Christopher B Forsyth

Christopher B Forsyth

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Christopher B Forsyth

Christopher B Forsyth

Publications by authors named "Christopher B Forsyth"

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58Publications

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Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging.

Ann N Y Acad Sci 2018 Aug 12. Epub 2018 Aug 12.

Department of Cell and Molecular Medicine, Rush University Medical Center, Chicago, Illinois.

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August 2018

Corrigendum to "Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain" [GENE 655 (2018) 1-12].

Gene 2018 Jun 12. Epub 2018 Jun 12.

Department of Bioengineering, University of Illinois at Chicago, IL, USA; Jesse Brown Veterans Affairs Medical Center (JBVAMC), Chicago, IL, USA. Electronic address:

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June 2018

Alcohol and Gut-Derived Inflammation.

Alcohol Res 2017 ;38(2):163-171

Faraz Bishehsari, M.D., Ph.D., is an Assistant Professor; Garth Swanson, M.D., is an Assistant Professor; Vishal Desai, M.D., is a Physician; Robin M. Voigt, Ph.D., is an Assistant Professor; Christopher B. Forsyth, Ph.D., is an Associate Professor; and Ali Keshavarzian, M.D., is a Professor, all in the Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois. Emmeline Magno, M.D., is an Internist in the Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.

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May 2018

Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain.

Gene 2018 May 20;655:1-12. Epub 2018 Feb 20.

Department of Bioengineering, University of Illinois at Chicago, IL, USA; Jesse Brown Veterans Affairs Medical Center (JBVAMC), Chicago, IL, USA. Electronic address:

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May 2018

Circadian Mechanisms in Alcohol Use Disorder and Tissue Injury.

Alcohol Clin Exp Res 2018 Apr 8;42(4):668-677. Epub 2018 Mar 8.

Division of Digestive Disease and Nutrition, Section of Gastroenterology, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.

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April 2018

Colon dysregulation in methamphetamine self-administering HIV-1 transgenic rats.

PLoS One 2018 2;13(1):e0190078. Epub 2018 Jan 2.

Department of Psychiatry, Rush University Medical Center, Chicago, IL, United States of America.

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February 2018

The Potential Role of Gut-Derived Inflammation in Multiple System Atrophy.

J Parkinsons Dis 2017 ;7(2):331-346

Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL, USA.

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January 2018

Diurnal variations in intestinal barrier integrity and liver pathology in mice: implications for alcohol binge.

Am J Physiol Gastrointest Liver Physiol 2018 Jan 26;314(1):G131-G141. Epub 2017 Oct 26.

Section of Gastroenterology, Division of Digestive Diseases and Nutrition, Department of Internal Medicine, Rush University Medical Center , Chicago, Illinois.

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January 2018

CREB Protein Mediates Alcohol-Induced Circadian Disruption and Intestinal Permeability.

Alcohol Clin Exp Res 2017 Dec 30;41(12):2007-2014. Epub 2017 Oct 30.

Division of Digestive Disease and Nutrition, Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois.

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December 2017

Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation.

PLoS One 2013 18;8(6):e67102. Epub 2013 Jun 18.

Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America ; Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

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October 2017

Alcohol Injury Damages Intestinal Stem Cells.

Alcohol Clin Exp Res 2017 Apr 10;41(4):727-734. Epub 2017 Mar 10.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.

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April 2017

Lower Neighborhood Socioeconomic Status Associated with Reduced Diversity of the Colonic Microbiota in Healthy Adults.

PLoS One 2016 9;11(2):e0148952. Epub 2016 Feb 9.

Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, United States of America.

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July 2016

The Gastrointestinal Microbiome: Alcohol Effects on the Composition of Intestinal Microbiota.

Alcohol Res 2015 ;37(2):223-36

Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.

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April 2016

The Circadian Clock Mutation Promotes Intestinal Dysbiosis.

Alcohol Clin Exp Res 2016 Feb;40(2):335-47

Department of Internal Medicine , Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois.

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February 2016

Alcohol induced alterations to the human fecal VOC metabolome.

PLoS One 2015 9;10(3):e0119362. Epub 2015 Mar 9.

Department of Medicine, Division of Digestive Diseases and Nutrition, Rush University Medical Center, Chicago, Illinois, United States of America; Department of Pharmacology, Rush University Medical Center, Chicago, Illinois, United States of America; Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois, United States of America; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

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January 2016

Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon.

