Christopher C W Hughes

Christopher C W Hughes

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Christopher C W Hughes

Christopher C W Hughes

Publications by authors named "Christopher C W Hughes"

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Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions.

Stem Cell Reports 2019 Mar 7;12(3):451-460. Epub 2019 Feb 7.

Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine CA 92697, USA; Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409424PMC
March 2019

Applications of tumor chip technology.

Lab Chip 2018 09;18(19):2893-2912

Department of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697, USA.

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http://xlink.rsc.org/?DOI=C8LC00330K
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http://dx.doi.org/10.1039/c8lc00330kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207449PMC
September 2018

Consensus guidelines for the use and interpretation of angiogenesis assays.

Angiogenesis 2018 08;21(3):425-532

Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10456-018-9613-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237663PMC
August 2018

A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function.

Lab Chip 2018 07;18(15):2167-2177

Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

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http://dx.doi.org/10.1039/c8lc00236cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057814PMC
July 2018

3D Anastomosed Microvascular Network Model with Living Capillary Networks and Endothelial Cell-Lined Microfluidic Channels.

Methods Mol Biol 2017 ;1612:325-344

Department of Biomedical Engineering, University of California, Irvine, CA, 92697, USA.

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http://dx.doi.org/10.1007/978-1-4939-7021-6_24DOI Listing
March 2018

Executive summary of the 12th HHT international scientific conference.

Angiogenesis 2018 02;21(1):169-181

Department of Pulmonology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1007/s10456-017-9585-2DOI Listing
February 2018

Multiscale modeling of glioblastoma.

Transl Cancer Res 2018 Feb;7(Suppl 1):S96-S98

Department of Mathematics, University of California, Irvine, USA.

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http://dx.doi.org/10.21037/tcr.2017.12.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130886PMC
February 2018

Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth.

Biomaterials 2017 02 24;116:118-129. Epub 2016 Nov 24.

Department of Biomedical Engineering, The Henry Samueli School of Engineering, UC Irvine, USA; Department of Molecular Biology and Biochemistry, School of Biological Sciences, UC Irvine, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, UC Irvine, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226635PMC
February 2017

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications.

Lab Chip 2017 01;17(3):511-520

Department of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697, USA. and Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA. and The Edwards Lifesciences Center for Advanced Cardiovascular Technology, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1039/c6lc01422dDOI Listing
January 2017

Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering.

Acta Biomater 2016 10 27;43:122-138. Epub 2016 Jul 27.

Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Department of Neurology, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2016.07.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386322PMC
October 2016

mTORC2 mediates CXCL12-induced angiogenesis.

Angiogenesis 2016 07 22;19(3):359-71. Epub 2016 Apr 22.

The Department of Molecular Biology and Biochemistry, University of California Irvine, 3219 McGaugh Hall, Mail Code: 3900, Irvine, CA, 92697, USA.

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http://dx.doi.org/10.1007/s10456-016-9509-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959910PMC
July 2016

Antibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma.

Cancer Immunol Res 2016 06 4;4(6):531-40. Epub 2016 Apr 4.

Hamon Center for Therapeutic Oncology Research, Departments of Surgery and Pharmacology, UT Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0250DOI Listing
June 2016

Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels.

Lab Chip 2016 Jan;16(2):282-90

Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA. and Department of Mechanical and Aerospace Engineering, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1039/c5lc01050kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869859PMC
January 2016

A role for partial endothelial-mesenchymal transitions in angiogenesis?

Arterioscler Thromb Vasc Biol 2015 Feb 25;35(2):303-8. Epub 2014 Nov 25.

From the Department of Molecular Biology and Biochemistry (K.M.W.-R., N.W., C.C.W.H.), Department of Biomedical Engineering (C.C.W.H.), and Edwards Lifesciences Center for Advanced Cardiovascular Technology (C.C.W.H.), University of California, Irvine.

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http://dx.doi.org/10.1161/ATVBAHA.114.303220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911209PMC
February 2015

A three-dimensional in vitro model of tumor cell intravasation.

