Christopher Chen

Christopher Chen

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Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion.

Brain Res 2019 Oct 12;1720:146294. Epub 2019 Jun 12.

Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8397, Japan.

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http://dx.doi.org/10.1016/j.brainres.2019.06.013DOI Listing
October 2019

Brain-derived and circulating vesicle profiles indicate neurovascular unit dysfunction in early Alzheimer's disease.

Brain Pathol 2019 Sep 31;29(5):593-605. Epub 2019 Jan 31.

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

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http://dx.doi.org/10.1111/bpa.12699DOI Listing
September 2019

Mechanisms Linking White Matter Lesions, Tract Integrity, and Depression in Alzheimer Disease.

Am J Geriatr Psychiatry 2019 Sep 18;27(9):948-959. Epub 2019 Apr 18.

Department of Neurology (CY, DL, KPN, RC, DN, NK), National Neuroscience Institute, Singapore, Singapore; Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program (FJ, HYS, JZ, NK), Duke-NUS Medical School, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10647481193033
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http://dx.doi.org/10.1016/j.jagp.2019.04.004DOI Listing
September 2019

Open Reconstructive Strategies for Chronic Achilles Tendon Ruptures.

Foot Ankle Clin 2019 Sep 18;24(3):425-437. Epub 2019 Jun 18.

Department of Orthopedic Surgery, University of Colorado School of Medicine, 12631 East 17th Avenue, B202, Aurora, CO 80045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.fcl.2019.04.002DOI Listing
September 2019

Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice.

Brain Behav Immun 2019 Aug 11;80:344-357. Epub 2019 Apr 11.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea; Neurobiology Programme, Life Sciences Institute, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2019.04.011DOI Listing
August 2019

Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved.

Ageing Res Rev 2019 Aug 19;53:100909. Epub 2019 May 19.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2019.100909DOI Listing
August 2019

Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A.

Cell Stem Cell 2019 Aug;25(2):273-289.e5

Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.07.007DOI Listing
August 2019

Souvenaid in the management of mild cognitive impairment: an expert consensus opinion.

Alzheimers Res Ther 2019 Aug 17;11(1):73. Epub 2019 Aug 17.

Department of Medicine, The University of Hong Kong and Hong Kong Brain Memory Centre, Hong Kong Special Administrative Region, China.

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http://dx.doi.org/10.1186/s13195-019-0528-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698334PMC
August 2019

Osteochondral Allograft Transplantation Surgery for Osteochondral Lesions of the Talus in Athletes.

J Foot Ankle Surg 2019 Jul 20;58(4):623-627. Epub 2019 Apr 20.

Associate Professor of Surgery, Department of Orthopaedic Surgery, Tripler Army Medical Center, Honolulu, HI. Electronic address:

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http://dx.doi.org/10.1053/j.jfas.2018.11.020DOI Listing
July 2019

Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

Authors:
Duncan Wilson Gareth Ambler Keon-Joo Lee Jae-Sung Lim Masayuki Shiozawa Masatoshi Koga Linxin Li Caroline Lovelock Hugues Chabriat Michael Hennerici Yuen Kwun Wong Henry Ka Fung Mak Luis Prats-Sánchez Alejandro Martínez-Domeño Shigeru Inamura Kazuhisa Yoshifuji Ethem Murat Arsava Solveig Horstmann Jan Purrucker Bonnie Yin Ka Lam Adrian Wong Young Dae Kim Tae-Jin Song Maarten Schrooten Robin Lemmens Sebastian Eppinger Thomas Gattringer Ender Uysal Zeynep Tanriverdi Natan M Bornstein Einor Ben Assayag Hen Hallevi Jun Tanaka Hideo Hara Shelagh B Coutts Lisa Hert Alexandros Polymeris David J Seiffge Philippe Lyrer Ale Algra Jaap Kappelle Rustam Al-Shahi Salman Hans R Jäger Gregory Y H Lip Heinrich P Mattle Leonidas D Panos Jean-Louis Mas Laurence Legrand Christopher Karayiannis Thanh Phan Sarah Gunkel Nicolas Christ Jill Abrigo Thomas Leung Winnie Chu Francesca Chappell Stephen Makin Derek Hayden David J Williams M Eline Kooi Dianne H K van Dam-Nolen Carmen Barbato Simone Browning Kim Wiegertjes Anil M Tuladhar Noortje Maaijwee Christine Guevarra Chathuri Yatawara Anne-Marie Mendyk Christine Delmaire Sebastian Köhler Robert van Oostenbrugge Ying Zhou Chao Xu Saima Hilal Bibek Gyanwali Christopher Chen Min Lou Julie Staals Régis Bordet Nagaendran Kandiah Frank-Erik de Leeuw Robert Simister Aad van der Lugt Peter J Kelly Joanna M Wardlaw Yannie Soo Felix Fluri Velandai Srikanth David Calvet Simon Jung Vincent I H Kwa Stefan T Engelter Nils Peters Eric E Smith Yusuke Yakushiji Dilek Necioglu Orken Franz Fazekas Vincent Thijs Ji Hoe Heo Vincent Mok Roland Veltkamp Hakan Ay Toshio Imaizumi Beatriz Gomez-Anson Kui Kai Lau Eric Jouvent Peter M Rothwell Kazunori Toyoda Hee-Joon Bae Joan Marti-Fabregas David J Werring

