Christopher D Huston

Christopher D Huston

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Christopher D Huston

Publications by authors named "Christopher D Huston"

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Piperazine-Derivative MMV665917: An Effective Drug in the Diarrheic Piglet Model of Cryptosporidium hominis.

J Infect Dis 2019 06;220(2):285-293

Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts.

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz105DOI Listing
June 2019

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have Activity against Cryptosporidium.

Antimicrob Agents Chemother 2018 12 26;62(12). Epub 2018 Nov 26.

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.

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http://aac.asm.org/lookup/doi/10.1128/AAC.00718-18
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http://dx.doi.org/10.1128/AAC.00718-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256802PMC
December 2018

Invadosome-Mediated Human Extracellular Matrix Degradation by Entamoeba histolytica.

Infect Immun 2018 09 22;86(9). Epub 2018 Aug 22.

Department of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont, USA

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http://dx.doi.org/10.1128/IAI.00287-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105895PMC
September 2018

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.

Structure 2017 10 31;25(10):1495-1505.e6. Epub 2017 Aug 31.

Molecular Medicine - Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, India. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.07.015DOI Listing
October 2017

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis.

PLoS Negl Trop Dis 2017 02 3;11(2):e0005373. Epub 2017 Feb 3.

California Institute for Biomedical Research, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0005373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310922PMC
February 2017

Knockdown of Five Genes Encoding Uncharacterized Proteins Inhibits Entamoeba histolytica Phagocytosis of Dead Host Cells.

Infect Immun 2016 Apr 24;84(4):1045-1053. Epub 2016 Mar 24.

Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA

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http://dx.doi.org/10.1128/IAI.01325-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807468PMC
April 2016

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments.

PLoS Negl Trop Dis 2015 Oct 8;9(10):e0003987. Epub 2015 Oct 8.

Medicines for Malaria Venture, Geneva, Switzerland; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0003987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598153PMC
October 2015

Immunization with the Entamoeba histolytica surface metalloprotease EhMSP-1 protects hamsters from amebic liver abscess.

Infect Immun 2015 Feb 1;83(2):713-20. Epub 2014 Dec 1.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, USA Department of Medicine, University of Vermont, Burlington, Vermont, USA

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http://dx.doi.org/10.1128/IAI.02490-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294257PMC
February 2015

SNAP-tag technology optimized for use in Entamoeba histolytica.

PLoS One 2013 31;8(12):e83997. Epub 2013 Dec 31.

University of Vermont Cellular, Molecular, and Biomedical Sciences Program, Burlington, Vermont, United States of America ; University of Vermont Microbiology and Molecular Genetics, Burlington, Vermont, United States of America ; University of Vermont Department of Medicine, Burlington, Vermont, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083997PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877135PMC
September 2014

Drug repurposing: mining protozoan proteomes for targets of known bioactive compounds.

J Am Med Inform Assoc 2014 Mar-Apr;21(2):238-44. Epub 2013 Jun 11.

Cell, Molecular, and Biomedical Sciences Graduate Program, University of Vermont College of Medicine, Burlington, Vermont, USA.

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http://dx.doi.org/10.1136/amiajnl-2013-001700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932453PMC
May 2014

Identification of Cryptosporidium parvum active chemical series by Repurposing the open access malaria box.

Antimicrob Agents Chemother 2014 May 24;58(5):2731-9. Epub 2014 Feb 24.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, USA.

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http://dx.doi.org/10.1128/AAC.02641-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993250PMC
May 2014

Drug repurposing screen reveals FDA-approved inhibitors of human HMG-CoA reductase and isoprenoid synthesis that block Cryptosporidium parvum growth.

Antimicrob Agents Chemother 2013 Apr 4;57(4):1804-14. Epub 2013 Feb 4.

Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA.

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http://dx.doi.org/10.1128/AAC.02460-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623326PMC
April 2013

Feed-forward regulation of phagocytosis by Entamoeba histolytica.

Infect Immun 2012 Dec 8;80(12):4456-62. Epub 2012 Oct 8.

Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA.

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http://dx.doi.org/10.1128/IAI.00671-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497417PMC
December 2012

Control of Entamoeba histolytica adherence involves metallosurface protease 1, an M8 family surface metalloprotease with homology to leishmanolysin.

