Christopher Cassa

Christopher Cassa

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Christopher Cassa

Christopher Cassa

Publications by authors named "Christopher Cassa"

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Author Correction: Predictable and precise template-free CRISPR editing of pathogenic variants.

Nature 2019 03;567(7746):E1-E2

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-0938-4DOI Listing
March 2019

Predictable and precise template-free CRISPR editing of pathogenic variants.

Nature 2018 11 7;563(7733):646-651. Epub 2018 Nov 7.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41586-018-0686-x
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http://dx.doi.org/10.1038/s41586-018-0686-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517069PMC
November 2018

A literature review at genome scale: improving clinical variant assessment.

Genet Med 2018 09 1;20(9):936-941. Epub 2018 Feb 1.

Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/gim.2017.230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070443PMC
September 2018

Mitigating false-positive associations in rare disease gene discovery.

Hum Mutat 2015 Oct;36(10):998-1003

Division of Genetics, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1002/humu.22847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576452PMC
October 2015

Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck.

PLoS Genet 2015 Aug 28;11(8):e1005436. Epub 2015 Aug 28.

Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552954PMC
August 2015

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

Authors:
Catherine A Brownstein Alan H Beggs Nils Homer Barry Merriman Timothy W Yu Katherine C Flannery Elizabeth T DeChene Meghan C Towne Sarah K Savage Emily N Price Ingrid A Holm Lovelace J Luquette Elaine Lyon Joseph Majzoub Peter Neupert David McCallie Peter Szolovits Huntington F Willard Nancy J Mendelsohn Renee Temme Richard S Finkel Sabrina W Yum Livija Medne Shamil R Sunyaev Ivan Adzhubey Christopher A Cassa Paul I W de Bakker Hatice Duzkale Piotr Dworzyński William Fairbrother Laurent Francioli Birgit H Funke Monica A Giovanni Robert E Handsaker Kasper Lage Matthew S Lebo Monkol Lek Ignaty Leshchiner Daniel G MacArthur Heather M McLaughlin Michael F Murray Tune H Pers Paz P Polak Soumya Raychaudhuri Heidi L Rehm Rachel Soemedi Nathan O Stitziel Sara Vestecka Jochen Supper Claudia Gugenmus Bernward Klocke Alexander Hahn Max Schubach Mortiz Menzel Saskia Biskup Peter Freisinger Mario Deng Martin Braun Sven Perner Richard J H Smith Janeen L Andorf Jian Huang Kelli Ryckman Val C Sheffield Edwin M Stone Thomas Bair E Ann Black-Ziegelbein Terry A Braun Benjamin Darbro Adam P DeLuca Diana L Kolbe Todd E Scheetz Aiden E Shearer Rama Sompallae Kai Wang Alexander G Bassuk Erik Edens Katherine Mathews Steven A Moore Oleg A Shchelochkov Pamela Trapane Aaron Bossler Colleen A Campbell Jonathan W Heusel Anne Kwitek Tara Maga Karin Panzer Thomas Wassink Douglas Van Daele Hela Azaiez Kevin Booth Nic Meyer Michael M Segal Marc S Williams Gerard Tromp Peter White Donald Corsmeier Sara Fitzgerald-Butt Gail Herman Devon Lamb-Thrush Kim L McBride David Newsom Christopher R Pierson Alexander T Rakowsky Aleš Maver Luca Lovrečić Anja Palandačić Borut Peterlin Ali Torkamani Anna Wedell Mikael Huss Andrey Alexeyenko Jessica M Lindvall Måns Magnusson Daniel Nilsson Henrik Stranneheim Fulya Taylan Christian Gilissen Alexander Hoischen Bregje van Bon Helger Yntema Marcel Nelen Weidong Zhang Jason Sager Lu Zhang Kathryn Blair Deniz Kural Michael Cariaso Greg G Lennon Asif Javed Saloni Agrawal Pauline C Ng Komal S Sandhu Shuba Krishna Vamsi Veeramachaneni Ofer Isakov Eran Halperin Eitan Friedman Noam Shomron Gustavo Glusman Jared C Roach Juan Caballero Hannah C Cox Denise Mauldin Seth A Ament Lee Rowen Daniel R Richards F Anthony San Lucas Manuel L Gonzalez-Garay C Thomas Caskey Yu Bai Ying Huang Fang Fang Yan Zhang Zhengyuan Wang Jorge Barrera Juan M Garcia-Lobo Domingo González-Lamuño Javier Llorca Maria C Rodriguez Ignacio Varela Martin G Reese Francisco M De La Vega Edward Kiruluta Michele Cargill Reece K Hart Jon M Sorenson Gholson J Lyon David A Stevenson Bruce E Bray Barry M Moore Karen Eilbeck Mark Yandell Hongyu Zhao Lin Hou Xiaowei Chen Xiting Yan Mengjie Chen Cong Li Can Yang Murat Gunel Peining Li Yong Kong Austin C Alexander Zayed I Albertyn Kym M Boycott Dennis E Bulman Paul M K Gordon A Micheil Innes Bartha M Knoppers Jacek Majewski Christian R Marshall Jillian S Parboosingh Sarah L Sawyer Mark E Samuels Jeremy Schwartzentruber Isaac S Kohane David M Margulies

Genome Biol 2014 Mar 25;15(3):R53. Epub 2014 Mar 25.

