Christopher D Heinen

Christopher D Heinen

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Christopher D Heinen

Christopher D Heinen

Publications by authors named "Christopher D Heinen"

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The mismatch repair-dependent DNA damage response: Mechanisms and implications.

DNA Repair (Amst) 2019 06 1;78:60-69. Epub 2019 Apr 1.

Center for Molecular Oncology, UConn Health, Farmington, CT 06030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.03.009DOI Listing
June 2019

Functional interrogation of Lynch syndrome-associated MSH2 missense variants via CRISPR-Cas9 gene editing in human embryonic stem cells.

Hum Mutat 2019 Jun 25. Epub 2019 Jun 25.

Center for Molecular Oncology and Institute for Systems Genomics, UConn Health, Farmington, Connecticut.

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http://dx.doi.org/10.1002/humu.23848DOI Listing
June 2019

ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage.

Proc Natl Acad Sci U S A 2018 02 29;115(7):1523-1528. Epub 2018 Jan 29.

Neag Comprehensive Cancer Center, UConn Health, Farmington, CT 06030-3101;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1720355115
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http://dx.doi.org/10.1073/pnas.1720355115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816205PMC
February 2018

Enhanced gene targeting to evaluate Lynch syndrome alterations.

Proc Natl Acad Sci U S A 2016 Apr 24;113(15):3918-20. Epub 2016 Mar 24.

Center for Molecular Medicine, University of Connecticut Health, Farmington, CT 06030; Neag Comprehensive Cancer Center, University of Connecticut Health, Farmington, CT 06030

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http://dx.doi.org/10.1073/pnas.1602650113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839465PMC
April 2016

Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer.

DNA Repair (Amst) 2016 Feb 2;38:127-134. Epub 2015 Dec 2.

Center for Molecular Medicine and Neag Comprehensive Cancer Center, University of Connecticut Health, Farmington, CT 06030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.11.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740212PMC
February 2016

Milestones of Lynch syndrome: 1895-2015.

Nat Rev Cancer 2015 03 12;15(3):181-94. Epub 2015 Feb 12.

Department of Medicine (Oncology), Stanford Cancer Institute, Stanford University, Grant Building S169, 1291 Welch Road, Stanford, California 94305, USA.

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http://www.nature.com/articles/nrc3878
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http://dx.doi.org/10.1038/nrc3878DOI Listing
March 2015

Human pluripotent stem cells have a novel mismatch repair-dependent damage response.

J Biol Chem 2014 Aug 10;289(35):24314-24. Epub 2014 Jul 10.

From the Center for Molecular Medicine and Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, Connecticut 06030-3101

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.570937
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http://dx.doi.org/10.1074/jbc.M114.570937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148860PMC
August 2014

Translating mismatch repair mechanism into cancer care.

Curr Drug Targets 2014 Jan;15(1):53-64

University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3101, USA.

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http://dx.doi.org/10.2174/1389450114666140106100128DOI Listing
January 2014

Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future.

Hum Mutat 2012 Dec 13;33(12):1617-25. Epub 2012 Aug 13.

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.

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http://doi.wiley.com/10.1002/humu.22168
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http://dx.doi.org/10.1002/humu.22168DOI Listing
December 2012

The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complex.

Mol Carcinog 2012 Aug 11;51(8):647-58. Epub 2011 Aug 11.

Neag Comprehensive Cancer Center and Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030-3101, USA.

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http://dx.doi.org/10.1002/mc.20838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220760PMC
August 2012

Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays.

Hered Cancer Clin Pract 2012 Jul 23;10(1). Epub 2012 Jul 23.

Neag Comprehensive Cancer Center and Center for Molecular Medicine, University of Connecticut Health Center, 233 Farmington Avenue, ML3101 Farmington, CT, USA.

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http://dx.doi.org/10.1186/1897-4287-10-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434035PMC
July 2012

Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy.

Cancer Causes Control 2012 Feb 21;23(2):355-61. Epub 2011 Dec 21.

Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT 06030-1845, USA.

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http://dx.doi.org/10.1007/s10552-011-9884-7DOI Listing
February 2012

DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication.

J Virol 2011 Dec 28;85(23):12241-53. Epub 2011 Sep 28.

