Christopher C Goodnow

Christopher C Goodnow

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Christopher C Goodnow

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Deletion of self-reactive CCR7- thymocytes in the absence of MHC expression on thymic epithelial cells.

Cell Death Differ 2019 Dec 24;26(12):2727-2739. Epub 2019 Apr 24.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1038/s41418-019-0331-8DOI Listing
December 2019

Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity.

Immunol Rev 2019 11 26;292(1):61-75. Epub 2019 Sep 26.

Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

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http://dx.doi.org/10.1111/imr.12808DOI Listing
November 2019

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3 regulatory T cells.

Immunol Cell Biol 2019 09 26;97(8):740-752. Epub 2019 Jun 26.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1111/imcb.12268DOI Listing
September 2019

B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects.

J Allergy Clin Immunol 2019 Jun 20;143(6):2302-2305. Epub 2019 Feb 20.

Immunology Division, Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.02.010DOI Listing
June 2019

DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns.

Cancer Cell 2019 02;35(2):297-314.e8

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia; St Vincent's Clinical School, UNSW, Sydney, NSW 2010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.01.004DOI Listing
February 2019

Molecular Profiling and Clonal Tracking of Secreted Rheumatoid Factors in Primary Sjögren's Syndrome.

Arthritis Rheumatol 2018 10 3;70(10):1617-1625. Epub 2018 Aug 3.

Flinders University and SA Pathology, Bedford Park, South Australia, Australia.

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http://dx.doi.org/10.1002/art.40539DOI Listing
October 2018

Understanding Immune Tolerance of Cancer: Re-Purposing Insights from Fetal Allografts and Microbes.

Bioessays 2018 08 4;40(8):e1800050. Epub 2018 Jun 4.

The Garvan Institute of Medical Research, Darlinghurst, 2010, NSW, Australia.

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http://dx.doi.org/10.1002/bies.201800050DOI Listing
August 2018

Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self-reactive thymocytes.

Immunology 2018 07 27;154(3):522-532. Epub 2018 Feb 27.

Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.

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http://dx.doi.org/10.1111/imm.12904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002238PMC
July 2018

αβ T-cell receptors with a central CDR3 cysteine are enriched in CD8αα intraepithelial lymphocytes and their thymic precursors.

Immunol Cell Biol 2018 07 3;96(6):553-561. Epub 2018 May 3.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia.

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http://dx.doi.org/10.1111/imcb.12047DOI Listing
July 2018

The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8 T Cell Tolerance Checkpoint to High-Dose Antigen.

Cell Rep 2018 07;24(3):577-584

John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183098
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http://dx.doi.org/10.1016/j.celrep.2018.06.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112980PMC
July 2018

Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation.

Immunol Cell Biol 2017 10 14;95(9):775-788. Epub 2017 Jun 14.

Immunology Division, Garvan Institute for Medical Research, Sydney, NSW, Australia.

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http://dx.doi.org/10.1038/icb.2017.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636941PMC
October 2017

Synergistic cooperation and crosstalk between and mutations that dysregulate CD79B and surface IgM.

J Exp Med 2017 Sep 12;214(9):2759-2776. Epub 2017 Jul 12.

Australian Cancer Research Foundation Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia

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http://dx.doi.org/10.1084/jem.20161454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584117PMC
September 2017

IL-2 prevents deletion of developing T-regulatory cells in the thymus.

Cell Death Differ 2017 06 12;24(6):1007-1016. Epub 2017 May 12.

Immunology Department, The John Curtin School of Medical Research, The Australian National University, Canberra 0200, Australia.

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http://dx.doi.org/10.1038/cdd.2017.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442470PMC
June 2017

Dedicator of cytokinesis 8-deficient CD4 T cells are biased to a T2 effector fate at the expense of T1 and T17 cells.

J Allergy Clin Immunol 2017 Mar 20;139(3):933-949. Epub 2016 Aug 20.

Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Australia; St Vincent's Clinical School, University of New South Wales, Darlinghurst, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.07.016DOI Listing
March 2017

IgD attenuates the IgM-induced anergy response in transitional and mature B cells.

Nat Commun 2016 11 10;7:13381. Epub 2016 Nov 10.

Department of Immunology, John Curtin School of Medical Research, The Australian National University, 131 Garran Rd, Acton, Australian Capital Territory 2601, Australia.

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http://dx.doi.org/10.1038/ncomms13381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109548PMC
November 2016

CD45-mediated control of TCR tuning in naïve and memory CD8 T cells.

Nat Commun 2016 11 14;7:13373. Epub 2016 Nov 14.

Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang 790-784, Korea.

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http://dx.doi.org/10.1038/ncomms13373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114568PMC
November 2016

Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo.

Blood 2016 09 25;128(12):1604-8. Epub 2016 Jul 25.

Australian Cancer Research Foundation Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia;

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http://dx.doi.org/10.1182/blood-2016-03-708065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034740PMC
September 2016

TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints.

Immunol Cell Biol 2016 08 5;94(7):709-13. Epub 2016 Apr 5.

Immunology-Oncology Section, Research Center, Maisonneuve-Rosemont Hospital, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/icb.2016.27DOI Listing
August 2016

DeepSNVMiner: a sequence analysis tool to detect emergent, rare mutations in subsets of cell populations.

PeerJ 2016 24;4:e2074. Epub 2016 May 24.

Department of Immunology, John Curtin School of Medical Research, Australian National University , Canberra ACT , Australia.

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http://dx.doi.org/10.7717/peerj.2074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888318PMC
June 2016

Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization.

J Exp Med 2016 06 13;213(7):1255-65. Epub 2016 Jun 13.

Department of Immunology, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, NSW 2010, Australia

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http://dx.doi.org/10.1084/jem.20151978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925023PMC
June 2016

A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred.

Hum Genome Var 2015 16;2:15013. Epub 2015 Apr 16.

Translational Research Unit, Canberra Hospital, Canberra, ACT, Australia; Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.

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http://dx.doi.org/10.1038/hgv.2015.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785559PMC
April 2016

A timeline demarcating two waves of clonal deletion and Foxp3 upregulation during thymocyte development.

Immunol Cell Biol 2016 Apr 29;94(4):357-66. Epub 2015 Oct 29.

Immunology Department, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.

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http://doi.wiley.com/10.1038/icb.2015.95
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http://dx.doi.org/10.1038/icb.2015.95DOI Listing
April 2016

SnapShot: Interactions between B Cells and T Cells.

Cell 2015 Aug;162(4):926-6.e1

Immunology Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia; St Vincent's Clinical School, 2010 UNSW, Australia.

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http://dx.doi.org/10.1016/j.cell.2015.07.055DOI Listing
August 2015

Delayed control of herpes simplex virus infection and impaired CD4(+) T-cell migration to the skin in mouse models of DOCK8 deficiency.

Immunol Cell Biol 2015 Jul 17;93(6):517-21. Epub 2015 Mar 17.

Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.

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http://dx.doi.org/10.1038/icb.2015.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496291PMC
July 2015

Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.

J Immunol 2015 Mar 6;194(6):2587-95. Epub 2015 Feb 6.

Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 2601, Australia;

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http://www.jimmunol.org/content/early/2015/02/05/jimmunol.14
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1400326
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http://dx.doi.org/10.4049/jimmunol.1400326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355390PMC
March 2015

T cell expansion is the limiting factor of virus control in mice with attenuated TCR signaling: implications for human immunodeficiency.

J Immunol 2015 Mar 11;194(6):2725-34. Epub 2015 Feb 11.

Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, 79106 Freiburg, Germany;

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http://dx.doi.org/10.4049/jimmunol.1400328DOI Listing
March 2015

Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100.

Blood 2014 Nov 18;124(19):2964-72. Epub 2014 Sep 18.

Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia; Translational Research Unit, Canberra Hospital, Canberra, ACT, Australia;

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http://dx.doi.org/10.1182/blood-2014-06-578542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321335PMC
November 2014

A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.

Immunology 2014 Apr;141(4):587-95

Department of Immunology, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.

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http://doi.wiley.com/10.1111/imm.12220
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http://dx.doi.org/10.1111/imm.12220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956432PMC
April 2014

Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance.

J Exp Med 2014 Mar 17;211(3):413-26. Epub 2014 Feb 17.

Department of Immunology, John Curtin School of Medical Research, 2 Australian Phenomics Facility, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.

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http://www.jem.org/lookup/doi/10.1084/jem.20131424
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http://dx.doi.org/10.1084/jem.20131424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949567PMC
March 2014

Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes.

Proc Natl Acad Sci U S A 2014 Mar 10;111(12):4513-8. Epub 2014 Mar 10.

Department of Immunology and Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.

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http://dx.doi.org/10.1073/pnas.1402739111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970522PMC
March 2014

DOCK8 is critical for the survival and function of NKT cells.

Blood 2013 Sep 8;122(12):2052-61. Epub 2013 Aug 8.

Medical Research Council Human Immunology Unit, Weatherall Institute for Molecular Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom;

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http://dx.doi.org/10.1182/blood-2013-02-482331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778549PMC
September 2013

Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.

