Christopher D Scharer

Vermont Center for Immunology and Infectious Diseases, Department of Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05405; and

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October 2020

Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons.

Authors:

George Andrew S Inglis Ying Zhou Dillon G Patterson Christopher D Scharer Yanfei Han Jeremy M Boss Zhexing Wen Andrew Escayg

Hum Mol Genet 2020 Aug;29(15):2579-2595

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

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August 2020

Antibody-secreting cell destiny emerges during the initial stages of B-cell activation.

Authors:

Christopher D Scharer Dillon G Patterson Tian Mi Madeline J Price Sakeenah L Hicks Jeremy M Boss

Nat Commun 2020 08 10;11(1):3989. Epub 2020 Aug 10.

Department of Microbiology and Immunology and the Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, 30322, USA.

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August 2020

Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment.

Authors:

Christopher M Collins Christopher D Scharer Thomas J Murphy Jeremy M Boss Samuel H Speck

PLoS Pathog 2020 04 30;16(4):e1008438. Epub 2020 Apr 30.

Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.

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April 2020

Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8 T cells.

Authors:

Sarah L Hayward Christopher D Scharer Emily K Cartwright Shiki Takamura Zheng-Rong Tiger Li Jeremy M Boss Jacob E Kohlmeier

Nat Immunol 2020 03 17;21(3):309-320. Epub 2020 Jan 17.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

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March 2020

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.

Immunity 2020 01;52(1):203

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January 2020

Signaling through the Inhibitory Fc Receptor FcγRIIB Induces CD8 T Cell Apoptosis to Limit T Cell Immunity.

Authors:

Anna B Morris Clara R Farley David F Pinelli Layne E Adams Mark S Cragg Jeremy M Boss Christopher D Scharer Miguel Fribourg Paolo Cravedi Peter S Heeger Mandy L Ford

Immunity 2020 01;52(1):136-150.e6

Department of Surgery, Emory University, Atlanta, GA, USA. Electronic address:

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January 2020

Understanding and measuring human B-cell tolerance and its breakdown in autoimmune disease.

Authors:

Kevin S Cashman Scott A Jenks Matthew C Woodruff Deepak Tomar Christopher M Tipton Christopher D Scharer F Eun-Hyung Lee Jeremy M Boss Iñaki Sanz

Immunol Rev 2019 11 22;292(1):76-89. Epub 2019 Nov 22.

Department of Medicine, Division of Rheumatology, Emory University, Atlanta, GA, USA.

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November 2019

A super enhancer controls expression and chromatin architecture within the MHC class II locus.

Authors:

Parimal Majumder Joshua T Lee Andrew R Rahmberg Gaurav Kumar Tian Mi Christopher D Scharer Jeremy M Boss

J Exp Med 2020 02;217(2)

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.

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February 2020

Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression.

Authors:

Sanjay Chandrasekaran Maiko Sasaki Christopher D Scharer Haydn T Kissick Dillon G Patterson Kelly R Magliocca John T Seykora Bishu Sapkota David A Gutman Lee A Cooper Gregory B Lesinski Edmund K Waller Susan N Thomas Sergei V Kotenko Jeremy M Boss Carlos S Moreno Robert A Swerlick Brian P Pollack

Mol Cancer Res 2019 12 23;17(12):2395-2409. Epub 2019 Sep 23.

Atlanta Veterans Affairs Medical Center, Atlanta, Georgia.

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December 2019

IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes.

Authors:

Madeline J Price Sakeenah L Hicks John E Bradley Troy D Randall Jeremy M Boss Christopher D Scharer

J Immunol 2019 10 9;203(8):2121-2129. Epub 2019 Sep 9.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322;

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October 2019

LSD1 Cooperates with Noncanonical NF-κB Signaling to Regulate Marginal Zone B Cell Development.

Authors:

Robert R Haines Christopher D Scharer Jenna L Lobby Jeremy M Boss

J Immunol 2019 10 6;203(7):1867-1881. Epub 2019 Sep 6.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322

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October 2019

Epigenetic programming underpins B cell dysfunction in human SLE.

Authors:

Christopher D Scharer Emily L Blalock Tian Mi Benjamin G Barwick Scott A Jenks Tsuneo Deguchi Kevin S Cashman Bridget E Neary Dillon G Patterson Sakeenah L Hicks Arezou Khosroshahi F Eun-Hyung Lee Chungwen Wei Iñaki Sanz Jeremy M Boss

Nat Immunol 2019 08 1;20(8):1071-1082. Epub 2019 Jul 1.

Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, USA.

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August 2019

IFNγ induces epigenetic programming of human T-bet B cells and promotes TLR7/8 and IL-21 induced differentiation.

Elife 2019 05 15;8. Epub 2019 May 15.

Department of Microbiology, The University of Alabama at Birmingham, Birmingham, United States.

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May 2019

T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells.

Immunity 2019 05 7;50(5):1172-1187.e7. Epub 2019 May 7.

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address:

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May 2019

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.