Department of Molecular, Microbial, and Structural Biology and Molecular Biology and Biochemistry Graduate Program, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030, USA.

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http://dx.doi.org/10.1128/JVI.05487-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209375PMC
December 2011

Human MSH2 (hMSH2) protein controls ATP processing by hMSH2-hMSH6.

J Biol Chem 2011 Nov 19;286(46):40287-95. Epub 2011 Sep 19.

University of Connecticut Health Center, Farmington, Connecticut 06030-3101, USA.

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http://dx.doi.org/10.1074/jbc.M111.297523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220577PMC
November 2011

Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families.

Mutat Res 2010 Nov 17;693(1-2):32-45. Epub 2009 Sep 17.

Neag Comprehensive Cancer Center and Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2009.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891646PMC
November 2010

Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo.

Hum Mutat 2010 Oct;31(10):E1699-708

Neag Comprehensive Cancer Center and Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030-3101, USA.

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http://dx.doi.org/10.1002/humu.21333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947597PMC
October 2010

Increased frequency of serrated aberrant crypt foci among smokers.

Am J Gastroenterol 2010 Jul 16;105(7):1648-54. Epub 2010 Mar 16.

Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT 06030-1845, USA.

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http://dx.doi.org/10.1038/ajg.2010.109DOI Listing
July 2010

Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.

DNA Repair (Amst) 2010 Feb 8;9(2):120-33. Epub 2009 Dec 8.

Neag Comprehensive Cancer Center and Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, ML3101, Farmington, CT 06030-3101, USA.

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http://dx.doi.org/10.1016/j.dnarep.2009.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819642PMC
February 2010

Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding.

J Biol Chem 2008 Nov 11;283(46):31641-8. Epub 2008 Sep 11.

Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

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http://dx.doi.org/10.1074/jbc.M806018200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581557PMC
November 2008

Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer.

Cancer Lett 2007 Apr 6;248(2):262-8. Epub 2006 Sep 6.

Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, CT, USA.

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http://dx.doi.org/10.1016/j.canlet.2006.08.003DOI Listing
April 2007

Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer.

Carcinogenesis 2007 Apr 4;28(4):769-76. Epub 2006 Nov 4.

Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT, USA.

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http://dx.doi.org/10.1093/carcin/bgl209DOI Listing
April 2007

Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans.

Cancer Res 2007 Apr;67(8):3551-4

Colon Cancer Prevention Program, NEAG Comprehensive Cancer Center, and Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0343DOI Listing
April 2007

Magnesium influences the discrimination and release of ADP by human RAD51.

DNA Repair (Amst) 2006 Jun 19;5(6):704-17. Epub 2006 Apr 19.

Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer, Genetics, The Ohio State University College of Medicine, The Ohio State University, Comprehensive Cancer Center, Columbus, OH 43102, USA.

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http://dx.doi.org/10.1016/j.dnarep.2006.03.004DOI Listing
June 2006

hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51.

J Biol Chem 2004 Jul 3;279(29):30385-94. Epub 2004 May 3.

Genetics and Molecular Biology Program, Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M306066200DOI Listing
July 2004

DNA repair and tumorigenesis: lessons from hereditary cancer syndromes.

Cancer Biol Ther 2002 Sep-Oct;1(5):477-85

Genetics and Molecular Biology Program, Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 233 S. 10th Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.4161/cbt.1.5.160DOI Listing
August 2003

The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway.

Gastroenterology 2002 Sep;123(3):751-63

Howard Hughes Medical Institute, Department of Molecular Genetics, University of Cincinnati College of Medicine, Ohio 45267-0524, USA.

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http://dx.doi.org/10.1053/gast.2002.35382DOI Listing
September 2002

HNPCC mutations in hMSH2 result in reduced hMSH2-hMSH6 molecular switch functions.

Cancer Cell 2002 Jun;1(5):469-78

Genetics and Molecular Biology Program, Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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June 2002

Biochemical characterization of the human RAD51 protein. III. Modulation of DNA binding by adenosine nucleotides.

J Biol Chem 2002 Apr 11;277(17):14434-42. Epub 2002 Feb 11.

Genetics and Molecular Biology Program, Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M109917200DOI Listing
April 2002