutaneous and anti-RNA polymerase III positive systemic sclerosis.

Clin Immunol 2019 02 14;199:18-24. Epub 2019 Feb 14.

Royal Free Hospital, Centre for Rheumatology and Connective Tissue Diseases, UCL, London, UK. Electronic address:

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February 2019

Autoimmunity and immunodeficiency at the crossroad: autoimmune disorders as the presenting feature of selective IgM deficiency.

BMJ Case Rep 2019 Jan 3;12(1). Epub 2019 Jan 3.

Department of Experimental Rheumatology, Centre for Rheumatology and Connective Tissue Diseases, Royal Free Hospital, London, UK.

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January 2019

Haemodynamic definitions and updated clinical classification of pulmonary hypertension.

Eur Respir J 2019 01 24;53(1). Epub 2019 Jan 24.

Pulmonary Circulation Unit, Pulmonary Division, Heart Institute (InCor), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.

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January 2019

Preliminary Validation of the Digital Ulcer Clinical Assessment Score in Systemic Sclerosis.

J Rheumatol 2019 06 15;46(6):603-608. Epub 2018 Nov 15.

From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero-Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA.

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June 2019

Author Correction: Major lung complications of systemic sclerosis.

Nat Rev Rheumatol 2018 Nov;14(11):682

Royal Free London NHS Foundation Trust, London, UK.

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November 2018

Major lung complications of systemic sclerosis.

Nat Rev Rheumatol 2018 09;14(9):511-527

Royal Free London NHS Foundation Trust, London, UK.

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September 2018

Reliability of digital ulcer definitions as proposed by the UK Scleroderma Study Group: A challenge for clinical trial design.

J Scleroderma Relat Disord 2018 Jun 27;3(2):170-174. Epub 2018 Mar 27.

Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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June 2018

Should all digital ulcers be included in future clinical trials of systemic sclerosis-related digital vasculopathy?

Med Hypotheses 2018 Jul 2;116:101-104. Epub 2018 May 2.

Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; NIHR Manchester Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, UK.

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July 2018

Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism.

FASEB J 2018 09 30;32(9):4941-4954. Epub 2018 Mar 30.

Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, United Kingdom; and.

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September 2018

The novel use of botulinum toxin A for the treatment of Raynaud's phenomenon in the toes.

BMJ Case Rep 2018 Mar 9;2018. Epub 2018 Mar 9.

UCL Centre for Nanotechnology and Regenerative Medicine, Royal Free Hospital, London, UK.

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March 2018

Reply.

Arthritis Rheumatol 2018 06 2;70(6):974. Epub 2018 May 2.

University of Manchester Salford Royal NHS Foundation Trust, and NIHR Manchester Musculoskeletal Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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June 2018

Distinctive clinical phenotype of anti-centromere antibody-positive diffuse systemic sclerosis.

Rheumatol Adv Pract 2018 7;2(1):rky002. Epub 2018 Mar 7.

Centre for Rheumatology and Connective Tissue Diseases, University College London Medical School, Royal Free Hospital, London, UK.

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March 2018

Autologous fat transfer in the successful treatment of upper limb linear morphoea.

Clin Exp Rheumatol 2018 Jul-Aug;36 Suppl 113(4):183. Epub 2018 Feb 14.

Department of Plastic and Reconstructive Surgery, University of Udine, Italy.

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January 2019

Development of systemic sclerosis in transgender females: a case series and review of the literature.

Clin Exp Rheumatol 2018 Jul-Aug;36 Suppl 113(4):50-52. Epub 2018 Feb 19.

Centre for Rheumatology and Connective Tissue Diseases, University College London, UK.

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January 2019

Predictors of hepatotoxicity and pancreatitis in children and adolescents with acute lymphoblastic leukemia treated according to contemporary regimens.

Pediatr Blood Cancer 2018 03 8;65(3). Epub 2017 Dec 8.

Division of Hematology, Oncology, & BMT, Children's Hospital Los Angeles, Los Angeles, California.

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March 2018