Christopher Chen

Christopher Chen

UNVERIFIED PROFILE

Are you Christopher Chen?   Register this Author

Register author
Christopher Chen

Christopher Chen

Publications by authors named "Christopher Chen"

Are you Christopher Chen?   Register this Author

100Publications

865Reads

10Profile Views

Psychometric Properties of the National Institute of Neurological Disorders and Stroke and Canadian Stroke Network Neuropsychological Battery in an Asian Older Adult Sample.

J Am Med Dir Assoc 2020 Jun 19;21(6):879-883.e1. Epub 2020 May 19.

Department of Pharmacology, National University of Singapore; The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; School of Public Health, Zhejiang University. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jamda.2020.03.022DOI Listing
June 2020

Pulsed SILAM Reveals In Vivo Dynamics of Murine Brain Protein Translation.

ACS Omega 2020 Jun 20;5(23):13528-13540. Epub 2020 May 20.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551 Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.9b04439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301365PMC
June 2020

The Impact of Strategic White Matter Hyperintensity Lesion Location on Language.

Am J Geriatr Psychiatry 2020 Jun 17. Epub 2020 Jun 17.

Memory Aging and Cognition Center, National University Health System (SH, EC, CC), Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore (SH, CC), Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jagp.2020.06.009DOI Listing
June 2020

Overcoming Resistance to Targeted Therapies in Gastrointestinal Cancers: Progress to Date and Progress to Come.

Am Soc Clin Oncol Educ Book 2020 May;40:161-173

Massachusetts General Hospital Cancer Center, Boston, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/EDBK_280871DOI Listing
May 2020

A Bile Duct-on-a-Chip With Organ-Level Functions.

Hepatology 2020 Apr 28;71(4):1350-1363. Epub 2019 Oct 28.

Division of Gastroenterology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30918
Publisher Site
http://dx.doi.org/10.1002/hep.30918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048662PMC
April 2020

Molecular Signatures of Beneficial Class Effects of Statins on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Circulation 2020 Apr 6;141(14):1208-1210. Epub 2020 Apr 6.

Stanford Cardiovascular Institute (L.T., A.O., C.L., T.K., C.L.C., S.-G.O., M.S., I.K., N.S., J.C.W.), Stanford University School of Medicine, CA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170011PMC
April 2020

Recovery of Tractions Exerted by Singe Cells in 3D Nonlinear Matrices.

J Biomech Eng 2020 Apr 22. Epub 2020 Apr 22.

Department of Aerospace and Mechanical, Engineering, University of Southern California, Los Angeles, California 90089.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1115/1.4046974DOI Listing
April 2020

The impact of depression on surgical outcome in Chiari malformation type I: an assessment based on the Chicago Chiari Outcome Scale.

J Neurosurg Spine 2020 Apr 24:1-8. Epub 2020 Apr 24.

1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2020.2.SPINE2069DOI Listing
April 2020

Frequency and Clinical Impact of Serious Adverse Events on Post-Stroke Recovery with NeuroAiD (MLC601) versus Placebo: The CHInese Medicine Neuroaid Efficacy on Stroke Recovery Study.

Cerebrovasc Dis 2020 3;49(2):192-199. Epub 2020 Mar 3.

Department of Pharmacology, National University of Singapore, Clinical Research Centre, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000506070DOI Listing
March 2020

Seymour Fractures: A Retrospective Review of Infection Rates, Treatment and Timing of Antibiotic Administration.

Pediatr Emerg Care 2020 Mar 6. Epub 2020 Mar 6.

From the Department of Orthopedics, School of Medicine, University of Colorado, Aurora, CO.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PEC.0000000000002009DOI Listing
March 2020

Securing the Safety Net and Protecting Public Health During a Pandemic: Medicaid's Response to COVID-19.

JAMA 2020 Mar 19. Epub 2020 Mar 19.

Massachusetts Medicaid MassHealth, Boston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2020.4272DOI Listing
March 2020

Voltage Imaging of Cardiac Cells and Tissue Using the Genetically Encoded Voltage Sensor Archon1.

iScience 2020 Mar 11;23(4):100974. Epub 2020 Mar 11.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2020.100974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160579PMC
March 2020

Therapeutic Targeting of MDR1 Expression by RORγ Antagonists Resensitizes Cross-Resistant CRPC to Taxane via Coordinated Induction of Cell Death Programs.