J Exp Med 2013 Feb 21;210(2):269-85. Epub 2013 Jan 21.

Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.

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http://dx.doi.org/10.1084/jem.20121458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570102PMC
February 2013

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.

J Exp Med 2012 Oct 1;209(11):1907-17. Epub 2012 Oct 1.

Department of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.

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http://dx.doi.org/10.1084/jem.20112744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478930PMC
October 2012

Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells.

PLoS One 2011 4;6(11):e26440. Epub 2011 Nov 4.

Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026440PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208548PMC
March 2012

Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL.

Leuk Res 2011 Nov 15;35(11):1512-9. Epub 2011 Aug 15.

Immunology Department, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S01452126110037
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http://dx.doi.org/10.1016/j.leukres.2011.07.024DOI Listing
November 2011

Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy.

J Allergy Clin Immunol 2011 May 12;127(5):1277-85.e5. Epub 2011 Feb 12.

Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1016/j.jaci.2010.12.1081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189857PMC
May 2011

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes.

Nat Immunol 2011 May 20;12(5):441-9. Epub 2011 Mar 20.

Ramaciotti Immunization Genomics Laboratory, Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1038/ni.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272780PMC
May 2011

How host defense is encoded in the mammalian genome.

Mamm Genome 2011 Feb 25;22(1-2):1-5. Epub 2010 Dec 25.

Department of Genetics, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/s00335-010-9312-4DOI Listing
February 2011

Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes.

J Immunol 2011 Feb 19;186(4):2024-32. Epub 2011 Jan 19.

Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia.

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http://dx.doi.org/10.4049/jimmunol.1002296DOI Listing
February 2011

Control systems and decision making for antibody production.

Nat Immunol 2010 Aug 20;11(8):681-8. Epub 2010 Jul 20.

John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.

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http://www.nature.com/articles/ni.1900
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http://dx.doi.org/10.1038/ni.1900DOI Listing
August 2010

T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency.

Proc Natl Acad Sci U S A 2010 Aug 28;107(33):14709-14. Epub 2010 Jul 28.

Immune Tolerance and Signalling Laboratory, Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra 0200, Australia.

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http://dx.doi.org/10.1073/pnas.1009209107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930471PMC
August 2010

Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation.

J Immunol 2010 Jul 26;185(1):231-8. Epub 2010 May 26.

John Curtin School of Medical Research, Australian National University, Canberra, Australia.

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http://dx.doi.org/10.4049/jimmunol.0903625DOI Listing
July 2010

Mouse strains with point mutations in TAP1 and TAP2.

Immunol Cell Biol 2010 Jan 1;88(1):72-8. Epub 2009 Sep 1.

Biochemistry and Molecular Biology, Research School of Biology, The Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1038/icb.2009.61DOI Listing
January 2010

A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration.

Proc Natl Acad Sci U S A 2009 Feb 5;106(7):2097-103. Epub 2009 Feb 5.

Department of Biochemistry, Institute for Childhood and Neglected Diseases, The Scripps Research Institute, ICND216, 10550 North Torrey Pines Road, La Jolla, CA 90237, USA.

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http://dx.doi.org/10.1073/pnas.0812819106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650114PMC
February 2009

Defective T-cell function leading to reduced antibody production in a kleisin-beta mutant mouse.

Immunology 2008 Oct 4;125(2):208-17. Epub 2008 Apr 4.

School of Biochemistry and Molecular Biology, The Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1111/j.1365-2567.2008.02831.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561126PMC
October 2008

A mechanism for Ikaros regulation of human globin gene switching.

Br J Haematol 2008 May 3;141(3):398-406. Epub 2008 Mar 3.

Institute for Molecular Bioscience, Queensland Bioscience Precinct, University of Queensland, Queensland, Australia.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07065.xDOI Listing
May 2008

Two levels of protection for the B cell genome during somatic hypermutation.

Nature 2008 Feb;451(7180):841-5

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1038/nature06547DOI Listing
February 2008

Nossal and Pike 1975: a turning point in the effort to define self-tolerance mechanisms.

J Immunol 2007 Nov;179(9):5617-8

Australian National University, Immunology and Genetics Division, Australian Phenomics Facility, John Curtin School of Medical Research, Canberra, australian Capital Territory, Australia.

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http://dx.doi.org/10.4049/jimmunol.179.9.5617DOI Listing
November 2007

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA.

Nature 2007 Nov;450(7167):299-303

Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia.

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http://dx.doi.org/10.1038/nature06253DOI Listing
November 2007