Alcohol Clin Exp Res 2015 Oct 2;39(10):1917-29. Epub 2015 Sep 2.

Center for Sleep & Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Illinois.

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October 2015

Alcohol and the Intestine.

Biomolecules 2015 Oct 15;5(4):2573-88. Epub 2015 Oct 15.

Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA.

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October 2015

Colonic bacterial composition in Parkinson's disease.

Mov Disord 2015 Sep 16;30(10):1351-60. Epub 2015 Jul 16.

Department of Neurology, Rush University Medical Center, Chicago, Illinois, USA.

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September 2015

The Role of miR-212 and iNOS in Alcohol-Induced Intestinal Barrier Dysfunction and Steatohepatitis.

Alcohol Clin Exp Res 2015 Sep 24;39(9):1632-41. Epub 2015 Jul 24.

Division of Digestive Diseases and Nutrition, Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois.

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September 2015

Abnormal lipopolysaccharide binding protein as marker of gastrointestinal inflammation in Parkinson disease.

Front Neurosci 2015 1;9:306. Epub 2015 Sep 1.

Department of Neurological Sciences, Rush University Medical Center Chicago, IL, USA.

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September 2015

Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness.

Redox Biol 2014 19;3:40-6. Epub 2014 Oct 19.

Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush University Medical Center, Chicago, IL, USA; Department of Pharmacology, Rush University Medical Center, Chicago, IL, USA; Department of Molecular Biophysics & Physiology, Rush University Medical Center, Chicago, IL, USA; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

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August 2015

Circadian disorganization alters intestinal microbiota.

PLoS One 2014 21;9(5):e97500. Epub 2014 May 21.

Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, United States of America; Department of Pharmacology, Rush University Medical Center, Chicago, Illinois, United States of America; Department of Physiology, Rush University Medical Center, Chicago, Illinois, United States of America; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

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June 2015

Circadian rhythms, alcohol and gut interactions.

Alcohol 2015 Jun 14;49(4):389-98. Epub 2014 Nov 14.

Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush University Medical Center, Chicago, IL, USA; Department of Pharmacology, Rush University Medical Center, Chicago, IL, USA; Department of Molecular Biophysics & Physiology, Rush University Medical Center, Chicago, IL, USA; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

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June 2015

HIV-associated mucosal gene expression: region-specific alterations.

AIDS 2015 Mar;29(5):537-46

aDepartment of Internal Medicine, Division of Gastroenterology, Hepatology, and Nutrition bDepartment of Pharmacology cDepartment of Physiology, Rush University Medical Center, Chicago, Illinois dDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands eDepartment of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois, USA fDepartment of Biochemistry, Rush University Medical Center gRuth M. Rothstein CORE Center/Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois, USA.

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March 2015

Simultaneous gas-chromatographic urinary measurement of sugar probes to assess intestinal permeability: use of time course analysis to optimize its use to assess regional gut permeability.

Clin Chim Acta 2015 Mar 12;442:24-32. Epub 2015 Jan 12.

Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, IL, United States; Department of Pharmacology, Rush University, Chicago, IL, United States; Department of Molecular Biophysics and Physiology, Rush University, Chicago, IL, United States; F.C. Donders Chair, Faculty of Science, University of Utrecht, Utrecht, The Netherlands. Electronic address:

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March 2015

In vitro evaluation of intestinal epithelial TLR activation in preventing food allergic responses.

Clin Immunol 2014 Oct 21;154(2):91-9. Epub 2014 Jul 21.

Department of Immunology/Microbiology, Rush University Medical Center, Chicago, IL, USA; Division of Pharmacology, Utrecht Institute Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands.

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October 2014

The role of miRNAs in alcohol-induced endotoxemia, dysfunction of mucosal immunity, and gut leakiness.

Alcohol Clin Exp Res 2014 Sep;38(9):2331-4

Section of Gastroenterology, Division of Digestive Diseases and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.

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September 2014

The approach to sample acquisition and its impact on the derived human fecal microbiome and VOC metabolome.

PLoS One 2013 18;8(11):e81163. Epub 2013 Nov 18.

Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, United States of America.

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June 2014

Regulation of Intestinal Immune Responses through TLR Activation: Implications for Pro- and Prebiotics.

Front Immunol 2014 18;5:60. Epub 2014 Feb 18.

Department of Immunology/Microbiology, Rush University Medical Center , Chicago, IL , USA ; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University , Utrecht , Netherlands.