Mol Cancer Ther 2020 02 11;19(2):364-374. Epub 2019 Nov 11.

Department of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-19-0327DOI Listing
February 2020

HIF1α Regulates Early Metabolic Changes due to Activation of Innate Immunity in Nuclear Reprogramming.

Stem Cell Reports 2020 02 11;14(2):192-200. Epub 2020 Feb 11.

Stanford Cardiovascular Institute, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305-5454, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2020.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013248PMC
February 2020

Cortical cerebral microinfarcts predict cognitive decline in memory clinic patients.

J Cereb Blood Flow Metab 2020 Jan 19;40(1):44-53. Epub 2019 Mar 19.

Department of Pharmacology, National University of Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0271678X19835565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928564PMC
January 2020

From Simple to Architecturally Complex Hydrogel Scaffolds for Cell and Tissue Engineering Applications: Opportunities Presented by Two-Photon Polymerization.

Adv Healthc Mater 2020 01 20;9(1):e1901217. Epub 2019 Nov 20.

Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.201901217DOI Listing
January 2020

Targeting bromodomain protein ANCCA/ATAD2 enhances the efficacy of DNA‑damaging chemotherapy agents and radiation.

Oncol Rep 2020 Jan 27;43(1):318-327. Epub 2019 Nov 27.

Department of Biochemistry and Molecular Medicine, University of California, Davis, Sacramento, CA 95817, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.2019.7418DOI Listing
January 2020

The prevalence and clinical associations of disproportionately enlarged subarachnoid space hydrocephalus (DESH), an imaging feature of idiopathic normal pressure hydrocephalus in community and memory clinic based Singaporean cohorts.

J Neurol Sci 2020 Jan 25;408:116510. Epub 2019 Oct 25.

Memory Ageing and Cognition Centre, National University Health System, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2019.116510DOI Listing
January 2020

Neuropsychiatric Correlates of Small Vessel Disease Progression in Incident Cognitive Decline: Independent and Interactive Effects.

J Alzheimers Dis 2020 ;73(3):1053-1062

Department of Pharmacology, National University of Singapore, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-190999DOI Listing
January 2020

MRI Markers of Mixed Pathology and Cognitive Impairment in Multiethnic Asians.

J Alzheimers Dis 2020 ;73(4):1501-1509

Department of Pharmacology, National University of Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-190866DOI Listing
January 2020

Cerebral microinfarcts affect brain structural network topology in cognitively impaired patients.

J Cereb Blood Flow Metab 2020 Jan 27:271678X20902187. Epub 2020 Jan 27.

Centre for Cognitive Neuroscience, Neuroscience and Behavioural Disorders Program, Duke-National University of Singapore Medical School, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0271678X20902187DOI Listing
January 2020

Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.

J Clin Invest 2019 12;129(12):5278-5293

USC Research Center for Liver Disease, Keck School of Medicine, University of Southern California (USC), Los Angeles, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI128289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877311PMC
December 2019

Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups.

Neurology 2019 12 11;93(24):e2257-e2271. Epub 2019 Nov 11.

From the Centre for Healthy Brain Ageing (J.W.L., J.D.C., R.J.C., H.B., D.M.L., N.A.K., P.S.S.), University of New South Wales, Sydney, Australia; Department of Neurology and Laboratory of Functional Neurosciences (O.G., M.B., M.R.), University Hospital of Amiens, France; Clinical Neurosciences (H.J., S.M., T.E.), Neurology, University of Helsinki and Helsinki University Hospital, Finland; Department of Internal Medicine (S.M.), Gerontology and Geriatrics Section, and Department of Cardiology (J.W.J.), Leiden University Medical Center, the Netherlands; Department of Neurology (S.M., B.S.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Department of Neurology (H.-J.B.), Seoul National University School of Medicine, Seoul National University Bundang Hospital, Seongnam; Department of Neurology (J.-S.L., B.-C.L.), Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; Department of Psychiatry and Neuropsychology (S.K., E.D.), School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University; Department of Neurology (J.S.), Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, the Netherlands; Memory Aging and Cognition Centre (C.C., X.X., E.J.C.), Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore; Centre for Population Health Sciences (X.X.), Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Neuroscience and Ageing Research Unit (R.O.A., A.O.), Institute for Advanced Medical Research and Training, and Department of Medicine (R.O.A.), College of Medicine, University of Ibadan, Nigeria; Institute of Neuroscience (R.N.K.), Newcastle University, Newcastle Upon Tyne, UK; Peninsula Clinical School (V.K.S., C.M.), Central Clinical School, Monash University; Department of Aged Care (C.M.), Alfred Health, Melbourne, Australia; National Neuroscience Institute (N.K., R.J.C.); Duke-NUS Medical School (N.K.), Singapore; Dementia Collaborative Research Centre (H.B., P.S.S.), University of New South Wales, Sydney, Australia; and University of Lille (R.B., S.B., H.H.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000008612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937495PMC
December 2019