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http://dx.doi.org/10.1186/gb-2014-15-3-r53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073084PMC
March 2014

Large numbers of genetic variants considered to be pathogenic are common in asymptomatic individuals.

Hum Mutat 2013 Sep 5;34(9):1216-20. Epub 2013 Aug 5.

Brigham and Women's Hospital, Division of Genetics Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/humu.22375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786140PMC
September 2013

A novel, privacy-preserving cryptographic approach for sharing sequencing data.

J Am Med Inform Assoc 2013 Jan 2;20(1):69-76. Epub 2012 Nov 2.

Division of Genetics, Brigham and Women's Hospital, Boston, MA 02215, USA.

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http://dx.doi.org/10.1136/amiajnl-2012-001366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555340PMC
January 2013

Disclosing pathogenic genetic variants to research participants: quantifying an emerging ethical responsibility.

Genome Res 2012 Mar 6;22(3):421-8. Epub 2012 Jan 6.

Children's Hospital Informatics Program, Children's Hospital Boston, Boston, Massachusetts 02115, USA.

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http://genome.cshlp.org/cgi/doi/10.1101/gr.127845.111
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http://dx.doi.org/10.1101/gr.127845.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290777PMC
March 2012

The Massachusetts Health and Homeland Alert Network: a scalable and secure public health knowledge management and notification system.

AMIA Annu Symp Proc 2008 Nov 6:893. Epub 2008 Nov 6.

Children's Hosp. Informatics Program, Boston, MA, USA.

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November 2008

Revealing the spatial distribution of a disease while preserving privacy.

Proc Natl Acad Sci U S A 2008 Nov 17;105(46):17608-13. Epub 2008 Nov 17.

Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA.

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http://dx.doi.org/10.1073/pnas.0801021105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584758PMC
November 2008

Re-identification of home addresses from spatial locations anonymized by Gaussian skew.

Int J Health Geogr 2008 Aug 12;7:45. Epub 2008 Aug 12.

Children's Hospital Informatics Program, Children's Hospital Boston, Boston, MA, USA.

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http://dx.doi.org/10.1186/1476-072X-7-45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526988PMC
August 2008

My sister's keeper?: genomic research and the identifiability of siblings.

BMC Med Genomics 2008 Jul 25;1:32. Epub 2008 Jul 25.

Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology, Boston, MA, USA.

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http://dx.doi.org/10.1186/1755-8794-1-32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503988PMC
July 2008

Multi-factor authentication using contents from disparate EHRs.

AMIA Annu Symp Proc 2007 Oct 11:891. Epub 2007 Oct 11.

Children's Hosp. Inform. Prog. At Harvard-MIT Div. of Hlth. Sci.& Techn., Cambridge, MA, USA.

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October 2007

Reverse geocoding: concerns about patient confidentiality in the display of geospatial health data.

AMIA Annu Symp Proc 2005 :905

Children's Hospital Informatics Program, Children's Hospital Boston.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560748PMC
February 2007

An unsupervised classification method for inferring original case locations from low-resolution disease maps.

Int J Health Geogr 2006 Dec 8;5:56. Epub 2006 Dec 8.

Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology, 1 Autumn St, Boston, MA, USA.

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http://dx.doi.org/10.1186/1476-072X-5-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702538PMC
December 2006

A context-sensitive approach to anonymizing spatial surveillance data: impact on outbreak detection.

J Am Med Inform Assoc 2006 Mar-Apr;13(2):160-5. Epub 2005 Dec 15.

Children's Hospital Boston, Informatics Program-Mandl Group, 1 Autumn Street, #721, Boston, MA 02215-5362 USA.

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http://dx.doi.org/10.1197/jamia.M1920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447544PMC
April 2006

A software tool for creating simulated outbreaks to benchmark surveillance systems.

BMC Med Inform Decis Mak 2005 Jul 14;5:22. Epub 2005 Jul 14.

Children's Hospital Informatics Program, Children's Hospital Boston, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/1472-6947-5-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182374PMC
July 2005