Lancet Neurol 2019 Jul 23;18(7):653-665. Epub 2019 May 23.

Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(19)30197-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562236PMC
July 2019

and cortical superficial siderosis in CAA: Meta-analysis and potential mechanisms.

Neurology 2019 Jul 26;93(4):e358-e371. Epub 2019 Jun 26.

From the Hemorrhagic Stroke Research Program, Department of Neurology (A.C., M.P., A.B., M.E.G., J.N.G., J.R., S.M.G., A.V.), Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston; Alzheimer Center and the Neuroscience Campus Amsterdam and Departments of Radiology and Nuclear Medicine (H.I.Z., F.B.), VU University Medical Center, the Netherlands; Karolinska Institutet (S.S., L.-O.W.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (K.K., J.R.C.), Mayo Clinic, Rochester, MN; Department of Medicine (Neurology) (A.S.), McMaster University and Population Health Research Institute, Hamilton, Canada; Memory, Aging and Cognition Center (S.H., Y.L.C., J.R.C., C.C.), National University Health System, Singapore; Department of Pharmacology (S.H., Y.L.C., J.R.C., C.C.), National University of Singapore; Department of Nuclear Medicine and Centre for PET (P.A.Y.), The University of Melbourne, Parkville, Australia; Department of Neuroradiology (G.B.), Université Paris-Descartes, INSERM U894, CH Sainte-Anne, Paris, France; Department of Neurology and Neuroscience Center (H.K.N., D.L.N., S.W.S.), Samsung Medical Center, Seoul, Republic of Korea; UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK; and Center for Genomic Medicine (J.R.) and Division of Neurocritical Care and Emergency Neurology (J.R.), Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000007818DOI Listing
July 2019

MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools.

Metabolites 2019 Jul 16;9(7). Epub 2019 Jul 16.

Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.3390/metabo9070144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680503PMC
July 2019

Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting.

Mol Biol Cell 2019 Jul 18;30(16):1974-1984. Epub 2019 Jul 18.

Biological Design Center, Department of Biomedical Engineering, Boston University, Boston, MA 02215.

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http://dx.doi.org/10.1091/mbc.E19-02-0076DOI Listing
July 2019

Sarco/Endoplasmic Reticulum Ca-ATPase is a more effective calcium remover than Sodium-Calcium Exchanger in human embryonic stem cell-derived cardiomyocytes.

Am J Physiol Heart Circ Physiol 2019 Jul 26. Epub 2019 Jul 26.

Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong.

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http://dx.doi.org/10.1152/ajpheart.00540.2018DOI Listing
July 2019

Prevalence and Risk Factors for Cognitive Impairment and Dementia in Indians: A Multiethnic Perspective from a Singaporean Study.

J Alzheimers Dis 2019 Jul 27. Epub 2019 Jul 27.

Memory Ageing and Cognition Center (MACC), National University Health System, Singapore.

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http://dx.doi.org/10.3233/JAD-190610DOI Listing
July 2019

The Informant AD8 Can Discriminate Patients with Dementia From Healthy Control Participants in an Asian Older Cohort.

J Am Med Dir Assoc 2019 Jun 17;20(6):775-779. Epub 2019 Jan 17.

Memory Ageing and Cognition Centre, National University Health System, Singapore; Department of Pharmacology, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jamda.2018.11.023DOI Listing
June 2019

Microfabricated blood vessels for modeling the vascular transport barrier.

Nat Protoc 2019 05 5;14(5):1425-1454. Epub 2019 Apr 5.

The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.

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http://www.nature.com/articles/s41596-019-0144-8
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http://dx.doi.org/10.1038/s41596-019-0144-8DOI Listing
May 2019

Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis.

Ophthalmology 2019 Apr 13;126(4):497-510. Epub 2018 Aug 13.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424641PMC
April 2019

SarcTrack.