Hearing handicap in Asian patients with dementia.

Am J Otolaryngol 2020 Mar - Apr;41(2):102377. Epub 2019 Dec 12.

Department of Otolaryngology, Head and Neck Surgery, National University Hospital, Singapore; Department of Otolaryngology, Head and Neck Surgery, National University Singapore, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjoto.2019.102377DOI Listing
December 2019

Sarco/endoplasmic reticulum Ca-ATPase is a more effective calcium remover than sodium-calcium exchanger in human embryonic stem cell-derived cardiomyocytes.

Am J Physiol Heart Circ Physiol 2019 11 26;317(5):H1105-H1115. Epub 2019 Jul 26.

Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Pokfulam, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00540.2018DOI Listing
November 2019

Genetic architecture of subcortical brain structures in 38,851 individuals.

Authors:
Claudia L Satizabal Hieab H H Adams Derrek P Hibar Charles C White Maria J Knol Jason L Stein Markus Scholz Muralidharan Sargurupremraj Neda Jahanshad Gennady V Roshchupkin Albert V Smith Joshua C Bis Xueqiu Jian Michelle Luciano Edith Hofer Alexander Teumer Sven J van der Lee Jingyun Yang Lisa R Yanek Tom V Lee Shuo Li Yanhui Hu Jia Yu Koh John D Eicher Sylvane Desrivières Alejandro Arias-Vasquez Ganesh Chauhan Lavinia Athanasiu Miguel E Rentería Sungeun Kim David Hoehn Nicola J Armstrong Qiang Chen Avram J Holmes Anouk den Braber Iwona Kloszewska Micael Andersson Thomas Espeseth Oliver Grimm Lucija Abramovic Saud Alhusaini Yuri Milaneschi Martina Papmeyer Tomas Axelsson Stefan Ehrlich Roberto Roiz-Santiañez Bernd Kraemer Asta K Håberg Hannah J Jones G Bruce Pike Dan J Stein Allison Stevens Janita Bralten Meike W Vernooij Tamara B Harris Irina Filippi A Veronica Witte Tulio Guadalupe Katharina Wittfeld Thomas H Mosley James T Becker Nhat Trung Doan Saskia P Hagenaars Yasaman Saba Gabriel Cuellar-Partida Najaf Amin Saima Hilal Kwangsik Nho Nazanin Mirza-Schreiber Konstantinos Arfanakis Diane M Becker David Ames Aaron L Goldman Phil H Lee Dorret I Boomsma Simon Lovestone Sudheer Giddaluru Stephanie Le Hellard Manuel Mattheisen Marc M Bohlken Dalia Kasperaviciute Lianne Schmaal Stephen M Lawrie Ingrid Agartz Esther Walton Diana Tordesillas-Gutierrez Gareth E Davies Jean Shin Jonathan C Ipser Louis N Vinke Martine Hoogman Tianye Jia Ralph Burkhardt Marieke Klein Fabrice Crivello Deborah Janowitz Owen Carmichael Unn K Haukvik Benjamin S Aribisala Helena Schmidt Lachlan T Strike Ching-Yu Cheng Shannon L Risacher Benno Pütz Debra A Fleischman Amelia A Assareh Venkata S Mattay Randy L Buckner Patrizia Mecocci Anders M Dale Sven Cichon Marco P Boks Mar Matarin Brenda W J H Penninx Vince D Calhoun M Mallar Chakravarty Andre F Marquand Christine Macare Shahrzad Kharabian Masouleh Jaap Oosterlaan Philippe Amouyel Katrin Hegenscheid Jerome I Rotter Andrew J Schork David C M Liewald Greig I de Zubicaray Tien Yin Wong Li Shen Philipp G Sämann Henry Brodaty Joshua L Roffman Eco J C de Geus Magda Tsolaki Susanne Erk Kristel R van Eijk Gianpiero L Cavalleri Nic J A van der Wee Andrew M McIntosh Randy L Gollub