Christopher D Brown

Christopher D Brown

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Christopher D Brown

Christopher D Brown

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A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.

Authors:
Jonathan P Bradfield Suzanne Vogelezang Janine F Felix Alessandra Chesi Øyvind Helgeland Momoko Horikoshi Ville Karhunen Estelle Lowry Diana L Cousminer Tarunveer S Ahluwalia Elisabeth Thiering Eileen Tai-Hui Boh Mohammad H Zafarmand Natalia Vilor-Tejedor Carol A Wang Raimo Joro Zhanghua Chen William J Gauderman Niina Pitkänen Esteban J Parra Lindsay Fernandez-Rhodes Akram Alyass Claire Monnereau John A Curtin Christian T Have Shana E McCormack Mette Hollensted Christine Frithioff-Bøjsøe Adan Valladares-Salgado Jesus Peralta-Romero Yik-Ying Teo Marie Standl Jaakko T Leinonen Jens-Christian Holm Triinu Peters Jesus Vioque Martine Vrijheid Angela Simpson Adnan Custovic Marc Vaudel Mickaël Canouil Virpi Lindi Mustafa Atalay Mika Kähönen Olli T Raitakari Barbera D C van Schaik Robert I Berkowitz Shelley A Cole V Saroja Voruganti Yujie Wang Heather M Highland Anthony G Comuzzie Nancy F Butte Anne E Justice Sheila Gahagan Estela Blanco Terho Lehtimäki Timo A Lakka Johannes Hebebrand Amélie Bonnefond Niels Grarup Philippe Froguel Leo-Pekka Lyytikäinen Miguel Cruz Sayuko Kobes Robert L Hanson Babette S Zemel Anke Hinney Koon K Teo David Meyre Kari E North Frank D Gilliland Hans Bisgaard Mariona Bustamante Klaus Bonnelykke Craig E Pennell Fernando Rivadeneira André G Uitterlinden Leslie J Baier Tanja G M Vrijkotte Joachim Heinrich Thorkild I A Sørensen Seang-Mei Saw Oluf Pedersen Torben Hansen Johan Eriksson Elisabeth Widén Mark I McCarthy Pål R Njølstad Christine Power Elina Hyppönen Sylvain Sebert Christopher D Brown Marjo-Riitta Järvelin Nicholas J Timpson Stefan Johansson Hakon Hakonarson Vincent W V Jaddoe S F A Grant

Hum Mol Genet 2019 10;28(19):3327-3338

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddz161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859434PMC
October 2019

Genomic architecture of Shh-dependent cochlear morphogenesis.

Development 2019 Sep 19;146(18). Epub 2019 Sep 19.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1242/dev.181339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765179PMC
September 2019

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.

Sci Adv 2019 09 4;5(9):eaaw3095. Epub 2019 Sep 4.

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.

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http://dx.doi.org/10.1126/sciadv.aaw3095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904961PMC
September 2019

Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver.

Am J Hum Genet 2019 Jul 13;105(1):89-107. Epub 2019 Jun 13.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612522PMC
July 2019

Inferring the Molecular Mechanisms of Noncoding Alzheimer's Disease-Associated Genetic Variants.

J Alzheimers Dis 2019 ;72(1):301-318

Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.3233/JAD-190568DOI Listing
January 2019

High-throughput characterization of genetic effects on DNA-protein binding and gene transcription.

Genome Res 2018 11 25;28(11):1701-1708. Epub 2018 Sep 25.

Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan 48202, USA.

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http://dx.doi.org/10.1101/gr.237354.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211638PMC
November 2018

INFERNO: inferring the molecular mechanisms of noncoding genetic variants.

Nucleic Acids Res 2018 09;46(17):8740-8753

Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1093/nar/gky686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158604PMC
September 2018

Transposable elements generate regulatory novelty in a tissue-specific fashion.

BMC Genomics 2018 Jun 18;19(1):468. Epub 2018 Jun 18.

Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1186/s12864-018-4850-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006921PMC
June 2018

Transposable elements are the primary source of novelty in primate gene regulation.

Genome Res 2017 10 30;27(10):1623-1633. Epub 2017 Aug 30.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gr.218149.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630026PMC
October 2017

Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease.

Am J Hum Genet 2017 Jun;100(6):940-953

Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473735PMC
June 2017

Bringing PLOS Genetics Editors to Preprint Servers.