Circ Res 2019 Apr;124(8):1172-1183

From the Department of Genetics (C.N.T., A.S., A.C.G., M.N., J.A.L.W., R.A., M.S., J.R., O.P., J.G.S., C.E.S.), Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485312PMC
April 2019

Medication compliance in Singaporean patients with Alzheimer's disease.

Singapore Med J 2019 Mar 22;60(3):154-160. Epub 2018 Jun 22.

Department of Pharmacology, National University of Singapore, Singapore.

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http://dx.doi.org/10.11622/smedj.2018076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441685PMC
March 2019

Does reducing blood pressure and cholesterol provide any HOPE for preventing cognitive decline and dementia?

Neurology 2019 Mar 27;92(13):593-594. Epub 2019 Feb 27.

From the Memory Aging & Cognition Centre (C.C.), Departments of Pharmacology and Psychological Medicine, National University Health System, Singapore; The George Institute for Global Health (C.S.A.), Faculty of Medicine, University of New South Wales, Sydney, Australia; and The George Institute for Global Health China at Peking University Health Sciences Center (C.S.A.), Beijing, China.

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http://dx.doi.org/10.1212/WNL.0000000000007175DOI Listing
March 2019

Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition.

Nat Commun 2019 03 8;10(1):1144. Epub 2019 Mar 8.

Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore, 117583, Singapore.

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http://dx.doi.org/10.1038/s41467-019-09030-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408581PMC
March 2019

Cortical cerebral microinfarcts predict cognitive decline in memory clinic patients.

J Cereb Blood Flow Metab 2019 Mar 19:271678X19835565. Epub 2019 Mar 19.

1 Department of Pharmacology, National University of Singapore, Singapore.

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http://dx.doi.org/10.1177/0271678X19835565DOI Listing
March 2019

Homocysteine and Cerebral Atrophy: The Epidemiology of Dementia in Singapore Study.

J Alzheimers Dis 2018 ;62(2):877-885

Memory Ageing and Cognition Center (MACC), National University Health System, Singapore.

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http://dx.doi.org/10.3233/JAD-170796DOI Listing
February 2019

Potential retinal biomarkers for dementia: what is new?

Curr Opin Neurol 2019 02;32(1):82-91

Singapore Eye Research Institute, Singapore National Eye Centre.

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http://dx.doi.org/10.1097/WCO.0000000000000645DOI Listing
February 2019

Studies of 3D directed cell migration enabled by direct laser writing of curved wave topography.

Biofabrication 2019 02 25;11(2):021001. Epub 2019 Feb 25.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States of America.

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http://dx.doi.org/10.1088/1758-5090/ab047fDOI Listing
February 2019

In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films.

J Vis Exp 2019 Feb 26(144). Epub 2019 Feb 26.

Harvard Medical School;

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http://dx.doi.org/10.3791/58728DOI Listing
February 2019

Mitochondrial Translocase of the Outer Membrane Alterations May Underlie Dysfunctional Oxidative Phosphorylation in Alzheimer's Disease.

J Alzheimers Dis 2018 ;61(2):793-801

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.3233/JAD-170613DOI Listing
January 2019

Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.

Brain Pathol 2019 01 17;29(1):63-74. Epub 2018 Oct 17.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore.

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http://dx.doi.org/10.1111/bpa.12631DOI Listing
January 2019

Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease.

J Neurol Sci 2019 01 31;396:94-101. Epub 2018 Oct 31.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2018.10.025DOI Listing
January 2019

The Clinical Utility of the TYM and RBANS in a One-Stop Memory Clinic in Singapore: A Pilot Study.

J Geriatr Psychiatry Neurol 2019 Jan 10:891988718824034. Epub 2019 Jan 10.

8 Department of Psychology, Faculty of Arts and Social Sciences, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1177/0891988718824034DOI Listing
January 2019

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimers Dement 2019 01;15(1):158-167

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.07.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338083PMC
January 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:
Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

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http://dx.doi.org/10.1212/WNL.0000000000006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905PMC
January 2019

Cerebellar modulation of the reward circuitry and social behavior.

Science 2019 01;363(6424)

Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY 10461, USA.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aav0581
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http://dx.doi.org/10.1126/science.aav0581DOI Listing
January 2019

Traditional Chinese herbal medicine for vascular dementia.

Cochrane Database Syst Rev 2018 Dec 6;12:CD010284. Epub 2018 Dec 6.

Cochrane Singapore, Singapore Clinical Research Institute, Nanos Building #02-01, 31 Biopolis Way, Singapore, Singapore, 138669.

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http://dx.doi.org/10.1002/14651858.CD010284.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516869PMC
December 2018

Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration.