Kazima B Bulayeva Manon Bernard Jennifer S Richards Jayandra J Himali Markus Loeffler Nanda Rommelse Wolfgang Hoffmann Lars T Westlye Maria C Valdés Hernández Narelle K Hansell Theo G M van Erp Christiane Wolf John B J Kwok Bruno Vellas Andreas Heinz Loes M Olde Loohuis Norman Delanty Beng-Choon Ho Christopher R K Ching Elena Shumskaya Baljeet Singh Albert Hofman Dennis van der Meer Georg Homuth Bruce M Psaty Mark E Bastin Grant W Montgomery Tatiana M Foroud Simone Reppermund Jouke-Jan Hottenga Andrew Simmons Andreas Meyer-Lindenberg Wiepke Cahn Christopher D Whelan Marjolein M J van Donkelaar Qiong Yang Norbert Hosten Robert C Green Anbupalam Thalamuthu Sebastian Mohnke Hilleke E Hulshoff Pol Honghuang Lin Clifford R Jack Peter R Schofield Thomas W Mühleisen Pauline Maillard Steven G Potkin Wei Wen Evan Fletcher Arthur W Toga Oliver Gruber Matthew Huentelman George Davey Smith Lenore J Launer Lars Nyberg Erik G Jönsson Benedicto Crespo-Facorro Nastassja Koen Douglas N Greve André G Uitterlinden Daniel R Weinberger Vidar M Steen Iryna O Fedko Nynke A Groenewold Wiro J Niessen Roberto Toro Christophe Tzourio William T Longstreth M Kamran Ikram Jordan W Smoller Marie-Jose van Tol Jessika E Sussmann Tomas Paus Hervé Lemaître Matthias L Schroeter Bernard Mazoyer Ole A Andreassen Florian Holsboer Chantal Depondt Dick J Veltman Jessica A Turner Zdenka Pausova Gunter Schumann Daan van Rooij Srdjan Djurovic Ian J Deary Katie L McMahon Bertram Müller-Myhsok Rachel M Brouwer Hilkka Soininen Massimo Pandolfo Thomas H Wassink Joshua W Cheung Thomas Wolfers Jean-Luc Martinot Marcel P Zwiers Matthias Nauck Ingrid Melle Nicholas G Martin Ryota Kanai Eric Westman René S Kahn Sanjay M Sisodiya Tonya White Arvin Saremi Hans van Bokhoven Han G Brunner Henry Völzke Margaret J Wright Dennis van 't Ent Markus M Nöthen Roel A Ophoff Jan K Buitelaar Guillén Fernández Perminder S Sachdev Marcella Rietschel Neeltje E M van Haren Simon E Fisher Alexa S Beiser Clyde Francks Andrew J Saykin Karen A Mather Nina Romanczuk-Seiferth Catharina A Hartman Anita L DeStefano Dirk J Heslenfeld Michael W Weiner Henrik Walter Pieter J Hoekstra Paul A Nyquist Barbara Franke David A Bennett Hans J Grabe Andrew D Johnson Christopher Chen Cornelia M van Duijn Oscar L Lopez Myriam Fornage Joanna M Wardlaw Reinhold Schmidt Charles DeCarli Philip L De Jager Arno Villringer Stéphanie Debette Vilmundur Gudnason Sarah E Medland Joshua M Shulman Paul M Thompson Sudha Seshadri M Arfan Ikram

Nat Genet 2019 11 21;51(11):1624-1636. Epub 2019 Oct 21.

Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-019-0511-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055269PMC
November 2019

Carcinoid Heart Disease: a Comprehensive Review.

Curr Cardiol Rep 2019 11 19;21(11):140. Epub 2019 Nov 19.

Department of Cardiology, Division of Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11886-019-1207-8DOI Listing
November 2019

Mixed-location cerebral microbleeds as a biomarker of neurodegeneration in a memory clinic population.

Aging (Albany NY) 2019 11 25;11(22):10581-10596. Epub 2019 Nov 25.