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June 2014

Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability.

Am J Physiol Gastrointest Liver Physiol 2013 Jul 9;305(2):G185-95. Epub 2013 May 9.

Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.

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July 2013

Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease.

PLoS One 2011 1;6(12):e28032. Epub 2011 Dec 1.

Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois, United States of America.

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May 2012

New molecular insights into inflammatory bowel disease-induced diarrhea.

Expert Rev Gastroenterol Hepatol 2011 Oct;5(5):615-25

Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA.

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October 2011

Role of snail activation in alcohol-induced iNOS-mediated disruption of intestinal epithelial cell permeability.

Alcohol Clin Exp Res 2011 Sep 27;35(9):1635-43. Epub 2011 Apr 27.

Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois 60612, USA.

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September 2011

Loss of p120 catenin upregulates transcription of pro-inflammatory adhesion molecules in human endothelial cells.

Microvasc Res 2011 Sep 30;82(2):105-12. Epub 2011 Apr 30.

Department of Pharmacology, Rush University Medical Center, Chicago, IL, USA.

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September 2011

Role of intestinal circadian genes in alcohol-induced gut leakiness.

Alcohol Clin Exp Res 2011 Jul 4;35(7):1305-14. Epub 2011 Apr 4.

Department of Medicine, Division of Digestive Diseases and Nutrition, Rush University Medical Center, 1725 W. Harrison, Chicago, IL 60612, USA.

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July 2011

Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice.

Part Fibre Toxicol 2011 Jun 9;8:19. Epub 2011 Jun 9.

Department of Medicine, Section of Gastroenterology and Nutrition Rush University Medical College, 1725 W Harrison Street, Chicago, IL 60612, USA.

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June 2011

Effects of aspirin on gastroduodenal permeability in alcoholics and controls.

Alcohol 2010 Aug 3;44(5):447-56. Epub 2010 Jul 3.

Department of Medicine, Rush University, Chicago, IL, USA.

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August 2010

Alcohol stimulates activation of Snail, epidermal growth factor receptor signaling, and biomarkers of epithelial-mesenchymal transition in colon and breast cancer cells.

Alcohol Clin Exp Res 2010 Jan 23;34(1):19-31. Epub 2009 Oct 23.

Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.

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January 2010

Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats.

Alcohol Clin Exp Res 2009 Oct 23;33(10):1836-46. Epub 2009 Jul 23.

Rush University Medical Center, Division of Digestive Diseases and Nutrition, Nutrition Rush University Medical Center, Chicago, Illinois 60612, USA.

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October 2009

Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage.

Alcohol Clin Exp Res 2009 Jul 9;33(7):1220-30. Epub 2009 Apr 9.

Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush University, Chicago, Illinois, USA.

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July 2009

Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage.

J Pharmacol Exp Ther 2009 Jun 10;329(3):952-8. Epub 2009 Mar 10.

Division of Digestive Disease and Nutrition, Department of Internal Medicine, Rush University, Chicago, IL, USA.

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June 2009

Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats.

J Hepatol 2009 Mar 29;50(3):538-47. Epub 2008 Dec 29.

Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA.

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March 2009

Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis.

Alcohol 2009 Mar;43(2):163-72

Department of Internal Medicine, Division of Digestive Diseases and Nutrition, and Rush University Medical Center, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA.

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March 2009

Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease.

Alcohol Clin Exp Res 2008 Feb 21;32(2):355-64. Epub 2007 Dec 21.

Division of Digestive Disease and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA.

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February 2008

Identification of pH-regulated antigen 1 released from Candida albicans as the major ligand for leukocyte integrin alphaMbeta2.

J Immunol 2007 Feb;178(4):2038-46

Joseph J. Jacobs Center for Thrombosis and Vascular Biology and Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA.

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February 2007

Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli.

J Gerontol A Biol Sci Med Sci 2005 Sep;60(9):1118-24

Department of Internal Medicine, Rush Medical College, Rush University Medical Center, Chicago, Illinois, USA.

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September 2005

Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway.

J Biol Chem 2003 Jul 30;278(27):24577-85. Epub 2003 Apr 30.

Department of Internal Medicine, Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.

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July 2003

Lymphocyte adhesion to Candida albicans.

Infect Immun 2002 Feb;70(2):517-27

Department of Microbiology and Immunology, Loyola University of Chicago, Maywood, Illinois 60153, USA.

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February 2002