Publications by authors named "Christopher D Scharer"

44Publications

Roadmap to a plasma cell: Epigenetic and transcriptional cues that guide B cell differentiation.

Immunol Rev 2020 Dec 5. Epub 2020 Dec 5.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

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December 2020

Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Prone Mice.

Immunohorizons 2020 Oct 23;4(10):679-687. Epub 2020 Oct 23.

Vermont Center for Immunology and Infectious Diseases, Department of Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05405; and

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October 2020

Antibody-secreting cell destiny emerges during the initial stages of B-cell activation.

Nat Commun 2020 08 10;11(1):3989. Epub 2020 Aug 10.

Department of Microbiology and Immunology and the Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, 30322, USA.

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August 2020

Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment.

PLoS Pathog 2020 04 30;16(4):e1008438. Epub 2020 Apr 30.

Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.

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April 2020

Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8 T cells.

Nat Immunol 2020 03 17;21(3):309-320. Epub 2020 Jan 17.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

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March 2020

IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes.

J Immunol 2019 10 9;203(8):2121-2129. Epub 2019 Sep 9.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322;

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October 2019

LSD1 Cooperates with Noncanonical NF-κB Signaling to Regulate Marginal Zone B Cell Development.

J Immunol 2019 10 6;203(7):1867-1881. Epub 2019 Sep 6.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322

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October 2019

The Histone Demethylase LSD1 Regulates B Cell Proliferation and Plasmablast Differentiation.

J Immunol 2018 11 19;201(9):2799-2811. Epub 2018 Sep 19.

Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322

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November 2018

Progressive Upregulation of Oxidative Metabolism Facilitates Plasmablast Differentiation to a T-Independent Antigen.

Cell Rep 2018 06;23(11):3152-3159

Department of Microbiology and Immunology and the Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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June 2018

B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation.

Nat Commun 2018 05 15;9(1):1900. Epub 2018 May 15.

Department of Microbiology & Immunology, Emory University School of Medicine, 1510 Clifton Rd., Rm 3001, Atlanta, GA, 30322, USA.

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May 2018

Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs.

Nat Commun 2018 04 27;9(1):1698. Epub 2018 Apr 27.

Department of Microbiology and Immunology, Emory University, Atlanta, GA, 30322, USA.

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April 2018

Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory.

J Immunol 2017 03 8;198(6):2238-2243. Epub 2017 Feb 8.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322; and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322

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March 2017

Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation.

Nat Immunol 2016 10 8;17(10):1216-1225. Epub 2016 Aug 8.

Department of Microbiology & Immunology Emory University School of Medicine Atlanta, GA, USA.

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October 2016

ZBTB32 Restricts the Duration of Memory B Cell Recall Responses.

J Immunol 2016 08 29;197(4):1159-68. Epub 2016 Jun 29.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;

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August 2016

ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in naïve SLE B cells.

Sci Rep 2016 06 1;6:27030. Epub 2016 Jun 1.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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June 2016

Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway.

Cell Rep 2015 Aug 13;12(8):1217-25. Epub 2015 Aug 13.

Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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August 2015

NF-κB regulates PD-1 expression in macrophages.

J Immunol 2015 May 25;194(9):4545-54. Epub 2015 Mar 25.

Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322; and

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May 2015

Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment.

Nucleic Acids Res 2015 Mar 9;43(6):3128-42. Epub 2015 Mar 9.

Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA

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March 2015

Chemically defined serum-free and xeno-free media for multiple cell lineages.

Ann Transl Med 2014 Oct;2(10):97

1 Jeevan Biosciences Inc., Dunwoody, GA, USA ; 2 Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA ; 3 Department of Biology, Georgia State University, Atlanta, GA, USA.

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October 2014

Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality.

In Vivo 2014 Sep-Oct;28(5):709-18

Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, U.S.A. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, U.S.A.

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May 2015

B cell differentiation is associated with reprogramming the CCCTC binding factor-dependent chromatin architecture of the murine MHC class II locus.

J Immunol 2014 Apr 14;192(8):3925-35. Epub 2014 Mar 14.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322.

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April 2014

Global DNA methylation remodeling accompanies CD8 T cell effector function.

J Immunol 2013 Sep 16;191(6):3419-29. Epub 2013 Aug 16.

Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.

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September 2013

Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells.

Cancer Res 2009 Jan;69(2):709-17

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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January 2009

Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells.

J Transl Med 2008 Dec 11;6:79. Epub 2008 Dec 11.

Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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December 2008