APL Bioeng 2018 Dec 26;2(4):046107. Epub 2018 Dec 26.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1063/1.5052239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481732PMC
December 2018

Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells.

Neuron 2018 11 4;100(3):564-578.e3. Epub 2018 Oct 4.

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273183082
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http://dx.doi.org/10.1016/j.neuron.2018.09.018DOI Listing
November 2018

Motile Dendritic Cells Sense and Respond to Substrate Geometry.

Ann Biomed Eng 2018 Sep 22;46(9):1348-1361. Epub 2018 May 22.

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.

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http://link.springer.com/10.1007/s10439-018-2041-7
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http://dx.doi.org/10.1007/s10439-018-2041-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095716PMC
September 2018

Visualization of Surfactant Dynamics to and along Oil-Water Interfaces Using Solvatochromic Fluorescent Surfactants.

Langmuir 2018 09 27;34(36):10512-10522. Epub 2018 Aug 27.

Department of Chemical and Biological Engineering , Princeton University , Princeton , New Jersey 08544 , United States.

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http://dx.doi.org/10.1021/acs.langmuir.8b01740DOI Listing
September 2018

Fabrication and Mechanical Properties Measurements of 3D Microtissues for the Study of Cell-Matrix Interactions.

Methods Mol Biol 2018 ;1722:303-328

Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/978-1-4939-7553-2_18DOI Listing
August 2018

Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies.

Neurology 2018 08 1;91(9):e832-e842. Epub 2018 Aug 1.

From the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000006079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133622PMC
August 2018

Prevalence and association of syphilis reactivity in an Asian memory clinic population.

Int J STD AIDS 2018 Aug 2:956462418787627. Epub 2018 Aug 2.

4 Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1177/0956462418787627DOI Listing
August 2018

Cerebrovascular disease influences functional and structural network connectivity in patients with amnestic mild cognitive impairment and Alzheimer's disease.

Alzheimers Res Ther 2018 08 18;10(1):82. Epub 2018 Aug 18.

Centre for Cognitive Neuroscience, Neuroscience and Behavioural Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.

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http://dx.doi.org/10.1186/s13195-018-0413-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098837PMC
August 2018

Efficacy, Safety, and Regulatory Approval of Food and Drug Administration-Designated Breakthrough and Nonbreakthrough Cancer Medicines.

J Clin Oncol 2018 06 24;36(18):1805-1812. Epub 2018 Apr 24.

Thomas J. Hwang, Jessica M. Franklin, Julie C. Lauffenburger, Bishal Gyawali, Aaron S. Kesselheim, and Jonathan J. Darrow, Brigham and Women's Hospital and Harvard Medical School; Christopher T. Chen, Dana-Farber Cancer Institute, Boston, MA; and Bishal Gyawali, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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http://ascopubs.org/doi/10.1200/JCO.2017.77.1592
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http://dx.doi.org/10.1200/JCO.2017.77.1592DOI Listing
June 2018

Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis.

Development 2018 04 30;145(9). Epub 2018 Apr 30.

Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA

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http://dx.doi.org/10.1242/dev.162123DOI Listing
April 2018

Marriage and risk of dementia: systematic review and meta-analysis of observational studies.

J Neurol Neurosurg Psychiatry 2018 03 28;89(3):227. Epub 2017 Nov 28.

Department of Medicine & Therapeutics, Faculty of Medicine, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Gerald Choa Neuroscience Research Centre, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1136/jnnp-2017-317178DOI Listing
March 2018

Differential Binding of Human ApoE Isoforms to Insulin Receptor is Associated with Aberrant Insulin Signaling in AD Brain Samples.

Neuromolecular Med 2018 03 15;20(1):124-132. Epub 2018 Feb 15.

Departments of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.

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http://dx.doi.org/10.1007/s12017-018-8480-3DOI Listing
March 2018

Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise.

Cell Stem Cell 2018 03;22(3):340-354

Biological Design Center, Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849079PMC
March 2018

Caregiver-Reported Sleep Disturbances Are Associated With Behavioral and Psychological Symptoms in an Asian Elderly Cohort With Cognitive Impairment-No Dementia.

J Geriatr Psychiatry Neurol 2018 03 19;31(2):70-75. Epub 2018 Mar 19.

1 Memory Ageing and Cognition Centre (MACC), National University Health System, Singapore.

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http://dx.doi.org/10.1177/0891988718758203DOI Listing
March 2018

Atom-Dependent Edge-Enhanced Second-Harmonic Generation on MoS Monolayers.

Nano Lett 2018 02 17;18(2):793-797. Epub 2018 Jan 17.

Department of Automatic Control Engineering, Feng Chia University , Taichung 40724, Taiwan.