Integr Biol (Camb) 2014 Jun;6(6):603-10

Department of Chemical Engineering and Materials Science, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1039/c3ib40170gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046910PMC
June 2014

Angiogenic sprouting is regulated by endothelial cell expression of Slug.

J Cell Sci 2014 May 19;127(Pt 9):2017-28. Epub 2014 Feb 19.

The Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1242/jcs.143420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004976PMC
May 2014

Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis.

Arterioscler Thromb Vasc Biol 2014 May 6;34(5):1011-9. Epub 2014 Mar 6.

From the Department of Molecular Biology and Biochemistry (S.A.P., M.E.Z., M.T.H., C.I.S., A.H.F., K.M.W.-R., J.P., C.C.W.H.), Department of Biomedical Engineering (X.C., C.C.W.H.), Edwards Lifesciences Center for Advanced Cardiovascular Technology (C.C.W.H.), and Chao Family Comprehensive Cancer Center (C.C.W.H.), University of California Irvine.

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http://dx.doi.org/10.1161/ATVBAHA.114.303352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993998PMC
May 2014

In vitro perfused human capillary networks.

Tissue Eng Part C Methods 2013 Sep 21;19(9):730-7. Epub 2013 Feb 21.

Department of Biomedical Engineering, University of California, Irvine, California, USA.

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http://dx.doi.org/10.1089/ten.TEC.2012.0430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719485PMC
September 2013

Full range physiological mass transport control in 3D tissue cultures.

Lab Chip 2013 Jan 22;13(1):81-9. Epub 2012 Oct 22.

Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1039/c2lc40787fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510322PMC
January 2013

Longitudinal in vivo imaging to assess blood flow and oxygenation in implantable engineered tissues.

Tissue Eng Part C Methods 2012 Sep 21;18(9):697-709. Epub 2012 May 21.

Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA.

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https://www.liebertpub.com/doi/10.1089/ten.tec.2011.0744
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http://dx.doi.org/10.1089/ten.TEC.2011.0744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427639PMC
September 2012

BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II.

Angiogenesis 2012 Sep 24;15(3):497-509. Epub 2012 May 24.

Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1007/s10456-012-9277-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423339PMC
September 2012

Macrophages and angiogenesis: a role for Wnt signaling.

Vasc Cell 2012 Aug 31;4(1):13. Epub 2012 Aug 31.

The Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.

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http://vascularcell.com/index.php/vc/article/view/10.1186-20
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http://dx.doi.org/10.1186/2045-824X-4-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479425PMC
August 2012

The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation.

Mol Biol Cell 2011 Oct 24;22(20):3791-800. Epub 2011 Aug 24.

Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1091/mbc.E11-05-0393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192859PMC
October 2011

Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2.

PLoS One 2009 Nov 16;4(11):e7841. Epub 2009 Nov 16.

Department of Molecular Biology and Biochemistry, UCI Institute for Immunology, University of California Irvine, Irvine, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007841PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773007PMC
November 2009

TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent.

Gene 2009 Apr 22;435(1-2):36-44. Epub 2009 Jan 22.

Department of Molecular Biology and Biochemistry, University of California Irvine, 92697, USA.

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http://dx.doi.org/10.1016/j.gene.2009.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674625PMC
April 2009

Optimized fibrin gel bead assay for the study of angiogenesis.

J Vis Exp 2007 29(3):186. Epub 2007 Apr 29.

Department of Molecular Biology and Biochemistry, University of California, Irvine, USA.

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http://dx.doi.org/10.3791/186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570172PMC
February 2009

Isolation of human umbilical vein endothelial cells (HUVEC).

J Vis Exp 2007 28(3):183. Epub 2007 Apr 28.

Department of Molecular Biology and Biochemistry, University of California, Irvine, USA.

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http://dx.doi.org/10.3791/183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576276PMC
February 2009

Christopher Hughes: an in vitro model for the study of angiogenesis (interview).

J Vis Exp 2007 28(3):175. Epub 2007 Apr 28.

Department of Molecular Biology and Biochemistry, University of California, Irvine, USA.