Memory Aging and Cognition Centre, National University Health System, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.102478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914397PMC
November 2019

Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion.

Brain Res 2019 10 12;1720:146294. Epub 2019 Jun 12.

Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8397, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainres.2019.06.013DOI Listing
October 2019

Brain-derived and circulating vesicle profiles indicate neurovascular unit dysfunction in early Alzheimer's disease.

Brain Pathol 2019 09 31;29(5):593-605. Epub 2019 Jan 31.

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bpa.12699DOI Listing
September 2019

Mechanisms Linking White Matter Lesions, Tract Integrity, and Depression in Alzheimer Disease.

Am J Geriatr Psychiatry 2019 09 18;27(9):948-959. Epub 2019 Apr 18.

Department of Neurology (CY, DL, KPN, RC, DN, NK), National Neuroscience Institute, Singapore, Singapore; Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program (FJ, HYS, JZ, NK), Duke-NUS Medical School, Singapore. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10647481193033
Publisher Site
http://dx.doi.org/10.1016/j.jagp.2019.04.004DOI Listing
September 2019

Open Reconstructive Strategies for Chronic Achilles Tendon Ruptures.

Foot Ankle Clin 2019 Sep 18;24(3):425-437. Epub 2019 Jun 18.

Department of Orthopedic Surgery, University of Colorado School of Medicine, 12631 East 17th Avenue, B202, Aurora, CO 80045, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fcl.2019.04.002DOI Listing
September 2019

Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion.

J Cereb Blood Flow Metab 2019 Sep 26:271678X19877403. Epub 2019 Sep 26.

Memory Aging and Cognition Centre, Department of Pharmacology, National University of Singapore, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0271678X19877403DOI Listing
September 2019

Additive effect of cerebral atrophy on cognition in dementia-free elderly with cerebrovascular disease.

Stroke Vasc Neurol 2019 Sep 20;4(3):135-140. Epub 2019 Jun 20.

Clinical Research Centre, Department of Pharmacology, National University Health System, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/svn-2018-000202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812662PMC
September 2019

Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice.

Brain Behav Immun 2019 08 11;80:344-357. Epub 2019 Apr 11.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea; Neurobiology Programme, Life Sciences Institute, National University of Singapore, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbi.2019.04.011DOI Listing
August 2019

Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved.

Ageing Res Rev 2019 08 19;53:100909. Epub 2019 May 19.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.100909DOI Listing
August 2019

Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A.

Cell Stem Cell 2019 08;25(2):273-289.e5

Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2019.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785828PMC
August 2019

Souvenaid in the management of mild cognitive impairment: an expert consensus opinion.

Alzheimers Res Ther 2019 08 17;11(1):73. Epub 2019 Aug 17.

Department of Medicine, The University of Hong Kong and Hong Kong Brain Memory Centre, Hong Kong Special Administrative Region, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13195-019-0528-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698334PMC
August 2019

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling.

Sci Adv 2019 08 28;5(8):eaav6789. Epub 2019 Aug 28.

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.aav6789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713506PMC
August 2019

Osteochondral Allograft Transplantation Surgery for Osteochondral Lesions of the Talus in Athletes.

J Foot Ankle Surg 2019 Jul 20;58(4):623-627. Epub 2019 Apr 20.

Associate Professor of Surgery, Department of Orthopaedic Surgery, Tripler Army Medical Center, Honolulu, HI. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.jfas.2018.11.020DOI Listing
July 2019

Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

Authors:
Duncan Wilson Gareth Ambler Keon-Joo Lee Jae-Sung Lim Masayuki Shiozawa Masatoshi Koga Linxin Li Caroline Lovelock Hugues Chabriat Michael Hennerici Yuen Kwun Wong Henry Ka Fung Mak Luis Prats-Sánchez Alejandro Martínez-Domeño Shigeru Inamura Kazuhisa Yoshifuji Ethem Murat Arsava Solveig Horstmann Jan Purrucker Bonnie Yin Ka Lam Adrian Wong Young Dae Kim Tae-Jin Song Maarten Schrooten Robin Lemmens Sebastian Eppinger Thomas Gattringer Ender Uysal Zeynep Tanriverdi Natan M Bornstein Einor Ben Assayag Hen Hallevi Jun Tanaka Hideo Hara Shelagh B Coutts Lisa Hert Alexandros Polymeris David J Seiffge Philippe Lyrer Ale Algra Jaap Kappelle Rustam Al-Shahi Salman Hans R Jäger Gregory Y H Lip Heinrich P Mattle Leonidas D Panos Jean-Louis Mas Laurence Legrand Christopher Karayiannis Thanh Phan Sarah Gunkel Nicolas Christ Jill Abrigo Thomas Leung Winnie Chu Francesca Chappell Stephen Makin Derek Hayden David J Williams M Eline Kooi Dianne H K van Dam-Nolen Carmen Barbato Simone Browning Kim Wiegertjes Anil M Tuladhar Noortje Maaijwee Christine Guevarra Chathuri Yatawara Anne-Marie Mendyk Christine Delmaire Sebastian Köhler Robert van Oostenbrugge Ying Zhou Chao Xu Saima Hilal Bibek Gyanwali Christopher Chen Min Lou Julie Staals Régis Bordet Nagaendran Kandiah Frank-Erik de Leeuw Robert Simister Aad van der Lugt Peter J Kelly Joanna M Wardlaw Yannie Soo Felix Fluri Velandai Srikanth David Calvet Simon Jung Vincent I H Kwa Stefan T Engelter Nils Peters Eric E Smith Yusuke Yakushiji Dilek Necioglu Orken Franz Fazekas Vincent Thijs Ji Hoe Heo Vincent Mok Roland Veltkamp Hakan Ay Toshio Imaizumi Beatriz Gomez-Anson Kui Kai Lau Eric Jouvent Peter M Rothwell Kazunori Toyoda Hee-Joon Bae Joan Marti-Fabregas David J Werring

Lancet Neurol 2019 07 23;18(7):653-665. Epub 2019 May 23.

Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14744422193019
Publisher Site
http://dx.doi.org/10.1016/S1474-4422(19)30197-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562236PMC
July 2019

and cortical superficial siderosis in CAA: Meta-analysis and potential mechanisms.

Neurology 2019 07 26;93(4):e358-e371. Epub 2019 Jun 26.

From the Hemorrhagic Stroke Research Program, Department of Neurology (A.C., M.P., A.B., M.E.G., J.N.G., J.R., S.M.G., A.V.), Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston; Alzheimer Center and the Neuroscience Campus Amsterdam and Departments of Radiology and Nuclear Medicine (H.I.Z., F.B.), VU University Medical Center, the Netherlands; Karolinska Institutet (S.S., L.-O.W.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (K.K., J.R.C.), Mayo Clinic, Rochester, MN; Department of Medicine (Neurology) (A.S.), McMaster University and Population Health Research Institute, Hamilton, Canada; Memory, Aging and Cognition Center (S.H., Y.L.C., J.R.C., C.C.), National University Health System, Singapore; Department of Pharmacology (S.H., Y.L.C., J.R.C., C.C.), National University of Singapore; Department of Nuclear Medicine and Centre for PET (P.A.Y.), The University of Melbourne, Parkville, Australia; Department of Neuroradiology (G.B.), Université Paris-Descartes, INSERM U894, CH Sainte-Anne, Paris, France; Department of Neurology and Neuroscience Center (H.K.N., D.L.N., S.W.S.), Samsung Medical Center, Seoul, Republic of Korea; UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK; and Center for Genomic Medicine (J.R.) and Division of Neurocritical Care and Emergency Neurology (J.R.), Massachusetts General Hospital, Harvard Medical School, Boston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669935PMC
July 2019

MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools.

Metabolites 2019 Jul 16;9(7). Epub 2019 Jul 16.

Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/metabo9070144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680503PMC
July 2019

Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting.

Mol Biol Cell 2019 07 18;30(16):1974-1984. Epub 2019 Jul 18.

Biological Design Center, Department of Biomedical Engineering, Boston University, Boston, MA 02215.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E19-02-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727772PMC
July 2019

The Informant AD8 Can Discriminate Patients with Dementia From Healthy Control Participants in an Asian Older Cohort.

J Am Med Dir Assoc 2019 06 17;20(6):775-779. Epub 2019 Jan 17.

Memory Ageing and Cognition Centre, National University Health System, Singapore; Department of Pharmacology, National University of Singapore, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jamda.2018.11.023DOI Listing
June 2019

Microfabricated blood vessels for modeling the vascular transport barrier.