PLoS Genet 2016 12 1;12(12):e1006448. Epub 2016 Dec 1.

Department of Biology and the Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131892PMC
December 2016

Increased burden of deleterious variants in essential genes in autism spectrum disorder.

Proc Natl Acad Sci U S A 2016 12 12;113(52):15054-15059. Epub 2016 Dec 12.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1613195113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206557PMC
December 2016

Context Specific and Differential Gene Co-expression Networks via Bayesian Biclustering.

PLoS Comput Biol 2016 07 28;12(7):e1004791. Epub 2016 Jul 28.

Department of Computer Science, Center for Statistics and Machine Learning, Princeton University, Princeton, New Jersey, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965098PMC
July 2016

Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations.

Mol Biol Evol 2016 Feb 17;33(2):501-17. Epub 2015 Nov 17.

Institute for Genomics and Systems Biology, The University of Chicago Department of Human Genetics, The University of Chicago Department of Ecology and Evolution, The University of Chicago Committee on Genetics, Genomics and Systems Biology, The University of Chicago.

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http://dx.doi.org/10.1093/molbev/msv248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866538PMC
February 2016

Crystal structure of rac-3-[2,3-bis-(phenyl-sulfan-yl)-3H-indol-3-yl]propanoic acid.

Acta Crystallogr E Crystallogr Commun 2015 Nov 31;71(Pt 11):1414-7. Epub 2015 Oct 31.

Department of Chemistry, University of Minnesota, Minneapolis, MN 55455-0431, USA.

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http://dx.doi.org/10.1107/S2056989015020241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645081PMC
November 2015

Whole-Genome Resequencing of Experimental Populations Reveals Polygenic Basis of Egg-Size Variation in Drosophila melanogaster.

Mol Biol Evol 2015 Oct 3;32(10):2616-32. Epub 2015 Jun 3.

Institute for Genomics and Systems Biology, The University of Chicago Department of Ecology and Evolution, The University of Chicago Committee on Genetics, Genomics & Systems Biology, The University of Chicago

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http://dx.doi.org/10.1093/molbev/msv136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576704PMC
October 2015

Diving deeper to predict noncoding sequence function.

Nat Methods 2015 Oct;12(10):925-6

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://www.nature.com/articles/nmeth.3604
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http://dx.doi.org/10.1038/nmeth.3604DOI Listing
October 2015

The Effect of Dexamethasone Iontophoresis on Decreasing Pain and Improving Function in Patients With Musculoskeletal Conditions.

J Sport Rehabil 2015 Aug 8;24(3):327-31. Epub 2014 Sep 8.

Athletic Training Program, University of Southern Mississippi, Hattiesburg, MS.

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http://dx.doi.org/10.1123/jsr.2014-0172DOI Listing
August 2015

Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes.

Clin Cancer Res 2015 Feb 9;21(4):870-81. Epub 2014 Dec 9.

Department of Medicine, The University of Chicago, Chicago, Illinois. The University of Chicago Comprehensive Cancer Center, Chicago, Illinois. Institute for Genomics and Systems Biology, The University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2481DOI Listing
February 2015

Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1.

Nat Commun 2015 Feb 4;6:6069. Epub 2015 Feb 4.

1] Center for Genomic &Computational Biology, Duke University School of Medicine, Durham, North Carolina 27708, USA [2] Department of Biostatistics &Bioinformatics, Duke University Medical School, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/ncomms7069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318120PMC
February 2015

Autonomous actions of the human growth hormone long-range enhancer.

Nucleic Acids Res 2015 Feb 6;43(4):2091-101. Epub 2015 Feb 6.

Department of Genetics, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA 19104, USA Department of Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1093/nar/gkv093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344525PMC
February 2015

Rare occurrence of EGFRvIII deletion in head and neck squamous cell carcinoma.

Oral Oncol 2015 Jan 23;51(1):53-8. Epub 2014 Sep 23.

Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL, USA; Institute for Genomics and Systems Biology, Chicago, IL, USA; The University of Chicago Comprehensive Cancer Research Center, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2014.08.014DOI Listing
January 2015

A novel mechanism of inherited TBG deficiency: mutation in a liver-specific enhancer.