Infect Immun 2012 Jun 26;80(6):2165-76. Epub 2012 Mar 26.

Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA.

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http://dx.doi.org/10.1128/IAI.06389-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370588PMC
June 2012

Entamoeba histolytica cell surface calreticulin binds human c1q and functions in amebic phagocytosis of host cells.

Infect Immun 2012 Jun 2;80(6):2008-18. Epub 2012 Apr 2.

Cell and Molecular Biology Program, University of Vermont College of Medicine, Burlington, Vermont, USA.

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http://dx.doi.org/10.1128/IAI.06287-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370593PMC
June 2012

A Sequential Model of Host Cell Killing and Phagocytosis by Entamoeba histolytica.

J Parasitol Res 2011 20;2011:926706. Epub 2011 Jan 20.

Department of Medicine, College of Medicine, The University of Vermont, Room 320 Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1155/2011/926706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038552PMC
July 2011

Evidence for a novel Entamoeba histolytica lectin activity that recognises carbohydrates present on ovalbumin.

Int J Parasitol 2011 Feb 31;41(2):137-44. Epub 2010 Aug 31.

Cell and Molecular Biology Program, University of Vermont College of Medicine, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1016/j.ijpara.2010.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003744PMC
February 2011

Evidence of a continuous endoplasmic reticulum in the protozoan parasite Entamoeba histolytica.

Eukaryot Cell 2008 Jul 15;7(7):1222-6. Epub 2008 Feb 15.

Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1128/EC.00007-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446670PMC
July 2008

Participation of the serine-rich Entamoeba histolytica protein in amebic phagocytosis of apoptotic host cells.

Infect Immun 2008 Mar 17;76(3):959-66. Epub 2007 Dec 17.

Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1128/IAI.01455-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258814PMC
March 2008

Identification and characterization of EhABC A1, an Entamoeba histolytica Group A ABC transporter with similarity to Ced-7.

Mol Biochem Parasitol 2006 Apr 17;146(2):272-6. Epub 2006 Jan 17.

Department of Medicine, University of Vermont College of Medicine, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2005.12.013DOI Listing
April 2006

Kinetics and strain variation of phagosome proteins of Entamoeba histolytica by proteomic analysis.

Mol Biochem Parasitol 2006 Feb 19;145(2):171-83. Epub 2005 Oct 19.

Department of Parasitology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

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http://dx.doi.org/10.1016/j.molbiopara.2005.10.001DOI Listing
February 2006

Entamoeba histolytica and Entamoeba dispar utilize externalized phosphatidylserine for recognition and phagocytosis of erythrocytes.

Infect Immun 2005 Jun;73(6):3422-30

Division of Infectious Diseases and International Health, P. O. Box 801340, Rm. 2115, MR4 Building, University of Virginia Health System, Charlottesville, VA 22908-1340, USA.

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http://iai.asm.org/cgi/doi/10.1128/IAI.73.6.3422-3430.2005
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http://dx.doi.org/10.1128/IAI.73.6.3422-3430.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1111853PMC
June 2005

Proteomic analysis of phagocytosis in the enteric protozoan parasite Entamoeba histolytica.

Eukaryot Cell 2005 Apr;4(4):827-31

Department of Parasitology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

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http://dx.doi.org/10.1128/EC.4.4.827-831.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087816PMC
April 2005

Parasite and host contributions to the pathogenesis of amebic colitis.

Trends Parasitol 2004 Jan;20(1):23-6

Department of Medicine, Division of Infectious Disease, University of Vermont College of Medicine, 304 Burgess Building, Fletcher Allen Health Care, 111 Colchester Avenue, Burlington, VT 05401, USA.

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http://dx.doi.org/10.1016/j.pt.2003.10.013DOI Listing
January 2004

Amebiasis.

N Engl J Med 2003 Apr;348(16):1565-73

International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.

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http://dx.doi.org/10.1056/NEJMra022710DOI Listing
April 2003

Apoptotic killing and phagocytosis of host cells by the parasite Entamoeba histolytica.

Infect Immun 2003 Feb;71(2):964-72

Department of Medicine, University of Virginia Health System, Charlottesville 22908.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC145391PMC
http://dx.doi.org/10.1128/iai.71.2.964-972.2003DOI Listing
February 2003