Nat Protoc 2019 05 5;14(5):1425-1454. Epub 2019 Apr 5.

The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41596-019-0144-8
Publisher Site
http://dx.doi.org/10.1038/s41596-019-0144-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046311PMC
May 2019

SarcTrack.

Circ Res 2019 04;124(8):1172-1183

From the Department of Genetics (C.N.T., A.S., A.C.G., M.N., J.A.L.W., R.A., M.S., J.R., O.P., J.G.S., C.E.S.), Harvard Medical School, Boston, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.118.314505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485312PMC
April 2019

The Clinical Utility of the TYM and RBANS in a One-Stop Memory Clinic in Singapore: A Pilot Study.

J Geriatr Psychiatry Neurol 2019 03 10;32(2):68-73. Epub 2019 Jan 10.

Department of Psychology, Faculty of Arts and Social Sciences, National University of Singapore, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0891988718824034DOI Listing
March 2019

Does reducing blood pressure and cholesterol provide any HOPE for preventing cognitive decline and dementia?

Neurology 2019 03 27;92(13):593-594. Epub 2019 Feb 27.

From the Memory Aging & Cognition Centre (C.C.), Departments of Pharmacology and Psychological Medicine, National University Health System, Singapore; The George Institute for Global Health (C.S.A.), Faculty of Medicine, University of New South Wales, Sydney, Australia; and The George Institute for Global Health China at Peking University Health Sciences Center (C.S.A.), Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007175DOI Listing
March 2019

Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition.

Nat Commun 2019 03 8;10(1):1144. Epub 2019 Mar 8.

Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore, 117583, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-09030-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408581PMC
March 2019

Potential retinal biomarkers for dementia: what is new?

Curr Opin Neurol 2019 02;32(1):82-91

Singapore Eye Research Institute, Singapore National Eye Centre.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WCO.0000000000000645DOI Listing
February 2019

Studies of 3D directed cell migration enabled by direct laser writing of curved wave topography.

Biofabrication 2019 02 25;11(2):021001. Epub 2019 Feb 25.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1758-5090/ab047fDOI Listing
February 2019

In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films.

J Vis Exp 2019 02 26(144). Epub 2019 Feb 26.

Harvard Medical School;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/58728DOI Listing
February 2019

Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease.

J Neurol Sci 2019 01 31;396:94-101. Epub 2018 Oct 31.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2018.10.025DOI Listing
January 2019

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimers Dement 2019 01;15(1):158-167

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2018.07.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338083PMC
January 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:
Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905PMC
January 2019

Cerebellar modulation of the reward circuitry and social behavior.

Science 2019 01;363(6424)

Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY 10461, USA.

View Article

Download full-text PDF

Source
http://www.sciencemag.org/lookup/doi/10.1126/science.aav0581
Publisher Site
http://dx.doi.org/10.1126/science.aav0581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711161PMC
January 2019

Prevalence and Risk Factors for Cognitive Impairment and Dementia in Indians: A Multiethnic Perspective from a Singaporean Study.

J Alzheimers Dis 2019 ;71(1):341-351

Memory Ageing and Cognition Center (MACC), National University Health System, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-190610DOI Listing
January 2019

Mixed-Location Cerebral Microbleeds: An Imaging Biomarker for Cerebrovascular Pathology in Cognitive Impairment and Dementia in a Memory Clinic Population.

J Alzheimers Dis 2019 ;71(4):1309-1320

Memory Aging & Cognition Centre, National University Health System, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-190540DOI Listing
January 2019

Traditional Chinese herbal medicine for vascular dementia.

Cochrane Database Syst Rev 2018 Dec 6;12:CD010284. Epub 2018 Dec 6.

Cochrane Singapore, Singapore Clinical Research Institute, Nanos Building #02-01, 31 Biopolis Way, Singapore, Singapore, 138669.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD010284.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516869PMC
December 2018

Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration.

APL Bioeng 2018 Dec 26;2(4):046107. Epub 2018 Dec 26.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1063/1.5052239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481732PMC
December 2018

Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells.

Neuron 2018 11 4;100(3):564-578.e3. Epub 2018 Oct 4.

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08966273183082
Publisher Site
http://dx.doi.org/10.1016/j.neuron.2018.09.018DOI Listing
November 2018