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http://dx.doi.org/10.3791/175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2535841PMC
February 2009

An optimized three-dimensional in vitro model for the analysis of angiogenesis.

Methods Enzymol 2008 ;443:65-82

Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California, USA.

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http://4designbiosciences.com/pubs/Nakatsu%20and%20Hughes%20
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http://linkinghub.elsevier.com/retrieve/pii/S007668790802004
Publisher Site
http://dx.doi.org/10.1016/S0076-6879(08)02004-1DOI Listing
January 2009

Endothelial-stromal interactions in angiogenesis.

Curr Opin Hematol 2008 May;15(3):204-9

Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California 92697, USA.

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https://insights.ovid.com/crossref?an=00062752-200805000-000
Publisher Site
http://dx.doi.org/10.1097/MOH.0b013e3282f97dbcDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606556PMC
May 2008

The effect of matrix density on the regulation of 3-D capillary morphogenesis.

Biophys J 2008 Mar 9;94(5):1930-41. Epub 2007 Nov 9.

Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697, USA.

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http://dx.doi.org/10.1529/biophysj.107.120774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242748PMC
March 2008

Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis.

Circ Res 2008 Mar;102(6):637-52

Department of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.107.16717
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http://dx.doi.org/10.1161/CIRCRESAHA.107.167171DOI Listing
March 2008

Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration.

Immunity 2007 Feb;26(2):227-39

Center for Immunology, Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1016/j.immuni.2006.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855210PMC
February 2007

Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early matrix metalloproteinase upregulation.

Tissue Eng 2006 Oct;12(10):2875-88

Department of Biomedical Engineering, University of California-Irvine, Irvine, California 92697-2575, USA.

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http://dx.doi.org/10.1089/ten.2006.12.2875DOI Listing
October 2006

HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes.

Biochem Biophys Res Commun 2006 Aug 8;346(3):637-48. Epub 2006 Jun 8.

Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.05.177DOI Listing
August 2006

Diffusion limits of an in vitro thick prevascularized tissue.

Tissue Eng 2005 Jan-Feb;11(1-2):257-66

Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697-2715, USA.

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http://dx.doi.org/10.1089/ten.2005.11.257DOI Listing
June 2005

Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA.

Int Immunol 2005 Jun 20;17(6):737-47. Epub 2005 May 20.

Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1093/intimm/dxh255DOI Listing
June 2005

Of mice and not men: differences between mouse and human immunology.

J Immunol 2004 Mar;172(5):2731-8

Center for Immunology and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697.

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http://dx.doi.org/10.4049/jimmunol.172.5.2731DOI Listing
March 2004

VEGF(121) and VEGF(165) regulate blood vessel diameter through vascular endothelial growth factor receptor 2 in an in vitro angiogenesis model.

Lab Invest 2003 Dec;83(12):1873-85

Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California 92697, USA.

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December 2003

Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1.

Microvasc Res 2003 Sep;66(2):102-12

Department of Molecular Biology and Biochemistry, 3219 McGaugh Hall, University of California, Irvine, Irvine, CA 92697, USA.

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September 2003

Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology.

J Biol Chem 2002 Dec 7;277(52):50768-75. Epub 2002 Oct 7.

Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, Long Beach, California 90822, USA.

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http://dx.doi.org/10.1074/jbc.M210106200DOI Listing
December 2002

Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression.

Microvasc Res 2002 Nov;64(3):372-83

Dept of Molecular Biology and Biochemistry, University of California-Irvine, Irvine, CA 92627-3900, USA.

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November 2002

B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis.

J Immunol 2002 Oct;169(7):3581-8

Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.4049/jimmunol.169.7.3581DOI Listing
October 2002

Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway.

J Immunol 2002 Oct;169(7):3717-25

Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.4049/jimmunol.169.7.3717DOI Listing
October 2002

Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM.

Microvasc Res 2002 Mar;63(2):159-71

Molecular Biology and Biochemistry, University of California at Irvine, Irvine, California 92697, USA.

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http://dx.doi.org/10.1006/mvre.2001.2380DOI Listing
March 2002