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http://dx.doi.org/10.1021/acs.nanolett.7b04006DOI Listing
February 2018

Vascular cognitive impairment.

Nat Rev Dis Primers 2018 02 15;4:18003. Epub 2018 Feb 15.

Alzheimer Center, Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, de Boelelaan 1118, 1081 HZ Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/nrdp.2018.3DOI Listing
February 2018

Service use, advance planning and lifestyle changes following cognitive screening in primary healthcare in Singapore.

Int Psychogeriatr 2018 01 20;30(1):139-145. Epub 2017 Sep 20.

Department of Pharmacology,National University of Singapore,Singapore.

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http://dx.doi.org/10.1017/S1041610217001971DOI Listing
January 2018

Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.

Dev Cell 2018 01 8;44(1):87-96.e5. Epub 2018 Jan 8.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421364PMC
January 2018

Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis.

BMC Cancer 2018 01 10;18(1):65. Epub 2018 Jan 10.

School of Public Health, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1186/s12885-017-3934-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763543PMC
January 2018

Serum Hepatocyte Growth Factor Is Associated with Small Vessel Disease in Alzheimer's Dementia.

Front Aging Neurosci 2018 23;10. Epub 2018 Jan 23.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.3389/fnagi.2018.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787106PMC
January 2018

Functional Imaging of Viral Transcription Factories Using 3D Fluorescence Microscopy.

J Vis Exp 2018 01 18(131). Epub 2018 Jan 18.

Department of Dermatology, University of California Davis School of Medicine, University of California, Davis;

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http://dx.doi.org/10.3791/56832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908662PMC
January 2018

Forces as regulators of cell adhesions.

Nat Rev Mol Cell Biol 2017 12 2;18(12):715. Epub 2017 Nov 2.

The Biological Design Center, Boston University, Massachusetts, MA 02215, USA; and Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, MA 02138, USA.

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http://dx.doi.org/10.1038/nrm.2017.112DOI Listing
December 2017

Partial Solar Radiation Exclusion with Color Shade Nets Reduces the Degradation of Organic Acids and Flavonoids of Grape Berry (Vitis vinifera L.).

J Agric Food Chem 2017 Dec 29;65(49):10693-10702. Epub 2017 Nov 29.

Department of Viticulture and Enology, University of California Davis , 1 Shields Avenue, Davis, California 95616, United States.

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http://dx.doi.org/10.1021/acs.jafc.7b04163DOI Listing
December 2017

A non-canonical Notch complex regulates adherens junctions and vascular barrier function.

Nature 2017 12 13;552(7684):258-262. Epub 2017 Nov 13.

The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nature24998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730479PMC
December 2017

Coronal CT is Comparable to MR Imaging in Aiding Diagnosis of Dementia in a Memory Clinic in Singapore.

Alzheimer Dis Assoc Disord 2018 Apr-Jun;32(2):94-100

Memory Aging & Cognition Centre, National University Health System.

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http://dx.doi.org/10.1097/WAD.0000000000000227DOI Listing
December 2017

Influence of cerebrovascular disease on brain networks in prodromal and clinical Alzheimer's disease.

Brain 2017 Nov;140(11):3012-3022

Centre for Cognitive Neuroscience, Neuroscience and Behavioural Disorders Programme, Duke-National University of Singapore Medical School, Singapore.

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http://dx.doi.org/10.1093/brain/awx224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841199PMC
November 2017

Using Retinal Imaging to Study Dementia.

J Vis Exp 2017 11 6(129). Epub 2017 Nov 6.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong;

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http://dx.doi.org/10.3791/56137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755325PMC
November 2017

Designer biomaterials for mechanobiology.

Nat Mater 2017 11;16(12):1164-1168

Biological Design Center and in the Department of Biomedical Engineering, Boston University, Boston, Massachusetts, 02215, USA, and at the Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, 02115, USA.

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http://dx.doi.org/10.1038/nmat5049DOI Listing
November 2017

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro.

Cell Rep 2017 Oct;21(2):508-516

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02139, USA; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173133
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http://dx.doi.org/10.1016/j.celrep.2017.09.043DOI Listing
October 2017

Making bone via nanoscale kicks.

Nat Biomed Eng 2017 Sep;1(9):689-690

Biological Design Center, Department of Biomedical Engineering, Boston University, 610 Commonwealth Avenue, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41551-017-0133-6DOI Listing
September 2017

Matrix degradability controls multicellularity of 3D cell migration.

Nat Commun 2017 08 29;8(1):371. Epub 2017 Aug 29.

The Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41467-017-00418-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575316PMC
August 2017