J Clin Endocrinol Metab 2015 Jan;100(1):E173-81

Departments of Medicine (A.M.F., T.P., J.F., A.P., V.T., R.E.W., A.M.D., S.R.), Pediatrics (R.E.W., S.R.), and Human Genetics (C.D.B., A.P., K.P.W., M.N.), and Committee on Genetics (S.R.), The University of Chicago, Chicago, Illinois 60637; Department of Endocrinology and Metabolic Diseases (L.C.M.), University of Duisburg-Essen, Essen 45147, Germany; and Department of Medicine (K.W.), Weill Cornell Medical College, The Methodist Hospital, Houston, Texas 77030.

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http://dx.doi.org/10.1210/jc.2014-3490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283011PMC
January 2015

Low-grade prostate cancer diverges early from high grade and metastatic disease.

Cancer Sci 2014 Aug;105(8):1079-85

Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, USA; Department of Medicine, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1111/cas.12460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317857PMC
August 2014

The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q).

Br J Haematol 2014 Aug 13;166(4):550-6. Epub 2014 Jun 13.

Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA; Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1111/bjh.12964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479678PMC
August 2014

Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels.

Am J Hum Genet 2014 Aug 31;95(2):194-208. Epub 2014 Jul 31.

Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA; Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA; Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA; Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129400PMC
August 2014

Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis.

Blood 2012 Apr 1;119(16):3724-33. Epub 2012 Mar 1.

Division of Hematology/Oncology, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1182/blood-2011-09-380634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335379PMC
April 2012

Fluorosugar chain termination agents as probes of the sequence specificity of a carbohydrate polymerase.

J Am Chem Soc 2012 Apr 10;134(15):6552-5. Epub 2012 Apr 10.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://pubs.acs.org/doi/10.1021/ja301723p
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http://dx.doi.org/10.1021/ja301723pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338147PMC
April 2012

A processive carbohydrate polymerase that mediates bifunctional catalysis using a single active site.

Biochemistry 2012 Feb 3;51(6):1148-59. Epub 2012 Feb 3.

Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706-1544, United States.

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http://dx.doi.org/10.1021/bi201820pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326345PMC
February 2012

Identification of functional elements and regulatory circuits by Drosophila modENCODE.

Science 2010 Dec 22;330(6012):1787-97. Epub 2010 Dec 22.

Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

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http://compbio.mit.edu/publications/46_modENCODE_Science_10.
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http://www.sciencemag.org/cgi/doi/10.1126/science.1198374
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http://dx.doi.org/10.1126/science.1198374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192495PMC
December 2010

A comprehensive map of insulator elements for the Drosophila genome.

PLoS Genet 2010 Jan 15;6(1):e1000814. Epub 2010 Jan 15.

Institute for Genomics and Systems Biology, Department of Human Genetics, and Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1371/journal.pgen.1000814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797089PMC
January 2010

Qualifying the relationship between sequence conservation and molecular function.

Genome Res 2008 Feb;18(2):201-5

Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://www.genome.org/cgi/doi/10.1101/gr.7205808
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http://dx.doi.org/10.1101/gr.7205808DOI Listing
February 2008

Functional architecture and evolution of transcriptional elements that drive gene coexpression.

Science 2007 Sep;317(5844):1557-60

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/science.1145893DOI Listing
September 2007

Framework for multivariate selectivity analysis, part I: theoretical and practical merits.

Appl Spectrosc 2005 Jun;59(6):787-803

InLight Solutions, 800 Bradbury SE, Albuquerque, New Mexico 87106, USA.

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http://journals.sagepub.com/doi/10.1366/0003702054280621
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http://dx.doi.org/10.1366/0003702054280621DOI Listing
June 2005

Framework for multivariate selectivity analysis, part II: experimental applications.

Appl Spectrosc 2005 Jun;59(6):804-15

InLight Solutions, Inc., 800 Bradbury SE, Albuquerque, New Mexico 87106, USA.

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http://dx.doi.org/10.1366/0003702054280739DOI Listing
June 2005

Discordance between net analyte signal theory and practical multivariate calibration.

Anal Chem 2004 Aug;76(15):4364-73

InLight Solutions, Inc., 800 Bradbury SE, Albuquerque, New Mexico 87106, USA.

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http://pubs.acs.org/doi/abs/10.1021/ac049953w
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http://dx.doi.org/10.1021/ac049953wDOI Listing
August 2004