Immunity 2018 10 9;49(4):725-739.e6. Epub 2018 Oct 9.

Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA. Electronic address:

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October 2018

The Histone Demethylase LSD1 Regulates B Cell Proliferation and Plasmablast Differentiation.

Authors:

Robert R Haines Benjamin G Barwick Christopher D Scharer Parimal Majumder Troy D Randall Jeremy M Boss

J Immunol 2018 11 19;201(9):2799-2811. Epub 2018 Sep 19.

Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322

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November 2018

Progressive Upregulation of Oxidative Metabolism Facilitates Plasmablast Differentiation to a T-Independent Antigen.

Authors:

Madeline J Price Dillon G Patterson Christopher D Scharer Jeremy M Boss

Cell Rep 2018 06;23(11):3152-3159

Department of Microbiology and Immunology and the Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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June 2018

B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation.

Authors:

Benjamin G Barwick Christopher D Scharer Ryan J Martinez Madeline J Price Alexander N Wein Robert R Haines Alexander P R Bally Jacob E Kohlmeier Jeremy M Boss

Nat Commun 2018 05 15;9(1):1900. Epub 2018 May 15.

Department of Microbiology & Immunology, Emory University School of Medicine, 1510 Clifton Rd., Rm 3001, Atlanta, GA, 30322, USA.

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May 2018

Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs.

Authors:

Christopher D Scharer Benjamin G Barwick Muyao Guo Alexander P R Bally Jeremy M Boss

Nat Commun 2018 04 27;9(1):1698. Epub 2018 Apr 27.

Department of Microbiology and Immunology, Emory University, Atlanta, GA, 30322, USA.

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April 2018

EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production.

Authors:

Muyao Guo Madeline J Price Dillon G Patterson Benjamin G Barwick Robert R Haines Anna K Kania John E Bradley Troy D Randall Jeremy M Boss Christopher D Scharer

J Immunol 2018 02 29;200(3):1039-1052. Epub 2017 Dec 29.

Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322;

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February 2018

Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory.

Authors:

Christopher D Scharer Alexander P R Bally Bhanu Gandham Jeremy M Boss

J Immunol 2017 03 8;198(6):2238-2243. Epub 2017 Feb 8.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322; and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322

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March 2017

Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation.

Authors:

Benjamin G Barwick Christopher D Scharer Alexander P R Bally Jeremy M Boss

Nat Immunol 2016 10 8;17(10):1216-1225. Epub 2016 Aug 8.

Department of Microbiology & Immunology Emory University School of Medicine Atlanta, GA, USA.

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October 2016

ZBTB32 Restricts the Duration of Memory B Cell Recall Responses.

Authors:

Arijita Jash Yinan Wang Florian J Weisel Christopher D Scharer Jeremy M Boss Mark J Shlomchik Deepta Bhattacharya

J Immunol 2016 08 29;197(4):1159-68. Epub 2016 Jun 29.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;

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August 2016

ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in naïve SLE B cells.

Authors:

Christopher D Scharer Emily L Blalock Benjamin G Barwick Robert R Haines Chungwen Wei Ignacio Sanz Jeremy M Boss

Sci Rep 2016 06 1;6:27030. Epub 2016 Jun 1.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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June 2016

Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway.

Authors:

Rheinallt M Jones Chirayu Desai Trevor M Darby Liping Luo Alexandra A Wolfarth Christopher D Scharer Courtney S Ardita April R Reedy Erin S Keebaugh Andrew S Neish

Cell Rep 2015 Aug 13;12(8):1217-25. Epub 2015 Aug 13.

Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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August 2015

NF-κB regulates PD-1 expression in macrophages.

Authors:

Alexander P R Bally Peiyuan Lu Yan Tang James W Austin Christopher D Scharer Rafi Ahmed Jeremy M Boss

J Immunol 2015 May 25;194(9):4545-54. Epub 2015 Mar 25.

Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322; and

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May 2015

Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment.

Authors:

Christopher D Scharer Nancy M Choi Benjamin G Barwick Parimal Majumder Sarah Lohsen Jeremy M Boss

Nucleic Acids Res 2015 Mar 9;43(6):3128-42. Epub 2015 Mar 9.

Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA

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March 2015

Chemically defined serum-free and xeno-free media for multiple cell lineages.

Authors:

Sümeyra Naz Usta Christopher D Scharer Jie Xu Teryl K Frey Rodney J Nash

Ann Transl Med 2014 Oct;2(10):97

1 Jeevan Biosciences Inc., Dunwoody, GA, USA ; 2 Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA ; 3 Department of Biology, Georgia State University, Atlanta, GA, USA.

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October 2014

Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality.

Authors:

Walter Guy Wiles Zhongming Mou Yang Du Alyssa B Long Christopher D Scharer Birdal Bilir Demetri D Spyropoulos Nancy A Jenkins Neal G Copeland W David Martin Carlos S Moreno

In Vivo 2014 Sep-Oct;28(5):709-18

Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, U.S.A. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, U.S.A.

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May 2015